Protein HGH1 homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLR7_LEIBR

TriTrypDb:

LbrM.33.2330 , LBRM2903_330030500

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HLR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLR7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	409	413	PF00656	0.446
CLV_C14_Caspase3-7	70	74	PF00656	0.450
CLV_NRD_NRD_1	109	111	PF00675	0.402
CLV_NRD_NRD_1	113	115	PF00675	0.292
CLV_NRD_NRD_1	40	42	PF00675	0.360
CLV_PCSK_SKI1_1	134	138	PF00082	0.357
CLV_PCSK_SKI1_1	237	241	PF00082	0.315
CLV_PCSK_SKI1_1	348	352	PF00082	0.431
CLV_PCSK_SKI1_1	401	405	PF00082	0.285
CLV_PCSK_SKI1_1	84	88	PF00082	0.475
DEG_APCC_DBOX_1	236	244	PF00400	0.354
DEG_APCC_DBOX_1	400	408	PF00400	0.280
DEG_APCC_KENBOX_2	52	56	PF00400	0.411
DEG_SCF_FBW7_1	383	390	PF00400	0.445
DOC_MAPK_gen_1	110	119	PF00069	0.357
DOC_MAPK_gen_1	53	62	PF00069	0.341
DOC_MAPK_MEF2A_6	134	143	PF00069	0.333
DOC_MAPK_MEF2A_6	237	246	PF00069	0.294
DOC_MAPK_MEF2A_6	53	62	PF00069	0.545
DOC_MAPK_NFAT4_5	134	142	PF00069	0.229
DOC_USP7_MATH_1	187	191	PF00917	0.313
DOC_USP7_MATH_1	2	6	PF00917	0.720
DOC_USP7_MATH_1	228	232	PF00917	0.695
DOC_USP7_MATH_1	368	372	PF00917	0.641
DOC_USP7_MATH_1	393	397	PF00917	0.443
DOC_USP7_MATH_1	49	53	PF00917	0.347
DOC_USP7_MATH_1	99	103	PF00917	0.428
DOC_USP7_UBL2_3	111	115	PF12436	0.375
DOC_WW_Pin1_4	269	274	PF00397	0.453
DOC_WW_Pin1_4	288	293	PF00397	0.201
DOC_WW_Pin1_4	383	388	PF00397	0.477
DOC_WW_Pin1_4	6	11	PF00397	0.683
LIG_14-3-3_CanoR_1	263	273	PF00244	0.498
LIG_APCC_ABBA_1	174	179	PF00400	0.447
LIG_APCC_ABBA_1	403	408	PF00400	0.368
LIG_APCC_ABBAyCdc20_2	173	179	PF00400	0.451
LIG_BIR_II_1	1	5	PF00653	0.449
LIG_FHA_1	138	144	PF00498	0.349
LIG_FHA_1	245	251	PF00498	0.489
LIG_FHA_1	384	390	PF00498	0.615
LIG_FHA_1	70	76	PF00498	0.232
LIG_FHA_1	90	96	PF00498	0.310
LIG_FHA_2	151	157	PF00498	0.406
LIG_FHA_2	305	311	PF00498	0.377
LIG_GBD_Chelix_1	325	333	PF00786	0.367
LIG_LIR_Apic_2	412	417	PF02991	0.544
LIG_LIR_Gen_1	28	36	PF02991	0.455
LIG_LIR_Gen_1	57	67	PF02991	0.378
LIG_LIR_Nem_3	28	33	PF02991	0.423
LIG_LIR_Nem_3	57	62	PF02991	0.365
LIG_NRBOX	239	245	PF00104	0.306
LIG_PCNA_yPIPBox_3	315	329	PF02747	0.472
LIG_Pex14_2	26	30	PF04695	0.285
LIG_Rb_LxCxE_1	307	327	PF01857	0.397
LIG_SH2_CRK	296	300	PF00017	0.458
LIG_SH2_PTP2	414	417	PF00017	0.583
LIG_SH2_STAP1	178	182	PF00017	0.495
LIG_SH2_STAP1	296	300	PF00017	0.235
LIG_SH2_STAT5	132	135	PF00017	0.481
LIG_SH2_STAT5	170	173	PF00017	0.322
LIG_SH2_STAT5	279	282	PF00017	0.457
LIG_SH2_STAT5	285	288	PF00017	0.439
LIG_SH2_STAT5	406	409	PF00017	0.397
LIG_SH2_STAT5	414	417	PF00017	0.467
LIG_SH2_STAT5	59	62	PF00017	0.399
LIG_SUMO_SIM_anti_2	138	143	PF11976	0.300
LIG_SUMO_SIM_anti_2	371	379	PF11976	0.609
LIG_SUMO_SIM_anti_2	89	95	PF11976	0.329
LIG_SUMO_SIM_par_1	135	140	PF11976	0.245
