Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLW9_LEIBR

TriTrypDb:

LbrM.33.2860 , LBRM2903_330036500

Length:

571

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLW9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	261	265	PF00656	0.525
CLV_C14_Caspase3-7	393	397	PF00656	0.595
CLV_NRD_NRD_1	51	53	PF00675	0.747
CLV_PCSK_KEX2_1	51	53	PF00082	0.747
CLV_PCSK_SKI1_1	214	218	PF00082	0.698
CLV_PCSK_SKI1_1	299	303	PF00082	0.523
CLV_PCSK_SKI1_1	353	357	PF00082	0.718
CLV_PCSK_SKI1_1	465	469	PF00082	0.406
CLV_PCSK_SKI1_1	538	542	PF00082	0.557
CLV_PCSK_SKI1_1	70	74	PF00082	0.644
CLV_PCSK_SKI1_1	79	83	PF00082	0.617
DEG_APCC_DBOX_1	450	458	PF00400	0.696
DEG_Nend_UBRbox_1	1	4	PF02207	0.663
DEG_SPOP_SBC_1	184	188	PF00917	0.620
DEG_SPOP_SBC_1	370	374	PF00917	0.590
DEG_SPOP_SBC_1	384	388	PF00917	0.486
DOC_ANK_TNKS_1	89	96	PF00023	0.502
DOC_CDC14_PxL_1	491	499	PF14671	0.531
DOC_CKS1_1	286	291	PF01111	0.520
DOC_PP2B_LxvP_1	489	492	PF13499	0.530
DOC_USP7_MATH_1	110	114	PF00917	0.698
DOC_USP7_MATH_1	139	143	PF00917	0.582
DOC_USP7_MATH_1	184	188	PF00917	0.691
DOC_USP7_MATH_1	235	239	PF00917	0.541
DOC_USP7_MATH_1	24	28	PF00917	0.544
DOC_USP7_MATH_1	267	271	PF00917	0.722
DOC_USP7_MATH_1	280	284	PF00917	0.646
DOC_USP7_MATH_1	358	362	PF00917	0.637
DOC_USP7_MATH_1	370	374	PF00917	0.703
DOC_USP7_MATH_1	385	389	PF00917	0.648
DOC_USP7_MATH_1	417	421	PF00917	0.758
DOC_USP7_MATH_1	562	566	PF00917	0.552
DOC_WW_Pin1_4	282	287	PF00397	0.654
DOC_WW_Pin1_4	475	480	PF00397	0.697
DOC_WW_Pin1_4	514	519	PF00397	0.521
DOC_WW_Pin1_4	9	14	PF00397	0.582
LIG_14-3-3_CanoR_1	2	9	PF00244	0.662
LIG_14-3-3_CanoR_1	221	227	PF00244	0.587
LIG_14-3-3_CanoR_1	243	248	PF00244	0.541
LIG_14-3-3_CanoR_1	306	311	PF00244	0.599
LIG_14-3-3_CanoR_1	364	369	PF00244	0.711
LIG_14-3-3_CanoR_1	561	569	PF00244	0.564
LIG_14-3-3_CanoR_1	70	77	PF00244	0.595
LIG_Actin_WH2_2	349	366	PF00022	0.493
LIG_BIR_III_4	203	207	PF00653	0.634
LIG_BIR_III_4	396	400	PF00653	0.731
LIG_BRCT_BRCA1_1	254	258	PF00533	0.770
LIG_BRCT_BRCA1_1	3	7	PF00533	0.747
LIG_BRCT_BRCA1_1	341	345	PF00533	0.709
LIG_FHA_1	147	153	PF00498	0.692
LIG_FHA_1	180	186	PF00498	0.497
LIG_FHA_1	203	209	PF00498	0.556
LIG_FHA_1	313	319	PF00498	0.485
LIG_FHA_1	32	38	PF00498	0.774
LIG_FHA_1	384	390	PF00498	0.502
LIG_FHA_1	462	468	PF00498	0.434
LIG_FHA_1	486	492	PF00498	0.525
LIG_FHA_2	466	472	PF00498	0.525
LIG_FHA_2	476	482	PF00498	0.658
LIG_LIR_Gen_1	342	352	PF02991	0.720
LIG_LIR_Nem_3	342	348	PF02991	0.720
LIG_LIR_Nem_3	372	378	PF02991	0.684
LIG_LIR_Nem_3	545	551	PF02991	0.509
LIG_MYND_1	269	273	PF01753	0.512
LIG_NBox_RRM_1	213	223	PF00076	0.465
LIG_PDZ_Class_2	566	571	PF00595	0.465
LIG_PTAP_UEV_1	491	496	PF05743	0.529
LIG_RPA_C_Fungi	154	166	PF08784	0.664
LIG_SH2_CRK	536	540	PF00017	0.446
LIG_SH2_PTP2	435	438	PF00017	0.362
LIG_SH2_STAP1	196	200	PF00017	0.527
LIG_SH2_STAP1	359	363	PF00017	0.712
LIG_SH2_STAP1	485	489	PF00017	0.524
LIG_SH2_STAP1	536	540	PF00017	0.511
LIG_SH2_STAT3	39	42	PF00017	0.511
LIG_SH2_STAT5	336	339	PF00017	0.557
