Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial SSU ribosomal protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HLW2_LEIBR

TriTrypDb:

LbrM.33.2780 , LBRM2903_330035600

Length:

678

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLW2

PDB structure(s): 7ane_l

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0043631	RNA polyadenylation	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	373	377	PF00656	0.642
CLV_C14_Caspase3-7	484	488	PF00656	0.518
CLV_NRD_NRD_1	228	230	PF00675	0.444
CLV_NRD_NRD_1	33	35	PF00675	0.485
CLV_NRD_NRD_1	389	391	PF00675	0.736
CLV_NRD_NRD_1	436	438	PF00675	0.455
CLV_NRD_NRD_1	602	604	PF00675	0.346
CLV_NRD_NRD_1	78	80	PF00675	0.404
CLV_NRD_NRD_1	85	87	PF00675	0.388
CLV_PCSK_KEX2_1	228	230	PF00082	0.444
CLV_PCSK_KEX2_1	389	391	PF00082	0.736
CLV_PCSK_KEX2_1	412	414	PF00082	0.397
CLV_PCSK_KEX2_1	436	438	PF00082	0.455
CLV_PCSK_KEX2_1	602	604	PF00082	0.346
CLV_PCSK_KEX2_1	78	80	PF00082	0.404
CLV_PCSK_KEX2_1	85	87	PF00082	0.388
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.416
CLV_PCSK_PC7_1	74	80	PF00082	0.472
CLV_PCSK_SKI1_1	146	150	PF00082	0.309
CLV_PCSK_SKI1_1	151	155	PF00082	0.313
CLV_PCSK_SKI1_1	166	170	PF00082	0.215
CLV_PCSK_SKI1_1	197	201	PF00082	0.481
CLV_PCSK_SKI1_1	486	490	PF00082	0.510
CLV_PCSK_SKI1_1	591	595	PF00082	0.473
CLV_Separin_Metazoa	265	269	PF03568	0.574
DEG_APCC_DBOX_1	165	173	PF00400	0.280
DEG_Nend_Nbox_1	1	3	PF02207	0.449
DEG_ODPH_VHL_1	417	428	PF01847	0.526
DEG_SPOP_SBC_1	361	365	PF00917	0.422
DOC_CYCLIN_RxL_1	329	338	PF00134	0.348
DOC_MAPK_gen_1	119	128	PF00069	0.355
DOC_MAPK_gen_1	545	552	PF00069	0.339
DOC_MAPK_gen_1	602	611	PF00069	0.375
DOC_MAPK_HePTP_8	105	117	PF00069	0.365
DOC_MAPK_MEF2A_6	108	117	PF00069	0.346
DOC_MAPK_MEF2A_6	545	552	PF00069	0.358
DOC_PP1_RVXF_1	330	337	PF00149	0.307
DOC_PP1_RVXF_1	507	513	PF00149	0.515
DOC_PP2B_LxvP_1	212	215	PF13499	0.426
DOC_PP2B_LxvP_1	416	419	PF13499	0.544
DOC_PP2B_PxIxI_1	112	118	PF00149	0.342
DOC_PP4_FxxP_1	255	258	PF00568	0.405
DOC_USP7_MATH_1	179	183	PF00917	0.585
DOC_USP7_MATH_1	248	252	PF00917	0.492
DOC_USP7_MATH_1	278	282	PF00917	0.494
DOC_USP7_MATH_1	293	297	PF00917	0.682
DOC_USP7_MATH_1	361	365	PF00917	0.548
DOC_USP7_MATH_1	370	374	PF00917	0.641
DOC_USP7_MATH_1	548	552	PF00917	0.460
DOC_USP7_MATH_1	630	634	PF00917	0.453
DOC_USP7_MATH_1	674	678	PF00917	0.467
DOC_USP7_MATH_1	73	77	PF00917	0.539
DOC_USP7_MATH_2	179	185	PF00917	0.517
DOC_USP7_MATH_2	559	565	PF00917	0.388
DOC_WW_Pin1_4	10	15	PF00397	0.368
DOC_WW_Pin1_4	269	274	PF00397	0.546
LIG_14-3-3_CanoR_1	157	162	PF00244	0.392
LIG_14-3-3_CanoR_1	197	205	PF00244	0.689
LIG_14-3-3_CanoR_1	277	284	PF00244	0.483
LIG_14-3-3_CanoR_1	310	316	PF00244	0.544
LIG_14-3-3_CanoR_1	360	368	PF00244	0.553
LIG_14-3-3_CanoR_1	491	495	PF00244	0.575
LIG_14-3-3_CanoR_1	643	650	PF00244	0.424
