Putative Golgi reassembly stacking protein (GRASP homologue)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Golgi reassembly stacking protein (GRASP homologue), putative

Species:

Leishmania braziliensis

UniProt:

A4HLV0_LEIBR

TriTrypDb:

LbrM.33.2660 , LBRM2903_330034300

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	6
GO:0016020	membrane	2	5
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HLV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLV0

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.385
CLV_C14_Caspase3-7	347	351	PF00656	0.571
CLV_NRD_NRD_1	207	209	PF00675	0.517
CLV_PCSK_KEX2_1	538	540	PF00082	0.682
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.660
CLV_PCSK_SKI1_1	162	166	PF00082	0.243
CLV_PCSK_SKI1_1	203	207	PF00082	0.385
DOC_CYCLIN_yCln2_LP_2	467	473	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	526	532	PF00134	0.656
DOC_MAPK_MEF2A_6	521	528	PF00069	0.648
DOC_PP2B_LxvP_1	467	470	PF13499	0.538
DOC_PP4_FxxP_1	498	501	PF00568	0.515
DOC_PP4_MxPP_1	389	392	PF00568	0.533
DOC_PP4_MxPP_1	522	525	PF00568	0.643
DOC_USP7_MATH_1	21	25	PF00917	0.603
DOC_USP7_MATH_1	26	30	PF00917	0.546
DOC_USP7_MATH_1	278	282	PF00917	0.553
DOC_USP7_MATH_1	363	367	PF00917	0.728
DOC_USP7_MATH_1	393	397	PF00917	0.698
DOC_USP7_MATH_1	462	466	PF00917	0.667
DOC_USP7_MATH_1	476	480	PF00917	0.587
DOC_WW_Pin1_4	153	158	PF00397	0.472
DOC_WW_Pin1_4	304	309	PF00397	0.582
DOC_WW_Pin1_4	348	353	PF00397	0.764
DOC_WW_Pin1_4	359	364	PF00397	0.732
DOC_WW_Pin1_4	425	430	PF00397	0.752
DOC_WW_Pin1_4	469	474	PF00397	0.615
DOC_WW_Pin1_4	53	58	PF00397	0.436
DOC_WW_Pin1_4	537	542	PF00397	0.565
LIG_14-3-3_CanoR_1	441	446	PF00244	0.558
LIG_14-3-3_CanoR_1	97	102	PF00244	0.299
LIG_APCC_ABBA_1	63	68	PF00400	0.402
LIG_BIR_III_2	140	144	PF00653	0.385
LIG_BIR_III_2	491	495	PF00653	0.555
LIG_BRCT_BRCA1_1	99	103	PF00533	0.301
LIG_deltaCOP1_diTrp_1	196	204	PF00928	0.385
LIG_EH_1	420	424	PF12763	0.711
LIG_EH1_1	46	54	PF00400	0.418
LIG_EVH1_1	330	334	PF00568	0.554
LIG_EVH1_1	387	391	PF00568	0.563
LIG_EVH1_1	498	502	PF00568	0.529
LIG_EVH1_2	524	528	PF00568	0.646
LIG_FHA_1	103	109	PF00498	0.484
LIG_FHA_1	214	220	PF00498	0.274
LIG_FHA_1	254	260	PF00498	0.385
LIG_FHA_1	307	313	PF00498	0.702
LIG_FHA_1	408	414	PF00498	0.610
LIG_FHA_1	441	447	PF00498	0.559
LIG_FHA_2	135	141	PF00498	0.385
LIG_FHA_2	232	238	PF00498	0.385
LIG_FHA_2	242	248	PF00498	0.292
LIG_FHA_2	301	307	PF00498	0.550
LIG_FHA_2	413	419	PF00498	0.585
LIG_FHA_2	69	75	PF00498	0.420
LIG_IRF3_LxIS_1	246	253	PF10401	0.243
LIG_LIR_Apic_2	115	120	PF02991	0.385
LIG_LIR_Apic_2	365	370	PF02991	0.656
LIG_LIR_Apic_2	372	377	PF02991	0.614
LIG_LIR_Apic_2	384	390	PF02991	0.524
LIG_LIR_Apic_2	496	501	PF02991	0.604
LIG_LIR_Gen_1	190	197	PF02991	0.441
LIG_LIR_Gen_1	281	291	PF02991	0.490
LIG_LIR_Gen_1	428	439	PF02991	0.838
LIG_LIR_Nem_3	100	106	PF02991	0.361
LIG_LIR_Nem_3	190	195	PF02991	0.441
LIG_LIR_Nem_3	281	286	PF02991	0.448
LIG_LIR_Nem_3	418	423	PF02991	0.712
LIG_LIR_Nem_3	428	434	PF02991	0.818
LIG_MYND_1	469	473	PF01753	0.532
LIG_PCNA_yPIPBox_3	178	189	PF02747	0.385
LIG_PROFILIN_1	499	505	PF00235	0.491
LIG_REV1ctd_RIR_1	86	94	PF16727	0.461
LIG_SH2_CRK	117	121	PF00017	0.385
LIG_SH2_CRK	367	371	PF00017	0.575
LIG_SH2_STAP1	160	164	PF00017	0.243
LIG_SH2_STAT5	109	112	PF00017	0.263
LIG_SH2_STAT5	117	120	PF00017	0.385
LIG_SH2_STAT5	170	173	PF00017	0.517
LIG_SH2_STAT5	497	500	PF00017	0.529
LIG_SH2_STAT5	527	530	PF00017	0.504
LIG_SH2_STAT5	92	95	PF00017	0.418
LIG_SH3_1	497	503	PF00018	0.593
