MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MYND finger, putative

Species:

Leishmania braziliensis

UniProt:

A4HLU1_LEIBR

TriTrypDb:

LbrM.33.2570 , LBRM2903_330033300

Length:

1036

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLU1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.510
CLV_C14_Caspase3-7	47	51	PF00656	0.587
CLV_C14_Caspase3-7	486	490	PF00656	0.338
CLV_C14_Caspase3-7	753	757	PF00656	0.457
CLV_C14_Caspase3-7	811	815	PF00656	0.599
CLV_NRD_NRD_1	112	114	PF00675	0.593
CLV_NRD_NRD_1	255	257	PF00675	0.590
CLV_NRD_NRD_1	42	44	PF00675	0.545
CLV_NRD_NRD_1	560	562	PF00675	0.415
CLV_NRD_NRD_1	651	653	PF00675	0.332
CLV_NRD_NRD_1	689	691	PF00675	0.520
CLV_NRD_NRD_1	824	826	PF00675	0.487
CLV_PCSK_KEX2_1	255	257	PF00082	0.587
CLV_PCSK_KEX2_1	42	44	PF00082	0.495
CLV_PCSK_KEX2_1	560	562	PF00082	0.415
CLV_PCSK_KEX2_1	650	652	PF00082	0.332
CLV_PCSK_KEX2_1	669	671	PF00082	0.332
CLV_PCSK_KEX2_1	689	691	PF00082	0.593
CLV_PCSK_KEX2_1	824	826	PF00082	0.487
CLV_PCSK_PC1ET2_1	669	671	PF00082	0.391
CLV_PCSK_PC7_1	556	562	PF00082	0.462
CLV_PCSK_SKI1_1	113	117	PF00082	0.695
CLV_PCSK_SKI1_1	145	149	PF00082	0.397
CLV_PCSK_SKI1_1	204	208	PF00082	0.534
CLV_PCSK_SKI1_1	282	286	PF00082	0.500
CLV_PCSK_SKI1_1	652	656	PF00082	0.391
CLV_PCSK_SKI1_1	851	855	PF00082	0.393
CLV_PCSK_SKI1_1	886	890	PF00082	0.529
DEG_APCC_DBOX_1	144	152	PF00400	0.459
DEG_APCC_DBOX_1	490	498	PF00400	0.511
DEG_APCC_DBOX_1	785	793	PF00400	0.527
DEG_COP1_1	80	89	PF00400	0.472
DEG_SPOP_SBC_1	246	250	PF00917	0.460
DEG_SPOP_SBC_1	421	425	PF00917	0.544
DOC_CKS1_1	1018	1023	PF01111	0.596
DOC_CKS1_1	511	516	PF01111	0.408
DOC_CKS1_1	832	837	PF01111	0.521
DOC_CYCLIN_RxL_1	142	150	PF00134	0.472
DOC_MAPK_gen_1	650	656	PF00069	0.468
DOC_MAPK_RevD_3	630	644	PF00069	0.585
DOC_PP1_SILK_1	141	146	PF00149	0.332
DOC_PP2B_LxvP_1	630	633	PF13499	0.555
DOC_PP4_FxxP_1	385	388	PF00568	0.447
DOC_USP7_MATH_1	1014	1018	PF00917	0.594
DOC_USP7_MATH_1	157	161	PF00917	0.514
DOC_USP7_MATH_1	246	250	PF00917	0.675
DOC_USP7_MATH_1	273	277	PF00917	0.524
DOC_USP7_MATH_1	415	419	PF00917	0.551
DOC_USP7_MATH_1	536	540	PF00917	0.579
DOC_USP7_MATH_1	744	748	PF00917	0.502
DOC_USP7_MATH_1	780	784	PF00917	0.483
DOC_USP7_MATH_1	973	977	PF00917	0.686
DOC_WW_Pin1_4	1017	1022	PF00397	0.536
DOC_WW_Pin1_4	13	18	PF00397	0.523
DOC_WW_Pin1_4	218	223	PF00397	0.530
DOC_WW_Pin1_4	268	273	PF00397	0.712
