LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Nucleoporin NUP89
Species:
Leishmania braziliensis
UniProt:
A4HLR6_LEIBR
TriTrypDb:
LbrM.33.2320 , LBRM2903_330030400 *
Length:
787

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005643 nuclear pore 3 7
GO:0032991 protein-containing complex 1 10
GO:0140513 nuclear protein-containing complex 2 10
GO:0031080 nuclear pore outer ring 3 4
GO:0016020 membrane 2 3
GO:0031090 organelle membrane 3 3
GO:0031965 nuclear membrane 4 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

A4HLR6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLR6

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 10
GO:0008104 protein localization 4 10
GO:0009987 cellular process 1 10
GO:0015031 protein transport 4 10
GO:0015931 nucleobase-containing compound transport 5 10
GO:0033036 macromolecule localization 2 10
GO:0045184 establishment of protein localization 3 10
GO:0050657 nucleic acid transport 6 10
GO:0050658 RNA transport 4 10
GO:0051028 mRNA transport 5 10
GO:0051179 localization 1 10
GO:0051234 establishment of localization 2 10
GO:0051236 establishment of RNA localization 3 10
GO:0051641 cellular localization 2 10
GO:0070727 cellular macromolecule localization 3 10
GO:0071702 organic substance transport 4 10
GO:0071705 nitrogen compound transport 4 10
GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery 6 1
GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery 7 1
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0006405 RNA export from nucleus 5 4
GO:0006406 mRNA export from nucleus 6 4
GO:0006606 protein import into nucleus 5 4
GO:0006886 intracellular protein transport 4 4
GO:0006913 nucleocytoplasmic transport 5 4
GO:0006996 organelle organization 4 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0016043 cellular component organization 3 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0033365 protein localization to organelle 5 4
GO:0034504 protein localization to nucleus 6 4
GO:0046907 intracellular transport 3 4
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051168 nuclear export 6 4
GO:0051169 nuclear transport 4 4
GO:0051170 import into nucleus 6 4
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0051276 chromosome organization 5 1
GO:0051649 establishment of localization in cell 3 4
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0072594 establishment of protein localization to organelle 4 4
GO:0080090 regulation of primary metabolic process 4 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0005198 structural molecule activity 1 10
