Putative phosphoglycerate mutase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoglycerate mutase, putative

Species:

Leishmania braziliensis

UniProt:

A4HLS3_LEIBR

TriTrypDb:

LbrM.33.2390 , LBRM2903_330031300

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLS3

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	1
GO:0006082	organic acid metabolic process	3	1
GO:0006090	pyruvate metabolic process	7	1
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006096	glycolytic process	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006757	obsolete ATP generation from ADP	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009132	nucleoside diphosphate metabolic process	5	1
GO:0009135	purine nucleoside diphosphate metabolic process	6	1
GO:0009141	nucleoside triphosphate metabolic process	5	1
GO:0009144	purine nucleoside triphosphate metabolic process	6	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009179	purine ribonucleoside diphosphate metabolic process	7	1
GO:0009185	ribonucleoside diphosphate metabolic process	6	1
GO:0009199	ribonucleoside triphosphate metabolic process	6	1
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009987	cellular process	1	1
GO:0016052	carbohydrate catabolic process	4	1
GO:0016310	phosphorylation	5	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0046031	ADP metabolic process	7	1
GO:0046034	ATP metabolic process	7	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046939	obsolete nucleotide phosphorylation	6	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004619	phosphoglycerate mutase activity	5	1
GO:0005488	binding	1	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0016853	isomerase activity	2	1
GO:0016866	intramolecular transferase activity	3	1
GO:0016868	intramolecular transferase activity, phosphotransferases	4	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0050897	cobalt ion binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	37	41	PF00656	0.576
CLV_C14_Caspase3-7	405	409	PF00656	0.411
CLV_NRD_NRD_1	15	17	PF00675	0.709
CLV_PCSK_KEX2_1	15	17	PF00082	0.797
CLV_PCSK_KEX2_1	190	192	PF00082	0.438
CLV_PCSK_KEX2_1	224	226	PF00082	0.447
CLV_PCSK_KEX2_1	437	439	PF00082	0.411
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.474
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.447
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.411
CLV_PCSK_PC7_1	11	17	PF00082	0.692
CLV_PCSK_PC7_1	433	439	PF00082	0.411
CLV_PCSK_SKI1_1	191	195	PF00082	0.354
CLV_PCSK_SKI1_1	258	262	PF00082	0.411
CLV_PCSK_SKI1_1	30	34	PF00082	0.819
CLV_PCSK_SKI1_1	497	501	PF00082	0.614
CLV_PCSK_SKI1_1	80	84	PF00082	0.588
DEG_APCC_DBOX_1	253	261	PF00400	0.352
DEG_MDM2_SWIB_1	435	442	PF02201	0.398
DEG_SCF_FBW7_1	102	109	PF00400	0.824
DEG_SPOP_SBC_1	127	131	PF00917	0.661
DEG_SPOP_SBC_1	21	25	PF00917	0.730
DEG_SPOP_SBC_1	315	319	PF00917	0.559
DEG_SPOP_SBC_1	70	74	PF00917	0.745
DOC_CKS1_1	103	108	PF01111	0.578
DOC_CKS1_1	210	215	PF01111	0.411
DOC_CKS1_1	328	333	PF01111	0.545
DOC_CYCLIN_RxL_1	493	504	PF00134	0.593
DOC_CYCLIN_yClb5_NLxxxL_5	477	486	PF00134	0.575
DOC_MAPK_gen_1	437	444	PF00069	0.354