DOC_WW_Pin1_4	461	466	PF00397	0.671
DOC_WW_Pin1_4	510	515	PF00397	0.403
DOC_WW_Pin1_4	580	585	PF00397	0.440
DOC_WW_Pin1_4	611	616	PF00397	0.523
DOC_WW_Pin1_4	751	756	PF00397	0.638
DOC_WW_Pin1_4	831	836	PF00397	0.564
LIG_14-3-3_CanoR_1	113	118	PF00244	0.507
LIG_14-3-3_CanoR_1	145	155	PF00244	0.350
LIG_14-3-3_CanoR_1	52	56	PF00244	0.478
LIG_14-3-3_CanoR_1	528	537	PF00244	0.361
LIG_14-3-3_CanoR_1	670	675	PF00244	0.241
LIG_14-3-3_CanoR_1	824	833	PF00244	0.585
LIG_14-3-3_CanoR_1	939	947	PF00244	0.552
LIG_BIR_II_1	1	5	PF00653	0.488
LIG_BIR_III_2	1029	1033	PF00653	0.424
LIG_BIR_III_4	795	799	PF00653	0.401
LIG_BRCT_BRCA1_1	247	251	PF00533	0.673
LIG_BRCT_BRCA1_1	333	337	PF00533	0.385
LIG_BRCT_BRCA1_1	790	794	PF00533	0.577
LIG_BRCT_BRCA1_1	808	812	PF00533	0.439
LIG_eIF4E_1	172	178	PF01652	0.478
LIG_eIF4E_1	437	443	PF01652	0.524
LIG_eIF4E_1	598	604	PF01652	0.535
LIG_EVH1_2	633	637	PF00568	0.494
LIG_FHA_1	1018	1024	PF00498	0.596
LIG_FHA_1	177	183	PF00498	0.532
LIG_FHA_1	19	25	PF00498	0.604
LIG_FHA_1	283	289	PF00498	0.385
LIG_FHA_1	350	356	PF00498	0.465
LIG_FHA_1	422	428	PF00498	0.627
LIG_FHA_1	52	58	PF00498	0.468
LIG_FHA_1	561	567	PF00498	0.407
LIG_FHA_1	627	633	PF00498	0.595
LIG_FHA_1	767	773	PF00498	0.550
LIG_FHA_1	826	832	PF00498	0.509
LIG_FHA_1	835	841	PF00498	0.479
LIG_FHA_1	901	907	PF00498	0.585
LIG_FHA_1	909	915	PF00498	0.422
LIG_FHA_2	14	20	PF00498	0.487
LIG_FHA_2	285	291	PF00498	0.544
LIG_FHA_2	384	390	PF00498	0.466
LIG_FHA_2	499	505	PF00498	0.430
LIG_FHA_2	511	517	PF00498	0.456
LIG_FHA_2	575	581	PF00498	0.539
LIG_FHA_2	795	801	PF00498	0.448
LIG_FHA_2	809	815	PF00498	0.548
LIG_FHA_2	83	89	PF00498	0.595
LIG_Integrin_RGD_1	478	480	PF01839	0.399
LIG_LIR_Apic_2	383	388	PF02991	0.454
LIG_LIR_Apic_2	829	835	PF02991	0.583
LIG_LIR_Gen_1	315	326	PF02991	0.406
LIG_LIR_Gen_1	381	388	PF02991	0.471
LIG_LIR_Gen_1	389	397	PF02991	0.496
LIG_LIR_Gen_1	434	443	PF02991	0.392
LIG_LIR_Gen_1	707	715	PF02991	0.433
LIG_LIR_Gen_1	88	99	PF02991	0.414
LIG_LIR_Nem_3	160	166	PF02991	0.442
LIG_LIR_Nem_3	224	230	PF02991	0.536
LIG_LIR_Nem_3	315	321	PF02991	0.523
LIG_LIR_Nem_3	381	385	PF02991	0.482
LIG_LIR_Nem_3	389	394	PF02991	0.495
LIG_LIR_Nem_3	434	440	PF02991	0.494
LIG_LIR_Nem_3	524	530	PF02991	0.462
LIG_LIR_Nem_3	636	640	PF02991	0.407
LIG_LIR_Nem_3	707	713	PF02991	0.618
LIG_LIR_Nem_3	800	806	PF02991	0.301
LIG_LIR_Nem_3	88	94	PF02991	0.423
