Radial spoke head protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Radial spokehead-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HLW1_LEIBR

TriTrypDb:

LbrM.33.2770 , LBRM2903_330035500

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0001534	radial spoke	2	7
GO:0032991	protein-containing complex	1	7
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLW1

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	7
GO:0006996	organelle organization	4	7
GO:0007017	microtubule-based process	2	7
GO:0007018	microtubule-based movement	3	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0022607	cellular component assembly	4	7
GO:0030030	cell projection organization	4	7
GO:0030031	cell projection assembly	5	7
GO:0044782	cilium organization	5	7
GO:0060271	cilium assembly	6	7
GO:0060294	cilium movement involved in cell motility	5	7
GO:0070925	organelle assembly	5	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:0120031	plasma membrane bounded cell projection assembly	6	7
GO:0120036	plasma membrane bounded cell projection organization	5	7
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0001578	microtubule bundle formation	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0035082	axoneme assembly	5	1
GO:0044458	motile cilium assembly	7	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	197	199	PF00675	0.538
CLV_NRD_NRD_1	228	230	PF00675	0.457
CLV_NRD_NRD_1	37	39	PF00675	0.265
CLV_PCSK_KEX2_1	197	199	PF00082	0.423
CLV_PCSK_KEX2_1	228	230	PF00082	0.457
CLV_PCSK_KEX2_1	37	39	PF00082	0.253
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.253
CLV_PCSK_PC7_1	193	199	PF00082	0.442
CLV_PCSK_SKI1_1	149	153	PF00082	0.319
CLV_PCSK_SKI1_1	228	232	PF00082	0.494
CLV_PCSK_SKI1_1	241	245	PF00082	0.555
DOC_CYCLIN_RxL_1	222	234	PF00134	0.268
DOC_MAPK_gen_1	37	43	PF00069	0.513
DOC_MAPK_MEF2A_6	108	115	PF00069	0.463
DOC_MAPK_MEF2A_6	145	154	PF00069	0.299
DOC_MAPK_NFAT4_5	108	116	PF00069	0.469
DOC_USP7_MATH_1	13	17	PF00917	0.418
DOC_USP7_MATH_1	132	136	PF00917	0.563
DOC_USP7_MATH_1	256	260	PF00917	0.429
DOC_WW_Pin1_4	15	20	PF00397	0.513
LIG_14-3-3_CanoR_1	174	182	PF00244	0.413
LIG_14-3-3_CanoR_1	22	32	PF00244	0.511
LIG_14-3-3_CanoR_1	233	239	PF00244	0.429
LIG_APCC_ABBA_1	150	155	PF00400	0.296
LIG_APCC_ABBAyCdc20_2	149	155	PF00400	0.296
LIG_BRCT_BRCA1_1	86	90	PF00533	0.356
LIG_deltaCOP1_diTrp_1	105	110	PF00928	0.361
LIG_FHA_1	175	181	PF00498	0.640
LIG_FHA_1	266	272	PF00498	0.562
LIG_FHA_1	77	83	PF00498	0.395
LIG_FHA_2	71	77	PF00498	0.440
LIG_IBAR_NPY_1	225	227	PF08397	0.408
LIG_LIR_Gen_1	254	265	PF02991	0.449
LIG_LIR_Gen_1	53	60	PF02991	0.411
LIG_LIR_Gen_1	79	86	PF02991	0.286
LIG_LIR_Nem_3	105	110	PF02991	0.193
LIG_LIR_Nem_3	254	260	PF02991	0.369
LIG_LIR_Nem_3	53	57	PF02991	0.411
LIG_LIR_Nem_3	69	74	PF02991	0.294
LIG_LIR_Nem_3	79	83	PF02991	0.272
