Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLS7_LEIBR

TriTrypDb:

LbrM.33.2430 , LBRM2903_330031700

Length:

867

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	9
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:1990904	ribonucleoprotein complex	2	9
GO:0005737	cytoplasm	2	1
GO:0005875	microtubule associated complex	2	9
GO:0030286	dynein complex	3	9
GO:1902494	catalytic complex	2	9

Expansion

Sequence features

A4HLS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLS7

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	9
GO:0007018	microtubule-based movement	3	9
GO:0009987	cellular process	1	9

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	9
GO:0003777	microtubule motor activity	2	9
GO:0008569	minus-end-directed microtubule motor activity	3	9
GO:0140657	ATP-dependent activity	1	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	52	56	PF00656	0.311
CLV_C14_Caspase3-7	775	779	PF00656	0.451
CLV_NRD_NRD_1	169	171	PF00675	0.570
CLV_NRD_NRD_1	332	334	PF00675	0.389
CLV_NRD_NRD_1	364	366	PF00675	0.289
CLV_NRD_NRD_1	738	740	PF00675	0.385
CLV_NRD_NRD_1	822	824	PF00675	0.412
CLV_PCSK_FUR_1	330	334	PF00082	0.485
CLV_PCSK_KEX2_1	169	171	PF00082	0.570
CLV_PCSK_KEX2_1	332	334	PF00082	0.380
CLV_PCSK_KEX2_1	366	368	PF00082	0.359
CLV_PCSK_KEX2_1	540	542	PF00082	0.655
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.359
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.655
CLV_PCSK_PC7_1	165	171	PF00082	0.567
CLV_PCSK_SKI1_1	200	204	PF00082	0.619
CLV_PCSK_SKI1_1	332	336	PF00082	0.448
CLV_PCSK_SKI1_1	42	46	PF00082	0.495
CLV_PCSK_SKI1_1	481	485	PF00082	0.445
CLV_PCSK_SKI1_1	513	517	PF00082	0.669
CLV_PCSK_SKI1_1	66	70	PF00082	0.407
CLV_PCSK_SKI1_1	841	845	PF00082	0.433
CLV_Separin_Metazoa	303	307	PF03568	0.559
DEG_APCC_DBOX_1	331	339	PF00400	0.289
DEG_COP1_1	641	649	PF00400	0.518
DEG_COP1_1	83	92	PF00400	0.481
DEG_MDM2_SWIB_1	860	867	PF02201	0.451
DOC_CKS1_1	273	278	PF01111	0.497
DOC_CKS1_1	284	289	PF01111	0.607
DOC_MAPK_gen_1	365	371	PF00069	0.460
DOC_MAPK_gen_1	513	521	PF00069	0.587
DOC_MAPK_gen_1	540	547	PF00069	0.422
DOC_MAPK_gen_1	739	746	PF00069	0.328
DOC_MAPK_gen_1	87	94	PF00069	0.539
DOC_MAPK_gen_1	98	105	PF00069	0.415
DOC_MAPK_MEF2A_6	739	746	PF00069	0.328
DOC_MAPK_MEF2A_6	87	96	PF00069	0.702
DOC_MAPK_MEF2A_6	98	105	PF00069	0.369
DOC_PP1_RVXF_1	365	372	PF00149	0.360
DOC_PP1_RVXF_1	40	47	PF00149	0.483
DOC_PP2B_LxvP_1	766	769	PF13499	0.533
DOC_SPAK_OSR1_1	576	580	PF12202	0.336
DOC_USP7_MATH_1	227	231	PF00917	0.745
DOC_USP7_MATH_1	250	254	PF00917	0.630
DOC_USP7_MATH_1	34	38	PF00917	0.446
DOC_USP7_MATH_1	393	397	PF00917	0.338
DOC_USP7_MATH_1	405	409	PF00917	0.364
DOC_USP7_MATH_1	439	443	PF00917	0.387
DOC_USP7_MATH_1	498	502	PF00917	0.574
DOC_USP7_MATH_1	578	582	PF00917	0.297
DOC_USP7_MATH_1	649	653	PF00917	0.380