DOC_PP1_RVXF_1	412	418	PF00149	0.411
DOC_PP4_FxxP_1	185	188	PF00568	0.517
DOC_USP7_MATH_1	119	123	PF00917	0.696
DOC_USP7_MATH_1	151	155	PF00917	0.800
DOC_USP7_MATH_1	156	160	PF00917	0.725
DOC_USP7_MATH_1	161	165	PF00917	0.646
DOC_USP7_MATH_1	166	170	PF00917	0.571
DOC_USP7_MATH_1	174	178	PF00917	0.458
DOC_USP7_MATH_1	21	25	PF00917	0.709
DOC_USP7_MATH_1	315	319	PF00917	0.756
DOC_USP7_MATH_1	70	74	PF00917	0.698
DOC_USP7_MATH_1	76	80	PF00917	0.634
DOC_USP7_UBL2_3	493	497	PF12436	0.546
DOC_WW_Pin1_4	102	107	PF00397	0.820
DOC_WW_Pin1_4	133	138	PF00397	0.747
DOC_WW_Pin1_4	209	214	PF00397	0.352
DOC_WW_Pin1_4	245	250	PF00397	0.352
DOC_WW_Pin1_4	300	305	PF00397	0.639
DOC_WW_Pin1_4	327	332	PF00397	0.548
DOC_WW_Pin1_4	43	48	PF00397	0.739
DOC_WW_Pin1_4	449	454	PF00397	0.411
LIG_14-3-3_CanoR_1	15	20	PF00244	0.762
LIG_14-3-3_CanoR_1	184	188	PF00244	0.516
LIG_14-3-3_CanoR_1	196	206	PF00244	0.411
LIG_14-3-3_CanoR_1	252	258	PF00244	0.352
LIG_14-3-3_CanoR_1	35	39	PF00244	0.643
LIG_14-3-3_CanoR_1	366	371	PF00244	0.509
LIG_14-3-3_CanoR_1	402	407	PF00244	0.352
LIG_14-3-3_CanoR_1	6	13	PF00244	0.699
LIG_Actin_WH2_2	346	362	PF00022	0.411
LIG_AP2alpha_1	406	410	PF02296	0.411
LIG_BIR_II_1	1	5	PF00653	0.787
LIG_BIR_III_2	44	48	PF00653	0.597
LIG_BIR_III_4	139	143	PF00653	0.601
LIG_BRCT_BRCA1_1	153	157	PF00533	0.571
LIG_BRCT_BRCA1_1	78	82	PF00533	0.567
LIG_eIF4E_1	494	500	PF01652	0.576
LIG_FAT_LD_1	370	378	PF03623	0.304
LIG_FHA_1	184	190	PF00498	0.516
LIG_FHA_1	402	408	PF00498	0.411
LIG_FHA_1	419	425	PF00498	0.411
LIG_FHA_1	97	103	PF00498	0.822
LIG_FHA_2	134	140	PF00498	0.595
LIG_FHA_2	324	330	PF00498	0.792
LIG_FHA_2	366	372	PF00498	0.509
LIG_Integrin_isoDGR_2	197	199	PF01839	0.411
LIG_LIR_Apic_2	183	188	PF02991	0.635
LIG_LIR_Apic_2	212	218	PF02991	0.352
LIG_LIR_Gen_1	445	455	PF02991	0.352
LIG_LIR_Nem_3	241	247	PF02991	0.398
LIG_LIR_Nem_3	381	386	PF02991	0.411
LIG_LIR_Nem_3	488	492	PF02991	0.631
LIG_MYND_1	121	125	PF01753	0.624
LIG_PCNA_yPIPBox_3	196	210	PF02747	0.411
LIG_Pex14_2	386	390	PF04695	0.411
LIG_Pex14_2	406	410	PF04695	0.183
LIG_Pex14_2	435	439	PF04695	0.398
LIG_REV1ctd_RIR_1	384	390	PF16727	0.411
LIG_SH2_CRK	388	392	PF00017	0.352
LIG_SH2_NCK_1	367	371	PF00017	0.509
LIG_SH2_STAT3	259	262	PF00017	0.411
LIG_SH2_STAT5	209	212	PF00017	0.411
LIG_SH2_STAT5	244	247	PF00017	0.366
LIG_SH2_STAT5	250	253	PF00017	0.335
LIG_SH2_STAT5	259	262	PF00017	0.312
LIG_SH2_STAT5	367	370	PF00017	0.411
LIG_SH2_STAT5	441	444	PF00017	0.509
LIG_SH3_3	118	124	PF00018	0.746
LIG_SH3_3	207	213	PF00018	0.411
LIG_SH3_3	292	298	PF00018	0.568
LIG_SH3_3	322	328	PF00018	0.583
LIG_SH3_3	412	418	PF00018	0.411
LIG_SUMO_SIM_anti_2	420	427	PF11976	0.415
LIG_SUMO_SIM_par_1	420	427	PF11976	0.415
LIG_SUMO_SIM_par_1	482	488	PF11976	0.592
LIG_WRC_WIRS_1	403	408	PF05994	0.352
LIG_WRC_WIRS_1	444	449	PF05994	0.411
MOD_CDK_SPK_2	133	138	PF00069	0.724
MOD_CDK_SPxxK_3	209	216	PF00069	0.352
MOD_CDK_SPxxK_3	245	252	PF00069	0.352
MOD_CK1_1	109	115	PF00069	0.792
MOD_CK1_1	126	132	PF00069	0.565
MOD_CK1_1	152	158	PF00069	0.769
MOD_CK1_1	169	175	PF00069	0.602
MOD_CK1_1	183	189	PF00069	0.613
MOD_CK1_1	22	28	PF00069	0.699
MOD_CK1_1	253	259	PF00069	0.411
