TBC1 domain family member 23

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rab-GTPase-TBC domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HLU8_LEIBR

TriTrypDb:

LbrM.33.2640 , LBRM2903_300009700

Length:

853

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	12
GO:0005829	cytosol	2	17
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	17
GO:0005802	trans-Golgi network	4	2
GO:0031984	organelle subcompartment	2	2
GO:0098791	Golgi apparatus subcompartment	3	2

Expansion

Sequence features

A4HLU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLU8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	17
GO:0009987	cellular process	1	17
GO:0016192	vesicle-mediated transport	4	17
GO:0016197	endosomal transport	4	17
GO:0016482	cytosolic transport	4	17
GO:0042147	retrograde transport, endosome to Golgi	5	17
GO:0046907	intracellular transport	3	17
GO:0051179	localization	1	17
GO:0051234	establishment of localization	2	17
GO:0051641	cellular localization	2	17
GO:0051649	establishment of localization in cell	3	17
GO:0016043	cellular component organization	3	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0099022	vesicle tethering	4	2
GO:0099041	vesicle tethering to Golgi	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.602
CLV_C14_Caspase3-7	360	364	PF00656	0.519
CLV_NRD_NRD_1	286	288	PF00675	0.339
CLV_NRD_NRD_1	493	495	PF00675	0.525
CLV_NRD_NRD_1	781	783	PF00675	0.683
CLV_PCSK_KEX2_1	286	288	PF00082	0.339
CLV_PCSK_KEX2_1	438	440	PF00082	0.629
CLV_PCSK_KEX2_1	493	495	PF00082	0.527
CLV_PCSK_KEX2_1	572	574	PF00082	0.554
CLV_PCSK_KEX2_1	637	639	PF00082	0.638
CLV_PCSK_KEX2_1	780	782	PF00082	0.693
CLV_PCSK_PC1ET2_1	438	440	PF00082	0.629
CLV_PCSK_PC1ET2_1	572	574	PF00082	0.554
CLV_PCSK_PC1ET2_1	637	639	PF00082	0.657
CLV_PCSK_SKI1_1	220	224	PF00082	0.450
CLV_PCSK_SKI1_1	256	260	PF00082	0.319
CLV_PCSK_SKI1_1	279	283	PF00082	0.336
CLV_PCSK_SKI1_1	286	290	PF00082	0.325
CLV_PCSK_SKI1_1	376	380	PF00082	0.445
DEG_APCC_DBOX_1	121	129	PF00400	0.503
DEG_APCC_DBOX_1	325	333	PF00400	0.397
DEG_Kelch_Keap1_1	64	69	PF01344	0.492
DEG_SCF_FBW7_1	388	393	PF00400	0.481
DEG_SPOP_SBC_1	675	679	PF00917	0.805
DOC_CKS1_1	775	780	PF01111	0.545
DOC_CKS1_1	848	853	PF01111	0.516
DOC_CYCLIN_RxL_1	276	285	PF00134	0.226
DOC_CYCLIN_yCln2_LP_2	246	252	PF00134	0.270
DOC_CYCLIN_yCln2_LP_2	308	314	PF00134	0.443
DOC_MAPK_gen_1	122	131	PF00069	0.410
DOC_MAPK_MEF2A_6	530	537	PF00069	0.472
DOC_PP1_RVXF_1	298	305	PF00149	0.443
DOC_PP1_RVXF_1	393	400	PF00149	0.443
DOC_PP2B_LxvP_1	783	786	PF13499	0.692
DOC_PP4_FxxP_1	238	241	PF00568	0.279
DOC_PP4_FxxP_1	261	264	PF00568	0.443
DOC_PP4_FxxP_1	347	350	PF00568	0.395
DOC_USP7_MATH_1	12	16	PF00917	0.686
DOC_USP7_MATH_1	138	142	PF00917	0.702
DOC_USP7_MATH_1	241	245	PF00917	0.400
