Putative recombinase rad51

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

recombinase rad51, putative

Species:

Leishmania braziliensis

UniProt:

A4HLW0_LEIBR

TriTrypDb:

LbrM.33.2760 , LBRM2903_330035400

Length:

684

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005657	replication fork	2	1
GO:0032991	protein-containing complex	1	1
GO:0033061	DNA recombinase mediator complex	2	1
GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex	3	1
GO:0033065	Rad51C-XRCC3 complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HLW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLW0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006281	DNA repair	5	7
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:0000707	meiotic DNA recombinase assembly	4	1
GO:0000730	DNA recombinase assembly	7	1
GO:0006310	DNA recombination	5	1
GO:0007131	reciprocal meiotic recombination	3	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0022607	cellular component assembly	4	1
GO:0035825	homologous recombination	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0061982	meiosis I cell cycle process	3	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065004	protein-DNA complex assembly	6	1
GO:0071824	protein-DNA complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090735	DNA repair complex assembly	6	1
GO:0140527	reciprocal homologous recombination	7	1
GO:1903046	meiotic cell cycle process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0008094	ATP-dependent activity, acting on DNA	2	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140097	catalytic activity, acting on DNA	3	8
GO:0140299	small molecule sensor activity	1	8
GO:0140612	DNA damage sensor activity	2	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:0140657	ATP-dependent activity	1	8
GO:0140664	ATP-dependent DNA damage sensor activity	3	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	64	68	PF00656	0.787
CLV_NRD_NRD_1	107	109	PF00675	0.684
CLV_NRD_NRD_1	332	334	PF00675	0.660
CLV_NRD_NRD_1	649	651	PF00675	0.448
CLV_NRD_NRD_1	664	666	PF00675	0.399
CLV_NRD_NRD_1	72	74	PF00675	0.735
CLV_PCSK_KEX2_1	334	336	PF00082	0.694
CLV_PCSK_KEX2_1	649	651	PF00082	0.443
CLV_PCSK_KEX2_1	72	74	PF00082	0.834
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.694
CLV_PCSK_SKI1_1	303	307	PF00082	0.467
CLV_PCSK_SKI1_1	436	440	PF00082	0.484
CLV_PCSK_SKI1_1	504	508	PF00082	0.274
CLV_PCSK_SKI1_1	586	590	PF00082	0.261
CLV_PCSK_SKI1_1	640	644	PF00082	0.449
CLV_PCSK_SKI1_1	72	76	PF00082	0.591
DEG_APCC_DBOX_1	103	111	PF00400	0.491
DEG_SPOP_SBC_1	161	165	PF00917	0.580