LIG_LYPXL_S_1	321	325	PF13949	0.516
LIG_LYPXL_yS_3	322	325	PF13949	0.520
LIG_NRBOX	143	149	PF00104	0.557
LIG_PCNA_PIPBox_1	1	10	PF02747	0.524
LIG_Pex14_1	318	322	PF04695	0.524
LIG_Pex14_1	91	95	PF04695	0.426
LIG_Pex14_2	58	62	PF04695	0.432
LIG_Pex14_2	984	988	PF04695	0.510
LIG_SH2_CRK	333	337	PF00017	0.624
LIG_SH2_CRK	391	395	PF00017	0.544
LIG_SH2_CRK	559	563	PF00017	0.434
LIG_SH2_CRK	803	807	PF00017	0.457
LIG_SH2_CRK	96	100	PF00017	0.560
LIG_SH2_GRB2like	1022	1025	PF00017	0.490
LIG_SH2_NCK_1	164	168	PF00017	0.310
LIG_SH2_PTP2	761	764	PF00017	0.297
LIG_SH2_SRC	437	440	PF00017	0.329
LIG_SH2_SRC	761	764	PF00017	0.524
LIG_SH2_STAP1	333	337	PF00017	0.535
LIG_SH2_STAP1	628	632	PF00017	0.585
LIG_SH2_STAT5	1022	1025	PF00017	0.443
LIG_SH2_STAT5	228	231	PF00017	0.469
LIG_SH2_STAT5	382	385	PF00017	0.468
LIG_SH2_STAT5	526	529	PF00017	0.398
LIG_SH2_STAT5	598	601	PF00017	0.520
LIG_SH2_STAT5	628	631	PF00017	0.453
LIG_SH2_STAT5	666	669	PF00017	0.332
LIG_SH2_STAT5	761	764	PF00017	0.524
LIG_SH2_STAT5	901	904	PF00017	0.423
LIG_SH2_STAT5	926	929	PF00017	0.456
LIG_SH2_STAT5	96	99	PF00017	0.535
LIG_SH3_3	1015	1021	PF00018	0.650
LIG_SH3_3	216	222	PF00018	0.473
LIG_SH3_3	269	275	PF00018	0.669
LIG_SH3_3	340	346	PF00018	0.487
LIG_SH3_3	459	465	PF00018	0.551
LIG_SH3_3	578	584	PF00018	0.476
LIG_SH3_3	695	701	PF00018	0.609
LIG_SH3_3	81	87	PF00018	0.606
LIG_SUMO_SIM_anti_2	236	245	PF11976	0.371
LIG_SUMO_SIM_par_1	451	456	PF11976	0.520
LIG_SUMO_SIM_par_1	600	608	PF11976	0.596
LIG_TRAF2_1	79	82	PF00917	0.603
LIG_TYR_ITIM	759	764	PF00017	0.310
LIG_TYR_ITIM	868	873	PF00017	0.597
LIG_TYR_ITIM	93	98	PF00017	0.518
LIG_WRC_WIRS_1	106	111	PF05994	0.483
LIG_WRC_WIRS_1	382	387	PF05994	0.401
MOD_CK1_1	1017	1023	PF00069	0.638
MOD_CK1_1	18	24	PF00069	0.570
MOD_CK1_1	221	227	PF00069	0.450
MOD_CK1_1	247	253	PF00069	0.616
MOD_CK1_1	309	315	PF00069	0.437
MOD_CK1_1	381	387	PF00069	0.549
MOD_CK1_1	423	429	PF00069	0.629
MOD_CK1_1	531	537	PF00069	0.377
MOD_CK1_1	613	619	PF00069	0.598
MOD_CK1_1	638	644	PF00069	0.588
MOD_CK1_1	942	948	PF00069	0.419
MOD_CK1_1	976	982	PF00069	0.492
MOD_CK2_1	309	315	PF00069	0.570
MOD_CK2_1	332	338	PF00069	0.613
MOD_CK2_1	383	389	PF00069	0.467
MOD_CK2_1	510	516	PF00069	0.407
MOD_CK2_1	574	580	PF00069	0.554
MOD_CK2_1	794	800	PF00069	0.555
MOD_CK2_1	82	88	PF00069	0.616
MOD_Cter_Amidation	648	651	PF01082	0.332
MOD_GlcNHglycan	1009	1012	PF01048	0.569