DOC_USP7_MATH_1	250	254	PF00917	0.401
DOC_USP7_MATH_1	627	631	PF00917	0.575
DOC_USP7_MATH_1	653	657	PF00917	0.630
DOC_USP7_MATH_1	713	717	PF00917	0.797
DOC_USP7_MATH_1	768	772	PF00917	0.687
DOC_USP7_MATH_1	773	777	PF00917	0.645
DOC_USP7_MATH_1	802	806	PF00917	0.718
DOC_WW_Pin1_4	386	391	PF00397	0.374
DOC_WW_Pin1_4	408	413	PF00397	0.414
DOC_WW_Pin1_4	419	424	PF00397	0.492
DOC_WW_Pin1_4	556	561	PF00397	0.541
DOC_WW_Pin1_4	752	757	PF00397	0.633
DOC_WW_Pin1_4	774	779	PF00397	0.734
DOC_WW_Pin1_4	786	791	PF00397	0.773
DOC_WW_Pin1_4	792	797	PF00397	0.727
DOC_WW_Pin1_4	798	803	PF00397	0.702
DOC_WW_Pin1_4	837	842	PF00397	0.654
DOC_WW_Pin1_4	847	852	PF00397	0.549
LIG_14-3-3_CanoR_1	326	330	PF00244	0.449
LIG_14-3-3_CanoR_1	365	369	PF00244	0.449
LIG_14-3-3_CanoR_1	439	448	PF00244	0.602
LIG_14-3-3_CanoR_1	470	477	PF00244	0.374
LIG_14-3-3_CanoR_1	816	822	PF00244	0.637
LIG_Actin_WH2_2	394	411	PF00022	0.419
LIG_APCC_ABBA_1	399	404	PF00400	0.486
LIG_BIR_II_1	1	5	PF00653	0.681
LIG_Clathr_ClatBox_1	128	132	PF01394	0.475
LIG_CORNRBOX	549	557	PF00104	0.318
LIG_deltaCOP1_diTrp_1	303	306	PF00928	0.421
LIG_EH1_1	551	559	PF00400	0.384
LIG_FHA_1	177	183	PF00498	0.436
LIG_FHA_1	207	213	PF00498	0.453
LIG_FHA_1	365	371	PF00498	0.451
LIG_FHA_1	420	426	PF00498	0.437
LIG_FHA_1	471	477	PF00498	0.493
LIG_FHA_1	543	549	PF00498	0.440
LIG_FHA_1	677	683	PF00498	0.529
LIG_FHA_1	843	849	PF00498	0.541
LIG_FHA_2	176	182	PF00498	0.518
LIG_FHA_2	266	272	PF00498	0.443
LIG_FHA_2	335	341	PF00498	0.325
LIG_FHA_2	409	415	PF00498	0.500
LIG_FHA_2	54	60	PF00498	0.660
LIG_FHA_2	562	568	PF00498	0.349
LIG_LIR_Apic_2	193	199	PF02991	0.442
LIG_LIR_Apic_2	236	241	PF02991	0.302
LIG_LIR_Apic_2	445	451	PF02991	0.472
LIG_LIR_Apic_2	716	720	PF02991	0.533
LIG_LIR_Gen_1	303	312	PF02991	0.319
LIG_LIR_Gen_1	398	407	PF02991	0.316
LIG_LIR_Gen_1	464	474	PF02991	0.396
LIG_LIR_Gen_1	827	837	PF02991	0.515
LIG_LIR_Nem_3	147	152	PF02991	0.532
LIG_LIR_Nem_3	303	307	PF02991	0.319
LIG_LIR_Nem_3	398	402	PF02991	0.429
LIG_LIR_Nem_3	464	469	PF02991	0.396
LIG_LIR_Nem_3	827	833	PF02991	0.499
LIG_NRBOX	124	130	PF00104	0.542
LIG_PCNA_PIPBox_1	274	283	PF02747	0.443
LIG_PCNA_yPIPBox_3	274	287	PF02747	0.443
LIG_PCNA_yPIPBox_3	71	80	PF02747	0.554
LIG_Pex14_2	576	580	PF04695	0.450
LIG_Pex14_2	830	834	PF04695	0.501
LIG_RPA_C_Fungi	811	823	PF08784	0.478
LIG_SH2_CRK	126	130	PF00017	0.368
LIG_SH2_CRK	228	232	PF00017	0.429
LIG_SH2_CRK	448	452	PF00017	0.705
LIG_SH2_GRB2like	196	199	PF00017	0.485
LIG_SH2_NCK_1	247	251	PF00017	0.482
LIG_SH2_PTP2	468	471	PF00017	0.380
LIG_SH2_SRC	247	250	PF00017	0.488
LIG_SH2_SRC	455	458	PF00017	0.482
LIG_SH2_SRC	740	743	PF00017	0.442
LIG_SH2_STAP1	152	156	PF00017	0.587
LIG_SH2_STAP1	295	299	PF00017	0.443
LIG_SH2_STAT3	262	265	PF00017	0.401
LIG_SH2_STAT3	601	604	PF00017	0.656
