Succinyl-CoA:3-ketoacid-coenzyme A transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

succinyl-coA:3-ketoacid-coenzyme A transferase, mitochondrial precursor, putative

Species:

Leishmania braziliensis

UniProt:

A4HLU7_LEIBR

TriTrypDb:

LbrM.33.2630 , LBRM2903_330033900

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HLU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLU7

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	12
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009987	cellular process	1	12
GO:0016042	lipid catabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044281	small molecule metabolic process	2	12
GO:0044282	small molecule catabolic process	3	12
GO:0046950	cellular ketone body metabolic process	3	12
GO:0046952	ketone body catabolic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901568	fatty acid derivative metabolic process	4	12
GO:1901569	fatty acid derivative catabolic process	5	12
GO:1901575	organic substance catabolic process	3	12
GO:1902224	ketone body metabolic process	4	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008260	succinyl-CoA:3-oxo-acid CoA-transferase activity	5	12
GO:0008410	CoA-transferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016782	transferase activity, transferring sulphur-containing groups	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.503
CLV_C14_Caspase3-7	281	285	PF00656	0.468
CLV_C14_Caspase3-7	489	493	PF00656	0.480
CLV_NRD_NRD_1	276	278	PF00675	0.264
CLV_NRD_NRD_1	3	5	PF00675	0.478
CLV_NRD_NRD_1	81	83	PF00675	0.326
CLV_PCSK_KEX2_1	252	254	PF00082	0.462
CLV_PCSK_KEX2_1	276	278	PF00082	0.267
CLV_PCSK_KEX2_1	3	5	PF00082	0.478
CLV_PCSK_KEX2_1	81	83	PF00082	0.324
CLV_PCSK_KEX2_1	96	98	PF00082	0.324
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.462
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.348
CLV_PCSK_SKI1_1	183	187	PF00082	0.341
CLV_PCSK_SKI1_1	277	281	PF00082	0.285
CLV_PCSK_SKI1_1	436	440	PF00082	0.257
CLV_PCSK_SKI1_1	441	445	PF00082	0.257
CLV_PCSK_SKI1_1	450	454	PF00082	0.257
CLV_PCSK_SKI1_1	52	56	PF00082	0.329
CLV_PCSK_SKI1_1	92	96	PF00082	0.321
DEG_MDM2_SWIB_1	164	171	PF02201	0.561
DEG_Nend_Nbox_1	1	3	PF02207	0.513
DEG_SPOP_SBC_1	486	490	PF00917	0.425
DOC_CYCLIN_RxL_1	446	455	PF00134	0.402
DOC_MAPK_gen_1	186	195	PF00069	0.468
DOC_MAPK_gen_1	273	282	PF00069	0.490
DOC_MAPK_gen_1	50	59	PF00069	0.516
DOC_MAPK_MEF2A_6	359	367	PF00069	0.457
DOC_PP2B_PxIxI_1	233	239	PF00149	0.402
DOC_PP4_FxxP_1	202	205	PF00568	0.457
DOC_USP7_MATH_1	187	191	PF00917	0.481
DOC_USP7_MATH_1	260	264	PF00917	0.702
DOC_USP7_MATH_1	400	404	PF00917	0.561
DOC_USP7_MATH_1	486	490	PF00917	0.425
DOC_USP7_UBL2_3	450	454	PF12436	0.437
DOC_USP7_UBL2_3	92	96	PF12436	0.455
LIG_14-3-3_CanoR_1	3	7	PF00244	0.409
LIG_14-3-3_CanoR_1	404	410	PF00244	0.616
LIG_14-3-3_CanoR_1	423	427	PF00244	0.410
LIG_14-3-3_CanoR_1	436	444	PF00244	0.414
LIG_14-3-3_CanoR_1	82	88	PF00244	0.535
LIG_Actin_WH2_2	439	456	PF00022	0.468
LIG_APCC_ABBA_1	308	313	PF00400	0.546
LIG_APCC_ABBA_1	57	62	PF00400	0.481
LIG_EH1_1	431	439	PF00400	0.561
LIG_FHA_1	24	30	PF00498	0.577
LIG_FHA_1	305	311	PF00498	0.561
LIG_FHA_1	75	81	PF00498	0.533
LIG_FHA_2	110	116	PF00498	0.499
LIG_FHA_2	459	465	PF00498	0.491
LIG_LIR_Apic_2	245	249	PF02991	0.483
LIG_LIR_Gen_1	177	187	PF02991	0.456
LIG_LIR_Gen_1	284	295	PF02991	0.493
LIG_LIR_Gen_1	353	363	PF02991	0.502
LIG_LIR_Nem_3	166	171	PF02991	0.467
LIG_LIR_Nem_3	177	182	PF02991	0.450
LIG_LIR_Nem_3	284	290	PF02991	0.493
LIG_LIR_Nem_3	353	358	PF02991	0.491
LIG_LIR_Nem_3	469	475	PF02991	0.274
LIG_MAD2	419	427	PF02301	0.410
LIG_Pex14_2	164	168	PF04695	0.524
LIG_SH2_CRK	179	183	PF00017	0.561
LIG_SH2_CRK	483	487	PF00017	0.486
LIG_SH2_GRB2like	287	290	PF00017	0.457
LIG_SH2_PTP2	287	290	PF00017	0.455
LIG_SH2_SRC	179	182	PF00017	0.503
