Putative cell division cycle 45 (CDC45)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cell division cycle 45 (CDC45), putative

Species:

Leishmania braziliensis

UniProt:

A4HLU5_LEIBR

TriTrypDb:

LbrM.33.2610 , LBRM2903_330033700

Length:

811

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:0031261	DNA replication preinitiation complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0032993	protein-DNA complex	2	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HLU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLU5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006270	DNA replication initiation	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0007049	cell cycle	2	6
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0051301	cell division	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0000727	double-strand break repair via break-induced replication	8	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022607	cellular component assembly	4	1
GO:0033554	cellular response to stress	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065004	protein-DNA complex assembly	6	1
GO:0071163	DNA replication preinitiation complex assembly	3	1
GO:0071824	protein-DNA complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1902977	mitotic DNA replication preinitiation complex assembly	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003682	chromatin binding	2	1
GO:0003688	DNA replication origin binding	7	1
GO:0003690	double-stranded DNA binding	5	1
GO:0003697	single-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0043565	sequence-specific DNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:1990837	sequence-specific double-stranded DNA binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.395
CLV_C14_Caspase3-7	234	238	PF00656	0.497
CLV_NRD_NRD_1	128	130	PF00675	0.234
CLV_NRD_NRD_1	151	153	PF00675	0.347
CLV_NRD_NRD_1	163	165	PF00675	0.217
CLV_NRD_NRD_1	167	169	PF00675	0.187
CLV_NRD_NRD_1	173	175	PF00675	0.235
CLV_NRD_NRD_1	176	178	PF00675	0.229
CLV_NRD_NRD_1	186	188	PF00675	0.253
CLV_NRD_NRD_1	21	23	PF00675	0.405
CLV_NRD_NRD_1	320	322	PF00675	0.253
CLV_NRD_NRD_1	362	364	PF00675	0.294
CLV_NRD_NRD_1	472	474	PF00675	0.253
CLV_NRD_NRD_1	524	526	PF00675	0.307
CLV_NRD_NRD_1	624	626	PF00675	0.322
CLV_NRD_NRD_1	627	629	PF00675	0.253
CLV_NRD_NRD_1	65	67	PF00675	0.191
CLV_NRD_NRD_1	748	750	PF00675	0.531
CLV_NRD_NRD_1	789	791	PF00675	0.643
CLV_PCSK_FUR_1	161	165	PF00082	0.253
CLV_PCSK_FUR_1	174	178	PF00082	0.253
CLV_PCSK_FUR_1	184	188	PF00082	0.178
CLV_PCSK_FUR_1	625	629	PF00082	0.307