DEG_SPOP_SBC_1	414	418	PF00917	0.518
DOC_CKS1_1	76	81	PF01111	0.548
DOC_CYCLIN_RxL_1	501	511	PF00134	0.534
DOC_MAPK_gen_1	17	26	PF00069	0.366
DOC_MAPK_MEF2A_6	253	262	PF00069	0.461
DOC_PP1_RVXF_1	301	308	PF00149	0.308
DOC_PP1_RVXF_1	502	508	PF00149	0.492
DOC_USP7_MATH_1	102	106	PF00917	0.574
DOC_USP7_MATH_1	111	115	PF00917	0.480
DOC_USP7_MATH_1	161	165	PF00917	0.593
DOC_USP7_MATH_1	189	193	PF00917	0.541
DOC_USP7_MATH_1	297	301	PF00917	0.446
DOC_USP7_MATH_1	414	418	PF00917	0.776
DOC_USP7_MATH_1	446	450	PF00917	0.375
DOC_USP7_MATH_1	552	556	PF00917	0.564
DOC_USP7_MATH_1	597	601	PF00917	0.527
DOC_USP7_MATH_1	679	683	PF00917	0.567
DOC_USP7_MATH_2	169	175	PF00917	0.553
DOC_WW_Pin1_4	162	167	PF00397	0.576
DOC_WW_Pin1_4	169	174	PF00397	0.549
DOC_WW_Pin1_4	335	340	PF00397	0.608
DOC_WW_Pin1_4	356	361	PF00397	0.534
DOC_WW_Pin1_4	486	491	PF00397	0.571
DOC_WW_Pin1_4	604	609	PF00397	0.512
DOC_WW_Pin1_4	75	80	PF00397	0.596
LIG_14-3-3_CanoR_1	104	108	PF00244	0.571
LIG_14-3-3_CanoR_1	155	160	PF00244	0.548
LIG_14-3-3_CanoR_1	175	181	PF00244	0.507
LIG_14-3-3_CanoR_1	309	313	PF00244	0.424
LIG_14-3-3_CanoR_1	379	387	PF00244	0.495
LIG_14-3-3_CanoR_1	432	436	PF00244	0.555
LIG_14-3-3_CanoR_1	586	592	PF00244	0.424
LIG_14-3-3_CanoR_1	625	631	PF00244	0.471
LIG_14-3-3_CanoR_1	672	678	PF00244	0.475
LIG_Actin_WH2_2	523	538	PF00022	0.404
LIG_Actin_WH2_2	615	633	PF00022	0.460
LIG_BIR_II_1	1	5	PF00653	0.551
LIG_BRCT_BRCA1_1	449	453	PF00533	0.486
LIG_BRCT_BRCA1_1	669	673	PF00533	0.461
LIG_DLG_GKlike_1	155	162	PF00625	0.552
LIG_FHA_1	192	198	PF00498	0.461
LIG_FHA_1	252	258	PF00498	0.512
LIG_FHA_1	294	300	PF00498	0.547
LIG_FHA_1	357	363	PF00498	0.604
LIG_FHA_1	517	523	PF00498	0.512
LIG_FHA_1	530	536	PF00498	0.420
LIG_FHA_1	583	589	PF00498	0.461
LIG_FHA_1	608	614	PF00498	0.473
LIG_FHA_2	118	124	PF00498	0.535
LIG_FHA_2	200	206	PF00498	0.451
LIG_FHA_2	509	515	PF00498	0.512
LIG_FHA_2	532	538	PF00498	0.413
LIG_FHA_2	76	82	PF00498	0.594
LIG_LIR_Gen_1	114	124	PF02991	0.721
LIG_LIR_Gen_1	205	215	PF02991	0.360
LIG_LIR_Gen_1	600	608	PF02991	0.404
LIG_LIR_Nem_3	114	119	PF02991	0.736
LIG_LIR_Nem_3	157	162	PF02991	0.555
LIG_LIR_Nem_3	205	210	PF02991	0.354
LIG_LIR_Nem_3	590	594	PF02991	0.512
LIG_LIR_Nem_3	600	604	PF02991	0.442
LIG_MAD2	640	648	PF02301	0.481
LIG_MYND_1	339	343	PF01753	0.570
LIG_NRBOX	382	388	PF00104	0.379
LIG_PCNA_yPIPBox_3	631	642	PF02747	0.441
LIG_Rb_LxCxE_1	1	20	PF01857	0.546
LIG_SH2_CRK	159	163	PF00017	0.561
LIG_SH2_CRK	391	395	PF00017	0.296
LIG_SH2_CRK	594	598	PF00017	0.512
LIG_SH2_NCK_1	207	211	PF00017	0.361
LIG_SH2_NCK_1	391	395	PF00017	0.301
