Cilia- and flagella-associated protein 91

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1, putative

Species:

Leishmania braziliensis

UniProt:

A4HLT5_LEIBR

TriTrypDb:

LbrM.33.2510 , LBRM2903_330032700

Length:

755

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005856	cytoskeleton	5	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0005930	axoneme	2	1

Expansion

Sequence features

A4HLT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLT5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.610
CLV_C14_Caspase3-7	226	230	PF00656	0.535
CLV_C14_Caspase3-7	389	393	PF00656	0.567
CLV_C14_Caspase3-7	418	422	PF00656	0.602
CLV_C14_Caspase3-7	51	55	PF00656	0.603
CLV_C14_Caspase3-7	709	713	PF00656	0.436
CLV_NRD_NRD_1	117	119	PF00675	0.657
CLV_NRD_NRD_1	124	126	PF00675	0.718
CLV_NRD_NRD_1	217	219	PF00675	0.232
CLV_NRD_NRD_1	261	263	PF00675	0.272
CLV_NRD_NRD_1	30	32	PF00675	0.610
CLV_NRD_NRD_1	306	308	PF00675	0.296
CLV_NRD_NRD_1	453	455	PF00675	0.423
CLV_NRD_NRD_1	634	636	PF00675	0.577
CLV_PCSK_FUR_1	213	217	PF00082	0.233
CLV_PCSK_FUR_1	632	636	PF00082	0.508
CLV_PCSK_FUR_1	639	643	PF00082	0.431
CLV_PCSK_KEX2_1	117	119	PF00082	0.657
CLV_PCSK_KEX2_1	124	126	PF00082	0.677
CLV_PCSK_KEX2_1	215	217	PF00082	0.232
CLV_PCSK_KEX2_1	261	263	PF00082	0.238
CLV_PCSK_KEX2_1	30	32	PF00082	0.605
CLV_PCSK_KEX2_1	306	308	PF00082	0.271
CLV_PCSK_KEX2_1	312	314	PF00082	0.443
CLV_PCSK_KEX2_1	445	447	PF00082	0.444
CLV_PCSK_KEX2_1	453	455	PF00082	0.414
CLV_PCSK_KEX2_1	561	563	PF00082	0.619
CLV_PCSK_KEX2_1	634	636	PF00082	0.544
CLV_PCSK_KEX2_1	641	643	PF00082	0.540
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.460
CLV_PCSK_PC1ET2_1	445	447	PF00082	0.502
CLV_PCSK_PC1ET2_1	561	563	PF00082	0.594
CLV_PCSK_PC1ET2_1	641	643	PF00082	0.469
CLV_PCSK_PC7_1	213	219	PF00082	0.242
CLV_PCSK_SKI1_1	124	128	PF00082	0.762
CLV_PCSK_SKI1_1	399	403	PF00082	0.630
CLV_PCSK_SKI1_1	561	565	PF00082	0.543
CLV_Separin_Metazoa	621	625	PF03568	0.608
DEG_APCC_DBOX_1	281	289	PF00400	0.474
DEG_Nend_Nbox_1	1	3	PF02207	0.584
DEG_SPOP_SBC_1	75	79	PF00917	0.490
DOC_CKS1_1	502	507	PF01111	0.530
DOC_CYCLIN_RxL_1	485	496	PF00134	0.582
DOC_MAPK_MEF2A_6	501	509	PF00069	0.531
DOC_PP1_RVXF_1	23	29	PF00149	0.665
DOC_PP2B_LxvP_1	340	343	PF13499	0.574
DOC_PP4_FxxP_1	29	32	PF00568	0.579
DOC_PP4_FxxP_1	436	439	PF00568	0.515
DOC_PP4_FxxP_1	714	717	PF00568	0.402
DOC_USP7_MATH_1	155	159	PF00917	0.699
DOC_USP7_MATH_1	361	365	PF00917	0.567
DOC_USP7_MATH_1	588	592	PF00917	0.390
DOC_USP7_MATH_1	75	79	PF00917	0.692
DOC_WW_Pin1_4	171	176	PF00397	0.431
DOC_WW_Pin1_4	182	187	PF00397	0.431
DOC_WW_Pin1_4	493	498	PF00397	0.502
DOC_WW_Pin1_4	501	506	PF00397	0.524
DOC_WW_Pin1_4	690	695	PF00397	0.583
DOC_WW_Pin1_4	749	754	PF00397	0.501
DOC_WW_Pin1_4	98	103	PF00397	0.510
LIG_14-3-3_CanoR_1	154	160	PF00244	0.706
LIG_14-3-3_CanoR_1	265	271	PF00244	0.377
LIG_14-3-3_CanoR_1	306	315	PF00244	0.456
LIG_14-3-3_CanoR_1	458	464	PF00244	0.564
LIG_14-3-3_CanoR_1	654	660	PF00244	0.508
LIG_14-3-3_CanoR_1	91	99	PF00244	0.746
LIG_BIR_III_4	475	479	PF00653	0.552
LIG_BRCT_BRCA1_1	330	334	PF00533	0.457
LIG_CaM_IQ_9	156	171	PF13499	0.385
LIG_CaM_IQ_9	205	220	PF13499	0.376
LIG_CaM_IQ_9	521	536	PF13499	0.383
LIG_Clathr_ClatBox_1	300	304	PF01394	0.376
LIG_FHA_1	105	111	PF00498	0.605
LIG_FHA_1	15	21	PF00498	0.515
LIG_FHA_1	183	189	PF00498	0.535
LIG_FHA_1	337	343	PF00498	0.600
LIG_FHA_1	344	350	PF00498	0.528
LIG_FHA_1	433	439	PF00498	0.546
LIG_FHA_1	494	500	PF00498	0.516
LIG_FHA_1	502	508	PF00498	0.488
LIG_FHA_2	224	230	PF00498	0.491
LIG_FHA_2	36	42	PF00498	0.709
LIG_FHA_2	49	55	PF00498	0.707
LIG_FHA_2	697	703	PF00498	0.622
LIG_LIR_Apic_2	174	180	PF02991	0.442
LIG_LIR_Apic_2	435	439	PF02991	0.556
LIG_LIR_Apic_2	712	717	PF02991	0.413
LIG_LIR_Apic_2	98	102	PF02991	0.508
LIG_LIR_Gen_1	234	243	PF02991	0.537
LIG_LIR_Gen_1	464	472	PF02991	0.529
LIG_LIR_Nem_3	234	240	PF02991	0.500
LIG_LIR_Nem_3	464	470	PF02991	0.523
LIG_LIR_Nem_3	646	652	PF02991	0.491
LIG_NRBOX	523	529	PF00104	0.388
LIG_PTB_Apo_2	39	46	PF02174	0.637
LIG_PTB_Apo_2	532	539	PF02174	0.384
LIG_PTB_Phospho_1	39	45	PF10480	0.507
LIG_REV1ctd_RIR_1	26	31	PF16727	0.683
LIG_REV1ctd_RIR_1	535	545	PF16727	0.408
LIG_SH2_CRK	129	133	PF00017	0.597
LIG_SH2_CRK	467	471	PF00017	0.525
LIG_SH2_GRB2like	196	199	PF00017	0.501
LIG_SH2_PTP2	237	240	PF00017	0.376
LIG_SH2_SRC	292	295	PF00017	0.535
LIG_SH2_SRC	465	468	PF00017	0.373
LIG_SH2_STAP1	16	20	PF00017	0.507
LIG_SH2_STAP1	649	653	PF00017	0.386
LIG_SH2_STAT3	2	5	PF00017	0.643
LIG_SH2_STAT5	16	19	PF00017	0.609
LIG_SH2_STAT5	177	180	PF00017	0.443
LIG_SH2_STAT5	237	240	PF00017	0.518
LIG_SH2_STAT5	292	295	PF00017	0.535
LIG_SH3_3	169	175	PF00018	0.431
LIG_SH3_3	29	35	PF00018	0.665
LIG_SH3_3	499	505	PF00018	0.521
LIG_SH3_3	691	697	PF00018	0.591
LIG_TRAF2_1	671	674	PF00917	0.412
LIG_TRAF2_1	698	701	PF00917	0.538
LIG_UBA3_1	239	246	PF00899	0.189
MOD_CDC14_SPxK_1	752	755	PF00782	0.470
MOD_CDK_SPK_2	493	498	PF00069	0.502
MOD_CDK_SPK_2	690	695	PF00069	0.666
MOD_CDK_SPxK_1	749	755	PF00069	0.448
MOD_CDK_SPxxK_3	501	508	PF00069	0.573
MOD_CK1_1	158	164	PF00069	0.415
MOD_CK1_1	223	229	PF00069	0.385
MOD_CK1_1	348	354	PF00069	0.586
MOD_CK1_1	63	69	PF00069	0.687
MOD_CK1_1	747	753	PF00069	0.548
MOD_CK1_1	83	89	PF00069	0.611
MOD_CK2_1	103	109	PF00069	0.581
MOD_CK2_1	142	148	PF00069	0.759
MOD_CK2_1	35	41	PF00069	0.570
MOD_CK2_1	667	673	PF00069	0.417
MOD_CK2_1	695	701	PF00069	0.572
MOD_Cter_Amidation	115	118	PF01082	0.802
MOD_DYRK1A_RPxSP_1	501	505	PF00069	0.520
MOD_GlcNHglycan	144	147	PF01048	0.707
MOD_GlcNHglycan	151	154	PF01048	0.636
MOD_GlcNHglycan	350	353	PF01048	0.735
MOD_GlcNHglycan	357	360	PF01048	0.509
MOD_GlcNHglycan	484	487	PF01048	0.587
MOD_GlcNHglycan	586	589	PF01048	0.449
MOD_GlcNHglycan	669	672	PF01048	0.485
MOD_GlcNHglycan	749	752	PF01048	0.424
