Putative ras-like small GTPases

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras-like small GTPases, putative

Species:

Leishmania braziliensis

UniProt:

A4HLV2_LEIBR

TriTrypDb:

LbrM.33.2680 , LBRM2903_330034500

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLV2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	5
GO:0003924	GTPase activity	7	5
GO:0003925	G protein activity	2	5
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	5
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0098772	molecular function regulator activity	1	5
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.356
CLV_C14_Caspase3-7	467	471	PF00656	0.322
CLV_NRD_NRD_1	133	135	PF00675	0.467
CLV_NRD_NRD_1	187	189	PF00675	0.399
CLV_NRD_NRD_1	22	24	PF00675	0.513
CLV_NRD_NRD_1	287	289	PF00675	0.372
CLV_NRD_NRD_1	300	302	PF00675	0.413
CLV_NRD_NRD_1	324	326	PF00675	0.241
CLV_NRD_NRD_1	445	447	PF00675	0.375
CLV_NRD_NRD_1	54	56	PF00675	0.587
CLV_PCSK_KEX2_1	132	134	PF00082	0.486
CLV_PCSK_KEX2_1	187	189	PF00082	0.399
CLV_PCSK_KEX2_1	21	23	PF00082	0.644
CLV_PCSK_KEX2_1	287	289	PF00082	0.372
CLV_PCSK_KEX2_1	324	326	PF00082	0.241
CLV_PCSK_KEX2_1	445	447	PF00082	0.372
CLV_PCSK_KEX2_1	54	56	PF00082	0.649
CLV_PCSK_KEX2_1	544	546	PF00082	0.624
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.241
CLV_PCSK_PC1ET2_1	544	546	PF00082	0.678
CLV_PCSK_PC7_1	18	24	PF00082	0.500
CLV_PCSK_PC7_1	540	546	PF00082	0.561
CLV_PCSK_SKI1_1	187	191	PF00082	0.478
CLV_PCSK_SKI1_1	248	252	PF00082	0.555
CLV_PCSK_SKI1_1	30	34	PF00082	0.541
CLV_PCSK_SKI1_1	462	466	PF00082	0.319
CLV_PCSK_SKI1_1	520	524	PF00082	0.517
DEG_Kelch_Keap1_1	295	300	PF01344	0.471
DOC_CYCLIN_yCln2_LP_2	379	385	PF00134	0.336
DOC_MAPK_gen_1	132	141	PF00069	0.495
DOC_MAPK_gen_1	187	198	PF00069	0.251
DOC_MAPK_gen_1	233	239	PF00069	0.302
DOC_MAPK_gen_1	30	38	PF00069	0.626
DOC_MAPK_gen_1	301	308	PF00069	0.346
DOC_MAPK_gen_1	324	331	PF00069	0.410
DOC_MAPK_gen_1	54	62	PF00069	0.615
DOC_MAPK_MEF2A_6	301	308	PF00069	0.346
DOC_MIT_MIM_1	211	220	PF04212	0.344
DOC_PP1_RVXF_1	85	92	PF00149	0.460
DOC_PP2B_LxvP_1	36	39	PF13499	0.606
DOC_PP2B_LxvP_1	60	63	PF13499	0.633
DOC_USP7_MATH_1	273	277	PF00917	0.491
DOC_USP7_MATH_1	495	499	PF00917	0.620
DOC_USP7_MATH_1	71	75	PF00917	0.613
DOC_USP7_UBL2_3	30	34	PF12436	0.540
DOC_USP7_UBL2_3	6	10	PF12436	0.565
DOC_WW_Pin1_4	357	362	PF00397	0.424
LIG_14-3-3_CanoR_1	142	150	PF00244	0.528
LIG_14-3-3_CanoR_1	216	224	PF00244	0.363
LIG_14-3-3_CanoR_1	225	229	PF00244	0.378
LIG_14-3-3_CanoR_1	278	282	PF00244	0.463
LIG_14-3-3_CanoR_1	287	293	PF00244	0.461
LIG_14-3-3_CanoR_1	375	383	PF00244	0.400
LIG_14-3-3_CanoR_1	497	505	PF00244	0.645
LIG_14-3-3_CanoR_1	520	525	PF00244	0.517
LIG_14-3-3_CanoR_1	54	60	PF00244	0.555
LIG_14-3-3_CanoR_1	75	81	PF00244	0.478
LIG_Actin_WH2_2	29	44	PF00022	0.548
LIG_APCC_ABBA_1	530	535	PF00400	0.566
LIG_BRCT_BRCA1_1	497	501	PF00533	0.420
LIG_BRCT_BRCA1_1	94	98	PF00533	0.453
LIG_BRCT_BRCA1_2	94	100	PF00533	0.453
LIG_deltaCOP1_diTrp_1	252	258	PF00928	0.357
LIG_Dynein_DLC8_1	45	51	PF01221	0.525
LIG_EH_1	380	384	PF12763	0.401
LIG_FHA_1	527	533	PF00498	0.526
LIG_FHA_1	54	60	PF00498	0.627
LIG_FHA_2	126	132	PF00498	0.600
LIG_FHA_2	216	222	PF00498	0.364
LIG_FHA_2	225	231	PF00498	0.391
LIG_FHA_2	340	346	PF00498	0.442
LIG_FHA_2	554	560	PF00498	0.645
LIG_Integrin_isoDGR_2	164	166	PF01839	0.446
LIG_LIR_Apic_2	149	153	PF02991	0.646
LIG_LIR_Gen_1	192	198	PF02991	0.330
LIG_LIR_Nem_3	192	196	PF02991	0.356
