UDP-glucose 4-epimerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

udp-glc 4'-epimerase, putative

Species:

Leishmania braziliensis

UniProt:

A4HLU3_LEIBR

TriTrypDb:

LbrM.33.2590 , LBRM2903_330033500

Length:

391

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLU3

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0005996	monosaccharide metabolic process	3	12
GO:0006012	galactose metabolic process	5	12
GO:0008152	metabolic process	1	12
GO:0019318	hexose metabolic process	4	12
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003978	UDP-glucose 4-epimerase activity	5	12
GO:0016853	isomerase activity	2	12
GO:0016854	racemase and epimerase activity	3	12
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	252	254	PF00675	0.267
CLV_NRD_NRD_1	328	330	PF00675	0.403
CLV_NRD_NRD_1	342	344	PF00675	0.496
CLV_NRD_NRD_1	62	64	PF00675	0.445
CLV_PCSK_KEX2_1	173	175	PF00082	0.335
CLV_PCSK_KEX2_1	328	330	PF00082	0.424
CLV_PCSK_KEX2_1	341	343	PF00082	0.442
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.335
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.557
CLV_PCSK_PC7_1	338	344	PF00082	0.617
CLV_PCSK_SKI1_1	137	141	PF00082	0.347
CLV_PCSK_SKI1_1	18	22	PF00082	0.333
CLV_PCSK_SKI1_1	254	258	PF00082	0.379
CLV_PCSK_SKI1_1	328	332	PF00082	0.443
CLV_PCSK_SKI1_1	68	72	PF00082	0.519
CLV_PCSK_SKI1_1	85	89	PF00082	0.347
CLV_Separin_Metazoa	19	23	PF03568	0.399
DEG_Nend_UBRbox_1	1	4	PF02207	0.346
DEG_SCF_FBW7_1	268	273	PF00400	0.321
DOC_CKS1_1	267	272	PF01111	0.305
DOC_CYCLIN_RxL_1	15	25	PF00134	0.321
DOC_MAPK_gen_1	253	262	PF00069	0.448
DOC_MAPK_MEF2A_6	342	351	PF00069	0.468
DOC_PP1_RVXF_1	76	83	PF00149	0.394
DOC_PP2B_LxvP_1	234	237	PF13499	0.340
DOC_PP4_FxxP_1	147	150	PF00568	0.305
DOC_USP7_MATH_1	167	171	PF00917	0.428
DOC_USP7_MATH_1	62	66	PF00917	0.223
DOC_WW_Pin1_4	175	180	PF00397	0.326
DOC_WW_Pin1_4	266	271	PF00397	0.305
DOC_WW_Pin1_4	296	301	PF00397	0.533
LIG_14-3-3_CanoR_1	125	131	PF00244	0.426
LIG_14-3-3_CanoR_1	22	31	PF00244	0.235
LIG_14-3-3_CanoR_1	316	321	PF00244	0.336
LIG_14-3-3_CanoR_1	85	93	PF00244	0.357
LIG_CaM_IQ_9	124	139	PF13499	0.448
LIG_deltaCOP1_diTrp_1	375	380	PF00928	0.421
LIG_EH1_1	14	22	PF00400	0.305
LIG_eIF4E_1	133	139	PF01652	0.386
LIG_eIF4E_1	180	186	PF01652	0.321
LIG_FHA_1	12	18	PF00498	0.340
LIG_FHA_1	141	147	PF00498	0.322
LIG_FHA_1	180	186	PF00498	0.350
LIG_FHA_1	307	313	PF00498	0.521
LIG_FHA_2	297	303	PF00498	0.531
LIG_IBAR_NPY_1	149	151	PF08397	0.386
LIG_LIR_Apic_2	265	270	PF02991	0.305
LIG_LIR_Gen_1	258	267	PF02991	0.312
LIG_LIR_Gen_1	277	284	PF02991	0.305
LIG_LIR_Gen_1	304	312	PF02991	0.415
LIG_LIR_Gen_1	364	374	PF02991	0.396
LIG_LIR_Nem_3	258	262	PF02991	0.312
