Retrotransposon hot spot (RHS) protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLT6_LEIBR

TriTrypDb:

LbrM.33.2520 , LBRM2903_330032800

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLT6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.604
CLV_C14_Caspase3-7	156	160	PF00656	0.753
CLV_NRD_NRD_1	100	102	PF00675	0.685
CLV_NRD_NRD_1	103	105	PF00675	0.711
CLV_NRD_NRD_1	109	111	PF00675	0.717
CLV_NRD_NRD_1	194	196	PF00675	0.368
CLV_NRD_NRD_1	20	22	PF00675	0.607
CLV_PCSK_FUR_1	101	105	PF00082	0.582
CLV_PCSK_FUR_1	107	111	PF00082	0.542
CLV_PCSK_FUR_1	95	99	PF00082	0.606
CLV_PCSK_KEX2_1	100	102	PF00082	0.656
CLV_PCSK_KEX2_1	103	105	PF00082	0.661
CLV_PCSK_KEX2_1	109	111	PF00082	0.600
CLV_PCSK_KEX2_1	194	196	PF00082	0.368
CLV_PCSK_KEX2_1	20	22	PF00082	0.607
CLV_PCSK_KEX2_1	97	99	PF00082	0.660
CLV_PCSK_PC7_1	93	99	PF00082	0.647
CLV_PCSK_SKI1_1	294	298	PF00082	0.385
DEG_SPOP_SBC_1	360	364	PF00917	0.604
DOC_ANK_TNKS_1	314	321	PF00023	0.592
DOC_MAPK_gen_1	310	318	PF00069	0.407
DOC_MAPK_gen_1	352	360	PF00069	0.492
DOC_PP2B_LxvP_1	297	300	PF13499	0.413
DOC_PP4_FxxP_1	296	299	PF00568	0.385
DOC_USP7_MATH_1	147	151	PF00917	0.683
DOC_USP7_MATH_1	153	157	PF00917	0.665
DOC_USP7_MATH_1	277	281	PF00917	0.333
DOC_WW_Pin1_4	284	289	PF00397	0.598
DOC_WW_Pin1_4	368	373	PF00397	0.768
DOC_WW_Pin1_4	38	43	PF00397	0.665
LIG_14-3-3_CanoR_1	21	31	PF00244	0.627
LIG_14-3-3_CanoR_1	355	361	PF00244	0.494
LIG_14-3-3_CanoR_1	56	62	PF00244	0.667
LIG_APCC_ABBA_1	293	298	PF00400	0.609
LIG_APCC_ABBA_1	370	375	PF00400	0.532
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_BIR_III_2	159	163	PF00653	0.736
LIG_BRCT_BRCA1_1	322	326	PF00533	0.548
LIG_deltaCOP1_diTrp_1	348	354	PF00928	0.559
LIG_EH1_1	207	215	PF00400	0.351
LIG_eIF4E_1	208	214	PF01652	0.591
LIG_FHA_1	76	82	PF00498	0.569
LIG_FHA_2	262	268	PF00498	0.597
LIG_FHA_2	339	345	PF00498	0.363
LIG_LIR_Nem_3	223	229	PF02991	0.369
LIG_LIR_Nem_3	238	243	PF02991	0.567
LIG_LIR_Nem_3	323	329	PF02991	0.576
LIG_LIR_Nem_3	351	357	PF02991	0.564
LIG_MYND_1	295	299	PF01753	0.391
LIG_Pex14_1	350	354	PF04695	0.554
LIG_Pex14_2	322	326	PF04695	0.431
LIG_Rb_LxCxE_1	302	319	PF01857	0.603
LIG_Rb_LxCxE_1	336	353	PF01857	0.342
LIG_REV1ctd_RIR_1	238	246	PF16727	0.460
LIG_SH2_CRK	327	331	PF00017	0.392
LIG_SH2_NCK_1	327	331	PF00017	0.625
LIG_SH2_SRC	217	220	PF00017	0.323
LIG_SH2_STAT5	217	220	PF00017	0.467
LIG_SH3_2	162	167	PF14604	0.494
LIG_SH3_3	159	165	PF00018	0.677
LIG_SH3_3	169	175	PF00018	0.597
LIG_SUMO_SIM_anti_2	336	341	PF11976	0.559
LIG_SUMO_SIM_par_1	356	364	PF11976	0.473
LIG_TYR_ITIM	215	220	PF00017	0.561
LIG_WRPW_2	293	296	PF00400	0.377
MOD_CK1_1	359	365	PF00069	0.613
MOD_CK2_1	261	267	PF00069	0.583
MOD_CK2_1	338	344	PF00069	0.394
MOD_GlcNHglycan	110	113	PF01048	0.689
MOD_GlcNHglycan	149	152	PF01048	0.715
MOD_GlcNHglycan	155	158	PF01048	0.737
MOD_GlcNHglycan	230	233	PF01048	0.491
MOD_GlcNHglycan	267	270	PF01048	0.631
MOD_GlcNHglycan	375	378	PF01048	0.519
MOD_GSK3_1	261	268	PF00069	0.591
MOD_GSK3_1	356	363	PF00069	0.562
MOD_GSK3_1	65	72	PF00069	0.600
MOD_GSK3_1	75	82	PF00069	0.600
MOD_N-GLC_1	119	124	PF02516	0.619
MOD_N-GLC_1	360	365	PF02516	0.614
MOD_NEK2_1	168	173	PF00069	0.490
MOD_NEK2_1	261	266	PF00069	0.457
MOD_NEK2_1	45	50	PF00069	0.732
MOD_NEK2_2	119	124	PF00069	0.587
MOD_NEK2_2	350	355	PF00069	0.465
MOD_PKA_1	103	109	PF00069	0.617
MOD_PKA_2	103	109	PF00069	0.695
MOD_PKA_2	23	29	PF00069	0.658
MOD_PKA_2	55	61	PF00069	0.609
MOD_PKB_1	101	109	PF00069	0.615
MOD_Plk_1	119	125	PF00069	0.586
MOD_Plk_1	360	366	PF00069	0.631
MOD_Plk_1	75	81	PF00069	0.620
MOD_Plk_2-3	69	75	PF00069	0.627
MOD_Plk_4	135	141	PF00069	0.725
MOD_Plk_4	277	283	PF00069	0.341
MOD_Plk_4	299	305	PF00069	0.495
MOD_Plk_4	361	367	PF00069	0.648
MOD_Plk_4	69	75	PF00069	0.579
MOD_Plk_4	76	82	PF00069	0.528
MOD_Plk_4	83	89	PF00069	0.503
MOD_ProDKin_1	284	290	PF00069	0.595
MOD_ProDKin_1	368	374	PF00069	0.763
MOD_ProDKin_1	38	44	PF00069	0.665
TRG_DiLeu_BaEn_2	222	228	PF01217	0.570
TRG_ENDOCYTIC_2	202	205	PF00928	0.498
TRG_ENDOCYTIC_2	217	220	PF00928	0.439
TRG_ENDOCYTIC_2	327	330	PF00928	0.388
TRG_ER_diArg_1	107	110	PF00400	0.610
TRG_ER_diArg_1	241	244	PF00400	0.488
TRG_ER_diArg_1	313	316	PF00400	0.618
TRG_ER_diArg_1	95	98	PF00400	0.647
TRG_ER_diArg_1	99	101	PF00400	0.647
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J871	Bodo saltans	34%	89%
E9B462	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q3W4	Leishmania major	79%	100%