Putative glycerolphosphate mutase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerolphosphate mutase, putative

Species:

Leishmania braziliensis

UniProt:

A4HLS2_LEIBR

TriTrypDb:

LbrM.33.2380 , LBRM2903_330031200

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLS2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.509
CLV_C14_Caspase3-7	447	451	PF00656	0.701
CLV_MEL_PAP_1	160	166	PF00089	0.411
CLV_NRD_NRD_1	103	105	PF00675	0.411
CLV_NRD_NRD_1	23	25	PF00675	0.634
CLV_NRD_NRD_1	255	257	PF00675	0.811
CLV_NRD_NRD_1	32	34	PF00675	0.472
CLV_NRD_NRD_1	419	421	PF00675	0.737
CLV_NRD_NRD_1	8	10	PF00675	0.665
CLV_PCSK_KEX2_1	103	105	PF00082	0.411
CLV_PCSK_KEX2_1	23	25	PF00082	0.615
CLV_PCSK_KEX2_1	255	257	PF00082	0.763
CLV_PCSK_KEX2_1	32	34	PF00082	0.472
CLV_PCSK_KEX2_1	7	9	PF00082	0.668
CLV_PCSK_KEX2_1	74	76	PF00082	0.411
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.411
CLV_PCSK_SKI1_1	141	145	PF00082	0.411
CLV_PCSK_SKI1_1	245	249	PF00082	0.558
CLV_PCSK_SKI1_1	32	36	PF00082	0.411
CLV_PCSK_SKI1_1	350	354	PF00082	0.475
DEG_APCC_DBOX_1	95	103	PF00400	0.383
DEG_MDM2_SWIB_1	308	315	PF02201	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.766
DEG_SPOP_SBC_1	247	251	PF00917	0.821
DEG_SPOP_SBC_1	470	474	PF00917	0.535
DOC_CYCLIN_RxL_1	347	356	PF00134	0.502
DOC_MAPK_gen_1	311	319	PF00069	0.411
DOC_MAPK_MEF2A_6	173	180	PF00069	0.552
DOC_MAPK_NFAT4_5	173	181	PF00069	0.558
DOC_PP2B_LxvP_1	178	181	PF13499	0.658
DOC_PP4_FxxP_1	313	316	PF00568	0.411
DOC_USP7_MATH_1	214	218	PF00917	0.688
DOC_USP7_MATH_1	226	230	PF00917	0.762
DOC_USP7_MATH_1	236	240	PF00917	0.766
DOC_USP7_MATH_1	247	251	PF00917	0.717
DOC_USP7_MATH_1	263	267	PF00917	0.550
DOC_USP7_MATH_1	405	409	PF00917	0.795
DOC_USP7_MATH_1	422	426	PF00917	0.549
DOC_USP7_MATH_1	432	436	PF00917	0.622
DOC_USP7_MATH_1	451	455	PF00917	0.508
DOC_USP7_MATH_1	470	474	PF00917	0.535
DOC_USP7_UBL2_3	241	245	PF12436	0.599
DOC_WW_Pin1_4	234	239	PF00397	0.779
DOC_WW_Pin1_4	428	433	PF00397	0.777
DOC_WW_Pin1_4	434	439	PF00397	0.694
DOC_WW_Pin1_4	471	476	PF00397	0.715
DOC_WW_Pin1_4	477	482	PF00397	0.750
DOC_WW_Pin1_4	51	56	PF00397	0.360
DOC_WW_Pin1_4	87	92	PF00397	0.411
LIG_14-3-3_CanoR_1	103	107	PF00244	0.411
LIG_14-3-3_CanoR_1	24	30	PF00244	0.566
LIG_14-3-3_CanoR_1	287	291	PF00244	0.512
LIG_14-3-3_CanoR_1	342	352	PF00244	0.488
LIG_14-3-3_CanoR_1	420	430	PF00244	0.574
LIG_14-3-3_CanoR_1	7	13	PF00244	0.542
LIG_14-3-3_CanoR_1	94	100	PF00244	0.411
LIG_Actin_WH2_2	157	175	PF00022	0.513
LIG_BRCT_BRCA1_1	164	168	PF00533	0.411
LIG_deltaCOP1_diTrp_1	368	377	PF00928	0.570
LIG_deltaCOP1_diTrp_1	484	487	PF00928	0.529
LIG_FHA_1	422	428	PF00498	0.738
LIG_FHA_2	16	22	PF00498	0.510
LIG_FHA_2	96	102	PF00498	0.411
LIG_GBD_Chelix_1	299	307	PF00786	0.411
LIG_LIR_Apic_2	237	243	PF02991	0.580
LIG_LIR_Apic_2	54	60	PF02991	0.411
LIG_LIR_Gen_1	165	176	PF02991	0.411
LIG_LIR_Gen_1	318	327	PF02991	0.411
LIG_LIR_Nem_3	165	171	PF02991	0.411
LIG_LIR_Nem_3	375	380	PF02991	0.702
LIG_LIR_Nem_3	83	89	PF02991	0.411
LIG_MLH1_MIPbox_1	164	168	PF16413	0.411
LIG_Pex14_2	308	312	PF04695	0.411
LIG_PTB_Apo_2	11	18	PF02174	0.648
LIG_SH2_CRK	128	132	PF00017	0.513
LIG_SH2_CRK	149	153	PF00017	0.411
LIG_SH2_GRB2like	51	54	PF00017	0.513
LIG_SH2_STAT3	12	15	PF00017	0.717
LIG_SH2_STAT5	86	89	PF00017	0.411
LIG_SH3_2	413	418	PF14604	0.822
