LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HLW8_LEIBR
TriTrypDb:
LbrM.33.2850 , LBRM2903_330036400
Length:
99

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

A4HLW8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLW8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 8 10 PF00675 0.396
CLV_PCSK_KEX2_1 8 10 PF00082 0.396
DEG_SCF_FBW7_1 79 85 PF00400 0.534
DOC_CKS1_1 68 73 PF01111 0.462
DOC_CKS1_1 79 84 PF01111 0.453
DOC_WW_Pin1_4 67 72 PF00397 0.443
DOC_WW_Pin1_4 78 83 PF00397 0.466
LIG_FHA_1 28 34 PF00498 0.497
LIG_LIR_Nem_3 30 34 PF02991 0.398
LIG_LIR_Nem_3 42 47 PF02991 0.377
LIG_Pex14_2 53 57 PF04695 0.435
LIG_SH2_PTP2 46 49 PF00017 0.423
LIG_SH2_STAP1 13 17 PF00017 0.357
LIG_SH2_STAT5 46 49 PF00017 0.401
LIG_SH2_STAT5 78 81 PF00017 0.492
LIG_SH2_STAT5 84 87 PF00017 0.506
MOD_GSK3_1 78 85 PF00069 0.507
MOD_NEK2_1 27 32 PF00069 0.498
MOD_NEK2_1 34 39 PF00069 0.372
MOD_Plk_2-3 87 93 PF00069 0.579
MOD_Plk_4 20 26 PF00069 0.391
MOD_ProDKin_1 67 73 PF00069 0.439
MOD_ProDKin_1 78 84 PF00069 0.467
MOD_SUMO_for_1 53 56 PF00179 0.491
TRG_ENDOCYTIC_2 31 34 PF00928 0.394
TRG_ENDOCYTIC_2 46 49 PF00928 0.423
TRG_ER_diArg_1 7 9 PF00400 0.601

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8S3 Leptomonas seymouri 90% 100%
A0A0S4J1K9 Bodo saltans 62% 100%
A0A1X0P3U8 Trypanosomatidae 67% 93%
A0A3Q8IHP4 Leishmania donovani 95% 100%
A4I997 Leishmania infantum 95% 100%
E9B497 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4Q3S9 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS