LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HLR8_LEIBR
TriTrypDb:
LbrM.33.2340 , LBRM2903_330030600
Length:
116

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HLR8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLR8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 110 114 PF00656 0.652
CLV_NRD_NRD_1 3 5 PF00675 0.630
CLV_PCSK_KEX2_1 3 5 PF00082 0.636
DEG_Nend_Nbox_1 1 3 PF02207 0.461
DOC_USP7_MATH_1 15 19 PF00917 0.497
LIG_FHA_1 35 41 PF00498 0.417
LIG_FHA_2 81 87 PF00498 0.622
LIG_OCRL_FandH_1 53 65 PF00620 0.351
LIG_SH2_GRB2like 25 28 PF00017 0.514
LIG_SH2_STAT5 23 26 PF00017 0.428
LIG_UBA3_1 101 109 PF00899 0.604
MOD_CK1_1 34 40 PF00069 0.428
MOD_CK2_1 80 86 PF00069 0.626
MOD_GlcNHglycan 17 20 PF01048 0.703
MOD_GlcNHglycan 33 36 PF01048 0.515
MOD_GSK3_1 15 22 PF00069 0.487
MOD_GSK3_1 72 79 PF00069 0.708
MOD_NEK2_1 10 15 PF00069 0.390
MOD_NEK2_1 42 47 PF00069 0.302
TRG_ER_diArg_1 2 4 PF00400 0.441
TRG_Pf-PMV_PEXEL_1 3 8 PF00026 0.695

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDB8 Leptomonas seymouri 69% 100%
A0A0S4J4D8 Bodo saltans 56% 100%
A0A1X0P3Q8 Trypanosomatidae 55% 97%
A0A3S7X6Z5 Leishmania donovani 86% 100%
A0A422N431 Trypanosoma rangeli 61% 97%
A4I944 Leishmania infantum 86% 100%
D0A6A7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 71% 96%
E9B444 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4Q3Y1 Leishmania major 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS