Putative carboxypeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan MA(E) Family M32

Species:

Leishmania braziliensis

UniProt:

A4HLW4_LEIBR

TriTrypDb:

LbrM.33.2810 , LBRM2903_330035900

Length:

498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 3
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 9

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLW4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	25
GO:0006807	nitrogen compound metabolic process	2	25
GO:0008152	metabolic process	1	25
GO:0019538	protein metabolic process	3	25
GO:0043170	macromolecule metabolic process	3	25
GO:0044238	primary metabolic process	2	25
GO:0071704	organic substance metabolic process	2	25
GO:1901564	organonitrogen compound metabolic process	3	25
GO:0006518	peptide metabolic process	4	1
GO:0043603	amide metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	25
GO:0004180	carboxypeptidase activity	5	25
GO:0004181	metallocarboxypeptidase activity	6	25
GO:0008233	peptidase activity	3	25
GO:0008235	metalloexopeptidase activity	5	25
GO:0008237	metallopeptidase activity	4	25
GO:0008238	exopeptidase activity	4	25
GO:0016787	hydrolase activity	2	25
GO:0140096	catalytic activity, acting on a protein	2	25
GO:0016853	isomerase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.353
CLV_NRD_NRD_1	333	335	PF00675	0.432
CLV_NRD_NRD_1	433	435	PF00675	0.281
CLV_NRD_NRD_1	489	491	PF00675	0.271
CLV_PCSK_KEX2_1	489	491	PF00082	0.341
CLV_PCSK_SKI1_1	124	128	PF00082	0.204
CLV_PCSK_SKI1_1	185	189	PF00082	0.456
CLV_PCSK_SKI1_1	334	338	PF00082	0.269
CLV_PCSK_SKI1_1	83	87	PF00082	0.408
CLV_PCSK_SKI1_1	90	94	PF00082	0.329
DEG_APCC_DBOX_1	333	341	PF00400	0.265
DEG_Nend_UBRbox_2	1	3	PF02207	0.488
DOC_USP7_MATH_1	146	150	PF00917	0.344
DOC_USP7_MATH_1	88	92	PF00917	0.500
DOC_USP7_UBL2_3	457	461	PF12436	0.326
DOC_WW_Pin1_4	148	153	PF00397	0.361
DOC_WW_Pin1_4	228	233	PF00397	0.270
LIG_14-3-3_CanoR_1	105	113	PF00244	0.447
LIG_14-3-3_CanoR_1	244	250	PF00244	0.482
LIG_14-3-3_CanoR_1	380	389	PF00244	0.212
LIG_14-3-3_CanoR_1	51	55	PF00244	0.458
LIG_14-3-3_CanoR_1	87	95	PF00244	0.380
LIG_Actin_WH2_2	169	187	PF00022	0.278
LIG_BIR_III_4	38	42	PF00653	0.295
LIG_BRCT_BRCA1_1	199	203	PF00533	0.265
LIG_BRCT_BRCA1_1	95	99	PF00533	0.295
LIG_deltaCOP1_diTrp_1	405	413	PF00928	0.341
LIG_eIF4E_1	469	475	PF01652	0.459
LIG_FHA_1	164	170	PF00498	0.415
LIG_FHA_1	245	251	PF00498	0.493
LIG_FHA_1	279	285	PF00498	0.296
LIG_FHA_1	306	312	PF00498	0.443
LIG_FHA_1	313	319	PF00498	0.405
