Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLV9_LEIBR

TriTrypDb:

LbrM.33.2750 , LBRM2903_330035300

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLV9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.618
CLV_NRD_NRD_1	172	174	PF00675	0.530
CLV_NRD_NRD_1	29	31	PF00675	0.569
CLV_NRD_NRD_1	437	439	PF00675	0.512
CLV_NRD_NRD_1	484	486	PF00675	0.547
CLV_PCSK_KEX2_1	172	174	PF00082	0.471
CLV_PCSK_KEX2_1	29	31	PF00082	0.476
CLV_PCSK_KEX2_1	437	439	PF00082	0.512
CLV_PCSK_KEX2_1	483	485	PF00082	0.571
CLV_PCSK_SKI1_1	100	104	PF00082	0.475
CLV_PCSK_SKI1_1	14	18	PF00082	0.555
CLV_PCSK_SKI1_1	339	343	PF00082	0.508
CLV_PCSK_SKI1_1	582	586	PF00082	0.725
DEG_APCC_DBOX_1	456	464	PF00400	0.651
DEG_SPOP_SBC_1	515	519	PF00917	0.518
DEG_SPOP_SBC_1	69	73	PF00917	0.535
DOC_CYCLIN_yCln2_LP_2	388	394	PF00134	0.524
DOC_MAPK_gen_1	38	46	PF00069	0.423
DOC_MAPK_RevD_3	472	485	PF00069	0.430
DOC_PP1_RVXF_1	337	344	PF00149	0.640
DOC_PP2B_LxvP_1	388	391	PF13499	0.515
DOC_USP7_MATH_1	135	139	PF00917	0.716
DOC_USP7_MATH_1	155	159	PF00917	0.656
DOC_USP7_MATH_1	160	164	PF00917	0.604
DOC_USP7_MATH_1	251	255	PF00917	0.536
DOC_USP7_MATH_1	371	375	PF00917	0.658
DOC_USP7_MATH_1	409	413	PF00917	0.392
DOC_USP7_MATH_1	456	460	PF00917	0.710
DOC_USP7_MATH_1	515	519	PF00917	0.732
DOC_WW_Pin1_4	270	275	PF00397	0.650
DOC_WW_Pin1_4	324	329	PF00397	0.682
DOC_WW_Pin1_4	529	534	PF00397	0.520
DOC_WW_Pin1_4	545	550	PF00397	0.428
DOC_WW_Pin1_4	7	12	PF00397	0.573
LIG_14-3-3_CanoR_1	41	45	PF00244	0.485
LIG_14-3-3_CanoR_1	457	461	PF00244	0.628
LIG_14-3-3_CanoR_1	483	491	PF00244	0.595
LIG_14-3-3_CanoR_1	94	102	PF00244	0.506
LIG_BRCT_BRCA1_1	177	181	PF00533	0.556
LIG_EH1_1	471	479	PF00400	0.342
LIG_EVH1_1	574	578	PF00568	0.721
LIG_FAT_LD_1	92	100	PF03623	0.341
LIG_FHA_1	149	155	PF00498	0.644
LIG_FHA_1	183	189	PF00498	0.339
LIG_FHA_1	207	213	PF00498	0.465
LIG_FHA_1	231	237	PF00498	0.497
LIG_FHA_1	31	37	PF00498	0.585
LIG_FHA_1	316	322	PF00498	0.580
LIG_FHA_1	359	365	PF00498	0.465
LIG_FHA_1	41	47	PF00498	0.529
LIG_FHA_1	412	418	PF00498	0.566
LIG_FHA_1	546	552	PF00498	0.690
LIG_FHA_1	553	559	PF00498	0.548
LIG_FHA_1	86	92	PF00498	0.400
LIG_GBD_Chelix_1	415	423	PF00786	0.332
LIG_GBD_Chelix_1	91	99	PF00786	0.343
LIG_LIR_Apic_2	573	577	PF02991	0.620
LIG_LIR_Gen_1	178	188	PF02991	0.489
LIG_LIR_Gen_1	266	275	PF02991	0.511
LIG_LIR_Gen_1	426	436	PF02991	0.500
LIG_LIR_Gen_1	49	55	PF02991	0.605
LIG_LIR_Nem_3	178	184	PF02991	0.476
LIG_LIR_Nem_3	266	271	PF02991	0.516
LIG_LIR_Nem_3	426	432	PF02991	0.501
LIG_LIR_Nem_3	49	53	PF02991	0.493
LIG_LIR_Nem_3	55	60	PF02991	0.524
LIG_NRBOX	431	437	PF00104	0.369
LIG_NRBOX	472	478	PF00104	0.497
LIG_PCNA_PIPBox_1	466	475	PF02747	0.601
LIG_PCNA_yPIPBox_3	466	475	PF02747	0.601
LIG_PDZ_Class_2	581	586	PF00595	0.463
LIG_Pex14_1	177	181	PF04695	0.556
LIG_Pex14_2	203	207	PF04695	0.585
LIG_SH2_CRK	246	250	PF00017	0.446
LIG_SH2_CRK	351	355	PF00017	0.381
LIG_SH2_NCK_1	246	250	PF00017	0.591
LIG_SH2_SRC	234	237	PF00017	0.495
LIG_SH2_STAP1	246	250	PF00017	0.497
LIG_SH2_STAP1	310	314	PF00017	0.522
LIG_SH2_STAP1	32	36	PF00017	0.590
LIG_SH2_STAP1	351	355	PF00017	0.506
LIG_SH2_STAT5	164	167	PF00017	0.518
LIG_SH2_STAT5	32	35	PF00017	0.589
LIG_SH2_STAT5	64	67	PF00017	0.626
LIG_SH3_3	119	125	PF00018	0.717
LIG_SH3_3	128	134	PF00018	0.584
LIG_SH3_3	209	215	PF00018	0.453
LIG_SH3_3	401	407	PF00018	0.551
LIG_SH3_3	494	500	PF00018	0.671
LIG_SH3_3	572	578	PF00018	0.728
LIG_SUMO_SIM_anti_2	187	192	PF11976	0.513
LIG_SUMO_SIM_anti_2	414	420	PF11976	0.332
LIG_SUMO_SIM_par_1	118	123	PF11976	0.465
LIG_SUMO_SIM_par_1	361	369	PF11976	0.574
LIG_TRAF2_1	2	5	PF00917	0.595
LIG_TRAF2_1	376	379	PF00917	0.711
LIG_TYR_ITIM	244	249	PF00017	0.697
LIG_TYR_ITIM	349	354	PF00017	0.362
LIG_UBA3_1	95	103	PF00899	0.370
LIG_WW_2	131	134	PF00397	0.497
LIG_WW_3	402	406	PF00397	0.521
MOD_CDK_SPxxK_3	324	331	PF00069	0.533
MOD_CDK_SPxxK_3	7	14	PF00069	0.573
MOD_CK1_1	111	117	PF00069	0.629
MOD_CK1_1	123	129	PF00069	0.611
MOD_CK1_1	254	260	PF00069	0.558
MOD_CK1_1	459	465	PF00069	0.581
MOD_GlcNHglycan	113	116	PF01048	0.549
MOD_GlcNHglycan	127	131	PF01048	0.605
MOD_GlcNHglycan	191	194	PF01048	0.549
MOD_GlcNHglycan	253	256	PF01048	0.503
MOD_GlcNHglycan	258	261	PF01048	0.520
MOD_GlcNHglycan	351	354	PF01048	0.513
MOD_GlcNHglycan	411	414	PF01048	0.374
MOD_GlcNHglycan	511	514	PF01048	0.681
MOD_GSK3_1	111	118	PF00069	0.438
MOD_GSK3_1	189	196	PF00069	0.515
MOD_GSK3_1	254	261	PF00069	0.527
MOD_GSK3_1	30	37	PF00069	0.574
MOD_GSK3_1	455	462	PF00069	0.632
MOD_GSK3_1	5	12	PF00069	0.590
MOD_GSK3_1	529	536	PF00069	0.719
MOD_GSK3_1	543	550	PF00069	0.639
MOD_GSK3_1	94	101	PF00069	0.591
MOD_LATS_1	66	72	PF00433	0.670
MOD_NEK2_1	120	125	PF00069	0.490
MOD_NEK2_1	191	196	PF00069	0.514
MOD_NEK2_1	229	234	PF00069	0.663
MOD_NEK2_1	245	250	PF00069	0.519
MOD_NEK2_1	292	297	PF00069	0.620
MOD_NEK2_1	329	334	PF00069	0.636
MOD_NEK2_1	349	354	PF00069	0.476
MOD_NEK2_1	552	557	PF00069	0.559
MOD_NEK2_1	562	567	PF00069	0.495
MOD_NEK2_1	60	65	PF00069	0.362
MOD_NEK2_2	308	313	PF00069	0.541
MOD_PIKK_1	14	20	PF00454	0.547
MOD_PIKK_1	94	100	PF00454	0.492
MOD_PKA_1	484	490	PF00069	0.503
MOD_PKA_2	111	117	PF00069	0.525
MOD_PKA_2	40	46	PF00069	0.478
MOD_PKA_2	456	462	PF00069	0.572
MOD_PKA_2	484	490	PF00069	0.503
MOD_PKA_2	495	501	PF00069	0.580
MOD_Plk_1	22	28	PF00069	0.466
MOD_Plk_4	115	121	PF00069	0.418
MOD_Plk_4	160	166	PF00069	0.601
MOD_Plk_4	23	29	PF00069	0.452
MOD_Plk_4	411	417	PF00069	0.500
MOD_Plk_4	547	553	PF00069	0.454
MOD_ProDKin_1	270	276	PF00069	0.649
MOD_ProDKin_1	324	330	PF00069	0.680
MOD_ProDKin_1	529	535	PF00069	0.521
MOD_ProDKin_1	545	551	PF00069	0.418
MOD_ProDKin_1	7	13	PF00069	0.572
MOD_SUMO_for_1	102	105	PF00179	0.472
MOD_SUMO_rev_2	512	518	PF00179	0.524
TRG_DiLeu_BaLyEn_6	240	245	PF01217	0.463
TRG_DiLeu_BaLyEn_6	360	365	PF01217	0.530
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.497
TRG_ENDOCYTIC_2	246	249	PF00928	0.532
TRG_ENDOCYTIC_2	351	354	PF00928	0.495
TRG_ER_diArg_1	172	174	PF00400	0.471
TRG_ER_diArg_1	28	30	PF00400	0.561
TRG_ER_diArg_1	436	438	PF00400	0.425
TRG_ER_diArg_1	482	485	PF00400	0.564
TRG_ER_diArg_1	520	523	PF00400	0.776
TRG_NES_CRM1_1	187	200	PF08389	0.587
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8S0	Leptomonas seymouri	35%	99%
A0A3S7X715	Leishmania donovani	62%	100%
E9AHR6	Leishmania infantum	62%	100%
E9B487	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
Q4Q3T9	Leishmania major	63%	99%