Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 12

Species:

Leishmania braziliensis

UniProt:

A4HLV7_LEIBR

TriTrypDb:

LbrM.33.2730 , LBRM2903_330035100

Length:

1044

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLV7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.516
CLV_C14_Caspase3-7	196	200	PF00656	0.465
CLV_C14_Caspase3-7	278	282	PF00656	0.485
CLV_C14_Caspase3-7	654	658	PF00656	0.586
CLV_C14_Caspase3-7	676	680	PF00656	0.558
CLV_C14_Caspase3-7	700	704	PF00656	0.543
CLV_C14_Caspase3-7	765	769	PF00656	0.379
CLV_NRD_NRD_1	1021	1023	PF00675	0.522
CLV_NRD_NRD_1	211	213	PF00675	0.541
CLV_NRD_NRD_1	607	609	PF00675	0.514
CLV_NRD_NRD_1	784	786	PF00675	0.385
CLV_PCSK_KEX2_1	1021	1023	PF00082	0.522
CLV_PCSK_KEX2_1	210	212	PF00082	0.546
CLV_PCSK_KEX2_1	416	418	PF00082	0.537
CLV_PCSK_KEX2_1	609	611	PF00082	0.439
CLV_PCSK_KEX2_1	784	786	PF00082	0.385
CLV_PCSK_KEX2_1	850	852	PF00082	0.468
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.537
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.405
CLV_PCSK_PC1ET2_1	850	852	PF00082	0.468
CLV_PCSK_SKI1_1	147	151	PF00082	0.389
CLV_PCSK_SKI1_1	40	44	PF00082	0.598
CLV_PCSK_SKI1_1	529	533	PF00082	0.507
CLV_PCSK_SKI1_1	593	597	PF00082	0.490
CLV_PCSK_SKI1_1	609	613	PF00082	0.332
CLV_PCSK_SKI1_1	784	788	PF00082	0.465
CLV_PCSK_SKI1_1	796	800	PF00082	0.548
CLV_Separin_Metazoa	447	451	PF03568	0.487
DEG_APCC_DBOX_1	209	217	PF00400	0.602
DEG_APCC_DBOX_1	574	582	PF00400	0.314
DEG_APCC_DBOX_1	783	791	PF00400	0.373
DEG_SPOP_SBC_1	280	284	PF00917	0.493
DOC_ANK_TNKS_1	416	423	PF00023	0.416
DOC_MAPK_DCC_7	221	229	PF00069	0.570
DOC_MAPK_DCC_7	833	841	PF00069	0.484
DOC_MAPK_gen_1	362	370	PF00069	0.379
DOC_MAPK_gen_1	850	858	PF00069	0.458
DOC_MAPK_MEF2A_6	221	229	PF00069	0.570
DOC_MAPK_MEF2A_6	833	841	PF00069	0.507
DOC_PP2B_LxvP_1	482	485	PF13499	0.497
DOC_PP2B_PxIxI_1	224	230	PF00149	0.554
DOC_PP4_FxxP_1	441	444	PF00568	0.647
DOC_PP4_FxxP_1	965	968	PF00568	0.479
DOC_PP4_FxxP_1	990	993	PF00568	0.516
DOC_USP7_MATH_1	1034	1038	PF00917	0.683
DOC_USP7_MATH_1	231	235	PF00917	0.494
DOC_USP7_MATH_1	459	463	PF00917	0.508
DOC_USP7_MATH_1	494	498	PF00917	0.658
DOC_USP7_MATH_1	638	642	PF00917	0.537
DOC_USP7_MATH_1	689	693	PF00917	0.533
DOC_USP7_MATH_1	732	736	PF00917	0.654
DOC_USP7_MATH_1	747	751	PF00917	0.639
DOC_USP7_MATH_1	753	757	PF00917	0.600
DOC_USP7_MATH_1	764	768	PF00917	0.480
DOC_USP7_MATH_1	996	1000	PF00917	0.580
DOC_WW_Pin1_4	1030	1035	PF00397	0.661
DOC_WW_Pin1_4	112	117	PF00397	0.519