DOC_USP7_MATH_1	694	698	PF00917	0.333
DOC_USP7_UBL2_3	513	517	PF12436	0.715
DOC_WW_Pin1_4	219	224	PF00397	0.736
DOC_WW_Pin1_4	264	269	PF00397	0.679
DOC_WW_Pin1_4	272	277	PF00397	0.676
DOC_WW_Pin1_4	283	288	PF00397	0.576
DOC_WW_Pin1_4	59	64	PF00397	0.434
DOC_WW_Pin1_4	75	80	PF00397	0.415
DOC_WW_Pin1_4	853	858	PF00397	0.373
LIG_14-3-3_CanoR_1	100	106	PF00244	0.388
LIG_14-3-3_CanoR_1	169	173	PF00244	0.570
LIG_14-3-3_CanoR_1	200	205	PF00244	0.792
LIG_14-3-3_CanoR_1	217	223	PF00244	0.568
LIG_14-3-3_CanoR_1	481	490	PF00244	0.498
LIG_14-3-3_CanoR_1	499	505	PF00244	0.599
LIG_14-3-3_CanoR_1	50	58	PF00244	0.507
LIG_14-3-3_CanoR_1	508	512	PF00244	0.667
LIG_14-3-3_CanoR_1	520	528	PF00244	0.536
LIG_14-3-3_CanoR_1	823	829	PF00244	0.401
LIG_Actin_WH2_2	251	266	PF00022	0.686
LIG_Actin_WH2_2	443	460	PF00022	0.276
LIG_AP2alpha_1	611	615	PF02296	0.415
LIG_BIR_II_1	1	5	PF00653	0.464
LIG_BRCT_BRCA1_1	19	23	PF00533	0.494
LIG_BRCT_BRCA1_1	251	255	PF00533	0.630
LIG_Clathr_ClatBox_1	238	242	PF01394	0.497
LIG_Clathr_ClatBox_1	289	293	PF01394	0.467
LIG_FHA_1	157	163	PF00498	0.537
LIG_FHA_1	177	183	PF00498	0.437
LIG_FHA_1	214	220	PF00498	0.579
LIG_FHA_1	255	261	PF00498	0.713
LIG_FHA_1	284	290	PF00498	0.549
LIG_FHA_1	346	352	PF00498	0.452
LIG_FHA_1	409	415	PF00498	0.385
LIG_FHA_1	46	52	PF00498	0.518
LIG_FHA_1	5	11	PF00498	0.474
LIG_FHA_1	708	714	PF00498	0.363
LIG_FHA_1	736	742	PF00498	0.405
LIG_FHA_1	771	777	PF00498	0.586
LIG_FHA_1	790	796	PF00498	0.397
LIG_FHA_1	89	95	PF00498	0.568
LIG_FHA_1	97	103	PF00498	0.348
LIG_FHA_2	10	16	PF00498	0.391
LIG_FHA_2	278	284	PF00498	0.597
LIG_FHA_2	617	623	PF00498	0.350
LIG_FHA_2	731	737	PF00498	0.447
LIG_FHA_2	798	804	PF00498	0.390
LIG_FHA_2	81	87	PF00498	0.590
LIG_GBD_Chelix_1	369	377	PF00786	0.485
LIG_Integrin_RGD_1	300	302	PF01839	0.672
LIG_LIR_Gen_1	252	263	PF02991	0.632
LIG_LIR_Gen_1	291	299	PF02991	0.500
LIG_LIR_Gen_1	339	347	PF02991	0.341
LIG_LIR_Gen_1	563	571	PF02991	0.317
LIG_LIR_Gen_1	7	16	PF02991	0.294
LIG_LIR_Gen_1	858	867	PF02991	0.359
LIG_LIR_Nem_3	252	258	PF02991	0.632
LIG_LIR_Nem_3	339	345	PF02991	0.347
LIG_LIR_Nem_3	556	560	PF02991	0.326
LIG_LIR_Nem_3	563	568	PF02991	0.295
LIG_LIR_Nem_3	7	11	PF02991	0.305
LIG_LIR_Nem_3	858	863	PF02991	0.347
LIG_NRBOX	414	420	PF00104	0.274
LIG_PCNA_yPIPBox_3	31	45	PF02747	0.422
LIG_Pex14_1	607	611	PF04695	0.357
LIG_Pex14_2	611	615	PF04695	0.472
LIG_Pex14_2	753	757	PF04695	0.307
LIG_Pex14_2	860	864	PF04695	0.431
LIG_SH2_CRK	342	346	PF00017	0.323
LIG_SH2_CRK	8	12	PF00017	0.291
LIG_SH2_NCK_1	8	12	PF00017	0.429
LIG_SH2_STAT5	342	345	PF00017	0.325
LIG_SH2_STAT5	587	590	PF00017	0.295
LIG_SH2_STAT5	658	661	PF00017	0.335
LIG_SH2_STAT5	662	665	PF00017	0.324
LIG_SH2_STAT5	798	801	PF00017	0.328
LIG_SH2_STAT5	818	821	PF00017	0.253
LIG_SH3_3	152	158	PF00018	0.668