LIG_LIR_Nem_3	277	281	PF02991	0.305
LIG_LIR_Nem_3	304	310	PF02991	0.392
LIG_LIR_Nem_3	364	370	PF02991	0.449
LIG_Pex14_1	363	367	PF04695	0.374
LIG_Pex14_2	306	310	PF04695	0.397
LIG_SH2_CRK	245	249	PF00017	0.373
LIG_SH2_GRB2like	116	119	PF00017	0.322
LIG_SH2_GRB2like	207	210	PF00017	0.305
LIG_SH2_NCK_1	367	371	PF00017	0.365
LIG_SH2_PTP2	102	105	PF00017	0.279
LIG_SH2_PTP2	259	262	PF00017	0.386
LIG_SH2_PTP2	278	281	PF00017	0.305
LIG_SH2_SRC	278	281	PF00017	0.305
LIG_SH2_STAP1	116	120	PF00017	0.340
LIG_SH2_STAT3	189	192	PF00017	0.335
LIG_SH2_STAT5	102	105	PF00017	0.338
LIG_SH2_STAT5	11	14	PF00017	0.321
LIG_SH2_STAT5	207	210	PF00017	0.342
LIG_SH2_STAT5	259	262	PF00017	0.386
LIG_SH2_STAT5	278	281	PF00017	0.305
LIG_SH2_STAT5	294	297	PF00017	0.305
LIG_SH3_1	173	179	PF00018	0.321
LIG_SH3_3	106	112	PF00018	0.305
LIG_SH3_3	161	167	PF00018	0.363
LIG_SH3_3	173	179	PF00018	0.308
LIG_SH3_3	245	251	PF00018	0.386
LIG_SUMO_SIM_anti_2	27	33	PF11976	0.251
LIG_SUMO_SIM_par_1	27	33	PF11976	0.225
LIG_SUMO_SIM_par_1	288	293	PF11976	0.260
LIG_SUMO_SIM_par_1	346	353	PF11976	0.448
LIG_TRAF2_1	353	356	PF00917	0.485
LIG_TYR_ITIM	365	370	PF00017	0.401
LIG_UBA3_1	123	132	PF00899	0.374
LIG_WRC_WIRS_1	307	312	PF05994	0.500
MOD_CDK_SPxxK_3	296	303	PF00069	0.532
MOD_CK2_1	155	161	PF00069	0.451
MOD_CK2_1	21	27	PF00069	0.326
MOD_CK2_1	316	322	PF00069	0.378
MOD_CK2_1	350	356	PF00069	0.480
MOD_GlcNHglycan	157	160	PF01048	0.344
MOD_GlcNHglycan	285	288	PF01048	0.399
MOD_GlcNHglycan	352	355	PF01048	0.446
MOD_GlcNHglycan	375	378	PF01048	0.414
MOD_GlcNHglycan	381	384	PF01048	0.431
MOD_GlcNHglycan	64	67	PF01048	0.470
MOD_GSK3_1	151	158	PF00069	0.269
MOD_GSK3_1	175	182	PF00069	0.381
MOD_GSK3_1	258	265	PF00069	0.328
MOD_GSK3_1	266	273	PF00069	0.297
MOD_GSK3_1	30	37	PF00069	0.344
MOD_GSK3_1	312	319	PF00069	0.419
MOD_LATS_1	280	286	PF00433	0.386
MOD_N-GLC_2	209	211	PF02516	0.318
MOD_NEK2_1	138	143	PF00069	0.313
MOD_NEK2_1	21	26	PF00069	0.259
MOD_NEK2_1	306	311	PF00069	0.399
MOD_NEK2_1	312	317	PF00069	0.368
MOD_NEK2_1	34	39	PF00069	0.394
MOD_NEK2_1	361	366	PF00069	0.451
MOD_PK_1	316	322	PF00069	0.427
MOD_PKA_1	328	334	PF00069	0.418
MOD_PKA_2	21	27	PF00069	0.217
MOD_PKA_2	328	334	PF00069	0.447
MOD_PKA_2	62	68	PF00069	0.235
MOD_ProDKin_1	175	181	PF00069	0.326
MOD_ProDKin_1	266	272	PF00069	0.305
MOD_ProDKin_1	296	302	PF00069	0.527
MOD_SUMO_for_1	70	73	PF00179	0.386
TRG_DiLeu_BaLyEn_6	228	233	PF01217	0.365
TRG_ENDOCYTIC_2	102	105	PF00928	0.279
TRG_ENDOCYTIC_2	245	248	PF00928	0.377
TRG_ENDOCYTIC_2	259	262	PF00928	0.246
TRG_ENDOCYTIC_2	278	281	PF00928	0.305
TRG_ENDOCYTIC_2	367	370	PF00928	0.370
TRG_ER_diArg_1	328	330	PF00400	0.429
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.319