DOC_WW_Pin1_4	518	523	PF00397	0.746
DOC_WW_Pin1_4	58	63	PF00397	0.483
DOC_WW_Pin1_4	757	762	PF00397	0.498
DOC_WW_Pin1_4	894	899	PF00397	0.374
DOC_WW_Pin1_4	920	925	PF00397	0.537
DOC_WW_Pin1_4	932	937	PF00397	0.664
DOC_WW_Pin1_4	964	969	PF00397	0.467
DOC_WW_Pin1_4	994	999	PF00397	0.627
LIG_14-3-3_CanoR_1	147	157	PF00244	0.423
LIG_14-3-3_CanoR_1	211	217	PF00244	0.524
LIG_14-3-3_CanoR_1	437	444	PF00244	0.517
LIG_14-3-3_CanoR_1	567	576	PF00244	0.426
LIG_14-3-3_CanoR_1	614	622	PF00244	0.352
LIG_14-3-3_CanoR_1	640	648	PF00244	0.403
LIG_14-3-3_CanoR_1	805	813	PF00244	0.458
LIG_14-3-3_CanoR_1	976	981	PF00244	0.604
LIG_Actin_WH2_2	251	268	PF00022	0.388
LIG_Actin_WH2_2	7	23	PF00022	0.454
LIG_BIR_III_2	768	772	PF00653	0.549
LIG_BRCT_BRCA1_1	216	220	PF00533	0.682
LIG_BRCT_BRCA1_1	474	478	PF00533	0.514
LIG_BRCT_BRCA1_1	491	495	PF00533	0.467
LIG_BRCT_BRCA1_1	978	982	PF00533	0.500
LIG_CaM_IQ_9	623	638	PF13499	0.351
LIG_Clathr_ClatBox_1	790	794	PF01394	0.446
LIG_deltaCOP1_diTrp_1	134	144	PF00928	0.376
LIG_eIF4E_1	576	582	PF01652	0.315
LIG_FHA_1	1021	1027	PF00498	0.697
LIG_FHA_1	260	266	PF00498	0.528
LIG_FHA_1	271	277	PF00498	0.611
LIG_FHA_1	316	322	PF00498	0.486
LIG_FHA_1	5	11	PF00498	0.493
LIG_FHA_1	53	59	PF00498	0.457
LIG_FHA_1	569	575	PF00498	0.578
LIG_FHA_1	617	623	PF00498	0.320
LIG_FHA_1	664	670	PF00498	0.574
LIG_FHA_1	705	711	PF00498	0.663
LIG_FHA_1	732	738	PF00498	0.382
LIG_FHA_1	864	870	PF00498	0.653
LIG_FHA_1	895	901	PF00498	0.571
LIG_FHA_2	129	135	PF00498	0.326
LIG_FHA_2	167	173	PF00498	0.470
LIG_FHA_2	176	182	PF00498	0.529
LIG_FHA_2	236	242	PF00498	0.513
LIG_FHA_2	340	346	PF00498	0.401
LIG_FHA_2	41	47	PF00498	0.474
LIG_FHA_2	530	536	PF00498	0.511
LIG_FHA_2	555	561	PF00498	0.503
LIG_FHA_2	698	704	PF00498	0.563
LIG_FHA_2	763	769	PF00498	0.414
LIG_FHA_2	897	903	PF00498	0.500
LIG_FHA_2	907	913	PF00498	0.461
LIG_Integrin_RGD_1	112	114	PF01839	0.447
LIG_LIR_Apic_2	439	444	PF02991	0.621
LIG_LIR_Apic_2	741	747	PF02991	0.326
LIG_LIR_Apic_2	75	79	PF02991	0.523
LIG_LIR_Gen_1	131	139	PF02991	0.358
LIG_LIR_Gen_1	396	404	PF02991	0.449
LIG_LIR_Gen_1	738	747	PF02991	0.327
LIG_LIR_Gen_1	878	886	PF02991	0.272
LIG_LIR_Nem_3	131	135	PF02991	0.415
LIG_LIR_Nem_3	396	401	PF02991	0.387
LIG_LIR_Nem_3	492	498	PF02991	0.576
LIG_LIR_Nem_3	61	67	PF02991	0.389
LIG_LIR_Nem_3	679	685	PF02991	0.477
LIG_LIR_Nem_3	776	780	PF02991	0.333
LIG_LIR_Nem_3	867	873	PF02991	0.581
LIG_LIR_Nem_3	878	882	PF02991	0.322
LIG_LRP6_Inhibitor_1	338	344	PF00058	0.342
LIG_LYPXL_yS_3	64	67	PF13949	0.335