LIG_SH3_3	220	226	PF00018	0.582
LIG_SH3_3	270	276	PF00018	0.638
LIG_SH3_3	281	287	PF00018	0.447
LIG_SH3_3	441	447	PF00018	0.406
LIG_SH3_3	508	514	PF00018	0.796
LIG_SH3_3	641	647	PF00018	0.431
LIG_SH3_3	690	696	PF00018	0.470
LIG_SH3_3	91	97	PF00018	0.465
LIG_SH3_4	513	520	PF00018	0.674
LIG_SUMO_SIM_anti_2	128	135	PF11976	0.446
LIG_SUMO_SIM_anti_2	356	361	PF11976	0.312
LIG_SUMO_SIM_anti_2	91	96	PF11976	0.434
LIG_SUMO_SIM_par_1	237	245	PF11976	0.605
LIG_SUMO_SIM_par_1	358	363	PF11976	0.398
LIG_SUMO_SIM_par_1	436	442	PF11976	0.455
LIG_SUMO_SIM_par_1	542	548	PF11976	0.540
LIG_TRAF2_1	137	140	PF00917	0.567
LIG_TRAF2_1	36	39	PF00917	0.330
LIG_UBA3_1	359	366	PF00899	0.479
LIG_WRC_WIRS_1	102	107	PF05994	0.373
LIG_WRC_WIRS_1	312	317	PF05994	0.457
LIG_WRC_WIRS_1	554	559	PF05994	0.468
MOD_CDK_SPxxK_3	59	66	PF00069	0.423
MOD_CK1_1	120	126	PF00069	0.687
MOD_CK1_1	188	194	PF00069	0.746
MOD_CK1_1	234	240	PF00069	0.651
MOD_CK1_1	248	254	PF00069	0.512
MOD_CK1_1	310	316	PF00069	0.523
MOD_CK1_1	408	414	PF00069	0.346
MOD_CK1_1	467	473	PF00069	0.538
MOD_CK1_1	49	55	PF00069	0.373
MOD_CK1_1	497	503	PF00069	0.690
MOD_CK1_1	504	510	PF00069	0.734
MOD_CK1_1	558	564	PF00069	0.505
MOD_CK1_1	652	658	PF00069	0.425
MOD_CK1_1	756	762	PF00069	0.317
MOD_CK1_1	786	792	PF00069	0.404
MOD_CK2_1	125	131	PF00069	0.681
MOD_CK2_1	146	152	PF00069	0.690
MOD_CK2_1	277	283	PF00069	0.579
MOD_CK2_1	567	573	PF00069	0.408
MOD_CK2_1	616	622	PF00069	0.355
MOD_CK2_1	80	86	PF00069	0.590
MOD_CK2_1	809	815	PF00069	0.295
MOD_CK2_1	9	15	PF00069	0.413
MOD_GlcNHglycan	134	137	PF01048	0.558
MOD_GlcNHglycan	187	190	PF01048	0.719
MOD_GlcNHglycan	195	198	PF01048	0.744
MOD_GlcNHglycan	234	237	PF01048	0.610
MOD_GlcNHglycan	309	312	PF01048	0.629
MOD_GlcNHglycan	395	398	PF01048	0.451
MOD_GlcNHglycan	431	435	PF01048	0.375
MOD_GlcNHglycan	496	499	PF01048	0.619
MOD_GlcNHglycan	51	54	PF01048	0.469
MOD_GlcNHglycan	521	524	PF01048	0.717
MOD_GlcNHglycan	546	550	PF01048	0.517
MOD_GlcNHglycan	557	560	PF01048	0.288
MOD_GlcNHglycan	569	572	PF01048	0.427
MOD_GlcNHglycan	625	628	PF01048	0.395
MOD_GlcNHglycan	635	638	PF01048	0.533
MOD_GlcNHglycan	707	710	PF01048	0.405
MOD_GlcNHglycan	784	788	PF01048	0.435
MOD_GSK3_1	101	108	PF00069	0.470
MOD_GSK3_1	164	171	PF00069	0.450
MOD_GSK3_1	213	220	PF00069	0.728
MOD_GSK3_1	227	234	PF00069	0.552
MOD_GSK3_1	241	248	PF00069	0.491
MOD_GSK3_1	250	257	PF00069	0.585
MOD_GSK3_1	307	314	PF00069	0.609
MOD_GSK3_1	45	52	PF00069	0.534
MOD_GSK3_1	463	470	PF00069	0.512
MOD_GSK3_1	494	501	PF00069	0.639
MOD_GSK3_1	503	510	PF00069	0.606
MOD_GSK3_1	588	595	PF00069	0.457
MOD_GSK3_1	645	652	PF00069	0.375
MOD_GSK3_1	753	760	PF00069	0.321
MOD_N-GLC_1	17	22	PF02516	0.461
MOD_N-GLC_1	231	236	PF02516	0.678
MOD_N-GLC_1	602	607	PF02516	0.457
MOD_NEK2_1	164	169	PF00069	0.451
MOD_NEK2_1	17	22	PF00069	0.418
