Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLS5_LEIBR

TriTrypDb:

LbrM.33.2410 , LBRM2903_330031500

Length:

934

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLS5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.784
CLV_NRD_NRD_1	132	134	PF00675	0.670
CLV_NRD_NRD_1	313	315	PF00675	0.596
CLV_NRD_NRD_1	706	708	PF00675	0.620
CLV_PCSK_KEX2_1	132	134	PF00082	0.701
CLV_PCSK_KEX2_1	706	708	PF00082	0.620
CLV_PCSK_SKI1_1	275	279	PF00082	0.488
CLV_PCSK_SKI1_1	75	79	PF00082	0.616
DEG_Nend_Nbox_1	1	3	PF02207	0.719
DEG_SPOP_SBC_1	432	436	PF00917	0.750
DEG_SPOP_SBC_1	506	510	PF00917	0.548
DEG_SPOP_SBC_1	568	572	PF00917	0.689
DEG_SPOP_SBC_1	637	641	PF00917	0.562
DEG_SPOP_SBC_1	912	916	PF00917	0.596
DOC_ANK_TNKS_1	893	900	PF00023	0.589
DOC_CKS1_1	724	729	PF01111	0.791
DOC_CKS1_1	868	873	PF01111	0.823
DOC_CKS1_1	87	92	PF01111	0.790
DOC_CYCLIN_RxL_1	112	123	PF00134	0.568
DOC_CYCLIN_RxL_1	540	551	PF00134	0.549
DOC_MAPK_FxFP_2	842	845	PF00069	0.761
DOC_MAPK_MEF2A_6	697	704	PF00069	0.648
DOC_PP1_RVXF_1	547	553	PF00149	0.685
DOC_PP2B_LxvP_1	119	122	PF13499	0.570
DOC_PP2B_LxvP_1	477	480	PF13499	0.791
DOC_PP2B_LxvP_1	828	831	PF13499	0.601
DOC_PP4_FxxP_1	784	787	PF00568	0.698
DOC_PP4_FxxP_1	842	845	PF00568	0.761
DOC_PP4_MxPP_1	451	454	PF00568	0.709
DOC_PP4_MxPP_1	838	841	PF00568	0.718
DOC_USP7_MATH_1	266	270	PF00917	0.703
DOC_USP7_MATH_1	413	417	PF00917	0.653
DOC_USP7_MATH_1	423	427	PF00917	0.734
DOC_USP7_MATH_1	432	436	PF00917	0.739
DOC_USP7_MATH_1	454	458	PF00917	0.826
DOC_USP7_MATH_1	468	472	PF00917	0.604
DOC_USP7_MATH_1	568	572	PF00917	0.815
DOC_USP7_MATH_1	637	641	PF00917	0.766
DOC_USP7_MATH_1	739	743	PF00917	0.602
DOC_USP7_MATH_1	762	766	PF00917	0.524
DOC_USP7_MATH_1	787	791	PF00917	0.706
DOC_USP7_MATH_1	906	910	PF00917	0.703
DOC_USP7_MATH_1	912	916	PF00917	0.678
DOC_WW_Pin1_4	239	244	PF00397	0.830
DOC_WW_Pin1_4	256	261	PF00397	0.557
DOC_WW_Pin1_4	303	308	PF00397	0.603
DOC_WW_Pin1_4	356	361	PF00397	0.518
DOC_WW_Pin1_4	466	471	PF00397	0.751
DOC_WW_Pin1_4	520	525	PF00397	0.820
DOC_WW_Pin1_4	534	539	PF00397	0.591
DOC_WW_Pin1_4	595	600	PF00397	0.429
DOC_WW_Pin1_4	723	728	PF00397	0.796
DOC_WW_Pin1_4	752	757	PF00397	0.787
DOC_WW_Pin1_4	785	790	PF00397	0.544
DOC_WW_Pin1_4	86	91	PF00397	0.684
DOC_WW_Pin1_4	867	872	PF00397	0.824
DOC_WW_Pin1_4	913	918	PF00397	0.781
LIG_14-3-3_CanoR_1	115	120	PF00244	0.660
LIG_14-3-3_CanoR_1	132	139	PF00244	0.745
LIG_14-3-3_CanoR_1	290	296	PF00244	0.487
LIG_14-3-3_CanoR_1	36	42	PF00244	0.554
LIG_14-3-3_CanoR_1	393	398	PF00244	0.641
LIG_14-3-3_CanoR_1	505	513	PF00244	0.803
LIG_14-3-3_CanoR_1	549	553	PF00244	0.687