LIG_LIR_Nem_3	85	89	PF02991	0.220
LIG_Pex14_1	269	273	PF04695	0.381
LIG_Pex14_1	44	48	PF04695	0.410
LIG_Pex14_2	7	11	PF04695	0.462
LIG_Pex14_2	86	90	PF04695	0.430
LIG_SH2_CRK	227	231	PF00017	0.494
LIG_SH2_PTP2	54	57	PF00017	0.458
LIG_SH2_SRC	54	57	PF00017	0.477
LIG_SH2_STAP1	125	129	PF00017	0.350
LIG_SH2_STAP1	9	13	PF00017	0.462
LIG_SH2_STAT5	169	172	PF00017	0.359
LIG_SH2_STAT5	54	57	PF00017	0.428
LIG_SH2_STAT5	72	75	PF00017	0.388
LIG_SH3_3	126	132	PF00018	0.344
LIG_SH3_3	62	68	PF00018	0.325
LIG_SUMO_SIM_par_1	30	36	PF11976	0.462
LIG_WRC_WIRS_1	83	88	PF05994	0.436
MOD_CDK_SPxxK_3	15	22	PF00069	0.319
MOD_CK1_1	130	136	PF00069	0.565
MOD_CK1_1	234	240	PF00069	0.452
MOD_CK1_1	33	39	PF00069	0.390
MOD_CK1_1	95	101	PF00069	0.416
MOD_CK2_1	140	146	PF00069	0.339
MOD_CK2_1	15	21	PF00069	0.247
MOD_CK2_1	239	245	PF00069	0.428
MOD_CK2_1	256	262	PF00069	0.376
MOD_CK2_1	70	76	PF00069	0.367
MOD_GlcNHglycan	132	135	PF01048	0.432
MOD_GlcNHglycan	2	5	PF01048	0.340
MOD_GlcNHglycan	202	205	PF01048	0.408
MOD_GlcNHglycan	241	244	PF01048	0.411
MOD_GlcNHglycan	265	268	PF01048	0.542
MOD_GlcNHglycan	99	102	PF01048	0.483
MOD_GSK3_1	140	147	PF00069	0.350
MOD_GSK3_1	78	85	PF00069	0.412
MOD_GSK3_1	92	99	PF00069	0.354
MOD_NEK2_1	231	236	PF00069	0.546
MOD_NEK2_1	239	244	PF00069	0.560
MOD_NEK2_1	25	30	PF00069	0.255
MOD_NEK2_1	82	87	PF00069	0.407
MOD_PKA_2	127	133	PF00069	0.522
MOD_PKA_2	173	179	PF00069	0.432
MOD_PKA_2	234	240	PF00069	0.528
MOD_Plk_2-3	140	146	PF00069	0.419
MOD_Plk_4	234	240	PF00069	0.476
MOD_Plk_4	85	91	PF00069	0.381
MOD_ProDKin_1	15	21	PF00069	0.390
MOD_SUMO_for_1	170	173	PF00179	0.518
MOD_SUMO_rev_2	100	110	PF00179	0.491
TRG_DiLeu_BaEn_3	105	111	PF01217	0.226
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.520
TRG_DiLeu_BaLyEn_6	248	253	PF01217	0.478
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.262
TRG_ENDOCYTIC_2	218	221	PF00928	0.297
TRG_ENDOCYTIC_2	227	230	PF00928	0.346
TRG_ENDOCYTIC_2	54	57	PF00928	0.271
TRG_ENDOCYTIC_2	71	74	PF00928	0.374
TRG_ENDOCYTIC_2	9	12	PF00928	0.437
TRG_ER_diArg_1	196	198	PF00400	0.528
TRG_ER_diArg_1	227	229	PF00400	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E1	Leptomonas seymouri	71%	86%
A0A0S4IRW1	Bodo saltans	33%	100%
A0A1X0P3V0	Trypanosomatidae	44%	92%
A0A3Q8IKD9	Leishmania donovani	85%	86%
A0A422P0B0	Trypanosoma rangeli	45%	92%
A4H541	Leishmania braziliensis	22%	100%
D0A660	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	92%
E9AHR8	Leishmania infantum	85%	86%
E9ALB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B489	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	86%
Q2KIU7	Bos taurus	25%	99%
Q4Q3T7	Leishmania major	85%	100%
Q5TYW6	Danio rerio	29%	99%
Q6DFN5	Xenopus tropicalis	29%	99%
Q9D9V4	Mus musculus	26%	99%
Q9H1X1	Homo sapiens	26%	99%
V5B8M6	Trypanosoma cruzi	44%	92%