MOD_GlcNHglycan	1014	1017	PF01048	0.693
MOD_GlcNHglycan	122	125	PF01048	0.717
MOD_GlcNHglycan	129	132	PF01048	0.739
MOD_GlcNHglycan	136	139	PF01048	0.475
MOD_GlcNHglycan	157	160	PF01048	0.493
MOD_GlcNHglycan	223	226	PF01048	0.550
MOD_GlcNHglycan	25	28	PF01048	0.534
MOD_GlcNHglycan	307	311	PF01048	0.493
MOD_GlcNHglycan	417	420	PF01048	0.718
MOD_GlcNHglycan	431	434	PF01048	0.639
MOD_GlcNHglycan	468	471	PF01048	0.377
MOD_GlcNHglycan	530	533	PF01048	0.559
MOD_GlcNHglycan	538	541	PF01048	0.555
MOD_GlcNHglycan	621	624	PF01048	0.760
MOD_GlcNHglycan	658	661	PF01048	0.242
MOD_GlcNHglycan	746	749	PF01048	0.566
MOD_GlcNHglycan	865	868	PF01048	0.600
MOD_GlcNHglycan	965	968	PF01048	0.504
MOD_GlcNHglycan	974	979	PF01048	0.597
MOD_GSK3_1	1002	1009	PF00069	0.641
MOD_GSK3_1	147	154	PF00069	0.600
MOD_GSK3_1	18	25	PF00069	0.452
MOD_GSK3_1	214	221	PF00069	0.548
MOD_GSK3_1	240	247	PF00069	0.560
MOD_GSK3_1	260	267	PF00069	0.570
MOD_GSK3_1	421	428	PF00069	0.747
MOD_GSK3_1	531	538	PF00069	0.494
MOD_GSK3_1	540	547	PF00069	0.405
MOD_GSK3_1	607	614	PF00069	0.624
MOD_GSK3_1	701	708	PF00069	0.423
MOD_GSK3_1	722	729	PF00069	0.506
MOD_GSK3_1	790	797	PF00069	0.581
MOD_GSK3_1	806	813	PF00069	0.432
MOD_GSK3_1	827	834	PF00069	0.531
MOD_GSK3_1	942	949	PF00069	0.501
MOD_GSK3_1	973	980	PF00069	0.707
MOD_N-GLC_1	264	269	PF02516	0.507
MOD_NEK2_1	1002	1007	PF00069	0.693
MOD_NEK2_1	126	131	PF00069	0.739
MOD_NEK2_1	134	139	PF00069	0.614
MOD_NEK2_1	147	152	PF00069	0.413
MOD_NEK2_1	178	183	PF00069	0.511
MOD_NEK2_1	324	329	PF00069	0.486
MOD_NEK2_1	332	337	PF00069	0.583
MOD_NEK2_1	498	503	PF00069	0.503
MOD_NEK2_1	535	540	PF00069	0.439
MOD_NEK2_1	579	584	PF00069	0.550
MOD_NEK2_1	597	602	PF00069	0.228
MOD_NEK2_1	656	661	PF00069	0.241
MOD_NEK2_1	703	708	PF00069	0.552
MOD_NEK2_1	750	755	PF00069	0.591
MOD_NEK2_1	794	799	PF00069	0.548
MOD_NEK2_1	812	817	PF00069	0.305
MOD_NEK2_1	921	926	PF00069	0.492
MOD_NEK2_1	94	99	PF00069	0.421
MOD_PIKK_1	540	546	PF00454	0.473
MOD_PIKK_1	598	604	PF00454	0.535
MOD_PIKK_1	638	644	PF00454	0.361
MOD_PIKK_1	701	707	PF00454	0.460
MOD_PIKK_1	722	728	PF00454	0.489
MOD_PIKK_1	812	818	PF00454	0.366
MOD_PIKK_1	977	983	PF00454	0.473
MOD_PKA_1	113	119	PF00069	0.496
MOD_PKA_1	560	566	PF00069	0.445
MOD_PKA_2	120	126	PF00069	0.748
MOD_PKA_2	51	57	PF00069	0.482
MOD_PKA_2	560	566	PF00069	0.445
MOD_PKA_2	656	662	PF00069	0.241
MOD_PKA_2	854	860	PF00069	0.453
