Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLU4_LEIBR

TriTrypDb:

LbrM.33.2600 , LBRM2903_330033600

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLU4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.677
CLV_C14_Caspase3-7	479	483	PF00656	0.578
CLV_NRD_NRD_1	193	195	PF00675	0.467
CLV_NRD_NRD_1	458	460	PF00675	0.424
CLV_NRD_NRD_1	46	48	PF00675	0.466
CLV_PCSK_FUR_1	190	194	PF00082	0.536
CLV_PCSK_KEX2_1	192	194	PF00082	0.480
CLV_PCSK_KEX2_1	458	460	PF00082	0.424
CLV_PCSK_KEX2_1	46	48	PF00082	0.466
CLV_PCSK_SKI1_1	193	197	PF00082	0.463
CLV_PCSK_SKI1_1	270	274	PF00082	0.499
CLV_PCSK_SKI1_1	365	369	PF00082	0.494
CLV_PCSK_SKI1_1	40	44	PF00082	0.446
DEG_APCC_DBOX_1	269	277	PF00400	0.509
DEG_APCC_DBOX_1	364	372	PF00400	0.491
DEG_COP1_1	343	352	PF00400	0.528
DEG_Nend_Nbox_1	1	3	PF02207	0.507
DEG_SPOP_SBC_1	337	341	PF00917	0.677
DOC_CKS1_1	474	479	PF01111	0.476
DOC_CYCLIN_RxL_1	190	197	PF00134	0.529
DOC_CYCLIN_yCln2_LP_2	519	525	PF00134	0.508
DOC_PP1_RVXF_1	38	44	PF00149	0.483
DOC_PP2B_LxvP_1	347	350	PF13499	0.530
DOC_USP7_MATH_1	113	117	PF00917	0.500
DOC_USP7_MATH_1	170	174	PF00917	0.592
DOC_USP7_MATH_1	286	290	PF00917	0.500
DOC_USP7_MATH_1	300	304	PF00917	0.626
DOC_USP7_MATH_1	350	354	PF00917	0.590
DOC_USP7_MATH_1	403	407	PF00917	0.579
DOC_WW_Pin1_4	370	375	PF00397	0.490
DOC_WW_Pin1_4	473	478	PF00397	0.508
DOC_WW_Pin1_4	77	82	PF00397	0.667
LIG_14-3-3_CanoR_1	130	135	PF00244	0.517
LIG_14-3-3_CanoR_1	136	140	PF00244	0.522
LIG_14-3-3_CanoR_1	198	204	PF00244	0.478
LIG_14-3-3_CanoR_1	23	32	PF00244	0.654
LIG_14-3-3_CanoR_1	262	268	PF00244	0.461
LIG_14-3-3_CanoR_1	325	333	PF00244	0.670
LIG_14-3-3_CanoR_1	379	385	PF00244	0.433
LIG_14-3-3_CanoR_1	475	485	PF00244	0.542
LIG_14-3-3_CanoR_1	88	92	PF00244	0.661
LIG_AP_GAE_1	248	254	PF02883	0.477
LIG_AP2alpha_2	83	85	PF02296	0.537
LIG_BRCT_BRCA1_1	288	292	PF00533	0.490
LIG_CaM_IQ_9	492	508	PF13499	0.339
LIG_deltaCOP1_diTrp_1	127	131	PF00928	0.523
LIG_EVH1_2	445	449	PF00568	0.373
LIG_FHA_1	179	185	PF00498	0.445
LIG_FHA_1	300	306	PF00498	0.759
LIG_FHA_1	388	394	PF00498	0.301
LIG_FHA_1	490	496	PF00498	0.398
LIG_FHA_1	514	520	PF00498	0.390
LIG_FHA_2	178	184	PF00498	0.613
LIG_FHA_2	218	224	PF00498	0.589
LIG_FHA_2	317	323	PF00498	0.722
LIG_FHA_2	396	402	PF00498	0.395
LIG_FHA_2	418	424	PF00498	0.515
LIG_FHA_2	477	483	PF00498	0.593
LIG_GBD_Chelix_1	504	512	PF00786	0.299
LIG_LIR_Apic_2	89	94	PF02991	0.604
LIG_LIR_Gen_1	127	134	PF02991	0.520
LIG_LIR_Gen_1	201	211	PF02991	0.530
LIG_LIR_Gen_1	248	257	PF02991	0.578
LIG_LIR_Nem_3	100	105	PF02991	0.436
LIG_LIR_Nem_3	127	131	PF02991	0.523
LIG_LIR_Nem_3	197	203	PF02991	0.532
LIG_LIR_Nem_3	248	254	PF02991	0.604
LIG_Pex14_2	124	128	PF04695	0.523
LIG_SH2_NCK_1	242	246	PF00017	0.554
LIG_SH2_STAP1	203	207	PF00017	0.471
LIG_SH2_STAT5	63	66	PF00017	0.483
LIG_SH3_3	282	288	PF00018	0.641
LIG_SH3_3	439	445	PF00018	0.408
LIG_SH3_3	78	84	PF00018	0.578
LIG_TRAF2_1	180	183	PF00917	0.530
LIG_UBA3_1	393	402	PF00899	0.305
LIG_WRC_WIRS_1	287	292	PF05994	0.490
LIG_WW_3	444	448	PF00397	0.393
MOD_CK1_1	11	17	PF00069	0.540
MOD_CK1_1	171	177	PF00069	0.601
MOD_CK1_1	243	249	PF00069	0.576