LIG_MAD2	660	668	PF02301	0.572
LIG_NRBOX	577	583	PF00104	0.320
LIG_NRP_CendR_1	1043	1044	PF00754	0.715
LIG_PCNA_yPIPBox_3	333	346	PF02747	0.555
LIG_Pex14_3	387	392	PF04695	0.297
LIG_PTB_Apo_2	535	542	PF02174	0.456
LIG_PTB_Phospho_1	535	541	PF10480	0.452
LIG_SH2_CRK	371	375	PF00017	0.369
LIG_SH2_CRK	541	545	PF00017	0.456
LIG_SH2_CRK	576	580	PF00017	0.454
LIG_SH2_CRK	744	748	PF00017	0.489
LIG_SH2_NCK_1	132	136	PF00017	0.436
LIG_SH2_PTP2	76	79	PF00017	0.579
LIG_SH2_SRC	132	135	PF00017	0.438
LIG_SH2_SRC	722	725	PF00017	0.455
LIG_SH2_SRC	76	79	PF00017	0.579
LIG_SH2_SRC	873	876	PF00017	0.541
LIG_SH2_STAP1	132	136	PF00017	0.398
LIG_SH2_STAP1	395	399	PF00017	0.444
LIG_SH2_STAP1	541	545	PF00017	0.593
LIG_SH2_STAP1	870	874	PF00017	0.573
LIG_SH2_STAT3	243	246	PF00017	0.483
LIG_SH2_STAT5	166	169	PF00017	0.467
LIG_SH2_STAT5	236	239	PF00017	0.438
LIG_SH2_STAT5	28	31	PF00017	0.579
LIG_SH2_STAT5	576	579	PF00017	0.357
LIG_SH2_STAT5	722	725	PF00017	0.407
LIG_SH2_STAT5	76	79	PF00017	0.579
LIG_SH2_STAT5	819	822	PF00017	0.473
LIG_SH3_1	76	82	PF00018	0.578
LIG_SH3_3	519	525	PF00018	0.685
LIG_SH3_3	59	65	PF00018	0.422
LIG_SH3_3	647	653	PF00018	0.544
LIG_SH3_3	662	668	PF00018	0.566
LIG_SH3_3	74	80	PF00018	0.528
LIG_SH3_3	859	865	PF00018	0.599
LIG_Sin3_3	540	547	PF02671	0.399
LIG_SUMO_SIM_anti_2	193	201	PF11976	0.377
LIG_SUMO_SIM_anti_2	309	318	PF11976	0.575
LIG_SUMO_SIM_anti_2	55	61	PF11976	0.409
LIG_SUMO_SIM_par_1	410	415	PF11976	0.328
LIG_TRAF2_1	178	181	PF00917	0.532
LIG_TRAF2_1	238	241	PF00917	0.439
LIG_TRAF2_1	444	447	PF00917	0.483
LIG_TRAF2_1	597	600	PF00917	0.491
LIG_TYR_ITIM	574	579	PF00017	0.412
LIG_UBA3_1	410	416	PF00899	0.489
LIG_UBA3_1	602	609	PF00899	0.328
LIG_WW_1	73	76	PF00397	0.572
MOD_CDK_SPK_2	920	925	PF00069	0.537
MOD_CDK_SPxxK_3	964	971	PF00069	0.469
MOD_CK1_1	270	276	PF00069	0.512
MOD_CK1_1	294	300	PF00069	0.527
MOD_CK1_1	311	317	PF00069	0.548
MOD_CK1_1	376	382	PF00069	0.455
MOD_CK1_1	415	421	PF00069	0.526
MOD_CK1_1	467	473	PF00069	0.575
MOD_CK1_1	555	561	PF00069	0.500
MOD_CK1_1	688	694	PF00069	0.511
MOD_CK1_1	735	741	PF00069	0.574
MOD_CK1_1	807	813	PF00069	0.488
MOD_CK1_1	878	884	PF00069	0.294
MOD_CK1_1	997	1003	PF00069	0.611
MOD_CK2_1	128	134	PF00069	0.340
MOD_CK2_1	175	181	PF00069	0.481
MOD_CK2_1	235	241	PF00069	0.459
MOD_CK2_1	339	345	PF00069	0.373
MOD_CK2_1	353	359	PF00069	0.564
MOD_CK2_1	40	46	PF00069	0.486
MOD_CK2_1	467	473	PF00069	0.519
MOD_CK2_1	554	560	PF00069	0.664
MOD_CK2_1	594	600	PF00069	0.549
MOD_CK2_1	639	645	PF00069	0.599