LIG_SH3_1	51	57	PF00018	0.435
LIG_SH3_3	214	220	PF00018	0.385
LIG_SH3_3	328	334	PF00018	0.789
LIG_SH3_3	349	355	PF00018	0.761
LIG_SH3_3	385	391	PF00018	0.696
LIG_SH3_3	467	473	PF00018	0.546
LIG_SH3_3	496	502	PF00018	0.658
LIG_SH3_3	51	57	PF00018	0.435
LIG_SH3_3	526	532	PF00018	0.656
LIG_SUMO_SIM_par_1	148	154	PF11976	0.385
LIG_TRAF2_1	303	306	PF00917	0.553
LIG_TRAF2_1	415	418	PF00917	0.585
LIG_TRAF2_1	424	427	PF00917	0.547
LIG_UBA3_1	181	189	PF00899	0.385
LIG_WRC_WIRS_1	514	519	PF05994	0.620
LIG_WW_1	524	527	PF00397	0.492
LIG_WW_3	11	15	PF00397	0.555
MOD_CDK_SPxxK_3	53	60	PF00069	0.441
MOD_CK1_1	253	259	PF00069	0.412
MOD_CK1_1	264	270	PF00069	0.646
MOD_CK1_1	29	35	PF00069	0.593
MOD_CK1_1	307	313	PF00069	0.592
MOD_CK1_1	339	345	PF00069	0.596
MOD_CK1_1	381	387	PF00069	0.618
MOD_CK1_1	474	480	PF00069	0.612
MOD_CK2_1	190	196	PF00069	0.257
MOD_CK2_1	231	237	PF00069	0.385
MOD_CK2_1	241	247	PF00069	0.292
MOD_CK2_1	300	306	PF00069	0.645
MOD_CK2_1	359	365	PF00069	0.607
MOD_CK2_1	412	418	PF00069	0.587
MOD_CK2_1	77	83	PF00069	0.346
MOD_GlcNHglycan	122	127	PF01048	0.273
MOD_GlcNHglycan	266	270	PF01048	0.584
MOD_GlcNHglycan	28	31	PF01048	0.576
MOD_GlcNHglycan	294	297	PF01048	0.537
MOD_GlcNHglycan	380	383	PF01048	0.576
MOD_GlcNHglycan	41	44	PF01048	0.339
MOD_GlcNHglycan	476	479	PF01048	0.702
MOD_GlcNHglycan	6	9	PF01048	0.630
MOD_GSK3_1	118	125	PF00069	0.338
MOD_GSK3_1	130	137	PF00069	0.436
MOD_GSK3_1	227	234	PF00069	0.385
MOD_GSK3_1	241	248	PF00069	0.243
MOD_GSK3_1	261	268	PF00069	0.578
MOD_GSK3_1	278	285	PF00069	0.547
MOD_GSK3_1	28	35	PF00069	0.560
MOD_GSK3_1	300	307	PF00069	0.548
MOD_GSK3_1	359	366	PF00069	0.669
MOD_GSK3_1	378	385	PF00069	0.564
MOD_GSK3_1	412	419	PF00069	0.586
MOD_GSK3_1	509	516	PF00069	0.599
MOD_GSK3_1	97	104	PF00069	0.340
MOD_N-GLC_1	231	236	PF02516	0.309
MOD_N-GLC_1	4	9	PF02516	0.560
MOD_N-GLC_1	484	489	PF02516	0.703
MOD_NEK2_1	250	255	PF00069	0.243
MOD_NEK2_1	292	297	PF00069	0.508
MOD_NEK2_1	88	93	PF00069	0.456
MOD_NEK2_2	382	387	PF00069	0.563
MOD_NMyristoyl	1	7	PF02799	0.700
MOD_PIKK_1	369	375	PF00454	0.573
MOD_PIKK_1	516	522	PF00454	0.668
MOD_PK_1	282	288	PF00069	0.543
MOD_PK_1	441	447	PF00069	0.559
MOD_PK_1	97	103	PF00069	0.314
MOD_PKA_2	13	19	PF00069	0.563
MOD_PKA_2	440	446	PF00069	0.556
MOD_Plk_1	21	27	PF00069	0.774
MOD_Plk_1	213	219	PF00069	0.243
MOD_Plk_1	231	237	PF00069	0.309
MOD_Plk_1	339	345	PF00069	0.580
MOD_Plk_1	382	388	PF00069	0.562
MOD_Plk_2-3	231	237	PF00069	0.385
MOD_Plk_2-3	241	247	PF00069	0.292
MOD_Plk_4	307	313	PF00069	0.567
MOD_Plk_4	382	388	PF00069	0.565
MOD_Plk_4	393	399	PF00069	0.543
MOD_Plk_4	441	447	PF00069	0.559
MOD_Plk_4	493	499	PF00069	0.548
MOD_Plk_4	88	94	PF00069	0.489
MOD_ProDKin_1	153	159	PF00069	0.472
MOD_ProDKin_1	304	310	PF00069	0.583
MOD_ProDKin_1	348	354	PF00069	0.763
MOD_ProDKin_1	359	365	PF00069	0.734
MOD_ProDKin_1	425	431	PF00069	0.753
MOD_ProDKin_1	469	475	PF00069	0.615
MOD_ProDKin_1	53	59	PF00069	0.436
MOD_SUMO_rev_2	161	166	PF00179	0.243
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.243
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.415
TRG_ENDOCYTIC_2	113	116	PF00928	0.385
TRG_ENDOCYTIC_2	192	195	PF00928	0.451
TRG_ENDOCYTIC_2	431	434	PF00928	0.693
TRG_ENDOCYTIC_2	527	530	PF00928	0.504
TRG_NES_CRM1_1	68	81	PF08389	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IU65	Leishmania donovani	67%	100%
E9AHQ6	Leishmania infantum	67%	100%
E9B477	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4Q3U9	Leishmania major	66%	100%