MOD_CK1_1	303	309	PF00069	0.636
MOD_CK1_1	316	322	PF00069	0.601
MOD_CK1_1	324	330	PF00069	0.665
MOD_CK1_1	345	351	PF00069	0.615
MOD_CK1_1	416	422	PF00069	0.661
MOD_CK2_1	170	176	PF00069	0.655
MOD_CK2_1	177	183	PF00069	0.559
MOD_CK2_1	198	204	PF00069	0.638
MOD_CK2_1	223	229	PF00069	0.566
MOD_CK2_1	249	255	PF00069	0.558
MOD_CK2_1	316	322	PF00069	0.628
MOD_CK2_1	340	346	PF00069	0.552
MOD_CK2_1	395	401	PF00069	0.383
MOD_CK2_1	86	92	PF00069	0.577
MOD_DYRK1A_RPxSP_1	77	81	PF00069	0.561
MOD_GlcNHglycan	10	13	PF01048	0.657
MOD_GlcNHglycan	170	173	PF01048	0.584
MOD_GlcNHglycan	18	21	PF01048	0.574
MOD_GlcNHglycan	234	237	PF01048	0.537
MOD_GlcNHglycan	242	245	PF01048	0.755
MOD_GlcNHglycan	248	251	PF01048	0.602
MOD_GlcNHglycan	302	305	PF01048	0.640
MOD_GlcNHglycan	315	318	PF01048	0.597
MOD_GlcNHglycan	352	355	PF01048	0.612
MOD_GlcNHglycan	415	418	PF01048	0.663
MOD_GlcNHglycan	99	102	PF01048	0.446
MOD_GSK3_1	168	175	PF00069	0.603
MOD_GSK3_1	299	306	PF00069	0.618
MOD_GSK3_1	312	319	PF00069	0.789
MOD_GSK3_1	323	330	PF00069	0.688
MOD_GSK3_1	336	343	PF00069	0.535
MOD_GSK3_1	348	355	PF00069	0.639
MOD_GSK3_1	413	420	PF00069	0.577
MOD_GSK3_1	73	80	PF00069	0.616
MOD_GSK3_1	8	15	PF00069	0.508
MOD_N-GLC_1	198	203	PF02516	0.552
MOD_N-GLC_1	23	28	PF02516	0.477
MOD_N-GLC_1	341	346	PF02516	0.542
MOD_N-GLC_2	54	56	PF02516	0.508
MOD_NEK2_1	1	6	PF00069	0.590
MOD_NEK2_1	22	27	PF00069	0.585
MOD_NEK2_1	232	237	PF00069	0.546
MOD_NEK2_1	305	310	PF00069	0.701
MOD_NEK2_1	395	400	PF00069	0.374
MOD_NEK2_1	425	430	PF00069	0.398
MOD_NEK2_1	508	513	PF00069	0.326
MOD_NEK2_1	73	78	PF00069	0.769
MOD_NEK2_2	135	140	PF00069	0.520
MOD_PIKK_1	261	267	PF00454	0.463
MOD_PIKK_1	3	9	PF00454	0.509
MOD_PKA_2	129	135	PF00069	0.517
MOD_PKA_2	22	28	PF00069	0.608
MOD_PKA_2	261	267	PF00069	0.463
MOD_PKA_2	324	330	PF00069	0.571
MOD_PKA_2	432	438	PF00069	0.314
MOD_PKA_2	87	93	PF00069	0.773
MOD_Plk_1	198	204	PF00069	0.567
MOD_Plk_1	222	228	PF00069	0.533
MOD_Plk_1	345	351	PF00069	0.531
MOD_Plk_1	508	514	PF00069	0.291
MOD_Plk_1	86	92	PF00069	0.577
MOD_Plk_2-3	223	229	PF00069	0.535
MOD_Plk_2-3	387	393	PF00069	0.306
MOD_Plk_2-3	87	93	PF00069	0.580
MOD_Plk_4	286	292	PF00069	0.487
MOD_Plk_4	395	401	PF00069	0.383
MOD_Plk_4	435	441	PF00069	0.394
MOD_Plk_4	508	514	PF00069	0.291
MOD_ProDKin_1	370	376	PF00069	0.487
MOD_ProDKin_1	473	479	PF00069	0.510
MOD_ProDKin_1	77	83	PF00069	0.658
MOD_SUMO_for_1	237	240	PF00179	0.537
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.478
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.437
TRG_ENDOCYTIC_2	203	206	PF00928	0.510
TRG_ER_diArg_1	189	192	PF00400	0.503
TRG_ER_diArg_1	193	195	PF00400	0.459
TRG_ER_diArg_1	457	459	PF00400	0.429
TRG_ER_diArg_1	46	49	PF00400	0.495
TRG_NLS_MonoExtC_3	139	145	PF00514	0.452
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	40	45	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	77	82	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF55	Leptomonas seymouri	55%	98%
A0A3S7X722	Leishmania donovani	70%	100%
E9AHP9	Leishmania infantum	71%	100%
E9B470	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q3V6	Leishmania major	70%	100%