MOD_CK2_1	753	759	PF00069	0.448
MOD_CK2_1	906	912	PF00069	0.454
MOD_CK2_1	975	981	PF00069	0.535
MOD_Cter_Amidation	1019	1022	PF01082	0.520
MOD_GlcNHglycan	1009	1012	PF01048	0.523
MOD_GlcNHglycan	1036	1039	PF01048	0.662
MOD_GlcNHglycan	117	120	PF01048	0.502
MOD_GlcNHglycan	269	272	PF01048	0.584
MOD_GlcNHglycan	277	280	PF01048	0.544
MOD_GlcNHglycan	293	296	PF01048	0.542
MOD_GlcNHglycan	301	304	PF01048	0.535
MOD_GlcNHglycan	310	313	PF01048	0.544
MOD_GlcNHglycan	329	332	PF01048	0.358
MOD_GlcNHglycan	355	358	PF01048	0.587
MOD_GlcNHglycan	417	420	PF01048	0.609
MOD_GlcNHglycan	469	472	PF01048	0.546
MOD_GlcNHglycan	491	494	PF01048	0.654
MOD_GlcNHglycan	554	557	PF01048	0.538
MOD_GlcNHglycan	585	589	PF01048	0.503
MOD_GlcNHglycan	596	599	PF01048	0.429
MOD_GlcNHglycan	642	645	PF01048	0.370
MOD_GlcNHglycan	686	690	PF01048	0.557
MOD_GlcNHglycan	691	694	PF01048	0.527
MOD_GlcNHglycan	715	718	PF01048	0.579
MOD_GlcNHglycan	734	737	PF01048	0.507
MOD_GlcNHglycan	749	752	PF01048	0.440
MOD_GlcNHglycan	808	812	PF01048	0.337
MOD_GlcNHglycan	994	997	PF01048	0.556
MOD_GSK3_1	1003	1010	PF00069	0.612
MOD_GSK3_1	1028	1035	PF00069	0.647
MOD_GSK3_1	148	155	PF00069	0.419
MOD_GSK3_1	193	200	PF00069	0.519
MOD_GSK3_1	227	234	PF00069	0.583
MOD_GSK3_1	275	282	PF00069	0.608
MOD_GSK3_1	286	293	PF00069	0.597
MOD_GSK3_1	311	318	PF00069	0.586
MOD_GSK3_1	54	61	PF00069	0.586
MOD_GSK3_1	610	617	PF00069	0.560
MOD_GSK3_1	685	692	PF00069	0.423
MOD_GSK3_1	731	738	PF00069	0.626
MOD_GSK3_1	753	760	PF00069	0.605
MOD_GSK3_1	928	935	PF00069	0.587
MOD_GSK3_1	941	948	PF00069	0.665
MOD_GSK3_1	992	999	PF00069	0.681
MOD_N-GLC_1	128	133	PF02516	0.311
MOD_N-GLC_1	249	254	PF02516	0.479
MOD_N-GLC_1	259	264	PF02516	0.498
MOD_N-GLC_1	467	472	PF02516	0.521
MOD_N-GLC_1	489	494	PF02516	0.502
MOD_N-GLC_1	552	557	PF02516	0.528
MOD_N-GLC_1	825	830	PF02516	0.545
MOD_N-GLC_1	928	933	PF02516	0.589
MOD_NEK2_1	1007	1012	PF00069	0.697
MOD_NEK2_1	117	122	PF00069	0.510
MOD_NEK2_1	150	155	PF00069	0.466
MOD_NEK2_1	259	264	PF00069	0.452
MOD_NEK2_1	299	304	PF00069	0.546
MOD_NEK2_1	339	344	PF00069	0.388
MOD_NEK2_1	353	358	PF00069	0.588
MOD_NEK2_1	489	494	PF00069	0.529
MOD_NEK2_1	615	620	PF00069	0.552
MOD_NEK2_1	697	702	PF00069	0.464
MOD_NEK2_2	231	236	PF00069	0.497
MOD_PIKK_1	117	123	PF00454	0.486
MOD_PIKK_1	4	10	PF00454	0.551
MOD_PIKK_1	997	1003	PF00454	0.687
MOD_PK_1	212	218	PF00069	0.565
MOD_PK_1	631	637	PF00069	0.371
MOD_PK_1	673	679	PF00069	0.356
MOD_PK_1	945	951	PF00069	0.624
MOD_PKA_2	1007	1013	PF00069	0.658
MOD_PKA_2	1020	1026	PF00069	0.672