LIG_14-3-3_CanoR_1	565	574	PF00244	0.722
LIG_14-3-3_CanoR_1	669	679	PF00244	0.640
LIG_14-3-3_CanoR_1	690	696	PF00244	0.568
LIG_14-3-3_CanoR_1	911	917	PF00244	0.646
LIG_BIR_III_2	559	563	PF00653	0.543
LIG_BRCT_BRCA1_1	293	297	PF00533	0.474
LIG_BRCT_BRCA1_1	602	606	PF00533	0.495
LIG_BRCT_BRCA1_1	754	758	PF00533	0.564
LIG_CSL_BTD_1	243	246	PF09270	0.564
LIG_CtBP_PxDLS_1	825	829	PF00389	0.577
LIG_EVH1_2	840	844	PF00568	0.713
LIG_FHA_1	384	390	PF00498	0.567
LIG_FHA_1	482	488	PF00498	0.807
LIG_FHA_1	650	656	PF00498	0.497
LIG_FHA_1	845	851	PF00498	0.684
LIG_FHA_1	925	931	PF00498	0.594
LIG_FHA_2	228	234	PF00498	0.631
LIG_FHA_2	37	43	PF00498	0.688
LIG_FHA_2	595	601	PF00498	0.424
LIG_FHA_2	627	633	PF00498	0.721
LIG_FHA_2	847	853	PF00498	0.665
LIG_FHA_2	99	105	PF00498	0.713
LIG_Integrin_isoDGR_2	318	320	PF01839	0.660
LIG_LIR_Apic_2	176	182	PF02991	0.623
LIG_LIR_Apic_2	354	360	PF02991	0.533
LIG_LIR_Apic_2	751	756	PF02991	0.535
LIG_LIR_Apic_2	852	858	PF02991	0.674
LIG_LIR_Gen_1	37	46	PF02991	0.532
LIG_LIR_Gen_1	603	614	PF02991	0.511
LIG_LIR_Gen_1	89	98	PF02991	0.641
LIG_LIR_Gen_1	99	110	PF02991	0.658
LIG_LIR_Nem_3	175	181	PF02991	0.645
LIG_LIR_Nem_3	37	41	PF02991	0.549
LIG_LIR_Nem_3	551	555	PF02991	0.683
LIG_LIR_Nem_3	698	702	PF02991	0.399
LIG_LIR_Nem_3	862	868	PF02991	0.769
LIG_LIR_Nem_3	89	95	PF02991	0.642
LIG_LIR_Nem_3	99	105	PF02991	0.658
LIG_LYPXL_yS_3	746	749	PF13949	0.789
LIG_NRBOX	159	165	PF00104	0.627
LIG_SH2_CRK	179	183	PF00017	0.660
LIG_SH2_CRK	455	459	PF00017	0.762
LIG_SH2_CRK	855	859	PF00017	0.663
LIG_SH2_NCK_1	102	106	PF00017	0.573
LIG_SH2_NCK_1	283	287	PF00017	0.534
LIG_SH2_NCK_1	38	42	PF00017	0.694
LIG_SH2_PTP2	357	360	PF00017	0.520
LIG_SH2_SRC	102	105	PF00017	0.573
LIG_SH2_SRC	555	558	PF00017	0.550
LIG_SH2_STAT5	159	162	PF00017	0.641
LIG_SH2_STAT5	350	353	PF00017	0.524
LIG_SH2_STAT5	357	360	PF00017	0.520
LIG_SH2_STAT5	38	41	PF00017	0.695
LIG_SH2_STAT5	482	485	PF00017	0.827
LIG_SH2_STAT5	555	558	PF00017	0.700
LIG_SH2_STAT5	601	604	PF00017	0.505
LIG_SH2_STAT5	87	90	PF00017	0.690
LIG_SH3_3	240	246	PF00018	0.571
LIG_SH3_3	252	258	PF00018	0.538
LIG_SH3_3	379	385	PF00018	0.660
LIG_SH3_3	455	461	PF00018	0.739
LIG_SH3_3	533	539	PF00018	0.665
LIG_SH3_3	627	633	PF00018	0.810
LIG_SH3_3	721	727	PF00018	0.789
LIG_SH3_3	742	748	PF00018	0.686
LIG_SH3_3	795	801	PF00018	0.739
LIG_SH3_3	818	824	PF00018	0.760
LIG_SH3_3	833	839	PF00018	0.712
LIG_SH3_3	865	871	PF00018	0.821
LIG_SH3_3	916	922	PF00018	0.731
LIG_SUMO_SIM_par_1	373	378	PF11976	0.611
LIG_SUMO_SIM_par_1	386	392	PF11976	0.553
LIG_SUMO_SIM_par_1	846	852	PF11976	0.759