LIG_SH2_PTP2	377	380	PF00017	0.405
LIG_SH2_SRC	207	210	PF00017	0.358
LIG_SH2_SRC	594	597	PF00017	0.404
LIG_SH2_STAP1	620	624	PF00017	0.461
LIG_SH2_STAT5	25	28	PF00017	0.490
LIG_SH2_STAT5	377	380	PF00017	0.385
LIG_SH2_STAT5	475	478	PF00017	0.520
LIG_SH3_1	337	343	PF00018	0.607
LIG_SH3_1	73	79	PF00018	0.569
LIG_SH3_2	170	175	PF14604	0.555
LIG_SH3_3	163	169	PF00018	0.696
LIG_SH3_3	316	322	PF00018	0.608
LIG_SH3_3	337	343	PF00018	0.747
LIG_SH3_3	567	573	PF00018	0.505
LIG_SH3_3	599	605	PF00018	0.506
LIG_SH3_3	73	79	PF00018	0.626
LIG_SUMO_SIM_anti_2	27	35	PF11976	0.534
LIG_SUMO_SIM_par_1	27	35	PF11976	0.534
LIG_SUMO_SIM_par_1	436	442	PF11976	0.327
LIG_TYR_ITIM	375	380	PF00017	0.417
LIG_WRC_WIRS_1	222	227	PF05994	0.504
LIG_WRC_WIRS_1	588	593	PF05994	0.512
LIG_WRC_WIRS_1	598	603	PF05994	0.442
LIG_WW_3	165	169	PF00397	0.698
LIG_WW_3	69	73	PF00397	0.565
MOD_CDC14_SPxK_1	165	168	PF00782	0.571
MOD_CDC14_SPxK_1	172	175	PF00782	0.553
MOD_CDC14_SPxK_1	489	492	PF00782	0.550
MOD_CDK_SPxK_1	162	168	PF00069	0.575
MOD_CDK_SPxK_1	169	175	PF00069	0.552
MOD_CDK_SPxK_1	486	492	PF00069	0.564
MOD_CDK_SPxxK_3	75	82	PF00069	0.552
MOD_CK1_1	174	180	PF00069	0.693
MOD_CK1_1	308	314	PF00069	0.420
MOD_CK1_1	349	355	PF00069	0.721
MOD_CK1_1	392	398	PF00069	0.447
MOD_CK1_1	417	423	PF00069	0.717
MOD_CK1_1	426	432	PF00069	0.625
MOD_CK1_1	607	613	PF00069	0.494
MOD_CK1_1	629	635	PF00069	0.658
MOD_CK1_1	9	15	PF00069	0.524
MOD_CK2_1	117	123	PF00069	0.534
MOD_CK2_1	199	205	PF00069	0.493
MOD_CK2_1	392	398	PF00069	0.531
MOD_CK2_1	508	514	PF00069	0.512
MOD_CK2_1	544	550	PF00069	0.509
MOD_CK2_1	75	81	PF00069	0.555
MOD_GlcNHglycan	11	14	PF01048	0.383
MOD_GlcNHglycan	113	116	PF01048	0.445
MOD_GlcNHglycan	150	153	PF01048	0.789
MOD_GlcNHglycan	178	181	PF01048	0.783
MOD_GlcNHglycan	244	248	PF01048	0.314
MOD_GlcNHglycan	424	428	PF01048	0.541
MOD_GlcNHglycan	467	470	PF01048	0.668
MOD_GlcNHglycan	546	549	PF01048	0.345
MOD_GlcNHglycan	55	58	PF01048	0.580
MOD_GlcNHglycan	554	557	PF01048	0.381
MOD_GlcNHglycan	644	647	PF01048	0.579
MOD_GlcNHglycan	95	98	PF01048	0.552
MOD_GSK3_1	139	146	PF00069	0.550
MOD_GSK3_1	176	183	PF00069	0.688
MOD_GSK3_1	187	194	PF00069	0.576
MOD_GSK3_1	217	224	PF00069	0.329
MOD_GSK3_1	293	300	PF00069	0.594
MOD_GSK3_1	301	308	PF00069	0.420
MOD_GSK3_1	342	349	PF00069	0.788
MOD_GSK3_1	352	359	PF00069	0.800
MOD_GSK3_1	4	11	PF00069	0.545
MOD_GSK3_1	409	416	PF00069	0.762
MOD_GSK3_1	524	531	PF00069	0.504
MOD_GSK3_1	577	584	PF00069	0.404
MOD_GSK3_1	603	610	PF00069	0.597
MOD_GSK3_1	61	68	PF00069	0.539
MOD_GSK3_1	673	680	PF00069	0.496