GO:0017056 structural constituent of nuclear pore 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 312 316 PF00656 0.577
CLV_C14_Caspase3-7 61 65 PF00656 0.510
CLV_NRD_NRD_1 28 30 PF00675 0.546
CLV_NRD_NRD_1 49 51 PF00675 0.331
CLV_NRD_NRD_1 514 516 PF00675 0.307
CLV_NRD_NRD_1 544 546 PF00675 0.406
CLV_NRD_NRD_1 552 554 PF00675 0.448
CLV_PCSK_KEX2_1 28 30 PF00082 0.546
CLV_PCSK_KEX2_1 49 51 PF00082 0.331
CLV_PCSK_KEX2_1 514 516 PF00082 0.265
CLV_PCSK_KEX2_1 544 546 PF00082 0.406
CLV_PCSK_KEX2_1 552 554 PF00082 0.448
CLV_PCSK_KEX2_1 757 759 PF00082 0.528
CLV_PCSK_PC1ET2_1 757 759 PF00082 0.529
CLV_PCSK_SKI1_1 224 228 PF00082 0.315
CLV_PCSK_SKI1_1 305 309 PF00082 0.348
CLV_PCSK_SKI1_1 354 358 PF00082 0.482
CLV_PCSK_SKI1_1 408 412 PF00082 0.502
CLV_PCSK_SKI1_1 544 548 PF00082 0.409
CLV_PCSK_SKI1_1 568 572 PF00082 0.463
CLV_PCSK_SKI1_1 678 682 PF00082 0.355
DEG_APCC_DBOX_1 304 312 PF00400 0.350
DEG_APCC_DBOX_1 543 551 PF00400 0.480
DEG_APCC_DBOX_1 666 674 PF00400 0.479
DEG_APCC_DBOX_1 704 712 PF00400 0.470
DEG_Nend_UBRbox_3 1 3 PF02207 0.603
DOC_CYCLIN_RxL_1 78 86 PF00134 0.448
DOC_MAPK_gen_1 544 550 PF00069 0.513
DOC_MAPK_MEF2A_6 224 231 PF00069 0.327
DOC_MAPK_MEF2A_6 390 397 PF00069 0.449
DOC_MAPK_MEF2A_6 408 417 PF00069 0.298
DOC_MAPK_RevD_3 530 545 PF00069 0.493
DOC_PIKK_1 149 156 PF02985 0.393
DOC_PP1_RVXF_1 214 221 PF00149 0.238
DOC_PP1_RVXF_1 493 499 PF00149 0.476
DOC_USP7_MATH_1 380 384 PF00917 0.465
DOC_USP7_MATH_1 519 523 PF00917 0.412
DOC_USP7_MATH_1 536 540 PF00917 0.314
DOC_USP7_MATH_1 570 574 PF00917 0.667
DOC_USP7_MATH_1 575 579 PF00917 0.649
DOC_USP7_MATH_1 626 630 PF00917 0.554
DOC_USP7_MATH_1 733 737 PF00917 0.388
DOC_USP7_MATH_1 8 12 PF00917 0.663
DOC_USP7_MATH_2 345 351 PF00917 0.514
DOC_USP7_UBL2_3 491 495 PF12436 0.470
DOC_WW_Pin1_4 178 183 PF00397 0.607
DOC_WW_Pin1_4 369 374 PF00397 0.543
DOC_WW_Pin1_4 573 578 PF00397 0.673
DOC_WW_Pin1_4 698 703 PF00397 0.638
LIG_14-3-3_CanoR_1 29 38 PF00244 0.448
LIG_14-3-3_CanoR_1 354 362 PF00244 0.369
LIG_14-3-3_CanoR_1 379 385 PF00244 0.459
LIG_14-3-3_CanoR_1 408 417 PF00244 0.465
LIG_14-3-3_CanoR_1 421 427 PF00244 0.317
LIG_14-3-3_CanoR_1 514 524 PF00244 0.417
LIG_14-3-3_CanoR_1 568 577 PF00244 0.468
LIG_14-3-3_CanoR_1 600 609 PF00244 0.435
LIG_14-3-3_CanoR_1 667 677 PF00244 0.409
LIG_14-3-3_CanoR_1 678 686 PF00244 0.390
LIG_14-3-3_CanoR_1 748 752 PF00244 0.498
LIG_14-3-3_CanoR_1 95 103 PF00244 0.407
LIG_Actin_WH2_2 35 51 PF00022 0.478
LIG_Actin_WH2_2 76 91 PF00022 0.391
LIG_APCC_ABBA_1 131 136 PF00400 0.337
LIG_BIR_III_4 17 21 PF00653 0.552