LIG_SH2_SRC	98	101	PF00017	0.499
LIG_SH2_STAP1	128	132	PF00017	0.503
LIG_SH2_STAP1	60	64	PF00017	0.532
LIG_SH2_STAT3	133	136	PF00017	0.561
LIG_SH2_STAT3	269	272	PF00017	0.350
LIG_SH2_STAT5	128	131	PF00017	0.457
LIG_SH2_STAT5	169	172	PF00017	0.468
LIG_SH2_STAT5	237	240	PF00017	0.457
LIG_SH2_STAT5	287	290	PF00017	0.455
LIG_SH2_STAT5	472	475	PF00017	0.283
LIG_SH2_STAT5	60	63	PF00017	0.563
LIG_SH2_STAT5	98	101	PF00017	0.506
LIG_SH3_3	228	234	PF00018	0.463
LIG_SH3_3	36	42	PF00018	0.402
LIG_SH3_3	386	392	PF00018	0.481
LIG_SUMO_SIM_par_1	306	313	PF11976	0.565
LIG_UBA3_1	45	52	PF00899	0.439
MOD_CK1_1	351	357	PF00069	0.457
MOD_CK2_1	109	115	PF00069	0.478
MOD_CK2_1	255	261	PF00069	0.580
MOD_GlcNHglycan	188	192	PF01048	0.268
MOD_GlcNHglycan	257	260	PF01048	0.632
MOD_GlcNHglycan	263	266	PF01048	0.579
MOD_GlcNHglycan	328	331	PF01048	0.355
MOD_GlcNHglycan	350	353	PF01048	0.262
MOD_GlcNHglycan	389	392	PF01048	0.331
MOD_GlcNHglycan	414	417	PF01048	0.319
MOD_GlcNHglycan	62	65	PF01048	0.361
MOD_GSK3_1	128	135	PF00069	0.459
MOD_GSK3_1	170	177	PF00069	0.586
MOD_GSK3_1	23	30	PF00069	0.503
MOD_GSK3_1	251	258	PF00069	0.477
MOD_GSK3_1	322	329	PF00069	0.568
MOD_GSK3_1	422	429	PF00069	0.524
MOD_N-GLC_1	304	309	PF02516	0.202
MOD_N-GLC_1	412	417	PF02516	0.405
MOD_NEK2_1	171	176	PF00069	0.613
MOD_NEK2_1	195	200	PF00069	0.457
MOD_NEK2_1	2	7	PF00069	0.402
MOD_NEK2_1	306	311	PF00069	0.402
MOD_NEK2_1	363	368	PF00069	0.494
MOD_NEK2_1	371	376	PF00069	0.470
MOD_NEK2_1	74	79	PF00069	0.507
MOD_PIKK_1	132	138	PF00454	0.561
MOD_PKA_2	195	201	PF00069	0.457
MOD_PKA_2	2	8	PF00069	0.396
MOD_PKA_2	422	428	PF00069	0.561
MOD_Plk_1	171	177	PF00069	0.478
MOD_Plk_1	304	310	PF00069	0.402
MOD_Plk_1	363	369	PF00069	0.457
MOD_Plk_1	55	61	PF00069	0.425
MOD_Plk_2-3	458	464	PF00069	0.457
MOD_Plk_4	283	289	PF00069	0.430
MOD_Plk_4	363	369	PF00069	0.481
MOD_Plk_4	83	89	PF00069	0.465
MOD_SUMO_rev_2	156	161	PF00179	0.521
MOD_SUMO_rev_2	415	421	PF00179	0.402
MOD_SUMO_rev_2	474	481	PF00179	0.345
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.561
TRG_ENDOCYTIC_2	179	182	PF00928	0.561
TRG_ENDOCYTIC_2	287	290	PF00928	0.490
TRG_ENDOCYTIC_2	472	475	PF00928	0.467
TRG_ER_diArg_1	2	4	PF00400	0.485
TRG_ER_diArg_1	80	82	PF00400	0.561
TRG_NLS_Bipartite_1	81	99	PF00514	0.503
TRG_NLS_MonoExtC_3	94	100	PF00514	0.503
TRG_NLS_MonoExtN_4	92	99	PF00514	0.503
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.268
TRG_Pf-PMV_PEXEL_1	97	102	PF00026	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P584	Leptomonas seymouri	41%	100%
A0A0N1I0F3	Leptomonas seymouri	79%	100%
A0A0S4JH09	Bodo saltans	59%	99%
A0A1X0NIU4	Trypanosomatidae	41%	99%
A0A1X0P425	Trypanosomatidae	63%	100%
A0A3Q8IC07	Leishmania donovani	45%	99%
A0A3Q8IMK1	Leishmania donovani	89%	100%
A0A3R7LBN6	Trypanosoma rangeli	63%	100%
A0A3S7X3G0	Leishmania donovani	45%	99%
A4I5L8	Leishmania infantum	45%	99%
A4I5L9	Leishmania infantum	45%	99%
B2GV06	Rattus norvegicus	52%	95%
D0A680	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9AHQ2	Leishmania infantum	89%	100%
E9B0W3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	99%
E9B0W4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	99%
E9B473	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
F1CYZ5	Acetobacterium woodii	26%	94%
P37766	Escherichia coli (strain K12)	24%	93%
P55809	Homo sapiens	54%	95%
Q09450	Caenorhabditis elegans	51%	95%
Q29551	Sus scrofa	54%	95%
Q4Q3V3	Leishmania major	89%	100%
Q4Q7A2	Leishmania major	46%	99%
Q4Q7A3	Leishmania major	45%	99%
Q54JD9	Dictyostelium discoideum	53%	97%
Q5XIJ9	Rattus norvegicus	52%	95%
Q8X5X6	Escherichia coli O157:H7	24%	93%
Q9BYC2	Homo sapiens	54%	95%
Q9D0K2	Mus musculus	52%	95%
Q9ESL0	Mus musculus	53%	95%
Q9JJN4	Mus musculus	53%	95%
Q9W058	Drosophila melanogaster	51%	96%
V5DQB8	Trypanosoma cruzi	64%	100%