2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

diphthamide biosynthesis enzyme Dph1/Dph2 domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HLV3_LEIBR

TriTrypDb:

LbrM.33.2690 , LBRM2903_330034600

Length:

764

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLV3

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	11
GO:0006448	regulation of translational elongation	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009889	regulation of biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0010468	regulation of gene expression	5	11
GO:0010556	regulation of macromolecule biosynthetic process	5	11
GO:0010608	post-transcriptional regulation of gene expression	6	11
GO:0017182	peptidyl-diphthamide metabolic process	7	11
GO:0017183	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	4	11
GO:0018193	peptidyl-amino acid modification	5	11
GO:0018202	peptidyl-histidine modification	6	11
GO:0019222	regulation of metabolic process	3	11
GO:0019538	protein metabolic process	3	11
GO:0031323	regulation of cellular metabolic process	4	11
GO:0031326	regulation of cellular biosynthetic process	5	11
GO:0034248	regulation of amide metabolic process	5	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0051171	regulation of nitrogen compound metabolic process	4	11
GO:0051246	regulation of protein metabolic process	5	11
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11
GO:0071704	organic substance metabolic process	2	11
GO:0080090	regulation of primary metabolic process	4	11
GO:1900247	regulation of cytoplasmic translational elongation	8	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016740	transferase activity	2	11
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	11
GO:0090560	2-(3-amino-3-carboxypropyl)histidine synthase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.421
CLV_C14_Caspase3-7	25	29	PF00656	0.530
CLV_C14_Caspase3-7	496	500	PF00656	0.481
CLV_C14_Caspase3-7	605	609	PF00656	0.523
CLV_C14_Caspase3-7	628	632	PF00656	0.406
CLV_MEL_PAP_1	725	731	PF00089	0.670
CLV_NRD_NRD_1	272	274	PF00675	0.431
CLV_NRD_NRD_1	36	38	PF00675	0.615
CLV_NRD_NRD_1	519	521	PF00675	0.362
CLV_PCSK_KEX2_1	272	274	PF00082	0.401
CLV_PCSK_KEX2_1	288	290	PF00082	0.277
CLV_PCSK_KEX2_1	36	38	PF00082	0.633
CLV_PCSK_KEX2_1	519	521	PF00082	0.282
CLV_PCSK_KEX2_1	565	567	PF00082	0.282
CLV_PCSK_KEX2_1	606	608	PF00082	0.356
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.529
CLV_PCSK_PC1ET2_1	565	567	PF00082	0.282
CLV_PCSK_PC1ET2_1	606	608	PF00082	0.362
CLV_PCSK_PC7_1	561	567	PF00082	0.282
CLV_PCSK_SKI1_1	102	106	PF00082	0.392
CLV_PCSK_SKI1_1	432	436	PF00082	0.301
CLV_PCSK_SKI1_1	651	655	PF00082	0.530
CLV_Separin_Metazoa	269	273	PF03568	0.374
DEG_Nend_Nbox_1	1	3	PF02207	0.578
DEG_SPOP_SBC_1	386	390	PF00917	0.645
DEG_SPOP_SBC_1	623	627	PF00917	0.562
DOC_MAPK_gen_1	565	572	PF00069	0.482
DOC_MAPK_MEF2A_6	532	541	PF00069	0.482
DOC_PP1_RVXF_1	321	327	PF00149	0.316
DOC_PP1_RVXF_1	44	51	PF00149	0.364
DOC_PP4_FxxP_1	610	613	PF00568	0.496
DOC_PP4_FxxP_1	65	68	PF00568	0.537
DOC_USP7_MATH_1	223	227	PF00917	0.496
DOC_USP7_MATH_1	384	388	PF00917	0.486
DOC_USP7_MATH_1	407	411	PF00917	0.462
DOC_USP7_MATH_1	623	627	PF00917	0.581
