Signal recognition particle receptor subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

signal recognition particle receptor beta subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HLX3_LEIBR

TriTrypDb:

LbrM.33.2900 , LBRM2903_330036900

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	6
GO:0016020	membrane	2	7
GO:0031090	organelle membrane	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0005785	signal recognition particle receptor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

Expansion

Sequence features

A4HLX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLX3

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045047	protein targeting to ER	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070972	protein localization to endoplasmic reticulum	6	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0017076	purine nucleotide binding	4	7
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003676	nucleic acid binding	3	1
GO:0003746	translation elongation factor activity	4	1
GO:0008135	translation factor activity, RNA binding	3	1
GO:0045182	translation regulator activity	1	1
GO:0090079	translation regulator activity, nucleic acid binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	317	321	PF00656	0.546
CLV_C14_Caspase3-7	324	328	PF00656	0.546
CLV_C14_Caspase3-7	390	394	PF00656	0.535
CLV_C14_Caspase3-7	76	80	PF00656	0.475
CLV_NRD_NRD_1	133	135	PF00675	0.757
CLV_NRD_NRD_1	226	228	PF00675	0.484
CLV_NRD_NRD_1	346	348	PF00675	0.419
CLV_NRD_NRD_1	367	369	PF00675	0.328
CLV_NRD_NRD_1	409	411	PF00675	0.577
CLV_NRD_NRD_1	416	418	PF00675	0.565
CLV_NRD_NRD_1	47	49	PF00675	0.642
CLV_PCSK_KEX2_1	133	135	PF00082	0.612
CLV_PCSK_KEX2_1	225	227	PF00082	0.490
CLV_PCSK_KEX2_1	346	348	PF00082	0.372
CLV_PCSK_KEX2_1	354	356	PF00082	0.316
CLV_PCSK_KEX2_1	367	369	PF00082	0.323
CLV_PCSK_KEX2_1	409	411	PF00082	0.584
CLV_PCSK_KEX2_1	416	418	PF00082	0.574
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.346
CLV_PCSK_SKI1_1	17	21	PF00082	0.661
CLV_PCSK_SKI1_1	242	246	PF00082	0.385
CLV_PCSK_SKI1_1	253	257	PF00082	0.238
CLV_PCSK_SKI1_1	297	301	PF00082	0.238
CLV_PCSK_SKI1_1	346	350	PF00082	0.349
CLV_PCSK_SKI1_1	367	371	PF00082	0.346
CLV_PCSK_SKI1_1	417	421	PF00082	0.577
CLV_PCSK_SKI1_1	48	52	PF00082	0.612
CLV_Separin_Metazoa	298	302	PF03568	0.438
DEG_SPOP_SBC_1	228	232	PF00917	0.619
DOC_ANK_TNKS_1	401	408	PF00023	0.665
DOC_ANK_TNKS_1	67	74	PF00023	0.462
DOC_CYCLIN_RxL_1	250	258	PF00134	0.438
DOC_CYCLIN_RxL_1	344	353	PF00134	0.546