LIG_SH2_STAT5	126	129	PF00017	0.404
LIG_SH2_STAT5	152	155	PF00017	0.540
LIG_SH2_STAT5	196	199	PF00017	0.491
LIG_SH2_STAT5	210	213	PF00017	0.185
LIG_SH2_STAT5	280	283	PF00017	0.397
LIG_SH2_STAT5	316	319	PF00017	0.327
LIG_SH2_STAT5	321	324	PF00017	0.317
LIG_SH2_STAT5	455	458	PF00017	0.342
LIG_SH2_STAT5	468	471	PF00017	0.347
LIG_SH2_STAT5	525	528	PF00017	0.407
LIG_SH2_STAT5	601	604	PF00017	0.656
LIG_SH2_STAT5	740	743	PF00017	0.503
LIG_SH3_3	22	28	PF00018	0.610
LIG_SH3_3	309	315	PF00018	0.322
LIG_SH3_3	420	426	PF00018	0.517
LIG_SH3_3	772	778	PF00018	0.782
LIG_SH3_3	796	802	PF00018	0.760
LIG_SH3_3	845	851	PF00018	0.597
LIG_SH3_3	89	95	PF00018	0.735
LIG_SUMO_SIM_anti_2	200	206	PF11976	0.330
LIG_SUMO_SIM_anti_2	731	739	PF11976	0.561
LIG_SUMO_SIM_par_1	127	133	PF11976	0.531
LIG_SUMO_SIM_par_1	287	294	PF11976	0.364
LIG_SxIP_EBH_1	539	550	PF03271	0.447
LIG_TRAF2_1	411	414	PF00917	0.367
LIG_TRAF2_1	442	445	PF00917	0.472
LIG_TRFH_1	399	403	PF08558	0.468
LIG_TYR_ITIM	226	231	PF00017	0.254
LIG_UBA3_1	26	34	PF00899	0.517
LIG_UBA3_1	329	335	PF00899	0.463
MOD_CDK_SPK_2	792	797	PF00069	0.546
MOD_CDK_SPxK_1	774	780	PF00069	0.543
MOD_CDK_SPxxK_3	774	781	PF00069	0.516
MOD_CK1_1	215	221	PF00069	0.481
MOD_CK1_1	374	380	PF00069	0.383
MOD_CK1_1	4	10	PF00069	0.621
MOD_CK1_1	462	468	PF00069	0.442
MOD_CK1_1	596	602	PF00069	0.518
MOD_CK1_1	63	69	PF00069	0.699
MOD_CK1_1	656	662	PF00069	0.628
MOD_CK1_1	685	691	PF00069	0.735
MOD_CK1_1	694	700	PF00069	0.726
MOD_CK1_1	800	806	PF00069	0.639
MOD_CK1_1	99	105	PF00069	0.573
MOD_CK2_1	12	18	PF00069	0.563
MOD_CK2_1	175	181	PF00069	0.457
MOD_CK2_1	334	340	PF00069	0.328
MOD_CK2_1	408	414	PF00069	0.505
MOD_CK2_1	53	59	PF00069	0.840
MOD_CK2_1	561	567	PF00069	0.345
MOD_CK2_1	63	69	PF00069	0.688
MOD_CK2_1	722	728	PF00069	0.643
MOD_CK2_1	773	779	PF00069	0.817
MOD_GlcNHglycan	14	17	PF01048	0.741
MOD_GlcNHglycan	214	217	PF01048	0.488
MOD_GlcNHglycan	373	376	PF01048	0.362
MOD_GlcNHglycan	433	436	PF01048	0.553
MOD_GlcNHglycan	595	598	PF01048	0.663
MOD_GlcNHglycan	655	658	PF01048	0.657
MOD_GlcNHglycan	685	688	PF01048	0.646
MOD_GlcNHglycan	690	693	PF01048	0.661
MOD_GlcNHglycan	696	699	PF01048	0.617
MOD_GlcNHglycan	73	76	PF01048	0.479
MOD_GlcNHglycan	763	766	PF01048	0.793
MOD_GlcNHglycan	770	773	PF01048	0.716
MOD_GlcNHglycan	804	807	PF01048	0.728
MOD_GlcNHglycan	817	820	PF01048	0.511
MOD_GSK3_1	1	8	PF00069	0.813
MOD_GSK3_1	111	118	PF00069	0.409
MOD_GSK3_1	134	141	PF00069	0.568
MOD_GSK3_1	171	178	PF00069	0.481
MOD_GSK3_1	214	221	PF00069	0.523
MOD_GSK3_1	290	297	PF00069	0.421
MOD_GSK3_1	321	328	PF00069	0.468
MOD_GSK3_1	386	393	PF00069	0.364
MOD_GSK3_1	427	434	PF00069	0.456
MOD_GSK3_1	561	568	PF00069	0.434
MOD_GSK3_1	60	67	PF00069	0.772
MOD_GSK3_1	649	656	PF00069	0.570
MOD_GSK3_1	663	670	PF00069	0.638