LIG_SH3_3	277	283	PF00018	0.544
LIG_SH3_3	407	413	PF00018	0.709
LIG_SH3_4	241	248	PF00018	0.580
LIG_SH3_CIN85_PxpxPR_1	413	418	PF14604	0.822
LIG_SUMO_SIM_par_1	330	335	PF11976	0.411
LIG_TRAF2_1	386	389	PF00917	0.727
LIG_WW_3	415	419	PF00397	0.824
MOD_CDK_SPxxK_3	234	241	PF00069	0.579
MOD_CDK_SPxxK_3	51	58	PF00069	0.411
MOD_CDK_SPxxK_3	87	94	PF00069	0.411
MOD_CK1_1	19	25	PF00069	0.575
MOD_CK1_1	230	236	PF00069	0.726
MOD_CK1_1	425	431	PF00069	0.786
MOD_CK1_1	439	445	PF00069	0.557
MOD_CK2_1	102	108	PF00069	0.411
MOD_CK2_1	441	447	PF00069	0.801
MOD_CK2_1	95	101	PF00069	0.411
MOD_Cter_Amidation	72	75	PF01082	0.411
MOD_GlcNHglycan	155	158	PF01048	0.355
MOD_GlcNHglycan	164	167	PF01048	0.357
MOD_GlcNHglycan	203	206	PF01048	0.677
MOD_GlcNHglycan	212	215	PF01048	0.630
MOD_GlcNHglycan	232	235	PF01048	0.835
MOD_GlcNHglycan	407	410	PF01048	0.700
MOD_GlcNHglycan	434	437	PF01048	0.698
MOD_GlcNHglycan	447	450	PF01048	0.755
MOD_GlcNHglycan	461	464	PF01048	0.539
MOD_GlcNHglycan	498	501	PF01048	0.592
MOD_GSK3_1	102	109	PF00069	0.390
MOD_GSK3_1	15	22	PF00069	0.556
MOD_GSK3_1	172	179	PF00069	0.632
MOD_GSK3_1	184	191	PF00069	0.597
MOD_GSK3_1	210	217	PF00069	0.660
MOD_GSK3_1	226	233	PF00069	0.811
MOD_GSK3_1	241	248	PF00069	0.787
MOD_GSK3_1	254	261	PF00069	0.558
MOD_GSK3_1	421	428	PF00069	0.734
MOD_GSK3_1	430	437	PF00069	0.710
MOD_GSK3_1	439	446	PF00069	0.507
MOD_GSK3_1	461	468	PF00069	0.598
MOD_N-GLC_1	134	139	PF02516	0.261
MOD_N-GLC_1	477	482	PF02516	0.521
MOD_N-GLC_2	184	186	PF02516	0.779
MOD_NEK2_1	1	6	PF00069	0.729
MOD_NEK2_1	106	111	PF00069	0.381
MOD_NEK2_1	134	139	PF00069	0.390
MOD_NEK2_1	153	158	PF00069	0.411
MOD_NEK2_1	167	172	PF00069	0.411
MOD_NEK2_1	210	215	PF00069	0.651
MOD_NEK2_1	254	259	PF00069	0.709
MOD_NEK2_1	452	457	PF00069	0.549
MOD_PIKK_1	106	112	PF00454	0.411
MOD_PIKK_1	219	225	PF00454	0.805
MOD_PIKK_1	465	471	PF00454	0.704
MOD_PKA_1	420	426	PF00069	0.832
MOD_PKA_1	8	14	PF00069	0.508
MOD_PKA_2	102	108	PF00069	0.411
MOD_PKA_2	162	168	PF00069	0.411
MOD_PKA_2	172	178	PF00069	0.411
MOD_PKA_2	254	260	PF00069	0.709
MOD_PKA_2	286	292	PF00069	0.507
MOD_PKA_2	488	494	PF00069	0.530
MOD_PKA_2	8	14	PF00069	0.508
MOD_PKA_2	95	101	PF00069	0.411
MOD_PKB_1	418	426	PF00069	0.832
MOD_Plk_1	106	112	PF00069	0.411
MOD_Plk_1	134	140	PF00069	0.411
MOD_Plk_1	367	373	PF00069	0.554
MOD_Plk_4	167	173	PF00069	0.429
MOD_Plk_4	25	31	PF00069	0.616
MOD_Plk_4	422	428	PF00069	0.574
MOD_ProDKin_1	234	240	PF00069	0.781
MOD_ProDKin_1	428	434	PF00069	0.776
MOD_ProDKin_1	471	477	PF00069	0.712
MOD_ProDKin_1	51	57	PF00069	0.360
MOD_ProDKin_1	87	93	PF00069	0.411
MOD_SUMO_rev_2	52	60	PF00179	0.411
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.468
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.513
TRG_ENDOCYTIC_2	128	131	PF00928	0.411
TRG_ENDOCYTIC_2	148	151	PF00928	0.411
TRG_ENDOCYTIC_2	197	200	PF00928	0.596
TRG_ER_diArg_1	102	104	PF00400	0.411
TRG_ER_diArg_1	23	25	PF00400	0.615
TRG_ER_diArg_1	254	256	PF00400	0.818
TRG_ER_diArg_1	31	33	PF00400	0.480
TRG_ER_diArg_1	417	420	PF00400	0.737
TRG_ER_diArg_1	7	9	PF00400	0.668
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHK5	Leptomonas seymouri	65%	100%
A0A3Q8IU44	Leishmania donovani	81%	100%
A4I981	Leishmania infantum	81%	100%
E9B448	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q3X7	Leishmania major	81%	100%