LIG_14-3-3_CanoR_1	72	78	PF00244	0.453
LIG_14-3-3_CanoR_1	9	13	PF00244	0.317
LIG_Actin_RPEL_3	115	134	PF02755	0.343
LIG_Actin_WH2_2	13	31	PF00022	0.548
LIG_APCC_ABBA_1	126	131	PF00400	0.384
LIG_APCC_ABBA_1	333	338	PF00400	0.292
LIG_APCC_ABBAyCdc20_2	332	338	PF00400	0.311
LIG_APCC_Cbox_1	617	623	PF00515	0.238
LIG_APCC_Cbox_2	617	623	PF00515	0.238
LIG_deltaCOP1_diTrp_1	135	144	PF00928	0.495
LIG_deltaCOP1_diTrp_1	472	476	PF00928	0.375
LIG_EH_1	345	349	PF12763	0.367
LIG_FHA_1	209	215	PF00498	0.480
LIG_FHA_2	204	210	PF00498	0.445
LIG_FHA_2	590	596	PF00498	0.308
LIG_GBD_Chelix_1	581	589	PF00786	0.455
LIG_LIR_Apic_2	252	258	PF02991	0.410
LIG_LIR_Apic_2	472	478	PF02991	0.355
LIG_LIR_Gen_1	217	227	PF02991	0.452
LIG_LIR_Gen_1	345	356	PF02991	0.384
LIG_LIR_Gen_1	471	481	PF02991	0.367
LIG_LIR_LC3C_4	579	583	PF02991	0.482
LIG_LIR_Nem_3	164	168	PF02991	0.400
LIG_LIR_Nem_3	18	24	PF02991	0.362
LIG_LIR_Nem_3	217	223	PF02991	0.346
LIG_LIR_Nem_3	313	318	PF02991	0.402
LIG_LIR_Nem_3	345	351	PF02991	0.395
LIG_LIR_Nem_3	38	44	PF02991	0.326
LIG_LIR_Nem_3	465	470	PF02991	0.517
LIG_LIR_Nem_3	471	476	PF02991	0.395
LIG_LIR_Nem_3	622	627	PF02991	0.370
LIG_LIR_Nem_3	645	650	PF02991	0.427
LIG_LYPXL_yS_3	315	318	PF13949	0.364
LIG_MAD2	653	661	PF02301	0.494
LIG_PCNA_PIPBox_1	264	273	PF02747	0.438
LIG_PCNA_PIPBox_1	99	108	PF02747	0.415
LIG_PCNA_yPIPBox_3	261	271	PF02747	0.531
LIG_PCNA_yPIPBox_3	323	334	PF02747	0.413
LIG_PCNA_yPIPBox_3	92	106	PF02747	0.426
LIG_SH2_CRK	150	154	PF00017	0.294
LIG_SH2_CRK	165	169	PF00017	0.327
LIG_SH2_GRB2like	475	478	PF00017	0.335
LIG_SH2_NCK_1	500	504	PF00017	0.360
LIG_SH2_NCK_1	562	566	PF00017	0.547
LIG_SH2_STAP1	669	673	PF00017	0.348
LIG_SH2_STAT3	381	384	PF00017	0.510
LIG_SH2_STAT5	16	19	PF00017	0.347
LIG_SH2_STAT5	167	170	PF00017	0.369
LIG_SH2_STAT5	220	223	PF00017	0.300
LIG_SH2_STAT5	225	228	PF00017	0.289
LIG_SH2_STAT5	231	234	PF00017	0.304
LIG_SH2_STAT5	357	360	PF00017	0.547
LIG_SH2_STAT5	475	478	PF00017	0.339
LIG_SH2_STAT5	533	536	PF00017	0.386
LIG_SH2_STAT5	627	630	PF00017	0.273
LIG_SH2_STAT5	647	650	PF00017	0.433
LIG_SH3_3	107	113	PF00018	0.340
LIG_SH3_3	306	312	PF00018	0.528
LIG_SH3_3	346	352	PF00018	0.366
LIG_SH3_3	532	538	PF00018	0.387
LIG_SH3_3	553	559	PF00018	0.381
LIG_SH3_3	59	65	PF00018	0.502
LIG_SH3_3	626	632	PF00018	0.503
LIG_SUMO_SIM_par_1	101	107	PF11976	0.359
LIG_TYR_ITIM	148	153	PF00017	0.293
MOD_CDK_SPK_2	269	274	PF00069	0.379
MOD_CK1_1	184	190	PF00069	0.661
MOD_CK1_1	203	209	PF00069	0.572
MOD_CK1_1	272	278	PF00069	0.532
MOD_CK1_1	285	291	PF00069	0.480
MOD_CK1_1	362	368	PF00069	0.527
MOD_CK1_1	404	410	PF00069	0.470
MOD_CK1_1	465	471	PF00069	0.453
MOD_CK1_1	490	496	PF00069	0.553
MOD_CK2_1	195	201	PF00069	0.769
MOD_CK2_1	203	209	PF00069	0.744
MOD_CK2_1	589	595	PF00069	0.321
MOD_GlcNHglycan	181	184	PF01048	0.722
MOD_GlcNHglycan	284	287	PF01048	0.614