MOD_NEK2_1	183	188	PF00069	0.501
MOD_NEK2_1	218	223	PF00069	0.556
MOD_NEK2_1	263	268	PF00069	0.671
MOD_NEK2_1	271	276	PF00069	0.672
MOD_NEK2_1	295	300	PF00069	0.576
MOD_NEK2_1	360	365	PF00069	0.522
MOD_NEK2_1	371	376	PF00069	0.526
MOD_NEK2_1	45	50	PF00069	0.426
MOD_NEK2_1	463	468	PF00069	0.492
MOD_NEK2_1	469	474	PF00069	0.531
MOD_NEK2_1	488	493	PF00069	0.562
MOD_NEK2_1	553	558	PF00069	0.405
MOD_NEK2_1	588	593	PF00069	0.355
MOD_NEK2_1	631	636	PF00069	0.517
MOD_NEK2_1	676	681	PF00069	0.397
MOD_NEK2_1	757	762	PF00069	0.336
MOD_NEK2_1	809	814	PF00069	0.344
MOD_NEK2_1	851	856	PF00069	0.360
MOD_NEK2_2	323	328	PF00069	0.514
MOD_PIKK_1	34	40	PF00454	0.466
MOD_PIKK_1	345	351	PF00454	0.451
MOD_PIKK_1	488	494	PF00454	0.683
MOD_PIKK_1	498	504	PF00454	0.556
MOD_PKA_2	164	170	PF00069	0.561
MOD_PKA_2	49	55	PF00069	0.486
MOD_PKA_2	498	504	PF00069	0.606
MOD_PKA_2	507	513	PF00069	0.734
MOD_PKA_2	519	525	PF00069	0.662
MOD_PKB_1	479	487	PF00069	0.481
MOD_Plk_1	17	23	PF00069	0.435
MOD_Plk_1	323	329	PF00069	0.517
MOD_Plk_1	371	377	PF00069	0.492
MOD_Plk_1	602	608	PF00069	0.359
MOD_Plk_1	757	763	PF00069	0.340
MOD_Plk_4	117	123	PF00069	0.603
MOD_Plk_4	234	240	PF00069	0.766
MOD_Plk_4	464	470	PF00069	0.532
MOD_Plk_4	592	598	PF00069	0.303
MOD_Plk_4	602	608	PF00069	0.305
MOD_Plk_4	667	673	PF00069	0.395
MOD_Plk_4	676	682	PF00069	0.400
MOD_Plk_4	730	736	PF00069	0.442
MOD_Plk_4	757	763	PF00069	0.323
MOD_Plk_4	824	830	PF00069	0.483
MOD_ProDKin_1	219	225	PF00069	0.733
MOD_ProDKin_1	264	270	PF00069	0.679
MOD_ProDKin_1	272	278	PF00069	0.676
MOD_ProDKin_1	283	289	PF00069	0.563
MOD_ProDKin_1	59	65	PF00069	0.425
MOD_ProDKin_1	75	81	PF00069	0.423
MOD_ProDKin_1	853	859	PF00069	0.375
MOD_SUMO_for_1	381	384	PF00179	0.395
MOD_SUMO_rev_2	49	59	PF00179	0.506
MOD_SUMO_rev_2	61	68	PF00179	0.530
TRG_DiLeu_BaEn_1	688	693	PF01217	0.307
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.517
TRG_ENDOCYTIC_2	342	345	PF00928	0.463
TRG_ENDOCYTIC_2	8	11	PF00928	0.297
TRG_ER_diArg_1	168	170	PF00400	0.556
TRG_ER_diArg_1	330	333	PF00400	0.318
TRG_ER_diArg_1	365	368	PF00400	0.277
TRG_ER_diArg_1	377	380	PF00400	0.386
TRG_ER_diArg_1	479	482	PF00400	0.518
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL0	Leptomonas seymouri	68%	99%
A0A0S4J7X8	Bodo saltans	49%	100%
A0A1X0P3P9	Trypanosomatidae	45%	100%
A0A3R7KEX8	Trypanosoma rangeli	49%	100%
A0A3S7X3V5	Leishmania donovani	27%	100%
A0A3S7X707	Leishmania donovani	85%	99%
A4HIS9	Leishmania braziliensis	27%	100%
A4I631	Leishmania infantum	27%	100%
A4I986	Leishmania infantum	85%	99%
D0A6A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B1B6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B453	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4Q6U8	Leishmania major	27%	100%
Q9GRN2	Leishmania major	84%	100%
V5DQD1	Trypanosoma cruzi	52%	100%