RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLT8_LEIBR

TriTrypDb:

LbrM.33.2540 , LBRM2903_330033000

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLT8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	421	425	PF00656	0.716
CLV_C14_Caspase3-7	72	76	PF00656	0.689
CLV_PCSK_KEX2_1	114	116	PF00082	0.519
CLV_PCSK_KEX2_1	316	318	PF00082	0.768
CLV_PCSK_KEX2_1	436	438	PF00082	0.576
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.601
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.768
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.576
CLV_PCSK_SKI1_1	19	23	PF00082	0.562
DEG_APCC_DBOX_1	210	218	PF00400	0.567
DEG_Nend_UBRbox_2	1	3	PF02207	0.494
DEG_SCF_FBW7_1	363	368	PF00400	0.542
DEG_SPOP_SBC_1	271	275	PF00917	0.445
DOC_CKS1_1	351	356	PF01111	0.543
DOC_CYCLIN_RxL_1	224	236	PF00134	0.360
DOC_PP1_RVXF_1	228	235	PF00149	0.369
DOC_PP2B_LxvP_1	423	426	PF13499	0.728
DOC_SPAK_OSR1_1	243	247	PF12202	0.509
DOC_USP7_MATH_1	14	18	PF00917	0.472
DOC_USP7_MATH_1	170	174	PF00917	0.783
DOC_USP7_MATH_1	198	202	PF00917	0.680
DOC_USP7_MATH_1	252	256	PF00917	0.596
DOC_USP7_MATH_1	286	290	PF00917	0.727
DOC_USP7_MATH_1	395	399	PF00917	0.564
DOC_USP7_MATH_1	63	67	PF00917	0.687
DOC_USP7_MATH_1	71	75	PF00917	0.787
DOC_WW_Pin1_4	272	277	PF00397	0.572
DOC_WW_Pin1_4	350	355	PF00397	0.697
DOC_WW_Pin1_4	361	366	PF00397	0.596
DOC_WW_Pin1_4	396	401	PF00397	0.764
LIG_14-3-3_CanoR_1	107	113	PF00244	0.522
LIG_14-3-3_CanoR_1	178	186	PF00244	0.627
LIG_14-3-3_CanoR_1	19	24	PF00244	0.485
LIG_14-3-3_CanoR_1	211	215	PF00244	0.569
LIG_14-3-3_CanoR_1	411	420	PF00244	0.595
LIG_14-3-3_CanoR_1	44	52	PF00244	0.549
LIG_BRCT_BRCA1_1	200	204	PF00533	0.689
LIG_BRCT_BRCA1_1	397	401	PF00533	0.509
LIG_EVH1_2	167	171	PF00568	0.513
LIG_FHA_1	107	113	PF00498	0.508
LIG_FHA_1	145	151	PF00498	0.586
LIG_FHA_1	30	36	PF00498	0.549
LIG_FHA_1	75	81	PF00498	0.538
LIG_FHA_2	28	34	PF00498	0.554
LIG_FHA_2	347	353	PF00498	0.570
LIG_LIR_Gen_1	104	112	PF02991	0.440
LIG_LIR_Gen_1	17	26	PF02991	0.466
LIG_LIR_Nem_3	104	108	PF02991	0.419
LIG_LIR_Nem_3	17	23	PF02991	0.459
LIG_PCNA_PIPBox_1	225	234	PF02747	0.352
LIG_SH2_CRK	105	109	PF00017	0.443
LIG_SH2_CRK	7	11	PF00017	0.434
LIG_SH2_NCK_1	251	255	PF00017	0.587
LIG_SH2_STAT5	20	23	PF00017	0.509
LIG_SH3_3	164	170	PF00018	0.784
LIG_SH3_3	20	26	PF00018	0.620
LIG_SH3_3	348	354	PF00018	0.565
LIG_SH3_3	64	70	PF00018	0.738
LIG_SUMO_SIM_par_1	108	113	PF11976	0.519
LIG_TRAF2_1	233	236	PF00917	0.555
LIG_TYR_ITIM	5	10	PF00017	0.425