MOD_PKA_2	436	442	PF00069	0.680
MOD_PKA_2	574	580	PF00069	0.326
MOD_PKA_2	615	621	PF00069	0.421
MOD_PKA_2	639	645	PF00069	0.524
MOD_PKA_2	747	753	PF00069	0.493
MOD_PKA_2	804	810	PF00069	0.454
MOD_PKA_2	863	869	PF00069	0.624
MOD_PKA_2	950	956	PF00069	0.588
MOD_PKA_2	975	981	PF00069	0.447
MOD_PKB_1	210	218	PF00069	0.506
MOD_PKB_1	608	616	PF00069	0.374
MOD_Plk_1	1013	1019	PF00069	0.513
MOD_Plk_1	128	134	PF00069	0.394
MOD_Plk_1	137	143	PF00069	0.380
MOD_Plk_1	259	265	PF00069	0.503
MOD_Plk_1	376	382	PF00069	0.455
MOD_Plk_1	40	46	PF00069	0.564
MOD_Plk_1	807	813	PF00069	0.580
MOD_Plk_1	825	831	PF00069	0.419
MOD_Plk_2-3	193	199	PF00069	0.312
MOD_Plk_4	1000	1006	PF00069	0.672
MOD_Plk_4	193	199	PF00069	0.490
MOD_Plk_4	259	265	PF00069	0.511
MOD_Plk_4	311	317	PF00069	0.549
MOD_Plk_4	376	382	PF00069	0.492
MOD_Plk_4	394	400	PF00069	0.431
MOD_Plk_4	54	60	PF00069	0.557
MOD_Plk_4	574	580	PF00069	0.406
MOD_Plk_4	673	679	PF00069	0.586
MOD_Plk_4	72	78	PF00069	0.468
MOD_Plk_4	735	741	PF00069	0.342
MOD_Plk_4	826	832	PF00069	0.493
MOD_Plk_4	906	912	PF00069	0.467
MOD_Plk_4	950	956	PF00069	0.545
MOD_ProDKin_1	1030	1036	PF00069	0.658
MOD_ProDKin_1	112	118	PF00069	0.509
MOD_ProDKin_1	518	524	PF00069	0.744
MOD_ProDKin_1	58	64	PF00069	0.482
MOD_ProDKin_1	757	763	PF00069	0.488
MOD_ProDKin_1	894	900	PF00069	0.365
MOD_ProDKin_1	920	926	PF00069	0.537
MOD_ProDKin_1	932	938	PF00069	0.667
MOD_ProDKin_1	964	970	PF00069	0.463
MOD_ProDKin_1	994	1000	PF00069	0.626
MOD_SUMO_rev_2	165	175	PF00179	0.367
MOD_SUMO_rev_2	234	244	PF00179	0.489
MOD_SUMO_rev_2	26	34	PF00179	0.591
MOD_SUMO_rev_2	848	856	PF00179	0.413
TRG_DiLeu_BaEn_1	253	258	PF01217	0.490
TRG_DiLeu_BaEn_1	794	799	PF01217	0.469
TRG_DiLeu_BaLyEn_6	965	970	PF01217	0.455
TRG_ENDOCYTIC_2	132	135	PF00928	0.426
TRG_ENDOCYTIC_2	146	149	PF00928	0.493
TRG_ENDOCYTIC_2	245	248	PF00928	0.423
TRG_ENDOCYTIC_2	371	374	PF00928	0.363
TRG_ENDOCYTIC_2	452	455	PF00928	0.516
TRG_ENDOCYTIC_2	541	544	PF00928	0.441
TRG_ENDOCYTIC_2	576	579	PF00928	0.475
TRG_ENDOCYTIC_2	64	67	PF00928	0.335
TRG_ENDOCYTIC_2	819	822	PF00928	0.461
TRG_ER_diArg_1	210	212	PF00400	0.497
TRG_NES_CRM1_1	377	390	PF08389	0.398
TRG_Pf-PMV_PEXEL_1	95	100	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9F7	Leptomonas seymouri	54%	100%
A0A3S5H7V1	Leishmania donovani	71%	99%
D0A666	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	97%
E9AHR4	Leishmania infantum	71%	99%
E9B485	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	99%
Q4Q3U1	Leishmania major	71%	100%