LIG_TRAF2_1	197	200	PF00917	0.693
LIG_TRFH_1	855	859	PF08558	0.542
LIG_TRFH_1	92	96	PF08558	0.693
LIG_TYR_ITIM	281	286	PF00017	0.518
LIG_WRC_WIRS_1	145	150	PF05994	0.560
LIG_WW_1	452	455	PF00397	0.710
LIG_WW_1	460	463	PF00397	0.734
LIG_WW_1	479	482	PF00397	0.769
MOD_CK1_1	215	221	PF00069	0.794
MOD_CK1_1	242	248	PF00069	0.782
MOD_CK1_1	268	274	PF00069	0.636
MOD_CK1_1	306	312	PF00069	0.619
MOD_CK1_1	37	43	PF00069	0.710
MOD_CK1_1	435	441	PF00069	0.847
MOD_CK1_1	466	472	PF00069	0.634
MOD_CK1_1	481	487	PF00069	0.805
MOD_CK1_1	501	507	PF00069	0.790
MOD_CK1_1	519	525	PF00069	0.557
MOD_CK1_1	537	543	PF00069	0.716
MOD_CK1_1	569	575	PF00069	0.734
MOD_CK1_1	607	613	PF00069	0.576
MOD_CK1_1	628	634	PF00069	0.593
MOD_CK1_1	638	644	PF00069	0.641
MOD_CK1_1	64	70	PF00069	0.668
MOD_CK1_1	649	655	PF00069	0.520
MOD_CK1_1	692	698	PF00069	0.680
MOD_CK1_1	788	794	PF00069	0.709
MOD_CK1_1	913	919	PF00069	0.595
MOD_CK2_1	121	127	PF00069	0.770
MOD_CK2_1	226	232	PF00069	0.746
MOD_CK2_1	36	42	PF00069	0.782
MOD_CK2_1	901	907	PF00069	0.857
MOD_Cter_Amidation	704	707	PF01082	0.401
MOD_GlcNHglycan	127	131	PF01048	0.651
MOD_GlcNHglycan	210	213	PF01048	0.738
MOD_GlcNHglycan	214	217	PF01048	0.723
MOD_GlcNHglycan	232	237	PF01048	0.524
MOD_GlcNHglycan	271	274	PF01048	0.540
MOD_GlcNHglycan	287	290	PF01048	0.505
MOD_GlcNHglycan	408	411	PF01048	0.741
MOD_GlcNHglycan	42	45	PF01048	0.731
MOD_GlcNHglycan	425	428	PF01048	0.756
MOD_GlcNHglycan	435	438	PF01048	0.790
MOD_GlcNHglycan	470	473	PF01048	0.826
MOD_GlcNHglycan	514	517	PF01048	0.730
MOD_GlcNHglycan	539	542	PF01048	0.703
MOD_GlcNHglycan	571	574	PF01048	0.821
MOD_GlcNHglycan	580	583	PF01048	0.604
MOD_GlcNHglycan	640	643	PF01048	0.682
MOD_GlcNHglycan	67	70	PF01048	0.700
MOD_GlcNHglycan	681	684	PF01048	0.574
MOD_GlcNHglycan	717	720	PF01048	0.702
MOD_GlcNHglycan	764	767	PF01048	0.529
MOD_GlcNHglycan	8	11	PF01048	0.679
MOD_GlcNHglycan	888	891	PF01048	0.790
MOD_GlcNHglycan	894	897	PF01048	0.753
MOD_GlcNHglycan	901	904	PF01048	0.678
MOD_GlcNHglycan	907	911	PF01048	0.649
MOD_GSK3_1	134	141	PF00069	0.716
MOD_GSK3_1	208	215	PF00069	0.619
MOD_GSK3_1	244	251	PF00069	0.682
MOD_GSK3_1	265	272	PF00069	0.745
MOD_GSK3_1	30	37	PF00069	0.738
MOD_GSK3_1	323	330	PF00069	0.545
MOD_GSK3_1	408	415	PF00069	0.810
MOD_GSK3_1	431	438	PF00069	0.818
MOD_GSK3_1	462	469	PF00069	0.689
MOD_GSK3_1	478	485	PF00069	0.780
MOD_GSK3_1	501	508	PF00069	0.786
MOD_GSK3_1	512	519	PF00069	0.644
MOD_GSK3_1	563	570	PF00069	0.777
MOD_GSK3_1	573	580	PF00069	0.688
MOD_GSK3_1	600	607	PF00069	0.486
MOD_GSK3_1	609	616	PF00069	0.465
MOD_GSK3_1	61	68	PF00069	0.631