DOC_CYCLIN_RxL_1	364	371	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	457	463	PF00134	0.620
DOC_MAPK_gen_1	225	235	PF00069	0.545
DOC_MAPK_gen_1	416	422	PF00069	0.774
DOC_MAPK_MEF2A_6	229	237	PF00069	0.552
DOC_MAPK_MEF2A_6	242	249	PF00069	0.564
DOC_PP1_RVXF_1	213	220	PF00149	0.576
DOC_PP1_RVXF_1	344	351	PF00149	0.549
DOC_PP2B_LxvP_1	30	33	PF13499	0.458
DOC_PP2B_LxvP_1	457	460	PF13499	0.630
DOC_PP2B_LxvP_1	69	72	PF13499	0.463
DOC_USP7_MATH_1	19	23	PF00917	0.400
DOC_USP7_MATH_1	445	449	PF00917	0.732
DOC_USP7_MATH_2	40	46	PF00917	0.414
DOC_WW_Pin1_4	144	149	PF00397	0.517
DOC_WW_Pin1_4	336	341	PF00397	0.546
DOC_WW_Pin1_4	67	72	PF00397	0.482
DOC_WW_Pin1_4	91	96	PF00397	0.570
LIG_14-3-3_CanoR_1	226	235	PF00244	0.549
LIG_14-3-3_CanoR_1	259	263	PF00244	0.549
LIG_14-3-3_CanoR_1	301	310	PF00244	0.466
LIG_Actin_WH2_2	428	444	PF00022	0.647
LIG_Actin_WH2_2	44	61	PF00022	0.397
LIG_APCC_ABBAyCdc20_2	417	423	PF00400	0.592
LIG_BIR_II_1	1	5	PF00653	0.531
LIG_BRCT_BRCA1_1	209	213	PF00533	0.261
LIG_BRCT_BRCA1_1	338	342	PF00533	0.546
LIG_BRCT_BRCA1_1	450	454	PF00533	0.714
LIG_deltaCOP1_diTrp_1	194	197	PF00928	0.419
LIG_EH1_1	342	350	PF00400	0.546
LIG_eIF4E_1	343	349	PF01652	0.546
LIG_FHA_1	145	151	PF00498	0.506
LIG_FHA_1	199	205	PF00498	0.513
LIG_FHA_1	228	234	PF00498	0.549
LIG_FHA_1	73	79	PF00498	0.528
LIG_FHA_2	315	321	PF00498	0.619
LIG_FHA_2	351	357	PF00498	0.546
LIG_FHA_2	478	484	PF00498	0.590
LIG_FHA_2	9	15	PF00498	0.503
LIG_GBD_Chelix_1	329	337	PF00786	0.346
LIG_HCF-1_HBM_1	474	477	PF13415	0.657
LIG_LIR_Gen_1	122	131	PF02991	0.491
LIG_LIR_Gen_1	194	203	PF02991	0.363
LIG_LIR_Gen_1	243	250	PF02991	0.594
LIG_LIR_Gen_1	451	462	PF02991	0.638
LIG_LIR_Nem_3	122	127	PF02991	0.487
LIG_LIR_Nem_3	194	198	PF02991	0.363
LIG_LIR_Nem_3	210	216	PF02991	0.233
LIG_LIR_Nem_3	243	249	PF02991	0.529
LIG_LIR_Nem_3	339	345	PF02991	0.546
LIG_LIR_Nem_3	451	457	PF02991	0.644
LIG_MAD2	285	293	PF02301	0.619
LIG_NRBOX	328	334	PF00104	0.520
LIG_SH2_SRC	206	209	PF00017	0.377
LIG_SH2_STAP1	477	481	PF00017	0.697
LIG_SH2_STAT5	144	147	PF00017	0.387
LIG_SH2_STAT5	186	189	PF00017	0.357
LIG_SH2_STAT5	206	209	PF00017	0.389
LIG_SH2_STAT5	23	26	PF00017	0.597
LIG_SH3_3	284	290	PF00018	0.546
LIG_SUMO_SIM_anti_2	478	484	PF11976	0.688
LIG_SUMO_SIM_par_1	308	315	PF11976	0.546
LIG_TRAF2_1	111	114	PF00917	0.389
LIG_TRAF2_1	41	44	PF00917	0.438
LIG_TYR_ITIM	204	209	PF00017	0.411
LIG_UBA3_1	234	242	PF00899	0.546
LIG_WRC_WIRS_1	187	192	PF05994	0.526
LIG_WRC_WIRS_1	208	213	PF05994	0.261
MOD_CK1_1	107	113	PF00069	0.419
MOD_CK1_1	129	135	PF00069	0.460
