Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLV4_LEIBR

TriTrypDb:

LbrM.33.2700 , LBRM2903_330034800

Length:

650

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLV4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.581
CLV_C14_Caspase3-7	625	629	PF00656	0.332
CLV_NRD_NRD_1	207	209	PF00675	0.482
CLV_NRD_NRD_1	216	218	PF00675	0.363
CLV_NRD_NRD_1	279	281	PF00675	0.430
CLV_NRD_NRD_1	537	539	PF00675	0.487
CLV_NRD_NRD_1	541	543	PF00675	0.468
CLV_NRD_NRD_1	544	546	PF00675	0.482
CLV_NRD_NRD_1	575	577	PF00675	0.508
CLV_NRD_NRD_1	99	101	PF00675	0.541
CLV_PCSK_FUR_1	277	281	PF00082	0.483
CLV_PCSK_FUR_1	535	539	PF00082	0.521
CLV_PCSK_FUR_1	542	546	PF00082	0.530
CLV_PCSK_KEX2_1	216	218	PF00082	0.329
CLV_PCSK_KEX2_1	279	281	PF00082	0.459
CLV_PCSK_KEX2_1	537	539	PF00082	0.492
CLV_PCSK_KEX2_1	541	543	PF00082	0.475
CLV_PCSK_KEX2_1	544	546	PF00082	0.490
CLV_PCSK_KEX2_1	575	577	PF00082	0.508
CLV_PCSK_KEX2_1	99	101	PF00082	0.541
CLV_PCSK_PC7_1	537	543	PF00082	0.591
CLV_PCSK_SKI1_1	197	201	PF00082	0.507
CLV_PCSK_SKI1_1	209	213	PF00082	0.336
CLV_PCSK_SKI1_1	280	284	PF00082	0.435
CLV_PCSK_SKI1_1	375	379	PF00082	0.667
CLV_PCSK_SKI1_1	455	459	PF00082	0.453
CLV_PCSK_SKI1_1	537	541	PF00082	0.511
CLV_PCSK_SKI1_1	67	71	PF00082	0.418
DEG_APCC_DBOX_1	279	287	PF00400	0.453
DEG_APCC_DBOX_1	536	544	PF00400	0.591
DEG_Nend_Nbox_1	1	3	PF02207	0.378
DOC_CDC14_PxL_1	518	526	PF14671	0.450
DOC_CKS1_1	16	21	PF01111	0.416
DOC_CYCLIN_RxL_1	450	461	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	409	415	PF00134	0.392
DOC_MAPK_gen_1	99	107	PF00069	0.452
DOC_MAPK_MEF2A_6	21	29	PF00069	0.326
DOC_MAPK_MEF2A_6	519	526	PF00069	0.334
DOC_MAPK_MEF2A_6	638	647	PF00069	0.361
DOC_MAPK_MEF2A_6	99	107	PF00069	0.452
DOC_MAPK_NFAT4_5	100	108	PF00069	0.509
DOC_PP1_RVXF_1	207	214	PF00149	0.423
DOC_PP1_SILK_1	286	291	PF00149	0.475
DOC_PP2B_LxvP_1	25	28	PF13499	0.323
DOC_PP2B_LxvP_1	409	412	PF13499	0.372
DOC_PP2B_LxvP_1	643	646	PF13499	0.383
DOC_USP7_MATH_1	508	512	PF00917	0.476
DOC_USP7_MATH_1	559	563	PF00917	0.643
DOC_USP7_UBL2_3	67	71	PF12436	0.291
DOC_WW_Pin1_4	15	20	PF00397	0.389
DOC_WW_Pin1_4	259	264	PF00397	0.441
DOC_WW_Pin1_4	29	34	PF00397	0.388
DOC_WW_Pin1_4	383	388	PF00397	0.742
DOC_WW_Pin1_4	477	482	PF00397	0.697
DOC_WW_Pin1_4	82	87	PF00397	0.644
LIG_14-3-3_CanoR_1	148	156	PF00244	0.583
LIG_14-3-3_CanoR_1	182	192	PF00244	0.547
LIG_14-3-3_CanoR_1	280	289	PF00244	0.487
LIG_14-3-3_CanoR_1	462	467	PF00244	0.605
LIG_14-3-3_CanoR_1	473	481	PF00244	0.747
LIG_Actin_WH2_2	459	475	PF00022	0.444
LIG_APCC_ABBA_1	515	520	PF00400	0.536
LIG_APCC_ABBAyCdc20_2	305	311	PF00400	0.511
LIG_BRCT_BRCA1_1	31	35	PF00533	0.497
LIG_BRCT_BRCA1_1	416	420	PF00533	0.458
LIG_BRCT_BRCA1_1	439	443	PF00533	0.401
LIG_BRCT_BRCA1_1	509	513	PF00533	0.467
LIG_BRCT_BRCA1_2	439	445	PF00533	0.421
LIG_Clathr_ClatBox_1	255	259	PF01394	0.334
LIG_DLG_GKlike_1	563	570	PF00625	0.561
LIG_eIF4E_1	331	337	PF01652	0.522
LIG_FHA_1	107	113	PF00498	0.269
LIG_FHA_1	126	132	PF00498	0.325
LIG_FHA_1	142	148	PF00498	0.553
LIG_FHA_1	151	157	PF00498	0.507
LIG_FHA_1	178	184	PF00498	0.494
LIG_FHA_1	201	207	PF00498	0.291
LIG_FHA_1	239	245	PF00498	0.514
LIG_FHA_1	51	57	PF00498	0.493
LIG_FHA_1	544	550	PF00498	0.531
LIG_FHA_2	172	178	PF00498	0.493
LIG_FHA_2	184	190	PF00498	0.349
LIG_FHA_2	380	386	PF00498	0.740
LIG_FHA_2	50	56	PF00498	0.393
LIG_FHA_2	620	626	PF00498	0.526
LIG_FHA_2	634	640	PF00498	0.483
LIG_FHA_2	70	76	PF00498	0.491
LIG_FXI_DFP_1	337	341	PF00024	0.301
LIG_GBD_Chelix_1	403	411	PF00786	0.436
LIG_KLC1_Yacidic_2	189	194	PF13176	0.494
LIG_LIR_Gen_1	215	226	PF02991	0.484
LIG_LIR_Gen_1	230	237	PF02991	0.494
LIG_LIR_Gen_1	440	448	PF02991	0.486
LIG_LIR_Gen_1	520	529	PF02991	0.464
LIG_LIR_Gen_1	566	574	PF02991	0.560
LIG_LIR_LC3C_4	203	207	PF02991	0.303
LIG_LIR_Nem_3	189	195	PF02991	0.378
LIG_LIR_Nem_3	230	236	PF02991	0.449
LIG_LIR_Nem_3	3	8	PF02991	0.472
LIG_LIR_Nem_3	32	38	PF02991	0.428
LIG_LIR_Nem_3	414	419	PF02991	0.357
LIG_LIR_Nem_3	516	521	PF02991	0.445
LIG_LIR_Nem_3	566	570	PF02991	0.557
LIG_LIR_Nem_3	583	589	PF02991	0.315
LIG_LIR_Nem_3	72	76	PF02991	0.555
LIG_MLH1_MIPbox_1	416	420	PF16413	0.458
LIG_NRBOX	358	364	PF00104	0.476
LIG_NRBOX	453	459	PF00104	0.512
LIG_NRBOX	602	608	PF00104	0.494
LIG_PCNA_PIPBox_1	185	194	PF02747	0.279
LIG_PCNA_yPIPBox_3	182	192	PF02747	0.288
LIG_Pex14_1	271	275	PF04695	0.385
LIG_Pex14_2	416	420	PF04695	0.385
LIG_PTB_Apo_2	585	592	PF02174	0.467
LIG_PTB_Phospho_1	585	591	PF10480	0.474
LIG_SH2_CRK	233	237	PF00017	0.278
LIG_SH2_CRK	499	503	PF00017	0.507
LIG_SH2_CRK	63	67	PF00017	0.330
LIG_SH2_GRB2like	76	79	PF00017	0.360
LIG_SH2_SRC	170	173	PF00017	0.314
LIG_SH2_SRC	26	29	PF00017	0.513
LIG_SH2_SRC	293	296	PF00017	0.527
LIG_SH2_STAP1	127	131	PF00017	0.453
LIG_SH2_STAP1	567	571	PF00017	0.599
LIG_SH2_STAT3	331	334	PF00017	0.496
LIG_SH2_STAT5	108	111	PF00017	0.389
LIG_SH2_STAT5	127	130	PF00017	0.264
LIG_SH2_STAT5	170	173	PF00017	0.436
LIG_SH2_STAT5	192	195	PF00017	0.415
LIG_SH2_STAT5	228	231	PF00017	0.368
LIG_SH2_STAT5	26	29	PF00017	0.421
LIG_SH2_STAT5	275	278	PF00017	0.454
LIG_SH2_STAT5	293	296	PF00017	0.443
LIG_SH2_STAT5	331	334	PF00017	0.277
LIG_SH2_STAT5	419	422	PF00017	0.446
LIG_SH2_STAT5	456	459	PF00017	0.397
LIG_SH2_STAT5	591	594	PF00017	0.407
LIG_SH2_STAT5	76	79	PF00017	0.512
LIG_SH3_3	13	19	PF00018	0.329
LIG_SH3_3	260	266	PF00018	0.608
LIG_SH3_3	381	387	PF00018	0.776
LIG_SH3_3	553	559	PF00018	0.593
LIG_SH3_3	59	65	PF00018	0.398
LIG_SH3_3	91	97	PF00018	0.432
LIG_SUMO_SIM_par_1	103	109	PF11976	0.375
LIG_SUMO_SIM_par_1	117	126	PF11976	0.413
LIG_SUMO_SIM_par_1	152	157	PF11976	0.349
LIG_SUMO_SIM_par_1	241	248	PF11976	0.592
LIG_SUMO_SIM_par_1	254	259	PF11976	0.394
LIG_SUMO_SIM_par_1	265	270	PF11976	0.315
LIG_SUMO_SIM_par_1	411	417	PF11976	0.278
LIG_TRAF2_1	72	75	PF00917	0.445
LIG_TYR_ITIM	226	231	PF00017	0.481
LIG_UBA3_1	642	649	PF00899	0.394
LIG_WRC_WIRS_1	355	360	PF05994	0.414
LIG_WW_3	96	100	PF00397	0.576
MOD_CDK_SPxK_1	15	21	PF00069	0.406
MOD_CDK_SPxK_1	82	88	PF00069	0.438
MOD_CK1_1	106	112	PF00069	0.367
MOD_CK1_1	150	156	PF00069	0.561
MOD_CK1_1	248	254	PF00069	0.355
MOD_CK1_1	366	372	PF00069	0.483
MOD_CK1_1	391	397	PF00069	0.672
MOD_CK1_1	414	420	PF00069	0.515
MOD_CK1_1	449	455	PF00069	0.447
MOD_CK1_1	479	485	PF00069	0.587
MOD_CK2_1	183	189	PF00069	0.452
MOD_CK2_1	240	246	PF00069	0.445
MOD_CK2_1	379	385	PF00069	0.700
MOD_CK2_1	419	425	PF00069	0.417
MOD_CK2_1	508	514	PF00069	0.474
MOD_CK2_1	563	569	PF00069	0.619
MOD_CK2_1	619	625	PF00069	0.564
MOD_CK2_1	69	75	PF00069	0.494
MOD_Cter_Amidation	302	305	PF01082	0.471
MOD_GlcNHglycan	128	131	PF01048	0.530
MOD_GlcNHglycan	200	203	PF01048	0.544
MOD_GlcNHglycan	43	46	PF01048	0.411
MOD_GlcNHglycan	576	579	PF01048	0.540
MOD_GSK3_1	11	18	PF00069	0.374
MOD_GSK3_1	183	190	PF00069	0.503
MOD_GSK3_1	271	278	PF00069	0.430
MOD_GSK3_1	379	386	PF00069	0.686
MOD_GSK3_1	437	444	PF00069	0.448
MOD_GSK3_1	471	478	PF00069	0.629
MOD_GSK3_1	480	487	PF00069	0.532
MOD_GSK3_1	559	566	PF00069	0.600
MOD_GSK3_1	570	577	PF00069	0.559
MOD_GSK3_1	82	89	PF00069	0.626
MOD_N-GLC_1	239	244	PF02516	0.500
MOD_N-GLC_2	47	49	PF02516	0.348
MOD_NEK2_1	103	108	PF00069	0.349
MOD_NEK2_1	11	16	PF00069	0.358
MOD_NEK2_1	141	146	PF00069	0.578
MOD_NEK2_1	183	188	PF00069	0.330
MOD_NEK2_1	245	250	PF00069	0.638
MOD_NEK2_1	389	394	PF00069	0.532
MOD_NEK2_1	446	451	PF00069	0.356
MOD_NEK2_1	513	518	PF00069	0.417
MOD_NEK2_1	543	548	PF00069	0.558
MOD_NEK2_1	570	575	PF00069	0.559