LIG_FHA_1	416	422	PF00498	0.313
LIG_FHA_1	446	452	PF00498	0.333
LIG_FHA_1	469	475	PF00498	0.329
LIG_FHA_1	477	483	PF00498	0.344
LIG_FHA_1	95	101	PF00498	0.232
LIG_FHA_2	117	123	PF00498	0.341
LIG_FHA_2	237	243	PF00498	0.404
LIG_FHA_2	393	399	PF00498	0.204
LIG_FHA_2	54	60	PF00498	0.453
LIG_LIR_Gen_1	151	160	PF02991	0.484
LIG_LIR_Gen_1	170	181	PF02991	0.334
LIG_LIR_Gen_1	18	28	PF02991	0.310
LIG_LIR_Gen_1	214	223	PF02991	0.265
LIG_LIR_Gen_1	297	307	PF02991	0.333
LIG_LIR_Gen_1	49	60	PF02991	0.263
LIG_LIR_Gen_1	8	17	PF02991	0.254
LIG_LIR_Nem_3	120	126	PF02991	0.310
LIG_LIR_Nem_3	151	156	PF02991	0.497
LIG_LIR_Nem_3	170	176	PF02991	0.331
LIG_LIR_Nem_3	18	23	PF02991	0.381
LIG_LIR_Nem_3	2	7	PF02991	0.315
LIG_LIR_Nem_3	214	218	PF02991	0.265
LIG_LIR_Nem_3	257	262	PF02991	0.443
LIG_LIR_Nem_3	297	302	PF02991	0.346
LIG_LIR_Nem_3	308	313	PF02991	0.362
LIG_LIR_Nem_3	412	416	PF02991	0.308
LIG_LIR_Nem_3	49	55	PF02991	0.335
LIG_LIR_Nem_3	8	14	PF02991	0.238
LIG_PCNA_yPIPBox_3	330	339	PF02747	0.229
LIG_Pex14_2	215	219	PF04695	0.352
LIG_SH2_CRK	173	177	PF00017	0.265
LIG_SH2_CRK	259	263	PF00017	0.280
LIG_SH2_PTP2	344	347	PF00017	0.352
LIG_SH2_STAP1	153	157	PF00017	0.326
LIG_SH2_STAP1	199	203	PF00017	0.344
LIG_SH2_STAP1	425	429	PF00017	0.265
LIG_SH2_STAT3	425	428	PF00017	0.265
LIG_SH2_STAT5	143	146	PF00017	0.411
LIG_SH2_STAT5	249	252	PF00017	0.455
LIG_SH2_STAT5	313	316	PF00017	0.390
LIG_SH2_STAT5	344	347	PF00017	0.387
LIG_SH2_STAT5	354	357	PF00017	0.211
LIG_SH2_STAT5	389	392	PF00017	0.295
LIG_SH2_STAT5	415	418	PF00017	0.346
LIG_SH3_3	479	485	PF00018	0.307
LIG_TRAF2_1	137	140	PF00917	0.323
LIG_UBA3_1	183	190	PF00899	0.295
LIG_UBA3_1	429	435	PF00899	0.459
LIG_WRC_WIRS_1	410	415	PF05994	0.204
MOD_CK1_1	117	123	PF00069	0.497
MOD_CK1_1	175	181	PF00069	0.254
MOD_CK1_1	192	198	PF00069	0.218
MOD_CK1_1	409	415	PF00069	0.232
MOD_CK1_1	53	59	PF00069	0.267
MOD_CK2_1	148	154	PF00069	0.298
MOD_CK2_1	192	198	PF00069	0.303
MOD_CK2_1	450	456	PF00069	0.204
MOD_CK2_1	53	59	PF00069	0.438
MOD_Cter_Amidation	100	103	PF01082	0.265
MOD_GlcNHglycan	191	194	PF01048	0.331
MOD_GlcNHglycan	70	73	PF01048	0.300
MOD_GlcNHglycan	90	93	PF01048	0.451
MOD_GSK3_1	105	112	PF00069	0.374
MOD_GSK3_1	250	257	PF00069	0.487
MOD_GSK3_1	90	97	PF00069	0.374
MOD_N-GLC_1	65	70	PF02516	0.204
MOD_NEK2_1	104	109	PF00069	0.455
MOD_NEK2_1	254	259	PF00069	0.336
MOD_NEK2_1	390	395	PF00069	0.445
MOD_NEK2_1	50	55	PF00069	0.418
MOD_PIKK_1	163	169	PF00454	0.265
MOD_PIKK_1	197	203	PF00454	0.451
MOD_PIKK_1	278	284	PF00454	0.257