CLV_PCSK_FUR_1	787	791	PF00082	0.685
CLV_PCSK_KEX2_1	128	130	PF00082	0.234
CLV_PCSK_KEX2_1	161	163	PF00082	0.253
CLV_PCSK_KEX2_1	166	168	PF00082	0.253
CLV_PCSK_KEX2_1	172	174	PF00082	0.253
CLV_PCSK_KEX2_1	176	178	PF00082	0.253
CLV_PCSK_KEX2_1	186	188	PF00082	0.161
CLV_PCSK_KEX2_1	320	322	PF00082	0.253
CLV_PCSK_KEX2_1	362	364	PF00082	0.294
CLV_PCSK_KEX2_1	623	625	PF00082	0.305
CLV_PCSK_KEX2_1	627	629	PF00082	0.253
CLV_PCSK_KEX2_1	65	67	PF00082	0.191
CLV_PCSK_KEX2_1	748	750	PF00082	0.531
CLV_PCSK_KEX2_1	789	791	PF00082	0.648
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.307
CLV_PCSK_PC7_1	162	168	PF00082	0.256
CLV_PCSK_PC7_1	182	188	PF00082	0.161
CLV_PCSK_PC7_1	623	629	PF00082	0.307
CLV_PCSK_SKI1_1	47	51	PF00082	0.254
CLV_PCSK_SKI1_1	488	492	PF00082	0.253
CLV_PCSK_SKI1_1	614	618	PF00082	0.254
CLV_PCSK_SKI1_1	628	632	PF00082	0.263
CLV_PCSK_SKI1_1	771	775	PF00082	0.487
DEG_APCC_DBOX_1	409	417	PF00400	0.507
DEG_APCC_DBOX_1	770	778	PF00400	0.488
DEG_COP1_1	785	794	PF00400	0.521
DEG_SPOP_SBC_1	578	582	PF00917	0.453
DOC_CKS1_1	743	748	PF01111	0.566
DOC_CYCLIN_RxL_1	628	639	PF00134	0.463
DOC_CYCLIN_RxL_1	768	779	PF00134	0.484
DOC_CYCLIN_yCln2_LP_2	96	102	PF00134	0.453
DOC_MAPK_DCC_7	628	638	PF00069	0.507
DOC_MAPK_FxFP_2	49	52	PF00069	0.453
DOC_MAPK_MEF2A_6	420	427	PF00069	0.507
DOC_MAPK_MEF2A_6	86	94	PF00069	0.492
DOC_PP1_RVXF_1	132	139	PF00149	0.453
DOC_PP1_RVXF_1	524	531	PF00149	0.507
DOC_PP1_RVXF_1	612	618	PF00149	0.453
DOC_PP2B_LxvP_1	28	31	PF13499	0.453
DOC_PP2B_LxvP_1	96	99	PF13499	0.453
DOC_PP4_FxxP_1	49	52	PF00568	0.453
DOC_PP4_FxxP_1	743	746	PF00568	0.543
DOC_USP7_MATH_1	252	256	PF00917	0.453
DOC_USP7_MATH_1	284	288	PF00917	0.453
DOC_USP7_MATH_1	36	40	PF00917	0.453
DOC_USP7_MATH_1	568	572	PF00917	0.529
DOC_USP7_MATH_1	57	61	PF00917	0.453
DOC_USP7_MATH_1	587	591	PF00917	0.432
DOC_USP7_MATH_1	651	655	PF00917	0.718
DOC_USP7_MATH_1	671	675	PF00917	0.619
DOC_USP7_MATH_1	686	690	PF00917	0.696
DOC_USP7_MATH_1	74	78	PF00917	0.453
DOC_USP7_MATH_2	508	514	PF00917	0.395
DOC_WW_Pin1_4	250	255	PF00397	0.446
DOC_WW_Pin1_4	512	517	PF00397	0.474
DOC_WW_Pin1_4	593	598	PF00397	0.453
DOC_WW_Pin1_4	742	747	PF00397	0.563
LIG_14-3-3_CanoR_1	13	18	PF00244	0.380
LIG_14-3-3_CanoR_1	286	293	PF00244	0.453
LIG_14-3-3_CanoR_1	362	371	PF00244	0.543
LIG_14-3-3_CanoR_1	383	388	PF00244	0.453
LIG_14-3-3_CanoR_1	446	455	PF00244	0.414
LIG_14-3-3_CanoR_1	537	544	PF00244	0.576
LIG_14-3-3_CanoR_1	607	611	PF00244	0.454
LIG_14-3-3_CanoR_1	614	620	PF00244	0.454
LIG_14-3-3_CanoR_1	627	637	PF00244	0.438