LIG_UBA3_1	203	208	PF00899	0.667
MOD_CK1_1	212	218	PF00069	0.602
MOD_CK1_1	272	278	PF00069	0.685
MOD_CK1_1	280	286	PF00069	0.703
MOD_CK1_1	288	294	PF00069	0.572
MOD_CK1_1	339	345	PF00069	0.782
MOD_CK1_1	361	367	PF00069	0.737
MOD_CK1_1	371	377	PF00069	0.703
MOD_CK1_1	74	80	PF00069	0.759
MOD_CK2_1	120	126	PF00069	0.549
MOD_CK2_1	250	256	PF00069	0.502
MOD_CK2_1	346	352	PF00069	0.753
MOD_GlcNHglycan	147	150	PF01048	0.678
MOD_GlcNHglycan	155	159	PF01048	0.755
MOD_GlcNHglycan	16	19	PF01048	0.482
MOD_GlcNHglycan	172	175	PF01048	0.690
MOD_GlcNHglycan	180	183	PF01048	0.695
MOD_GlcNHglycan	252	255	PF01048	0.505
MOD_GlcNHglycan	341	344	PF01048	0.791
MOD_GlcNHglycan	359	363	PF01048	0.702
MOD_GlcNHglycan	370	373	PF01048	0.761
MOD_GlcNHglycan	387	390	PF01048	0.591
MOD_GlcNHglycan	429	432	PF01048	0.652
MOD_GlcNHglycan	62	66	PF01048	0.618
MOD_GlcNHglycan	80	83	PF01048	0.747
MOD_GlcNHglycan	88	91	PF01048	0.435
MOD_GSK3_1	106	113	PF00069	0.491
MOD_GSK3_1	270	277	PF00069	0.665
MOD_GSK3_1	280	287	PF00069	0.677
MOD_GSK3_1	335	342	PF00069	0.593
MOD_GSK3_1	346	353	PF00069	0.722
MOD_GSK3_1	361	368	PF00069	0.647
MOD_GSK3_1	381	388	PF00069	0.686
MOD_GSK3_1	395	402	PF00069	0.742
MOD_GSK3_1	74	81	PF00069	0.637
MOD_GSK3_1	82	89	PF00069	0.636
MOD_N-GLC_1	45	50	PF02516	0.447
MOD_NEK2_1	108	113	PF00069	0.519
MOD_NEK2_1	78	83	PF00069	0.782
MOD_PIKK_1	120	126	PF00454	0.605
MOD_PIKK_1	198	204	PF00454	0.624
MOD_PIKK_1	399	405	PF00454	0.474
MOD_PKA_1	322	328	PF00069	0.549
MOD_PKA_2	106	112	PF00069	0.514
MOD_PKA_2	210	216	PF00069	0.558
MOD_Plk_1	310	316	PF00069	0.599
MOD_Plk_1	358	364	PF00069	0.560
MOD_Plk_1	45	51	PF00069	0.546
MOD_Plk_4	310	316	PF00069	0.588
MOD_Plk_4	418	424	PF00069	0.602
MOD_ProDKin_1	272	278	PF00069	0.576
MOD_ProDKin_1	350	356	PF00069	0.697
MOD_ProDKin_1	361	367	PF00069	0.595
MOD_ProDKin_1	396	402	PF00069	0.757
MOD_SUMO_rev_2	318	325	PF00179	0.665
TRG_DiLeu_BaEn_1	53	58	PF01217	0.483
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.425
TRG_ENDOCYTIC_2	105	108	PF00928	0.420
TRG_ENDOCYTIC_2	20	23	PF00928	0.418
TRG_ENDOCYTIC_2	7	10	PF00928	0.415
TRG_NES_CRM1_1	410	424	PF08389	0.635
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	230	235	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILE8	Leptomonas seymouri	47%	100%
A0A1X0P415	Trypanosomatidae	31%	100%
A0A3Q8IH00	Leishmania donovani	74%	98%
E9AHP4	Leishmania infantum	73%	98%
E9B464	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	99%
Q4Q3W2	Leishmania major	74%	100%
V5B8P7	Trypanosoma cruzi	28%	100%