MOD_PIKK_1	292	298	PF00454	0.399
MOD_PIKK_1	326	332	PF00454	0.348
MOD_PK_1	109	115	PF00069	0.295
MOD_PKA_2	104	110	PF00069	0.395
MOD_PKA_2	114	120	PF00069	0.371
MOD_PKA_2	243	249	PF00069	0.331
MOD_PKA_2	476	482	PF00069	0.411
MOD_PKA_2	50	56	PF00069	0.211
MOD_Plk_1	250	256	PF00069	0.372
MOD_Plk_2-3	450	456	PF00069	0.204
MOD_Plk_4	109	115	PF00069	0.401
MOD_Plk_4	139	145	PF00069	0.445
MOD_Plk_4	175	181	PF00069	0.347
MOD_Plk_4	192	198	PF00069	0.351
MOD_Plk_4	250	256	PF00069	0.339
MOD_Plk_4	294	300	PF00069	0.326
MOD_Plk_4	450	456	PF00069	0.320
MOD_Plk_4	6	12	PF00069	0.327
MOD_ProDKin_1	148	154	PF00069	0.361
MOD_ProDKin_1	228	234	PF00069	0.270
MOD_SUMO_for_1	34	37	PF00179	0.265
MOD_SUMO_rev_2	116	126	PF00179	0.448
MOD_SUMO_rev_2	436	442	PF00179	0.265
MOD_SUMO_rev_2	53	63	PF00179	0.295
TRG_DiLeu_BaEn_1	351	356	PF01217	0.204
TRG_DiLeu_BaEn_1	59	64	PF01217	0.265
TRG_DiLeu_BaEn_4	139	145	PF01217	0.411
TRG_ENDOCYTIC_2	153	156	PF00928	0.346
TRG_ENDOCYTIC_2	173	176	PF00928	0.361
TRG_ENDOCYTIC_2	259	262	PF00928	0.331
TRG_ENDOCYTIC_2	344	347	PF00928	0.368
TRG_ENDOCYTIC_2	389	392	PF00928	0.335
TRG_ENDOCYTIC_2	4	7	PF00928	0.365
TRG_ER_diArg_1	488	490	PF00400	0.341
TRG_ER_FFAT_2	49	59	PF00635	0.204
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.227
TRG_Pf-PMV_PEXEL_1	277	282	PF00026	0.301
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IZ28	Bodo saltans	44%	100%
A0A1X0NY67	Trypanosomatidae	52%	98%
A0A1X0P441	Trypanosomatidae	57%	99%
A0A1X0P598	Trypanosomatidae	58%	99%
A0A3Q8IBW2	Leishmania donovani	52%	99%
A0A3Q8IJY8	Leishmania donovani	46%	100%
A0A3Q8IU74	Leishmania donovani	86%	100%
A0A3S7WSA3	Leishmania donovani	55%	99%
A0A422P042	Trypanosoma rangeli	58%	99%
A0A422P4R1	Trypanosoma rangeli	53%	99%
A4H716	Leishmania braziliensis	54%	100%
A4HVE5	Leishmania infantum	55%	99%
A4HVW0	Leishmania infantum	52%	99%
A4I993	Leishmania infantum	85%	100%
A4IC85	Leishmania infantum	46%	100%
D0A656	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	99%
E9AP43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	99%
E9B493	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
P42663	Thermus aquaticus	34%	97%
P50848	Bacillus subtilis (strain 168)	34%	99%
Q4Q0D4	Leishmania major	48%	100%
Q4Q3T3	Leishmania major	84%	100%
Q4QFW7	Leishmania major	52%	100%
Q4QGE5	Leishmania major	56%	100%
Q5SLM3	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	32%	98%
Q8U3L0	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	32%	100%
V5DQA0	Trypanosoma cruzi	60%	99%