Replication endonuclease

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLT7_LEIBR

TriTrypDb:

LbrM.33.2530 , LBRM2903_330032900

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLT7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.440
CLV_NRD_NRD_1	136	138	PF00675	0.715
CLV_NRD_NRD_1	161	163	PF00675	0.604
CLV_NRD_NRD_1	181	183	PF00675	0.554
CLV_NRD_NRD_1	4	6	PF00675	0.630
CLV_NRD_NRD_1	55	57	PF00675	0.416
CLV_PCSK_KEX2_1	136	138	PF00082	0.641
CLV_PCSK_KEX2_1	161	163	PF00082	0.509
CLV_PCSK_KEX2_1	170	172	PF00082	0.462
CLV_PCSK_KEX2_1	181	183	PF00082	0.529
CLV_PCSK_KEX2_1	34	36	PF00082	0.410
CLV_PCSK_KEX2_1	4	6	PF00082	0.659
CLV_PCSK_KEX2_1	55	57	PF00082	0.416
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.418
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.507
CLV_PCSK_PC7_1	51	57	PF00082	0.411
CLV_PCSK_SKI1_1	124	128	PF00082	0.420
CLV_PCSK_SKI1_1	51	55	PF00082	0.417
CLV_PCSK_SKI1_1	87	91	PF00082	0.400
DEG_Nend_UBRbox_3	1	3	PF02207	0.636
DOC_CKS1_1	66	71	PF01111	0.568
DOC_MAPK_gen_1	169	177	PF00069	0.628
DOC_PP1_RVXF_1	159	166	PF00149	0.609
DOC_USP7_MATH_1	196	200	PF00917	0.495
DOC_USP7_MATH_1	272	276	PF00917	0.690
DOC_WW_Pin1_4	286	291	PF00397	0.455
DOC_WW_Pin1_4	65	70	PF00397	0.572
LIG_14-3-3_CanoR_1	136	140	PF00244	0.672
LIG_14-3-3_CanoR_1	181	185	PF00244	0.500
LIG_APCC_ABBAyCdc20_2	137	143	PF00400	0.650
LIG_BRCT_BRCA1_1	221	225	PF00533	0.602
LIG_FHA_1	140	146	PF00498	0.593
LIG_FHA_1	155	161	PF00498	0.484
LIG_FHA_1	292	298	PF00498	0.656
LIG_FHA_1	76	82	PF00498	0.457
LIG_FHA_2	130	136	PF00498	0.594
LIG_KLC1_Yacidic_2	248	253	PF13176	0.583
LIG_LIR_Apic_2	142	147	PF02991	0.544
LIG_LIR_Gen_1	16	27	PF02991	0.470
LIG_LIR_Gen_1	164	173	PF02991	0.587
LIG_LIR_Nem_3	122	126	PF02991	0.425
LIG_LIR_Nem_3	164	168	PF02991	0.639
LIG_LIR_Nem_3	183	187	PF02991	0.375
LIG_LIR_Nem_3	222	228	PF02991	0.578
LIG_LIR_Nem_3	24	30	PF02991	0.412
LIG_LIR_Nem_3	246	252	PF02991	0.550
LIG_LIR_Nem_3	52	57	PF02991	0.411
LIG_LYPXL_S_1	26	30	PF13949	0.508
LIG_PDZ_Class_1	297	302	PF00595	0.700
LIG_Pex14_2	123	127	PF04695	0.389
LIG_Pex14_2	26	30	PF04695	0.488
LIG_PTB_Apo_2	20	27	PF02174	0.463
LIG_SH2_CRK	184	188	PF00017	0.451
LIG_SH2_CRK	93	97	PF00017	0.404
LIG_SH2_NCK_1	42	46	PF00017	0.442
LIG_SH2_PTP2	144	147	PF00017	0.613
LIG_SH2_STAT5	144	147	PF00017	0.581
LIG_SH2_STAT5	251	254	PF00017	0.493
LIG_SH3_3	63	69	PF00018	0.519
LIG_SH3_3	9	15	PF00018	0.638
LIG_SH3_3	98	104	PF00018	0.529
LIG_SH3_4	209	216	PF00018	0.540
LIG_SUMO_SIM_par_1	78	85	PF11976	0.560
LIG_TRAF2_1	229	232	PF00917	0.533
LIG_TRAF2_1	239	242	PF00917	0.540
MOD_CK1_1	125	131	PF00069	0.528
MOD_CK2_1	129	135	PF00069	0.545
MOD_CK2_1	272	278	PF00069	0.746
MOD_GlcNHglycan	58	61	PF01048	0.385
MOD_GSK3_1	125	132	PF00069	0.427
MOD_GSK3_1	135	142	PF00069	0.543
MOD_N-GLC_1	154	159	PF02516	0.447
MOD_N-GLC_1	297	302	PF02516	0.719
MOD_NEK2_1	219	224	PF00069	0.439
MOD_NEK2_1	44	49	PF00069	0.539
MOD_NEK2_1	97	102	PF00069	0.424
MOD_PIKK_1	14	20	PF00454	0.509
MOD_PIKK_1	187	193	PF00454	0.671
MOD_PKA_2	135	141	PF00069	0.671
MOD_PKA_2	180	186	PF00069	0.458
MOD_PKA_2	205	211	PF00069	0.597
MOD_PKA_2	262	268	PF00069	0.573
MOD_Plk_1	154	160	PF00069	0.610
MOD_Plk_1	163	169	PF00069	0.587
MOD_Plk_2-3	148	154	PF00069	0.655
MOD_Plk_4	255	261	PF00069	0.498
MOD_ProDKin_1	286	292	PF00069	0.452
MOD_ProDKin_1	65	71	PF00069	0.567
MOD_SUMO_for_1	239	242	PF00179	0.511
MOD_SUMO_rev_2	199	204	PF00179	0.535
TRG_DiLeu_BaEn_1	84	89	PF01217	0.512
TRG_DiLeu_LyEn_5	84	89	PF01217	0.482
TRG_ENDOCYTIC_2	184	187	PF00928	0.445
TRG_ENDOCYTIC_2	27	30	PF00928	0.384
TRG_ENDOCYTIC_2	93	96	PF00928	0.393
TRG_ER_diArg_1	160	162	PF00400	0.700
TRG_ER_diArg_1	54	56	PF00400	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE06	Leptomonas seymouri	63%	97%
A0A0S4JDA2	Bodo saltans	25%	94%
A0A1X0P3S3	Trypanosomatidae	43%	100%
A0A3S7X717	Leishmania donovani	79%	97%
A0A422NI03	Trypanosoma rangeli	43%	100%
D0A689	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AHP3	Leishmania infantum	79%	97%
E9B463	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	97%
Q4Q3W3	Leishmania major	79%	100%
V5DQC4	Trypanosoma cruzi	43%	100%