MOD_GSK3_1	685	692	PF00069	0.410
MOD_GSK3_1	711	718	PF00069	0.679
MOD_GSK3_1	748	755	PF00069	0.538
MOD_GSK3_1	906	913	PF00069	0.675
MOD_LATS_1	136	142	PF00433	0.564
MOD_LATS_1	431	437	PF00433	0.734
MOD_N-GLC_1	441	446	PF02516	0.831
MOD_N-GLC_1	56	61	PF02516	0.532
MOD_NEK2_1	113	118	PF00069	0.573
MOD_NEK2_1	412	417	PF00069	0.578
MOD_NEK2_1	56	61	PF00069	0.785
MOD_NEK2_1	564	569	PF00069	0.713
MOD_NEK2_1	609	614	PF00069	0.507
MOD_NEK2_1	646	651	PF00069	0.670
MOD_NEK2_1	671	676	PF00069	0.648
MOD_NEK2_2	327	332	PF00069	0.499
MOD_PIKK_1	244	250	PF00454	0.607
MOD_PIKK_1	523	529	PF00454	0.733
MOD_PIKK_1	748	754	PF00454	0.541
MOD_PIKK_1	800	806	PF00454	0.555
MOD_PKA_1	132	138	PF00069	0.573
MOD_PKA_2	132	138	PF00069	0.702
MOD_PKA_2	313	319	PF00069	0.629
MOD_PKA_2	432	438	PF00069	0.719
MOD_PKA_2	504	510	PF00069	0.801
MOD_PKA_2	548	554	PF00069	0.686
MOD_PKA_2	564	570	PF00069	0.723
MOD_PKA_2	689	695	PF00069	0.572
MOD_PKA_2	739	745	PF00069	0.544
MOD_PKA_2	910	916	PF00069	0.619
MOD_PKB_1	381	389	PF00069	0.606
MOD_Plk_1	56	62	PF00069	0.531
MOD_Plk_1	692	698	PF00069	0.672
MOD_Plk_2-3	104	110	PF00069	0.765
MOD_Plk_4	159	165	PF00069	0.740
MOD_Plk_4	291	297	PF00069	0.479
MOD_Plk_4	306	312	PF00069	0.517
MOD_Plk_4	327	333	PF00069	0.495
MOD_Plk_4	507	513	PF00069	0.723
MOD_Plk_4	525	531	PF00069	0.636
MOD_Plk_4	56	62	PF00069	0.531
MOD_Plk_4	583	589	PF00069	0.644
MOD_Plk_4	600	606	PF00069	0.437
MOD_ProDKin_1	239	245	PF00069	0.830
MOD_ProDKin_1	256	262	PF00069	0.558
MOD_ProDKin_1	303	309	PF00069	0.604
MOD_ProDKin_1	356	362	PF00069	0.517
MOD_ProDKin_1	466	472	PF00069	0.752
MOD_ProDKin_1	520	526	PF00069	0.822
MOD_ProDKin_1	534	540	PF00069	0.592
MOD_ProDKin_1	595	601	PF00069	0.424
MOD_ProDKin_1	723	729	PF00069	0.798
MOD_ProDKin_1	752	758	PF00069	0.789
MOD_ProDKin_1	785	791	PF00069	0.546
MOD_ProDKin_1	86	92	PF00069	0.686
MOD_ProDKin_1	867	873	PF00069	0.823
MOD_ProDKin_1	913	919	PF00069	0.773
MOD_SUMO_for_1	143	146	PF00179	0.566
MOD_SUMO_rev_2	140	145	PF00179	0.564
TRG_DiLeu_BaEn_1	657	662	PF01217	0.373
TRG_DiLeu_BaEn_4	199	205	PF01217	0.566
TRG_ENDOCYTIC_2	102	105	PF00928	0.671
TRG_ENDOCYTIC_2	283	286	PF00928	0.527
TRG_ENDOCYTIC_2	38	41	PF00928	0.544
TRG_ENDOCYTIC_2	455	458	PF00928	0.832
TRG_ENDOCYTIC_2	746	749	PF00928	0.718
TRG_ENDOCYTIC_2	92	95	PF00928	0.649
TRG_ER_diArg_1	131	133	PF00400	0.585
TRG_ER_diArg_1	706	708	PF00400	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N1	Leptomonas seymouri	44%	100%
A0A3S7X6V6	Leishmania donovani	71%	100%
A4I984	Leishmania infantum	71%	100%
E9B451	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q9GRN4	Leishmania major	72%	99%