LIG_UBA3_1	75	84	PF00899	0.474
MOD_CDK_SPK_2	288	293	PF00069	0.467
MOD_CDK_SPxxK_3	269	276	PF00069	0.454
MOD_CK1_1	150	156	PF00069	0.353
MOD_CK1_1	19	25	PF00069	0.575
MOD_CK1_1	268	274	PF00069	0.470
MOD_CK1_1	9	15	PF00069	0.669
MOD_CK2_1	132	138	PF00069	0.377
MOD_CK2_1	180	186	PF00069	0.405
MOD_CK2_1	304	310	PF00069	0.228
MOD_CK2_1	321	327	PF00069	0.481
MOD_CK2_1	328	334	PF00069	0.484
MOD_CK2_1	368	374	PF00069	0.626
MOD_CK2_1	391	397	PF00069	0.399
MOD_CK2_1	99	105	PF00069	0.388
MOD_GlcNHglycan	18	21	PF01048	0.547
MOD_GlcNHglycan	182	185	PF01048	0.487
MOD_GlcNHglycan	368	371	PF01048	0.346
MOD_GlcNHglycan	63	66	PF01048	0.495
MOD_GlcNHglycan	97	100	PF01048	0.447
MOD_GSK3_1	128	135	PF00069	0.427
MOD_GSK3_1	2	9	PF00069	0.655
MOD_GSK3_1	223	230	PF00069	0.535
MOD_GSK3_1	262	269	PF00069	0.391
MOD_GSK3_1	328	335	PF00069	0.481
MOD_GSK3_1	379	386	PF00069	0.563
MOD_GSK3_1	387	394	PF00069	0.463
MOD_GSK3_1	95	102	PF00069	0.474
MOD_N-GLC_1	145	150	PF02516	0.307
MOD_N-GLC_1	244	249	PF02516	0.316
MOD_N-GLC_1	286	291	PF02516	0.234
MOD_N-GLC_1	95	100	PF02516	0.341
MOD_NEK2_1	137	142	PF00069	0.291
MOD_NEK2_1	147	152	PF00069	0.328
MOD_NEK2_1	244	249	PF00069	0.290
MOD_NEK2_1	26	31	PF00069	0.357
MOD_NEK2_1	266	271	PF00069	0.400
MOD_NEK2_1	328	333	PF00069	0.408
MOD_NEK2_1	355	360	PF00069	0.497
MOD_NEK2_1	399	404	PF00069	0.386
MOD_NEK2_1	61	66	PF00069	0.357
MOD_OFUCOSY	284	290	PF10250	0.220
MOD_OFUCOSY	97	103	PF10250	0.385
MOD_PK_1	341	347	PF00069	0.485
MOD_PKA_2	262	268	PF00069	0.529
MOD_Plk_1	13	19	PF00069	0.362
MOD_Plk_1	137	143	PF00069	0.309
MOD_Plk_1	233	239	PF00069	0.468
MOD_Plk_1	399	405	PF00069	0.356
MOD_Plk_4	128	134	PF00069	0.386
MOD_Plk_4	137	143	PF00069	0.320
MOD_Plk_4	294	300	PF00069	0.412
MOD_Plk_4	328	334	PF00069	0.489
MOD_Plk_4	89	95	PF00069	0.237
MOD_ProDKin_1	269	275	PF00069	0.454
MOD_ProDKin_1	288	294	PF00069	0.201
MOD_ProDKin_1	383	389	PF00069	0.463
MOD_ProDKin_1	6	12	PF00069	0.680
TRG_DiLeu_BaEn_2	27	33	PF01217	0.370
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.358
TRG_ENDOCYTIC_2	178	181	PF00928	0.402
TRG_ENDOCYTIC_2	296	299	PF00928	0.523
TRG_ENDOCYTIC_2	59	62	PF00928	0.335
TRG_ER_diArg_1	275	278	PF00400	0.374
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.248
TRG_Pf-PMV_PEXEL_1	248	253	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	278	283	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMC4	Leptomonas seymouri	68%	97%
A0A0S4J7H7	Bodo saltans	35%	100%
A0A1X0P3N1	Trypanosomatidae	48%	100%
A0A3Q8IGP7	Leishmania donovani	76%	100%
A0A422N467	Trypanosoma rangeli	49%	100%
A4I943	Leishmania infantum	76%	100%
D0A6A8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B443	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q3Y2	Leishmania major	77%	94%
V5BTV3	Trypanosoma cruzi	49%	95%