Putative mitochondrial processing peptidase alpha subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial-processing peptidase subunit alpha

Species:

Leishmania braziliensis

UniProt:

A4HLX2_LEIBR

TriTrypDb:

LbrM.33.2890 , LBRM2903_330036800

Length:

483

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0017087	mitochondrial processing peptidase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HLX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLX2

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004175	endopeptidase activity	4	2
GO:0004222	metalloendopeptidase activity	5	2
GO:0005488	binding	1	11
GO:0008233	peptidase activity	3	2
GO:0008237	metallopeptidase activity	4	2
GO:0016787	hydrolase activity	2	2
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.291
CLV_NRD_NRD_1	193	195	PF00675	0.335
CLV_NRD_NRD_1	470	472	PF00675	0.278
CLV_PCSK_KEX2_1	16	18	PF00082	0.493
CLV_PCSK_KEX2_1	193	195	PF00082	0.335
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.301
CLV_PCSK_SKI1_1	149	153	PF00082	0.402
CLV_PCSK_SKI1_1	200	204	PF00082	0.259
CLV_PCSK_SKI1_1	30	34	PF00082	0.305
CLV_PCSK_SKI1_1	325	329	PF00082	0.298

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDS4	Leptomonas seymouri	77%	100%
A0A1X0NSX1	Trypanosomatidae	67%	100%
A0A3Q8IMP0	Leishmania donovani	90%	100%
A0A422N4E4	Trypanosoma rangeli	64%	100%
A4I9A1	Leishmania infantum	90%	100%
C9ZJC5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9B4A1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O04308	Arabidopsis thaliana	24%	97%
O32965	Mycobacterium leprae (strain TN)	22%	100%
O75439	Homo sapiens	22%	99%

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