DOC_USP7_MATH_1	630	634	PF00917	0.567
DOC_USP7_MATH_1	71	75	PF00917	0.784
DOC_USP7_MATH_1	91	95	PF00917	0.722
DOC_WW_Pin1_4	331	336	PF00397	0.520
DOC_WW_Pin1_4	350	355	PF00397	0.457
DOC_WW_Pin1_4	613	618	PF00397	0.482
DOC_WW_Pin1_4	729	734	PF00397	0.552
DOC_WW_Pin1_4	756	761	PF00397	0.532
DOC_WW_Pin1_4	95	100	PF00397	0.509
LIG_14-3-3_CanoR_1	150	157	PF00244	0.537
LIG_14-3-3_CanoR_1	173	182	PF00244	0.676
LIG_14-3-3_CanoR_1	272	282	PF00244	0.462
LIG_14-3-3_CanoR_1	385	395	PF00244	0.622
LIG_14-3-3_CanoR_1	424	434	PF00244	0.294
LIG_14-3-3_CanoR_1	532	541	PF00244	0.452
LIG_14-3-3_CanoR_1	678	682	PF00244	0.671
LIG_14-3-3_CanoR_1	685	693	PF00244	0.667
LIG_deltaCOP1_diTrp_1	337	341	PF00928	0.292
LIG_deltaCOP1_diTrp_1	372	383	PF00928	0.473
LIG_FHA_1	128	134	PF00498	0.427
LIG_FHA_1	285	291	PF00498	0.470
LIG_FHA_1	460	466	PF00498	0.307
LIG_FHA_1	551	557	PF00498	0.497
LIG_FHA_1	701	707	PF00498	0.615
LIG_FHA_1	87	93	PF00498	0.579
LIG_FHA_2	247	253	PF00498	0.417
LIG_FHA_2	332	338	PF00498	0.361
LIG_FHA_2	494	500	PF00498	0.473
LIG_FHA_2	623	629	PF00498	0.631
LIG_Integrin_RGD_1	26	28	PF01839	0.538
LIG_LIR_Apic_2	608	613	PF02991	0.515
LIG_LIR_Apic_2	63	68	PF02991	0.536
LIG_LIR_Gen_1	398	408	PF02991	0.510
LIG_LIR_Gen_1	420	430	PF02991	0.536
LIG_LIR_Gen_1	588	597	PF02991	0.482
LIG_LIR_Gen_1	643	653	PF02991	0.418
LIG_LIR_Gen_1	98	108	PF02991	0.345
LIG_LIR_Nem_3	337	341	PF02991	0.375
LIG_LIR_Nem_3	398	404	PF02991	0.474
LIG_LIR_Nem_3	420	425	PF02991	0.529
LIG_LIR_Nem_3	547	552	PF02991	0.534
LIG_LIR_Nem_3	567	571	PF02991	0.350
LIG_LIR_Nem_3	588	593	PF02991	0.482
LIG_LIR_Nem_3	643	649	PF02991	0.412
LIG_LIR_Nem_3	719	725	PF02991	0.550
LIG_LIR_Nem_3	98	103	PF02991	0.350
LIG_PCNA_PIPBox_1	711	720	PF02747	0.613
LIG_PCNA_yPIPBox_3	711	720	PF02747	0.565
LIG_PTB_Apo_2	376	383	PF02174	0.272
LIG_PTB_Phospho_1	376	382	PF10480	0.274
LIG_Rb_pABgroove_1	712	720	PF01858	0.512
LIG_SH2_CRK	100	104	PF00017	0.438
LIG_SH2_CRK	597	601	PF00017	0.408
LIG_SH2_NCK_1	597	601	PF00017	0.408
LIG_SH2_PTP2	235	238	PF00017	0.562
LIG_SH2_PTP2	722	725	PF00017	0.626
LIG_SH2_SRC	132	135	PF00017	0.620
LIG_SH2_STAP1	313	317	PF00017	0.287
LIG_SH2_STAP1	642	646	PF00017	0.433
LIG_SH2_STAP1	718	722	PF00017	0.589
LIG_SH2_STAT5	132	135	PF00017	0.620
LIG_SH2_STAT5	235	238	PF00017	0.482
LIG_SH2_STAT5	382	385	PF00017	0.520
LIG_SH2_STAT5	401	404	PF00017	0.371
LIG_SH2_STAT5	568	571	PF00017	0.475
LIG_SH2_STAT5	642	645	PF00017	0.503
LIG_SH2_STAT5	722	725	PF00017	0.626
LIG_SH3_3	154	160	PF00018	0.785
LIG_SH3_3	179	185	PF00018	0.466
LIG_SH3_3	299	305	PF00018	0.563
LIG_SH3_3	378	384	PF00018	0.490
LIG_SH3_3	590	596	PF00018	0.562
LIG_SH3_3	757	763	PF00018	0.545
LIG_SUMO_SIM_anti_2	114	120	PF11976	0.436
LIG_SUMO_SIM_anti_2	263	269	PF11976	0.258
LIG_SUMO_SIM_par_1	619	629	PF11976	0.513
LIG_TRAF2_1	680	683	PF00917	0.619
MOD_CDK_SPxxK_3	95	102	PF00069	0.518
MOD_CK1_1	146	152	PF00069	0.635
MOD_CK1_1	226	232	PF00069	0.337
MOD_CK1_1	284	290	PF00069	0.300
MOD_CK1_1	387	393	PF00069	0.478
MOD_CK1_1	476	482	PF00069	0.630
MOD_CK1_1	53	59	PF00069	0.541
MOD_CK1_1	598	604	PF00069	0.398
MOD_CK1_1	645	651	PF00069	0.547
MOD_CK1_1	87	93	PF00069	0.529
MOD_CK2_1	293	299	PF00069	0.534