MOD_NEK2_1	69	74	PF00069	0.477
MOD_PIKK_1	183	189	PF00454	0.288
MOD_PIKK_1	27	33	PF00454	0.412
MOD_PIKK_1	310	316	PF00454	0.735
MOD_PIKK_1	527	533	PF00454	0.547
MOD_PIKK_1	543	549	PF00454	0.437
MOD_PK_1	462	468	PF00069	0.640
MOD_PKA_1	304	310	PF00069	0.507
MOD_PKA_2	135	141	PF00069	0.450
MOD_PKA_2	147	153	PF00069	0.547
MOD_PKA_2	472	478	PF00069	0.658
MOD_PKA_2	543	549	PF00069	0.478
MOD_PKA_2	574	580	PF00069	0.501
MOD_Plk_1	178	184	PF00069	0.502
MOD_Plk_1	239	245	PF00069	0.492
MOD_Plk_1	251	257	PF00069	0.419
MOD_Plk_1	513	519	PF00069	0.459
MOD_Plk_4	103	109	PF00069	0.426
MOD_Plk_4	11	17	PF00069	0.394
MOD_Plk_4	117	123	PF00069	0.385
MOD_Plk_4	150	156	PF00069	0.594
MOD_Plk_4	187	193	PF00069	0.372
MOD_Plk_4	240	246	PF00069	0.523
MOD_Plk_4	251	257	PF00069	0.564
MOD_Plk_4	271	277	PF00069	0.348
MOD_Plk_4	327	333	PF00069	0.322
MOD_Plk_4	354	360	PF00069	0.384
MOD_Plk_4	411	417	PF00069	0.404
MOD_Plk_4	437	443	PF00069	0.439
MOD_Plk_4	513	519	PF00069	0.439
MOD_ProDKin_1	15	21	PF00069	0.395
MOD_ProDKin_1	259	265	PF00069	0.436
MOD_ProDKin_1	29	35	PF00069	0.386
MOD_ProDKin_1	383	389	PF00069	0.743
MOD_ProDKin_1	477	483	PF00069	0.699
MOD_ProDKin_1	82	88	PF00069	0.651
MOD_SUMO_rev_2	265	274	PF00179	0.529
TRG_DiLeu_BaEn_1	179	184	PF01217	0.307
TRG_DiLeu_BaEn_1	324	329	PF01217	0.570
TRG_DiLeu_LyEn_5	179	184	PF01217	0.307
TRG_ENDOCYTIC_2	218	221	PF00928	0.363
TRG_ENDOCYTIC_2	228	231	PF00928	0.368
TRG_ENDOCYTIC_2	233	236	PF00928	0.379
TRG_ENDOCYTIC_2	26	29	PF00928	0.402
TRG_ENDOCYTIC_2	499	502	PF00928	0.551
TRG_ENDOCYTIC_2	5	8	PF00928	0.460
TRG_ENDOCYTIC_2	567	570	PF00928	0.563
TRG_ENDOCYTIC_2	63	66	PF00928	0.393
TRG_ER_diArg_1	216	218	PF00400	0.415
TRG_ER_diArg_1	276	279	PF00400	0.457
TRG_ER_diArg_1	535	538	PF00400	0.506
TRG_ER_diArg_1	540	542	PF00400	0.499
TRG_ER_diArg_1	543	545	PF00400	0.497
TRG_ER_diArg_1	574	576	PF00400	0.521
TRG_ER_diArg_1	98	100	PF00400	0.557
TRG_NES_CRM1_1	327	339	PF08389	0.285
TRG_Pf-PMV_PEXEL_1	182	187	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	368	373	PF00026	0.566
TRG_PTS1	647	650	PF00515	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF78	Leptomonas seymouri	60%	100%
A0A0S4IPL3	Bodo saltans	32%	100%
A0A1X0P3T8	Trypanosomatidae	34%	100%
A0A3Q8IHN4	Leishmania donovani	75%	100%
A0A3R7MTT7	Trypanosoma rangeli	38%	100%
D0A669	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AHR1	Leishmania infantum	75%	100%
E9B482	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q3U4	Leishmania major	75%	99%