MOD_CK1_1	270	276	PF00069	0.635
MOD_CK1_1	300	306	PF00069	0.614
MOD_CK1_1	318	324	PF00069	0.789
MOD_CK1_1	34	40	PF00069	0.703
MOD_CK1_1	344	350	PF00069	0.431
MOD_CK1_1	4	10	PF00069	0.678
MOD_CK1_1	457	463	PF00069	0.411
MOD_CK1_1	502	508	PF00069	0.618
MOD_CK2_1	111	117	PF00069	0.735
MOD_CK2_1	156	162	PF00069	0.575
MOD_CK2_1	366	372	PF00069	0.509
MOD_CK2_1	482	488	PF00069	0.553
MOD_Cter_Amidation	222	225	PF01082	0.447
MOD_GlcNHglycan	108	111	PF01048	0.814
MOD_GlcNHglycan	158	161	PF01048	0.642
MOD_GlcNHglycan	24	27	PF01048	0.783
MOD_GlcNHglycan	269	272	PF01048	0.692
MOD_GlcNHglycan	280	285	PF01048	0.642
MOD_GlcNHglycan	287	290	PF01048	0.504
MOD_GlcNHglycan	299	302	PF01048	0.527
MOD_GlcNHglycan	343	346	PF01048	0.691
MOD_GlcNHglycan	394	397	PF01048	0.352
MOD_GlcNHglycan	40	43	PF01048	0.597
MOD_GlcNHglycan	504	507	PF01048	0.612
MOD_GSK3_1	1	8	PF00069	0.756
MOD_GSK3_1	108	115	PF00069	0.720
MOD_GSK3_1	119	126	PF00069	0.641
MOD_GSK3_1	129	136	PF00069	0.737
MOD_GSK3_1	15	22	PF00069	0.711
MOD_GSK3_1	151	158	PF00069	0.717
MOD_GSK3_1	174	181	PF00069	0.761
MOD_GSK3_1	205	212	PF00069	0.304
MOD_GSK3_1	314	321	PF00069	0.698
MOD_GSK3_1	323	330	PF00069	0.691
MOD_GSK3_1	34	41	PF00069	0.528
MOD_GSK3_1	424	431	PF00069	0.411
MOD_GSK3_1	98	105	PF00069	0.633
MOD_N-GLC_1	323	328	PF02516	0.747
MOD_N-GLC_1	97	102	PF02516	0.590
MOD_NEK2_1	1	6	PF00069	0.707
MOD_NEK2_1	108	113	PF00069	0.591
MOD_NEK2_1	178	183	PF00069	0.642
MOD_NEK2_1	19	24	PF00069	0.711
MOD_NEK2_1	314	319	PF00069	0.561
MOD_NEK2_1	392	397	PF00069	0.523
MOD_NEK2_1	499	504	PF00069	0.625
MOD_NEK2_1	81	86	PF00069	0.650
MOD_PIKK_1	166	172	PF00454	0.808
MOD_PIKK_1	272	278	PF00454	0.603
MOD_PIKK_1	50	56	PF00454	0.836
MOD_PIKK_1	6	12	PF00454	0.536
MOD_PIKK_1	88	94	PF00454	0.579
MOD_PK_1	366	372	PF00069	0.276
MOD_PKA_1	15	21	PF00069	0.737
MOD_PKA_2	15	21	PF00069	0.768
MOD_PKA_2	183	189	PF00069	0.532
MOD_PKA_2	253	259	PF00069	0.352
MOD_PKA_2	267	273	PF00069	0.518
MOD_PKA_2	34	40	PF00069	0.492
MOD_PKA_2	365	371	PF00069	0.509
MOD_PKA_2	401	407	PF00069	0.352
MOD_PKA_2	5	11	PF00069	0.698
MOD_Plk_1	149	155	PF00069	0.570
MOD_Plk_1	204	210	PF00069	0.276
MOD_Plk_1	323	329	PF00069	0.562
MOD_Plk_1	97	103	PF00069	0.635
MOD_Plk_4	174	180	PF00069	0.752
MOD_Plk_4	205	211	PF00069	0.304
MOD_Plk_4	336	342	PF00069	0.658
MOD_Plk_4	402	408	PF00069	0.352
MOD_Plk_4	98	104	PF00069	0.586
MOD_ProDKin_1	102	108	PF00069	0.823
MOD_ProDKin_1	133	139	PF00069	0.747
MOD_ProDKin_1	209	215	PF00069	0.352
MOD_ProDKin_1	245	251	PF00069	0.352
MOD_ProDKin_1	300	306	PF00069	0.637
MOD_ProDKin_1	327	333	PF00069	0.546
MOD_ProDKin_1	43	49	PF00069	0.730
MOD_ProDKin_1	449	455	PF00069	0.411
TRG_DiLeu_BaEn_3	281	287	PF01217	0.549
TRG_ENDOCYTIC_2	367	370	PF00928	0.283
TRG_ENDOCYTIC_2	383	386	PF00928	0.457
TRG_ENDOCYTIC_2	441	444	PF00928	0.509
TRG_ER_diArg_1	251	254	PF00400	0.374
TRG_ER_diArg_1	357	360	PF00400	0.411
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZZ8	Leptomonas seymouri	55%	85%
A0A3S7X6Z7	Leishmania donovani	78%	100%
A4I982	Leishmania infantum	78%	100%
E9B449	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q3X6	Leishmania major	78%	100%