MOD_CK2_1	368	374	PF00069	0.535
MOD_CK2_1	388	394	PF00069	0.374
MOD_CK2_1	613	619	PF00069	0.335
MOD_CK2_1	677	683	PF00069	0.467
MOD_Cter_Amidation	563	566	PF01082	0.335
MOD_GlcNHglycan	145	148	PF01048	0.557
MOD_GlcNHglycan	152	155	PF01048	0.648
MOD_GlcNHglycan	186	189	PF01048	0.438
MOD_GlcNHglycan	242	245	PF01048	0.546
MOD_GlcNHglycan	275	278	PF01048	0.527
MOD_GlcNHglycan	295	298	PF01048	0.556
MOD_GlcNHglycan	313	316	PF01048	0.321
MOD_GlcNHglycan	346	349	PF01048	0.657
MOD_GlcNHglycan	410	413	PF01048	0.396
MOD_GlcNHglycan	438	442	PF01048	0.510
MOD_GlcNHglycan	493	496	PF01048	0.417
MOD_GlcNHglycan	52	55	PF01048	0.507
MOD_GlcNHglycan	534	537	PF01048	0.354
MOD_GlcNHglycan	688	691	PF01048	0.587
MOD_GlcNHglycan	698	701	PF01048	0.573
MOD_GlcNHglycan	760	763	PF01048	0.779
MOD_GlcNHglycan	81	84	PF01048	0.620
MOD_GlcNHglycan	89	92	PF01048	0.511
MOD_GSK3_1	146	153	PF00069	0.648
MOD_GSK3_1	18	25	PF00069	0.601
MOD_GSK3_1	280	287	PF00069	0.373
MOD_GSK3_1	305	312	PF00069	0.411
MOD_GSK3_1	384	391	PF00069	0.581
MOD_GSK3_1	527	534	PF00069	0.428
MOD_GSK3_1	641	648	PF00069	0.341
MOD_GSK3_1	696	703	PF00069	0.659
MOD_GSK3_1	87	94	PF00069	0.510
MOD_NEK2_1	225	230	PF00069	0.340
MOD_NEK2_1	240	245	PF00069	0.354
MOD_NEK2_1	452	457	PF00069	0.423
MOD_NEK2_1	485	490	PF00069	0.448
MOD_NEK2_1	50	55	PF00069	0.460
MOD_NEK2_1	540	545	PF00069	0.426
MOD_NEK2_1	706	711	PF00069	0.691
MOD_PIKK_1	550	556	PF00454	0.447
MOD_PIKK_1	707	713	PF00454	0.613
MOD_PKA_2	149	155	PF00069	0.530
MOD_PKA_2	18	24	PF00069	0.700
MOD_PKA_2	226	232	PF00069	0.320
MOD_PKA_2	280	286	PF00069	0.535
MOD_PKA_2	305	311	PF00069	0.399
MOD_PKA_2	384	390	PF00069	0.393
MOD_PKA_2	531	537	PF00069	0.342
MOD_PKA_2	598	604	PF00069	0.371
MOD_PKA_2	677	683	PF00069	0.613
MOD_PKB_1	17	25	PF00069	0.633
MOD_Plk_1	195	201	PF00069	0.335
MOD_Plk_1	452	458	PF00069	0.413
MOD_Plk_4	281	287	PF00069	0.289
MOD_Plk_4	645	651	PF00069	0.309
MOD_Plk_4	700	706	PF00069	0.642
MOD_ProDKin_1	331	337	PF00069	0.512
MOD_ProDKin_1	350	356	PF00069	0.456
MOD_ProDKin_1	613	619	PF00069	0.335
MOD_ProDKin_1	729	735	PF00069	0.553
MOD_ProDKin_1	756	762	PF00069	0.535
MOD_ProDKin_1	95	101	PF00069	0.496
MOD_SUMO_for_1	138	141	PF00179	0.551
MOD_SUMO_rev_2	134	140	PF00179	0.648
MOD_SUMO_rev_2	248	256	PF00179	0.402
TRG_DiLeu_BaEn_1	398	403	PF01217	0.406
TRG_DiLeu_BaEn_1	461	466	PF01217	0.299
TRG_DiLeu_BaEn_1	8	13	PF01217	0.447
TRG_ENDOCYTIC_2	100	103	PF00928	0.512
TRG_ENDOCYTIC_2	401	404	PF00928	0.419
TRG_ENDOCYTIC_2	422	425	PF00928	0.436
TRG_ENDOCYTIC_2	549	552	PF00928	0.389
TRG_ENDOCYTIC_2	722	725	PF00928	0.626
TRG_ER_diArg_1	17	20	PF00400	0.595
TRG_ER_diArg_1	271	273	PF00400	0.418
TRG_ER_diArg_1	36	38	PF00400	0.359
TRG_ER_diArg_1	519	522	PF00400	0.361
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.344
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D8	Leptomonas seymouri	52%	99%
A0A1X0P3T2	Trypanosomatidae	38%	100%
A0A3S5ISG6	Trypanosoma rangeli	37%	100%
A0A3S7X6Z1	Leishmania donovani	73%	100%
D0A670	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AHQ9	Leishmania infantum	72%	99%
E9B480	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q3U6	Leishmania major	73%	100%
V5BP75	Trypanosoma cruzi	36%	100%