LIG_BIR_II_1	1	5	PF00653	0.617
LIG_BIR_III_2	251	255	PF00653	0.453
LIG_CaM_IQ_9	338	353	PF13499	0.453
LIG_FHA_1	325	331	PF00498	0.453
LIG_FHA_1	481	487	PF00498	0.526
LIG_FHA_1	567	573	PF00498	0.425
LIG_FHA_1	692	698	PF00498	0.538
LIG_FHA_1	707	713	PF00498	0.370
LIG_FHA_1	763	769	PF00498	0.474
LIG_FHA_1	786	792	PF00498	0.538
LIG_FHA_2	224	230	PF00498	0.475
LIG_FHA_2	234	240	PF00498	0.428
LIG_FHA_2	384	390	PF00498	0.508
LIG_FHA_2	791	797	PF00498	0.562
LIG_GBD_Chelix_1	611	619	PF00786	0.253
LIG_LIR_Apic_2	389	395	PF02991	0.391
LIG_LIR_Apic_2	740	746	PF02991	0.543
LIG_LIR_Gen_1	385	395	PF02991	0.467
LIG_LIR_Gen_1	58	68	PF02991	0.459
LIG_LIR_Gen_1	600	610	PF02991	0.481
LIG_LIR_Gen_1	708	715	PF02991	0.468
LIG_LIR_Gen_1	88	99	PF02991	0.453
LIG_LIR_Gen_1	9	19	PF02991	0.372
LIG_LIR_Nem_3	103	108	PF02991	0.453
LIG_LIR_Nem_3	117	122	PF02991	0.453
LIG_LIR_Nem_3	324	328	PF02991	0.453
LIG_LIR_Nem_3	385	391	PF02991	0.469
LIG_LIR_Nem_3	58	64	PF02991	0.459
LIG_LIR_Nem_3	600	605	PF02991	0.529
LIG_LIR_Nem_3	613	619	PF02991	0.454
LIG_LIR_Nem_3	708	714	PF02991	0.470
LIG_LIR_Nem_3	88	94	PF02991	0.453
LIG_LIR_Nem_3	9	14	PF02991	0.369
LIG_NBox_RRM_1	551	561	PF00076	0.453
LIG_NRBOX	412	418	PF00104	0.453
LIG_PCNA_yPIPBox_3	446	455	PF02747	0.505
LIG_PCNA_yPIPBox_3	79	91	PF02747	0.395
LIG_Pex14_2	49	53	PF04695	0.453
LIG_REV1ctd_RIR_1	148	157	PF16727	0.453
LIG_SH2_CRK	586	590	PF00017	0.453
LIG_SH2_NCK_1	586	590	PF00017	0.471
LIG_SH2_PTP2	711	714	PF00017	0.530
LIG_SH2_SRC	273	276	PF00017	0.456
LIG_SH2_STAP1	293	297	PF00017	0.453
LIG_SH2_STAP1	325	329	PF00017	0.507
LIG_SH2_STAP1	477	481	PF00017	0.453
LIG_SH2_STAT3	393	396	PF00017	0.453
LIG_SH2_STAT5	105	108	PF00017	0.453
LIG_SH2_STAT5	273	276	PF00017	0.456
LIG_SH2_STAT5	318	321	PF00017	0.453
LIG_SH2_STAT5	328	331	PF00017	0.453
LIG_SH2_STAT5	44	47	PF00017	0.453
LIG_SH2_STAT5	503	506	PF00017	0.507
LIG_SH2_STAT5	711	714	PF00017	0.552
LIG_SH2_STAT5	732	735	PF00017	0.455
LIG_SH2_STAT5	750	753	PF00017	0.449
LIG_SH2_STAT5	767	770	PF00017	0.575
LIG_SH3_1	586	592	PF00018	0.507
LIG_SH3_2	589	594	PF14604	0.507
LIG_SH3_3	502	508	PF00018	0.398
LIG_SH3_3	586	592	PF00018	0.507
LIG_SH3_3	661	667	PF00018	0.660
LIG_SH3_3	724	730	PF00018	0.509
LIG_SUMO_SIM_anti_2	294	299	PF11976	0.453
LIG_SUMO_SIM_anti_2	706	716	PF11976	0.499
LIG_SUMO_SIM_anti_2	805	811	PF11976	0.612
LIG_SUMO_SIM_par_1	111	117	PF11976	0.453
LIG_SUMO_SIM_par_1	539	545	PF11976	0.456
LIG_SUMO_SIM_par_1	634	639	PF11976	0.453
LIG_SUMO_SIM_par_1	674	680	PF11976	0.484
LIG_SUMO_SIM_par_1	706	716	PF11976	0.517
LIG_SUMO_SIM_par_1	770	776	PF11976	0.483