MOD_GlcNHglycan	82	85	PF01048	0.579
MOD_GlcNHglycan	94	97	PF01048	0.793
MOD_GSK3_1	142	149	PF00069	0.570
MOD_GSK3_1	167	174	PF00069	0.311
MOD_GSK3_1	225	232	PF00069	0.337
MOD_GSK3_1	44	51	PF00069	0.541
MOD_GSK3_1	552	559	PF00069	0.576
MOD_GSK3_1	584	591	PF00069	0.365
MOD_GSK3_1	63	70	PF00069	0.424
MOD_GSK3_1	76	83	PF00069	0.578
MOD_N-GLC_1	104	109	PF02516	0.570
MOD_N-GLC_1	47	52	PF02516	0.549
MOD_NEK2_1	266	271	PF00069	0.378
MOD_NEK2_1	305	310	PF00069	0.419
MOD_NEK2_1	60	65	PF00069	0.608
MOD_NEK2_1	67	72	PF00069	0.576
MOD_NEK2_1	76	81	PF00069	0.643
MOD_PIKK_1	146	152	PF00454	0.504
MOD_PIKK_1	287	293	PF00454	0.331
MOD_PIKK_1	328	334	PF00454	0.600
MOD_PIKK_1	598	604	PF00454	0.539
MOD_PKA_1	561	567	PF00069	0.372
MOD_PKA_2	266	272	PF00069	0.433
MOD_PKA_2	305	311	PF00069	0.316
MOD_PKA_2	561	567	PF00069	0.372
MOD_PKA_2	653	659	PF00069	0.553
MOD_PKA_2	92	98	PF00069	0.688
MOD_Plk_1	220	226	PF00069	0.300
MOD_Plk_1	35	41	PF00069	0.686
MOD_Plk_1	656	662	PF00069	0.473
MOD_Plk_1	665	671	PF00069	0.461
MOD_Plk_1	672	678	PF00069	0.419
MOD_Plk_1	86	92	PF00069	0.514
MOD_Plk_2-3	229	235	PF00069	0.331
MOD_Plk_4	158	164	PF00069	0.281
MOD_Plk_4	266	272	PF00069	0.411
MOD_Plk_4	35	41	PF00069	0.632
MOD_Plk_4	432	438	PF00069	0.561
MOD_Plk_4	446	452	PF00069	0.403
MOD_Plk_4	588	594	PF00069	0.447
MOD_ProDKin_1	171	177	PF00069	0.266
MOD_ProDKin_1	182	188	PF00069	0.266
MOD_ProDKin_1	493	499	PF00069	0.504
MOD_ProDKin_1	501	507	PF00069	0.526
MOD_ProDKin_1	690	696	PF00069	0.585
MOD_ProDKin_1	749	755	PF00069	0.511
MOD_ProDKin_1	98	104	PF00069	0.507
MOD_SUMO_for_1	507	510	PF00179	0.467
MOD_SUMO_rev_2	229	238	PF00179	0.289
MOD_SUMO_rev_2	727	735	PF00179	0.486
TRG_DiLeu_BaEn_1	206	211	PF01217	0.281
TRG_DiLeu_BaEn_1	519	524	PF01217	0.328
TRG_DiLeu_BaEn_3	701	707	PF01217	0.374
TRG_DiLeu_BaLyEn_6	523	528	PF01217	0.389
TRG_ENDOCYTIC_2	237	240	PF00928	0.360
TRG_ENDOCYTIC_2	467	470	PF00928	0.522
TRG_ER_diArg_1	123	125	PF00400	0.712
TRG_ER_diArg_1	213	216	PF00400	0.268
TRG_ER_diArg_1	261	263	PF00400	0.321
TRG_ER_diArg_1	29	31	PF00400	0.614
TRG_ER_diArg_1	305	307	PF00400	0.456
TRG_ER_diArg_1	528	531	PF00400	0.409
TRG_ER_diArg_1	632	635	PF00400	0.596
TRG_ER_diArg_1	90	93	PF00400	0.748
TRG_Pf-PMV_PEXEL_1	545	550	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	614	618	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	624	628	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8T7	Leptomonas seymouri	60%	99%
A0A0S4J7Y8	Bodo saltans	33%	100%
A0A1X0P3Q9	Trypanosomatidae	40%	100%
A0A3Q8IGQ6	Leishmania donovani	81%	100%
A0A422NI23	Trypanosoma rangeli	40%	100%
D0A691	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AHP1	Leishmania infantum	81%	100%
E9B461	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q386N1	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	41%	100%
Q4Q3W5	Leishmania major	81%	100%
V5BP91	Trypanosoma cruzi	40%	100%