LIG_LIR_Nem_3	252	257	PF02991	0.365
LIG_LIR_Nem_3	490	496	PF02991	0.529
LIG_LRP6_Inhibitor_1	369	375	PF00058	0.305
LIG_LYPXL_yS_3	311	314	PF13949	0.410
LIG_PDZ_Class_3	560	565	PF00595	0.675
LIG_Pex14_1	254	258	PF04695	0.297
LIG_Pex14_2	189	193	PF04695	0.336
LIG_REV1ctd_RIR_1	187	195	PF16727	0.455
LIG_SH2_CRK	476	480	PF00017	0.337
LIG_SH2_CRK	493	497	PF00017	0.538
LIG_SH2_GRB2like	402	405	PF00017	0.397
LIG_SH2_STAT3	257	260	PF00017	0.371
LIG_SH2_STAT5	257	260	PF00017	0.440
LIG_SH2_STAT5	281	284	PF00017	0.303
LIG_SH2_STAT5	476	479	PF00017	0.342
LIG_SH3_3	355	361	PF00018	0.410
LIG_SH3_3	379	385	PF00018	0.336
LIG_SH3_3	512	518	PF00018	0.455
LIG_SUMO_SIM_par_1	137	145	PF11976	0.601
LIG_TYR_ITIM	309	314	PF00017	0.245
LIG_UBA3_1	138	146	PF00899	0.501
LIG_UBA3_1	319	326	PF00899	0.288
LIG_WRC_WIRS_1	527	532	PF05994	0.514
MOD_CK1_1	295	301	PF00069	0.517
MOD_CK1_1	58	64	PF00069	0.577
MOD_CK1_1	74	80	PF00069	0.637
MOD_CK2_1	215	221	PF00069	0.388
MOD_CK2_1	224	230	PF00069	0.447
MOD_CK2_1	339	345	PF00069	0.245
MOD_CK2_1	357	363	PF00069	0.245
MOD_GlcNHglycan	415	418	PF01048	0.430
MOD_GlcNHglycan	515	518	PF01048	0.494
MOD_GlcNHglycan	7	10	PF01048	0.711
MOD_GlcNHglycan	71	74	PF01048	0.589
MOD_GlcNHglycan	78	81	PF01048	0.676
MOD_GlcNHglycan	94	97	PF01048	0.673
MOD_GSK3_1	269	276	PF00069	0.440
MOD_GSK3_1	288	295	PF00069	0.366
MOD_GSK3_1	335	342	PF00069	0.248
MOD_GSK3_1	71	78	PF00069	0.577
MOD_NEK2_1	269	274	PF00069	0.286
MOD_NEK2_1	277	282	PF00069	0.354
MOD_NEK2_1	413	418	PF00069	0.448
MOD_NEK2_1	48	53	PF00069	0.489
MOD_NEK2_1	76	81	PF00069	0.678
MOD_NEK2_2	273	278	PF00069	0.396
MOD_PIKK_1	102	108	PF00454	0.752
MOD_PIKK_1	175	181	PF00454	0.417
MOD_PIKK_1	215	221	PF00454	0.340
MOD_PIKK_1	46	52	PF00454	0.598
MOD_PK_1	55	61	PF00069	0.579
MOD_PKA_2	141	147	PF00069	0.614
MOD_PKA_2	17	23	PF00069	0.673
MOD_PKA_2	215	221	PF00069	0.351
MOD_PKA_2	224	230	PF00069	0.378
MOD_PKA_2	277	283	PF00069	0.317
MOD_PKA_2	374	380	PF00069	0.417
MOD_PKA_2	391	397	PF00069	0.426
MOD_PKA_2	447	453	PF00069	0.528
MOD_PKA_2	46	52	PF00069	0.589
MOD_PKA_2	496	502	PF00069	0.478
MOD_PKA_2	53	59	PF00069	0.588
MOD_PKA_2	539	545	PF00069	0.562
MOD_PKA_2	74	80	PF00069	0.676
MOD_PKA_2	92	98	PF00069	0.428
MOD_Plk_1	125	131	PF00069	0.541
MOD_Plk_1	182	188	PF00069	0.408
MOD_Plk_4	277	283	PF00069	0.360
MOD_Plk_4	315	321	PF00069	0.275
MOD_Plk_4	55	61	PF00069	0.614
MOD_ProDKin_1	357	363	PF00069	0.263
MOD_SUMO_rev_2	226	235	PF00179	0.379
MOD_SUMO_rev_2	295	304	PF00179	0.521
MOD_SUMO_rev_2	35	44	PF00179	0.476
TRG_DiLeu_BaEn_3	230	236	PF01217	0.481
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.310
TRG_ENDOCYTIC_2	311	314	PF00928	0.279
TRG_ENDOCYTIC_2	493	496	PF00928	0.532
TRG_ER_diArg_1	132	134	PF00400	0.602
TRG_ER_diArg_1	186	188	PF00400	0.311
TRG_ER_diArg_1	21	23	PF00400	0.637
TRG_ER_diArg_1	286	288	PF00400	0.370
TRG_ER_diArg_1	444	446	PF00400	0.379
TRG_NES_CRM1_1	525	539	PF08389	0.650
TRG_Pf-PMV_PEXEL_1	23	28	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X1	Leptomonas seymouri	74%	100%
A0A1X0P4K3	Trypanosomatidae	56%	100%
A0A3R7M8S7	Trypanosoma rangeli	54%	100%
A0A3S7X732	Leishmania donovani	84%	100%
D0A671	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AHQ8	Leishmania infantum	84%	100%
E9B479	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q3U7	Leishmania major	84%	100%
Q6PGG6	Mus musculus	33%	98%
Q9SHS8	Arabidopsis thaliana	26%	100%
V5B8N5	Trypanosoma cruzi	58%	100%