HIT-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HIT zinc finger, putative

Species:

Leishmania braziliensis

UniProt:

A4HLS4_LEIBR

TriTrypDb:

LbrM.33.2400 , LBRM2903_330031400

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0070761	pre-snoRNP complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HLS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLS4

Function

Biological processes
Term	Name	Level	Count
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000470	maturation of LSU-rRNA	9	1
GO:0000491	small nucleolar ribonucleoprotein complex assembly	7	1
GO:0000492	box C/D snoRNP assembly	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006403	RNA localization	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0033036	macromolecule localization	2	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048254	snoRNA localization	4	1
GO:0051179	localization	1	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.506
CLV_NRD_NRD_1	74	76	PF00675	0.574
CLV_PCSK_KEX2_1	72	74	PF00082	0.695
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.690
CLV_PCSK_PC7_1	69	75	PF00082	0.553
CLV_PCSK_SKI1_1	115	119	PF00082	0.822
CLV_PCSK_SKI1_1	164	168	PF00082	0.489
CLV_PCSK_SKI1_1	174	178	PF00082	0.441
DEG_APCC_DBOX_1	182	190	PF00400	0.563
DEG_Nend_UBRbox_1	1	4	PF02207	0.430
DEG_SPOP_SBC_1	102	106	PF00917	0.730
DEG_SPOP_SBC_1	47	51	PF00917	0.646
DOC_CKS1_1	84	89	PF01111	0.509
DOC_USP7_MATH_1	21	25	PF00917	0.529
DOC_USP7_MATH_1	36	40	PF00917	0.413
DOC_USP7_MATH_1	47	51	PF00917	0.688
DOC_USP7_MATH_1	94	98	PF00917	0.605
DOC_USP7_UBL2_3	26	30	PF12436	0.497
DOC_WW_Pin1_4	103	108	PF00397	0.788
DOC_WW_Pin1_4	166	171	PF00397	0.528
DOC_WW_Pin1_4	83	88	PF00397	0.501
LIG_14-3-3_CanoR_1	14	22	PF00244	0.446
LIG_14-3-3_CanoR_1	162	170	PF00244	0.569
LIG_BIR_III_2	100	104	PF00653	0.708
LIG_FHA_1	47	53	PF00498	0.543
LIG_FHA_2	146	152	PF00498	0.392
LIG_FHA_2	84	90	PF00498	0.708
LIG_LIR_Nem_3	198	202	PF02991	0.456
LIG_PTB_Apo_2	193	200	PF02174	0.532
LIG_SH2_NCK_1	194	198	PF00017	0.547
LIG_SH2_STAT3	147	150	PF00017	0.563
LIG_SH2_STAT5	147	150	PF00017	0.563
LIG_SH2_STAT5	22	25	PF00017	0.517
LIG_SH2_STAT5	54	57	PF00017	0.395
LIG_SH3_3	128	134	PF00018	0.629
LIG_TRAF2_1	135	138	PF00917	0.544
LIG_TRAF2_1	148	151	PF00917	0.332
MOD_CDK_SPK_2	83	88	PF00069	0.501
MOD_CDK_SPxxK_3	83	90	PF00069	0.509
MOD_CK1_1	113	119	PF00069	0.627
MOD_CK1_1	181	187	PF00069	0.546
MOD_CK2_1	145	151	PF00069	0.579
MOD_CK2_1	83	89	PF00069	0.618
MOD_GlcNHglycan	111	115	PF01048	0.721
MOD_GlcNHglycan	164	167	PF01048	0.555
MOD_GlcNHglycan	19	22	PF01048	0.344
MOD_GlcNHglycan	37	41	PF01048	0.410
MOD_GSK3_1	102	109	PF00069	0.728
MOD_GSK3_1	162	169	PF00069	0.541
MOD_GSK3_1	17	24	PF00069	0.529
MOD_GSK3_1	175	182	PF00069	0.485
MOD_LATS_1	160	166	PF00433	0.360
MOD_N-GLC_1	123	128	PF02516	0.574
MOD_N-GLC_1	45	50	PF02516	0.556
MOD_NEK2_1	55	60	PF00069	0.478
MOD_Plk_1	123	129	PF00069	0.803
MOD_Plk_4	55	61	PF00069	0.560
MOD_ProDKin_1	103	109	PF00069	0.788
MOD_ProDKin_1	166	172	PF00069	0.520
MOD_ProDKin_1	83	89	PF00069	0.505
TRG_DiLeu_BaEn_2	78	84	PF01217	0.473
TRG_ER_diArg_1	13	16	PF00400	0.517
TRG_ER_diArg_1	161	164	PF00400	0.617
TRG_ER_diArg_1	183	186	PF00400	0.524
TRG_ER_diArg_1	73	75	PF00400	0.574
TRG_NLS_MonoExtN_4	26	33	PF00514	0.497
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTG1	Leptomonas seymouri	48%	78%
A0A3S7X700	Leishmania donovani	73%	98%
A4I983	Leishmania infantum	73%	98%
D0A6A4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B450	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	99%
Q4Q3X5	Leishmania major	72%	100%