MOD_GSK3_1	98	105	PF00069	0.780
MOD_N-GLC_1	117	122	PF02516	0.603
MOD_N-GLC_1	544	549	PF02516	0.310
MOD_NEK2_1	176	181	PF00069	0.551
MOD_NEK2_1	260	265	PF00069	0.569
MOD_NEK2_1	301	306	PF00069	0.304
MOD_NEK2_1	307	312	PF00069	0.378
MOD_NEK2_1	32	37	PF00069	0.581
MOD_NEK2_1	389	394	PF00069	0.435
MOD_NEK2_1	439	444	PF00069	0.397
MOD_NEK2_1	458	463	PF00069	0.651
MOD_NEK2_1	473	478	PF00069	0.629
MOD_NEK2_1	507	512	PF00069	0.512
MOD_NEK2_1	587	592	PF00069	0.517
MOD_NEK2_1	642	647	PF00069	0.504
MOD_NEK2_1	654	659	PF00069	0.360
MOD_NEK2_1	673	678	PF00069	0.661
MOD_NEK2_1	98	103	PF00069	0.743
MOD_NEK2_2	199	204	PF00069	0.515
MOD_PIKK_1	251	257	PF00454	0.461
MOD_PIKK_1	667	673	PF00454	0.672
MOD_PK_1	143	149	PF00069	0.531
MOD_PKA_1	143	149	PF00069	0.531
MOD_PKA_2	154	160	PF00069	0.616
MOD_PKA_2	174	180	PF00069	0.518
MOD_PKA_2	308	314	PF00069	0.420
MOD_PKA_2	378	384	PF00069	0.432
MOD_PKA_2	431	437	PF00069	0.326
MOD_PKA_2	447	453	PF00069	0.435
MOD_PKA_2	459	465	PF00069	0.618
MOD_PKA_2	98	104	PF00069	0.626
MOD_Plk_1	364	370	PF00069	0.486
MOD_Plk_2-3	364	370	PF00069	0.404
MOD_Plk_2-3	399	405	PF00069	0.366
MOD_Plk_4	132	138	PF00069	0.505
MOD_Plk_4	282	288	PF00069	0.461
MOD_Plk_4	297	303	PF00069	0.360
MOD_Plk_4	367	373	PF00069	0.526
MOD_Plk_4	392	398	PF00069	0.493
MOD_Plk_4	47	53	PF00069	0.507
MOD_Plk_4	481	487	PF00069	0.553
MOD_Plk_4	508	514	PF00069	0.512
MOD_Plk_4	597	603	PF00069	0.471
MOD_ProDKin_1	162	168	PF00069	0.575
MOD_ProDKin_1	169	175	PF00069	0.552
MOD_ProDKin_1	335	341	PF00069	0.608
MOD_ProDKin_1	356	362	PF00069	0.520
MOD_ProDKin_1	486	492	PF00069	0.564
MOD_ProDKin_1	604	610	PF00069	0.512
MOD_ProDKin_1	75	81	PF00069	0.596
MOD_SUMO_rev_2	398	408	PF00179	0.533
TRG_DiLeu_BaEn_1	651	656	PF01217	0.301
TRG_DiLeu_BaLyEn_6	489	494	PF01217	0.645
TRG_DiLeu_BaLyEn_6	501	506	PF01217	0.439
TRG_DiLeu_BaLyEn_6	583	588	PF01217	0.461
TRG_ENDOCYTIC_2	159	162	PF00928	0.562
TRG_ENDOCYTIC_2	207	210	PF00928	0.358
TRG_ENDOCYTIC_2	377	380	PF00928	0.384
TRG_ER_diArg_1	502	505	PF00400	0.485
TRG_ER_diArg_1	648	650	PF00400	0.443
TRG_ER_diArg_1	71	73	PF00400	0.728
TRG_NLS_MonoExtC_3	332	337	PF00514	0.742
TRG_NLS_MonoExtN_4	333	338	PF00514	0.725
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	504	508	PF00026	0.347
TRG_Pf-PMV_PEXEL_1	72	77	PF00026	0.693

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGS3	Leishmania donovani	68%	100%
D0A661	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AHR7	Leishmania infantum	69%	100%
E9B488	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4Q3T8	Leishmania major	67%	100%
V5BTS0	Trypanosoma cruzi	34%	100%