MOD_CK1_1	188	194	PF00069	0.472
MOD_CK1_1	240	246	PF00069	0.546
MOD_CK1_1	261	267	PF00069	0.592
MOD_CK1_1	377	383	PF00069	0.546
MOD_CK1_1	394	400	PF00069	0.546
MOD_CK1_1	448	454	PF00069	0.739
MOD_CK1_1	88	94	PF00069	0.573
MOD_CK2_1	129	135	PF00069	0.424
MOD_CK2_1	188	194	PF00069	0.517
MOD_CK2_1	477	483	PF00069	0.550
MOD_CK2_1	8	14	PF00069	0.502
MOD_Cter_Amidation	407	410	PF01082	0.564
MOD_Cter_Amidation	414	417	PF01082	0.566
MOD_GlcNHglycan	1	4	PF01048	0.694
MOD_GlcNHglycan	128	131	PF01048	0.759
MOD_GlcNHglycan	190	193	PF01048	0.641
MOD_GlcNHglycan	239	242	PF01048	0.346
MOD_GlcNHglycan	265	268	PF01048	0.406
MOD_GSK3_1	144	151	PF00069	0.567
MOD_GSK3_1	387	394	PF00069	0.483
MOD_GSK3_1	85	92	PF00069	0.499
MOD_N-GLC_1	107	112	PF02516	0.698
MOD_N-GLC_1	394	399	PF02516	0.238
MOD_N-GLC_1	8	13	PF02516	0.704
MOD_NEK2_1	198	203	PF00069	0.513
MOD_NEK2_1	207	212	PF00069	0.364
MOD_NEK2_1	255	260	PF00069	0.506
MOD_NEK2_1	350	355	PF00069	0.552
MOD_NEK2_1	90	95	PF00069	0.454
MOD_PIKK_1	109	115	PF00454	0.389
MOD_PK_1	134	140	PF00069	0.413
MOD_PK_1	387	393	PF00069	0.535
MOD_PKA_2	228	234	PF00069	0.552
MOD_PKA_2	258	264	PF00069	0.555
MOD_PKA_2	276	282	PF00069	0.406
MOD_PKA_2	391	397	PF00069	0.483
MOD_PKB_1	225	233	PF00069	0.648
MOD_Plk_1	148	154	PF00069	0.400
MOD_Plk_1	394	400	PF00069	0.438
MOD_Plk_1	448	454	PF00069	0.558
MOD_Plk_1	8	14	PF00069	0.502
MOD_Plk_2-3	314	320	PF00069	0.546
MOD_Plk_4	119	125	PF00069	0.489
MOD_Plk_4	171	177	PF00069	0.444
MOD_Plk_4	179	185	PF00069	0.444
MOD_Plk_4	198	204	PF00069	0.458
MOD_Plk_4	207	213	PF00069	0.364
MOD_Plk_4	229	235	PF00069	0.546
MOD_Plk_4	3	9	PF00069	0.521
MOD_Plk_4	394	400	PF00069	0.460
MOD_Plk_4	42	48	PF00069	0.409
MOD_ProDKin_1	144	150	PF00069	0.517
MOD_ProDKin_1	336	342	PF00069	0.546
MOD_ProDKin_1	67	73	PF00069	0.485
MOD_ProDKin_1	91	97	PF00069	0.567
MOD_SUMO_rev_2	468	478	PF00179	0.661
TRG_DiLeu_BaEn_1	194	199	PF01217	0.238
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.546
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.438
TRG_ENDOCYTIC_2	206	209	PF00928	0.411
TRG_ENDOCYTIC_2	438	441	PF00928	0.655
TRG_ER_diArg_1	225	227	PF00400	0.691
TRG_ER_diArg_1	345	347	PF00400	0.619
TRG_ER_diArg_1	366	368	PF00400	0.532
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.238
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2X6	Leptomonas seymouri	50%	100%
A0A3S7X750	Leishmania donovani	69%	100%
A4I9A2	Leishmania infantum	69%	100%
E9B4A2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q3S4	Leishmania major	69%	100%