LIG_SH2_STAT5	435	438	PF00017	0.362
LIG_SH2_STAT5	466	469	PF00017	0.524
LIG_SH3_2	269	274	PF14604	0.519
LIG_SH3_3	221	227	PF00018	0.719
LIG_SH3_3	266	272	PF00018	0.551
LIG_SH3_3	281	287	PF00018	0.576
LIG_SH3_3	423	429	PF00018	0.681
LIG_SH3_3	433	439	PF00018	0.597
LIG_SH3_3	489	495	PF00018	0.529
LIG_SH3_3	51	57	PF00018	0.731
LIG_SUMO_SIM_par_1	326	335	PF11976	0.439
LIG_SUMO_SIM_par_1	441	448	PF11976	0.621
LIG_SUMO_SIM_par_1	486	493	PF11976	0.526
LIG_TRAF2_1	102	105	PF00917	0.774
LIG_TRFH_1	435	439	PF08558	0.494
LIG_TYR_ITIM	433	438	PF00017	0.333
LIG_UBA3_1	530	534	PF00899	0.655
LIG_WW_3	271	275	PF00397	0.524
MOD_CDK_SPK_2	475	480	PF00069	0.483
MOD_CK1_1	112	118	PF00069	0.772
MOD_CK1_1	174	180	PF00069	0.720
MOD_CK1_1	202	208	PF00069	0.468
MOD_CK1_1	225	231	PF00069	0.590
MOD_CK1_1	285	291	PF00069	0.564
MOD_CK1_1	459	465	PF00069	0.536
MOD_CK1_1	484	490	PF00069	0.751
MOD_CK1_1	506	512	PF00069	0.737
MOD_CK2_1	465	471	PF00069	0.532
MOD_GlcNHglycan	112	115	PF01048	0.687
MOD_GlcNHglycan	119	122	PF01048	0.645
MOD_GlcNHglycan	141	144	PF01048	0.649
MOD_GlcNHglycan	20	23	PF01048	0.713
MOD_GlcNHglycan	224	227	PF01048	0.501
MOD_GlcNHglycan	237	240	PF01048	0.714
MOD_GlcNHglycan	249	252	PF01048	0.698
MOD_GlcNHglycan	299	302	PF01048	0.678
MOD_GlcNHglycan	3	6	PF01048	0.661
MOD_GlcNHglycan	419	422	PF01048	0.550
MOD_GlcNHglycan	505	508	PF01048	0.618
MOD_GlcNHglycan	564	567	PF01048	0.564
MOD_GSK3_1	105	112	PF00069	0.664
MOD_GSK3_1	113	120	PF00069	0.654
MOD_GSK3_1	179	186	PF00069	0.656
MOD_GSK3_1	222	229	PF00069	0.683
MOD_GSK3_1	243	250	PF00069	0.694
MOD_GSK3_1	293	300	PF00069	0.689
MOD_GSK3_1	456	463	PF00069	0.579
MOD_GSK3_1	481	488	PF00069	0.665
MOD_GSK3_1	59	66	PF00069	0.707
MOD_N-GLC_1	174	179	PF02516	0.717
MOD_N-GLC_1	243	248	PF02516	0.511
MOD_N-GLC_1	280	285	PF02516	0.555
MOD_N-GLC_1	408	413	PF02516	0.507
MOD_N-GLC_1	58	63	PF02516	0.504
MOD_N-GLC_2	544	546	PF02516	0.626
MOD_NEK2_1	1	6	PF00069	0.661
MOD_NEK2_1	16	21	PF00069	0.695
MOD_NEK2_1	247	252	PF00069	0.512
MOD_NEK2_1	312	317	PF00069	0.484
MOD_NEK2_1	363	368	PF00069	0.478
MOD_NEK2_1	456	461	PF00069	0.623
MOD_NEK2_1	7	12	PF00069	0.660
MOD_PIKK_1	100	106	PF00454	0.667
MOD_PIKK_1	25	31	PF00454	0.514
MOD_PIKK_1	38	44	PF00454	0.453
MOD_PKA_2	1	7	PF00069	0.661
MOD_PKA_2	363	369	PF00069	0.538
MOD_Plk_1	243	249	PF00069	0.511
MOD_Plk_1	485	491	PF00069	0.592
MOD_Plk_2-3	481	487	PF00069	0.528
MOD_Plk_4	189	195	PF00069	0.676
MOD_Plk_4	226	232	PF00069	0.503
MOD_ProDKin_1	282	288	PF00069	0.654
MOD_ProDKin_1	475	481	PF00069	0.704
MOD_ProDKin_1	514	520	PF00069	0.521
MOD_ProDKin_1	9	15	PF00069	0.582
TRG_ENDOCYTIC_2	196	199	PF00928	0.530
TRG_ENDOCYTIC_2	435	438	PF00928	0.362
TRG_ENDOCYTIC_2	536	539	PF00928	0.668
TRG_ER_diArg_1	50	52	PF00400	0.745
TRG_ER_diArg_1	558	561	PF00400	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBA9	Leptomonas seymouri	31%	96%
A0A3Q8IF25	Leishmania donovani	63%	99%
A4I998	Leishmania infantum	64%	99%
E9B498	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
Q4Q3S8	Leishmania major	63%	100%