MOD_GlcNHglycan	467	470	PF01048	0.466
MOD_GlcNHglycan	54	57	PF01048	0.585
MOD_GlcNHglycan	563	566	PF01048	0.486
MOD_GlcNHglycan	644	647	PF01048	0.479
MOD_GlcNHglycan	656	660	PF01048	0.445
MOD_GSK3_1	157	164	PF00069	0.363
MOD_GSK3_1	184	191	PF00069	0.720
MOD_GSK3_1	195	202	PF00069	0.680
MOD_GSK3_1	203	210	PF00069	0.702
MOD_GSK3_1	272	279	PF00069	0.557
MOD_GSK3_1	298	305	PF00069	0.663
MOD_GSK3_1	356	363	PF00069	0.454
MOD_GSK3_1	529	536	PF00069	0.478
MOD_GSK3_1	563	570	PF00069	0.513
MOD_GSK3_1	655	662	PF00069	0.424
MOD_N-GLC_1	184	189	PF02516	0.567
MOD_N-GLC_1	248	253	PF02516	0.453
MOD_NEK2_1	199	204	PF00069	0.741
MOD_NEK2_1	253	258	PF00069	0.397
MOD_NEK2_1	427	432	PF00069	0.443
MOD_NEK2_1	44	49	PF00069	0.589
MOD_NEK2_1	589	594	PF00069	0.302
MOD_NEK2_1	655	660	PF00069	0.397
MOD_NEK2_1	8	13	PF00069	0.365
MOD_NEK2_2	67	72	PF00069	0.564
MOD_NEK2_2	73	78	PF00069	0.507
MOD_PIKK_1	276	282	PF00454	0.619
MOD_PIKK_1	45	51	PF00454	0.590
MOD_PKA_2	179	185	PF00069	0.654
MOD_PKA_2	203	209	PF00069	0.661
MOD_PKA_2	276	282	PF00069	0.472
MOD_PKA_2	359	365	PF00069	0.574
MOD_PKA_2	490	496	PF00069	0.449
MOD_PKA_2	642	648	PF00069	0.404
MOD_PKA_2	73	79	PF00069	0.516
MOD_PKA_2	8	14	PF00069	0.366
MOD_PKB_1	308	316	PF00069	0.468
MOD_Plk_1	200	206	PF00069	0.510
MOD_Plk_1	208	214	PF00069	0.627
MOD_Plk_1	471	477	PF00069	0.371
MOD_Plk_4	404	410	PF00069	0.481
MOD_Plk_4	462	468	PF00069	0.411
MOD_Plk_4	529	535	PF00069	0.459
MOD_Plk_4	548	554	PF00069	0.407
MOD_Plk_4	611	617	PF00069	0.344
MOD_ProDKin_1	10	16	PF00069	0.364
MOD_ProDKin_1	269	275	PF00069	0.551
MOD_SUMO_for_1	260	263	PF00179	0.483
MOD_SUMO_rev_2	32	37	PF00179	0.421
TRG_DiLeu_BaEn_1	326	331	PF01217	0.406
TRG_DiLeu_BaEn_1	338	343	PF01217	0.422
TRG_DiLeu_BaEn_4	461	467	PF01217	0.598
TRG_DiLeu_BaEn_4	484	490	PF01217	0.400
TRG_ENDOCYTIC_2	150	153	PF00928	0.308
TRG_ENDOCYTIC_2	165	168	PF00928	0.444
TRG_ENDOCYTIC_2	220	223	PF00928	0.304
TRG_ENDOCYTIC_2	315	318	PF00928	0.364
TRG_ENDOCYTIC_2	647	650	PF00928	0.374
TRG_ER_diArg_1	227	229	PF00400	0.443
TRG_ER_diArg_1	308	311	PF00400	0.587
TRG_ER_diArg_1	388	390	PF00400	0.504
TRG_ER_diArg_1	435	437	PF00400	0.450
TRG_ER_diArg_1	601	603	PF00400	0.344
TRG_ER_diArg_1	71	74	PF00400	0.471
TRG_ER_diArg_1	77	79	PF00400	0.390
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	197	201	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	653	657	PF00026	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Z6	Leptomonas seymouri	69%	92%
A0A0S4IW89	Bodo saltans	35%	100%
A0A1X0P3U7	Trypanosomatidae	51%	93%
A0A3S7X701	Leishmania donovani	87%	100%
A0A422P030	Trypanosoma rangeli	53%	96%
D0A659	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	91%
E9AHR9	Leishmania infantum	87%	100%
E9B490	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q3T6	Leishmania major	87%	100%
V5BP67	Trypanosoma cruzi	51%	98%