Acid Phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Acid Phosphatase

Gene product:

magnesium-dependent phosphatase-1/HAD phosphatase, family IIIC, putative

Species:

Leishmania braziliensis

UniProt:

A4HLS8_LEIBR

TriTrypDb:

LbrM.33.2440 , LBRM2903_330031900

Length:

201

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLS8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016791	phosphatase activity	5	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0003993	acid phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	67	71	PF00082	0.292
CLV_PCSK_SKI1_1	97	101	PF00082	0.449
DEG_APCC_DBOX_1	66	74	PF00400	0.298
DEG_SPOP_SBC_1	85	89	PF00917	0.298
DOC_CKS1_1	28	33	PF01111	0.445
DOC_MAPK_MEF2A_6	55	62	PF00069	0.439
DOC_PP1_RVXF_1	16	23	PF00149	0.314
DOC_USP7_MATH_1	146	150	PF00917	0.445
DOC_USP7_MATH_1	196	200	PF00917	0.561
DOC_USP7_MATH_1	74	78	PF00917	0.192
DOC_USP7_MATH_1	85	89	PF00917	0.297
DOC_WW_Pin1_4	27	32	PF00397	0.370
DOC_WW_Pin1_4	37	42	PF00397	0.337
LIG_14-3-3_CanoR_1	169	178	PF00244	0.192
LIG_BIR_II_1	1	5	PF00653	0.714
LIG_CSL_BTD_1	28	31	PF09270	0.383
LIG_FHA_1	87	93	PF00498	0.418
LIG_FHA_2	102	108	PF00498	0.234
LIG_GBD_Chelix_1	20	28	PF00786	0.298
LIG_LIR_Apic_2	173	178	PF02991	0.461
LIG_LIR_Gen_1	149	157	PF02991	0.303
LIG_LIR_Nem_3	82	86	PF02991	0.371
LIG_Pex14_1	79	83	PF04695	0.383
LIG_SH2_STAP1	151	155	PF00017	0.445
LIG_SH2_STAT5	176	179	PF00017	0.314
LIG_SH2_STAT5	83	86	PF00017	0.383
LIG_SH3_2	41	46	PF14604	0.418
LIG_SH3_3	38	44	PF00018	0.374
LIG_SH3_4	43	50	PF00018	0.445
MOD_CDC14_SPxK_1	40	43	PF00782	0.398
MOD_CDK_SPxK_1	37	43	PF00069	0.404
MOD_CK1_1	2	8	PF00069	0.657
MOD_CK2_1	144	150	PF00069	0.418
MOD_CK2_1	53	59	PF00069	0.445
MOD_GlcNHglycan	54	58	PF01048	0.423
MOD_N-GLC_1	158	163	PF02516	0.314
MOD_NEK2_1	24	29	PF00069	0.297
MOD_NEK2_1	84	89	PF00069	0.314
MOD_Plk_4	24	30	PF00069	0.225
MOD_Plk_4	48	54	PF00069	0.413
MOD_Plk_4	79	85	PF00069	0.356
MOD_ProDKin_1	27	33	PF00069	0.370
MOD_ProDKin_1	37	43	PF00069	0.337
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.383
TRG_ENDOCYTIC_2	151	154	PF00928	0.445
TRG_ENDOCYTIC_2	83	86	PF00928	0.383
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.308
TRG_PTS1	198	201	PF00515	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5R9	Leptomonas seymouri	68%	100%
A0A0S4J859	Bodo saltans	45%	100%
A0A1X0P3P5	Trypanosomatidae	56%	99%
A0A3Q8IDV7	Leishmania donovani	83%	100%
A0A3S5IR86	Trypanosoma rangeli	58%	100%
A4I987	Leishmania infantum	84%	100%
D0A698	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9B454	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O94279	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q86V88	Homo sapiens	30%	100%
Q9D967	Mus musculus	30%	100%
Q9GRN1	Leishmania major	84%	100%
V5B8Q4	Trypanosoma cruzi	56%	81%