LIG_SUMO_SIM_par_1	805	811	PF11976	0.576
LIG_SUMO_SIM_par_1	98	104	PF11976	0.453
LIG_TRAF2_1	227	230	PF00917	0.507
LIG_TRAF2_1	334	337	PF00917	0.429
LIG_TRAF2_2	254	259	PF00917	0.453
LIG_TRFH_1	53	57	PF08558	0.453
LIG_TYR_ITSM	707	714	PF00017	0.389
LIG_UBA3_1	772	778	PF00899	0.488
LIG_WRC_WIRS_1	599	604	PF05994	0.453
LIG_WRPW_2	119	122	PF00400	0.453
LIG_WW_3	745	749	PF00397	0.591
MOD_CDK_SPxK_1	742	748	PF00069	0.563
MOD_CDK_SPxxK_3	742	749	PF00069	0.528
MOD_CK1_1	219	225	PF00069	0.463
MOD_CK1_1	233	239	PF00069	0.431
MOD_CK1_1	257	263	PF00069	0.395
MOD_CK1_1	509	515	PF00069	0.421
MOD_CK1_1	590	596	PF00069	0.529
MOD_CK1_1	601	607	PF00069	0.489
MOD_CK1_1	689	695	PF00069	0.677
MOD_CK1_1	776	782	PF00069	0.634
MOD_CK2_1	223	229	PF00069	0.475
MOD_CK2_1	285	291	PF00069	0.453
MOD_CK2_1	369	375	PF00069	0.456
MOD_CK2_1	512	518	PF00069	0.563
MOD_CK2_1	57	63	PF00069	0.453
MOD_CK2_1	671	677	PF00069	0.553
MOD_CK2_1	74	80	PF00069	0.453
MOD_CK2_1	790	796	PF00069	0.639
MOD_GlcNHglycan	208	211	PF01048	0.344
MOD_GlcNHglycan	264	267	PF01048	0.307
MOD_GlcNHglycan	287	290	PF01048	0.232
MOD_GlcNHglycan	398	401	PF01048	0.246
MOD_GlcNHglycan	4	7	PF01048	0.563
MOD_GlcNHglycan	538	541	PF01048	0.307
MOD_GlcNHglycan	654	657	PF01048	0.579
MOD_GlcNHglycan	658	661	PF01048	0.666
MOD_GlcNHglycan	664	667	PF01048	0.595
MOD_GlcNHglycan	679	682	PF01048	0.591
MOD_GlcNHglycan	686	689	PF01048	0.732
MOD_GSK3_1	13	20	PF00069	0.374
MOD_GSK3_1	178	185	PF00069	0.415
MOD_GSK3_1	216	223	PF00069	0.475
MOD_GSK3_1	250	257	PF00069	0.453
MOD_GSK3_1	337	344	PF00069	0.453
MOD_GSK3_1	36	43	PF00069	0.453
MOD_GSK3_1	434	441	PF00069	0.507
MOD_GSK3_1	446	453	PF00069	0.419
MOD_GSK3_1	475	482	PF00069	0.453
MOD_GSK3_1	506	513	PF00069	0.449
MOD_GSK3_1	615	622	PF00069	0.456
MOD_GSK3_1	652	659	PF00069	0.713
MOD_GSK3_1	689	696	PF00069	0.515
MOD_GSK3_1	773	780	PF00069	0.506
MOD_N-GLC_1	656	661	PF02516	0.617
MOD_N-GLC_1	763	768	PF02516	0.556
MOD_NEK2_1	106	111	PF00069	0.453
MOD_NEK2_1	341	346	PF00069	0.453
MOD_NEK2_1	369	374	PF00069	0.530
MOD_NEK2_1	382	387	PF00069	0.416
MOD_NEK2_1	40	45	PF00069	0.455
MOD_NEK2_1	416	421	PF00069	0.475
MOD_NEK2_1	530	535	PF00069	0.395
MOD_NEK2_1	615	620	PF00069	0.453
MOD_NEK2_1	636	641	PF00069	0.453
MOD_NEK2_1	773	778	PF00069	0.496
MOD_PIKK_1	252	258	PF00454	0.453
MOD_PIKK_1	411	417	PF00454	0.395
MOD_PIKK_1	530	536	PF00454	0.395
MOD_PKA_1	362	368	PF00069	0.395
MOD_PKA_2	12	18	PF00069	0.385
MOD_PKA_2	175	181	PF00069	0.395
MOD_PKA_2	21	27	PF00069	0.396
MOD_PKA_2	285	291	PF00069	0.468
MOD_PKA_2	361	367	PF00069	0.528
MOD_PKA_2	382	388	PF00069	0.469
MOD_PKA_2	411	417	PF00069	0.471
MOD_PKA_2	506	512	PF00069	0.395
MOD_PKA_2	536	542	PF00069	0.507
MOD_PKA_2	606	612	PF00069	0.453
MOD_PKB_1	467	475	PF00069	0.450
MOD_PKB_1	760	768	PF00069	0.564
MOD_Plk_1	219	225	PF00069	0.507
MOD_Plk_1	293	299	PF00069	0.453
MOD_Plk_1	479	485	PF00069	0.455
MOD_Plk_1	509	515	PF00069	0.447
MOD_Plk_1	68	74	PF00069	0.431
MOD_Plk_1	762	768	PF00069	0.485
MOD_Plk_2-3	216	222	PF00069	0.507
MOD_Plk_2-3	231	237	PF00069	0.397
MOD_Plk_2-3	480	486	PF00069	0.507
MOD_Plk_4	13	19	PF00069	0.369
MOD_Plk_4	293	299	PF00069	0.453
MOD_Plk_4	324	330	PF00069	0.453
MOD_Plk_4	383	389	PF00069	0.471
MOD_Plk_4	40	46	PF00069	0.453
MOD_Plk_4	450	456	PF00069	0.395
MOD_Plk_4	498	504	PF00069	0.453
MOD_Plk_4	568	574	PF00069	0.507
MOD_Plk_4	606	612	PF00069	0.453
MOD_Plk_4	671	677	PF00069	0.486
MOD_Plk_4	693	699	PF00069	0.540
MOD_Plk_4	763	769	PF00069	0.474
MOD_ProDKin_1	250	256	PF00069	0.446
MOD_ProDKin_1	512	518	PF00069	0.474
MOD_ProDKin_1	593	599	PF00069	0.453
MOD_ProDKin_1	742	748	PF00069	0.563
TRG_AP2beta_CARGO_1	613	623	PF09066	0.453
TRG_DiLeu_BaEn_1	377	382	PF01217	0.453
TRG_DiLeu_BaEn_1	770	775	PF01217	0.486
TRG_DiLeu_BaEn_2	62	68	PF01217	0.453
TRG_DiLeu_BaLyEn_6	632	637	PF01217	0.502
TRG_DiLeu_BaLyEn_6	724	729	PF01217	0.583
TRG_ENDOCYTIC_2	105	108	PF00928	0.453
TRG_ENDOCYTIC_2	119	122	PF00928	0.453
TRG_ENDOCYTIC_2	61	64	PF00928	0.453
TRG_ENDOCYTIC_2	711	714	PF00928	0.454
TRG_ER_diArg_1	127	129	PF00400	0.434
TRG_ER_diArg_1	161	164	PF00400	0.453
TRG_ER_diArg_1	165	168	PF00400	0.453
TRG_ER_diArg_1	173	176	PF00400	0.453
TRG_ER_diArg_1	183	186	PF00400	0.473
TRG_ER_diArg_1	187	190	PF00400	0.434
TRG_ER_diArg_1	319	321	PF00400	0.453
TRG_ER_diArg_1	361	363	PF00400	0.494
TRG_ER_diArg_1	410	413	PF00400	0.591
TRG_ER_diArg_1	464	467	PF00400	0.464
TRG_ER_diArg_1	623	625	PF00400	0.522
TRG_ER_diArg_1	64	66	PF00400	0.391
TRG_ER_diArg_1	747	749	PF00400	0.575
TRG_ER_diArg_1	759	762	PF00400	0.502
TRG_ER_diArg_1	786	789	PF00400	0.631
TRG_NES_CRM1_1	331	343	PF08389	0.453
TRG_NLS_Bipartite_1	161	176	PF00514	0.395
TRG_NLS_MonoExtC_3	171	176	PF00514	0.395
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.253
TRG_Pf-PMV_PEXEL_1	525	529	PF00026	0.273
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.191

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5R4	Leptomonas seymouri	65%	98%
A0A3Q8IF06	Leishmania donovani	81%	100%
E9AHQ0	Leishmania infantum	81%	100%
E9B471	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q08032	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
Q4Q3V5	Leishmania major	82%	99%