MOD_PKA_2	863	869	PF00069	0.516
MOD_PKB_1	111	119	PF00069	0.499
MOD_Plk_1	264	270	PF00069	0.507
MOD_Plk_1	498	504	PF00069	0.411
MOD_Plk_1	635	641	PF00069	0.353
MOD_Plk_1	780	786	PF00069	0.563
MOD_Plk_1	922	928	PF00069	0.490
MOD_Plk_2-3	260	266	PF00069	0.509
MOD_Plk_2-3	82	88	PF00069	0.567
MOD_Plk_2-3	968	974	PF00069	0.688
MOD_Plk_4	1014	1020	PF00069	0.641
MOD_Plk_4	151	157	PF00069	0.587
MOD_Plk_4	178	184	PF00069	0.599
MOD_Plk_4	247	253	PF00069	0.442
MOD_Plk_4	274	280	PF00069	0.435
MOD_Plk_4	332	338	PF00069	0.635
MOD_Plk_4	705	711	PF00069	0.450
MOD_Plk_4	717	723	PF00069	0.459
MOD_Plk_4	730	736	PF00069	0.379
MOD_Plk_4	827	833	PF00069	0.559
MOD_Plk_4	897	903	PF00069	0.534
MOD_Plk_4	922	928	PF00069	0.428
MOD_Plk_4	94	100	PF00069	0.459
MOD_ProDKin_1	1017	1023	PF00069	0.528
MOD_ProDKin_1	13	19	PF00069	0.527
MOD_ProDKin_1	218	224	PF00069	0.511
MOD_ProDKin_1	268	274	PF00069	0.705
MOD_ProDKin_1	461	467	PF00069	0.668
MOD_ProDKin_1	510	516	PF00069	0.404
MOD_ProDKin_1	580	586	PF00069	0.440
MOD_ProDKin_1	611	617	PF00069	0.524
MOD_ProDKin_1	751	757	PF00069	0.625
MOD_ProDKin_1	831	837	PF00069	0.570
MOD_SUMO_rev_2	107	116	PF00179	0.703
TRG_DiLeu_BaEn_1	173	178	PF01217	0.560
TRG_DiLeu_BaEn_1	236	241	PF01217	0.333
TRG_DiLeu_BaEn_3	389	395	PF01217	0.338
TRG_DiLeu_BaEn_3	524	530	PF01217	0.299
TRG_DiLeu_BaEn_4	787	793	PF01217	0.344
TRG_ENDOCYTIC_2	172	175	PF00928	0.482
TRG_ENDOCYTIC_2	227	230	PF00928	0.530
TRG_ENDOCYTIC_2	322	325	PF00928	0.443
TRG_ENDOCYTIC_2	333	336	PF00928	0.535
TRG_ENDOCYTIC_2	382	385	PF00928	0.468
TRG_ENDOCYTIC_2	391	394	PF00928	0.485
TRG_ENDOCYTIC_2	437	440	PF00928	0.452
TRG_ENDOCYTIC_2	526	529	PF00928	0.337
TRG_ENDOCYTIC_2	761	764	PF00928	0.297
TRG_ENDOCYTIC_2	803	806	PF00928	0.457
TRG_ENDOCYTIC_2	870	873	PF00928	0.492
TRG_ENDOCYTIC_2	95	98	PF00928	0.539
TRG_ER_diArg_1	41	43	PF00400	0.549
TRG_ER_diArg_1	559	561	PF00400	0.413
TRG_ER_diArg_1	650	652	PF00400	0.332
TRG_ER_diArg_1	688	690	PF00400	0.593
TRG_ER_diArg_1	823	825	PF00400	0.463
TRG_Pf-PMV_PEXEL_1	692	696	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	777	781	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7B7	Leptomonas seymouri	45%	100%
A0A1X0P408	Trypanosomatidae	30%	100%
A0A3Q8IDX1	Leishmania donovani	74%	100%
E9AHP7	Leishmania infantum	74%	100%
E9B467	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q3V9	Leishmania major	74%	100%