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X4	Leptomonas seymouri	84%	100%
A0A0S4JG28	Bodo saltans	54%	100%
A0A1X0NTG2	Trypanosomatidae	24%	90%
A0A1X0P4J8	Trypanosomatidae	67%	100%
A0A3Q8IHM5	Leishmania donovani	89%	100%
A0A3R7MTU6	Trypanosoma rangeli	66%	100%
A0QSK6	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	24%	100%
B0M3E8	Pisum sativum	32%	100%
B0RVL0	Xanthomonas campestris pv. campestris (strain B100)	24%	100%
D0A685	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	99%
D4GU72	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	22%	100%
E8MF10	Bifidobacterium longum subsp. longum (strain ATCC 15707 / DSM 20219 / JCM 1217 / NCTC 11818 / E194b)	35%	100%
E9AHP8	Leishmania infantum	90%	100%
E9B469	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
F8C4X8	Thermodesulfobacterium geofontis (strain OPF15)	25%	100%
O54067	Rhizobium meliloti (strain 1021)	22%	100%
O64749	Arabidopsis thaliana	33%	94%
O65780	Cyamopsis tetragonoloba	34%	100%
O65781	Cyamopsis tetragonoloba	34%	100%
O84903	Lactobacillus casei	41%	100%
P09147	Escherichia coli (strain K12)	34%	100%
P13226	Streptomyces lividans	37%	100%
P18645	Rattus norvegicus	31%	100%
P21977	Streptococcus thermophilus	39%	100%
P22715	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	35%	100%
P24325	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	31%	100%
P26391	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	23%	100%
P26503	Rhizobium meliloti (strain 1021)	37%	100%
P27830	Escherichia coli (strain K12)	25%	100%
P33119	Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)	37%	100%
P35673	Erwinia amylovora	34%	100%
P37759	Escherichia coli (strain K12)	23%	100%
P37761	Neisseria gonorrhoeae	24%	100%
P37777	Shigella flexneri	26%	100%
P39858	Staphylococcus aureus	21%	100%
P44914	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	24%	100%
P47364	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	31%	100%
P55180	Bacillus subtilis (strain 168)	33%	100%
P55293	Escherichia coli	23%	100%
P55294	Neisseria meningitidis serogroup B (strain MC58)	26%	100%
P55462	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	26%	100%
P56985	Neisseria meningitidis serogroup B (strain MC58)	33%	100%
P56986	Neisseria meningitidis serogroup C	34%	100%
P56997	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	33%	100%
P75517	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	31%	100%
P95780	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	23%	100%
P96995	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	42%	100%
P9WN64	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	24%	100%
P9WN65	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	24%	100%
Q04973	Salmonella typhi	23%	100%
Q05026	Neisseria gonorrhoeae	32%	100%
Q14376	Homo sapiens	31%	100%
Q3T105	Bos taurus	31%	100%
Q42605	Arabidopsis thaliana	32%	100%
Q43070	Pisum sativum	32%	100%
Q45291	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	39%	100%
Q4Q3V7	Leishmania major	88%	100%
Q54WS6	Dictyostelium discoideum	22%	90%
Q553X7	Dictyostelium discoideum	32%	100%
Q56093	Salmonella typhi	35%	100%
Q564Q1	Caenorhabditis elegans	30%	100%
Q57301	Yersinia enterocolitica	34%	100%
Q57664	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	28%	100%
Q58455	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	22%	100%
Q59083	Azospirillum brasilense	37%	100%
Q59678	Mannheimia haemolytica	30%	100%
Q59745	Rhizobium leguminosarum bv. trifolii	35%	100%
Q5R8D0	Pongo abelii	31%	100%
Q652A8	Oryza sativa subsp. japonica	35%	100%
Q6E7F4	Escherichia coli	24%	100%
Q6K2E1	Oryza sativa subsp. japonica	35%	100%
Q6ZDJ7	Oryza sativa subsp. japonica	35%	96%
Q7WTB1	Lactobacillus helveticus	41%	100%
Q8H0B2	Oryza sativa subsp. japonica	34%	96%
Q8H0B6	Oryza sativa subsp. japonica	35%	100%
Q8H930	Oryza sativa subsp. japonica	32%	93%
Q8LDN8	Arabidopsis thaliana	33%	100%
Q8LNZ3	Oryza sativa subsp. japonica	34%	100%
Q8R059	Mus musculus	32%	100%
Q9C7W7	Arabidopsis thaliana	33%	100%
Q9CNY5	Pasteurella multocida (strain Pm70)	32%	100%
Q9F7D4	Yersinia pestis	34%	100%
Q9FI17	Arabidopsis thaliana	33%	90%
Q9KDV3	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	42%	100%
Q9S642	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	26%	100%
Q9SA77	Arabidopsis thaliana	34%	93%
Q9SN58	Arabidopsis thaliana	34%	100%
Q9SUN3	Arabidopsis thaliana	34%	95%
Q9T0A7	Arabidopsis thaliana	34%	100%
Q9W0P5	Drosophila melanogaster	34%	100%
Q9Y7X5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q9ZAE8	Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)	26%	100%
V5DQC0	Trypanosoma cruzi	69%	93%