MOD_GSK3_1	681	688	PF00069	0.722
MOD_GSK3_1	763	770	PF00069	0.580
MOD_GSK3_1	797	804	PF00069	0.743
MOD_GSK3_1	95	102	PF00069	0.546
MOD_N-GLC_1	282	287	PF02516	0.226
MOD_N-GLC_1	408	413	PF02516	0.503
MOD_NEK2_1	206	211	PF00069	0.462
MOD_NEK2_1	282	287	PF00069	0.414
MOD_NEK2_1	331	336	PF00069	0.550
MOD_NEK2_1	345	350	PF00069	0.447
MOD_NEK2_1	505	510	PF00069	0.477
MOD_NEK2_1	542	547	PF00069	0.492
MOD_NEK2_1	682	687	PF00069	0.613
MOD_NEK2_1	763	768	PF00069	0.683
MOD_NEK2_2	96	101	PF00069	0.594
MOD_PIKK_1	150	156	PF00454	0.398
MOD_PIKK_1	390	396	PF00454	0.428
MOD_PIKK_1	459	465	PF00454	0.546
MOD_PKA_1	572	578	PF00069	0.426
MOD_PKA_2	325	331	PF00069	0.401
MOD_PKA_2	364	370	PF00069	0.546
MOD_PKA_2	469	475	PF00069	0.416
MOD_PKA_2	572	578	PF00069	0.532
MOD_PKA_2	746	752	PF00069	0.670
MOD_PKA_2	815	821	PF00069	0.471
MOD_Plk_1	147	153	PF00069	0.540
MOD_Plk_1	218	224	PF00069	0.288
MOD_Plk_1	835	841	PF00069	0.775
MOD_Plk_4	206	212	PF00069	0.317
MOD_Plk_4	218	224	PF00069	0.381
MOD_Plk_4	250	256	PF00069	0.353
MOD_Plk_4	325	331	PF00069	0.286
MOD_Plk_4	374	380	PF00069	0.461
MOD_Plk_4	746	752	PF00069	0.642
MOD_ProDKin_1	386	392	PF00069	0.370
MOD_ProDKin_1	408	414	PF00069	0.416
MOD_ProDKin_1	419	425	PF00069	0.485
MOD_ProDKin_1	556	562	PF00069	0.536
MOD_ProDKin_1	752	758	PF00069	0.632
MOD_ProDKin_1	774	780	PF00069	0.737
MOD_ProDKin_1	786	792	PF00069	0.774
MOD_ProDKin_1	798	804	PF00069	0.710
MOD_ProDKin_1	837	843	PF00069	0.655
MOD_ProDKin_1	847	853	PF00069	0.539
MOD_SUMO_rev_2	444	451	PF00179	0.544
MOD_SUMO_rev_2	63	72	PF00179	0.610
TRG_DiLeu_BaEn_1	219	224	PF01217	0.277
TRG_DiLeu_BaEn_1	514	519	PF01217	0.384
TRG_DiLeu_BaEn_1	733	738	PF01217	0.607
TRG_DiLeu_BaEn_4	514	520	PF01217	0.384
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.519
TRG_DiLeu_BaLyEn_6	284	289	PF01217	0.443
TRG_DiLeu_BaLyEn_6	544	549	PF01217	0.386
TRG_ENDOCYTIC_2	126	129	PF00928	0.352
TRG_ENDOCYTIC_2	228	231	PF00928	0.369
TRG_ENDOCYTIC_2	468	471	PF00928	0.407
TRG_ER_diArg_1	286	288	PF00400	0.341
TRG_ER_diArg_1	492	494	PF00400	0.532
TRG_ER_diArg_1	780	782	PF00400	0.555
TRG_Pf-PMV_PEXEL_1	287	292	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P357	Leptomonas seymouri	56%	100%
A0A0S4JBQ9	Bodo saltans	27%	92%
A0A1X0P274	Trypanosomatidae	31%	100%
A0A3Q8IGR4	Leishmania donovani	76%	99%
A0A3R7MQU5	Trypanosoma rangeli	35%	100%
A0A3S7X2Z8	Leishmania donovani	76%	97%
A4HHY0	Leishmania braziliensis	98%	100%
A4I560	Leishmania infantum	76%	77%
C9ZQI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AHQ3	Leishmania infantum	76%	99%
E9B0F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%
E9B474	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%
Q4Q3V2	Leishmania major	76%	100%
Q4Q7S6	Leishmania major	76%	100%
V5DD41	Trypanosoma cruzi	34%	100%