LIG_deltaCOP1_diTrp_1 270 276 PF00928 0.529
LIG_eIF4E_1 222 228 PF01652 0.437
LIG_eIF4E_1 726 732 PF01652 0.416
LIG_FHA_1 126 132 PF00498 0.424
LIG_FHA_1 230 236 PF00498 0.375
LIG_FHA_1 283 289 PF00498 0.337
LIG_FHA_1 355 361 PF00498 0.479
LIG_FHA_1 412 418 PF00498 0.515
LIG_FHA_1 482 488 PF00498 0.475
LIG_FHA_1 541 547 PF00498 0.434
LIG_FHA_1 608 614 PF00498 0.443
LIG_FHA_1 669 675 PF00498 0.359
LIG_FHA_1 679 685 PF00498 0.336
LIG_FHA_1 773 779 PF00498 0.457
LIG_FHA_2 117 123 PF00498 0.426
LIG_FHA_2 201 207 PF00498 0.446
LIG_FHA_2 310 316 PF00498 0.533
LIG_FHA_2 524 530 PF00498 0.544
LIG_FHA_2 581 587 PF00498 0.473
LIG_FHA_2 59 65 PF00498 0.433
LIG_FHA_2 636 642 PF00498 0.471
LIG_FHA_2 769 775 PF00498 0.427
LIG_GBD_Chelix_1 280 288 PF00786 0.391
LIG_LIR_Gen_1 188 198 PF02991 0.500
LIG_LIR_Gen_1 217 228 PF02991 0.329
LIG_LIR_Gen_1 255 265 PF02991 0.477
LIG_LIR_Gen_1 33 42 PF02991 0.482
LIG_LIR_Gen_1 338 345 PF02991 0.448
LIG_LIR_Gen_1 425 434 PF02991 0.370
LIG_LIR_Gen_1 507 517 PF02991 0.479
LIG_LIR_Gen_1 738 749 PF02991 0.400
LIG_LIR_Nem_3 188 193 PF02991 0.539
LIG_LIR_Nem_3 217 223 PF02991 0.355
LIG_LIR_Nem_3 255 261 PF02991 0.426
LIG_LIR_Nem_3 33 38 PF02991 0.488
LIG_LIR_Nem_3 338 344 PF02991 0.455
LIG_LIR_Nem_3 425 430 PF02991 0.371
LIG_LIR_Nem_3 507 512 PF02991 0.491
LIG_LIR_Nem_3 589 595 PF02991 0.386
LIG_LIR_Nem_3 738 744 PF02991 0.394
LIG_MYND_1 729 733 PF01753 0.418
LIG_NRBOX 644 650 PF00104 0.281
LIG_PCNA_yPIPBox_3 480 491 PF02747 0.310
LIG_Pex14_1 272 276 PF04695 0.455
LIG_SH2_CRK 741 745 PF00017 0.511
LIG_SH2_NCK_1 5 9 PF00017 0.639
LIG_SH2_SRC 137 140 PF00017 0.547
LIG_SH2_SRC 160 163 PF00017 0.389
LIG_SH2_SRC 5 8 PF00017 0.523
LIG_SH2_SRC 726 729 PF00017 0.412
LIG_SH2_STAP1 103 107 PF00017 0.522
LIG_SH2_STAP1 160 164 PF00017 0.375
LIG_SH2_STAP1 258 262 PF00017 0.447
LIG_SH2_STAP1 391 395 PF00017 0.408
LIG_SH2_STAP1 427 431 PF00017 0.343
LIG_SH2_STAT3 437 440 PF00017 0.469
LIG_SH2_STAT5 222 225 PF00017 0.437
LIG_SH2_STAT5 509 512 PF00017 0.445
LIG_SH2_STAT5 594 597 PF00017 0.460
LIG_SH2_STAT5 726 729 PF00017 0.447
LIG_SH2_STAT5 87 90 PF00017 0.420
LIG_SH3_3 117 123 PF00018 0.470
LIG_SH3_3 243 249 PF00018 0.589
LIG_SH3_3 396 402 PF00018 0.432
LIG_SH3_3 727 733 PF00018 0.318
LIG_Sin3_3 190 197 PF02671 0.465
LIG_SUMO_SIM_anti_2 357 364 PF11976 0.368
LIG_SUMO_SIM_anti_2 507 514 PF11976 0.455
LIG_SUMO_SIM_par_1 357 364 PF11976 0.368
LIG_TRAF2_1 119 122 PF00917 0.457
LIG_TRAF2_1 242 245 PF00917 0.453
LIG_TRAF2_1 297 300 PF00917 0.381
MOD_CDK_SPxxK_3 698 705 PF00069 0.564
MOD_CK1_1 178 184 PF00069 0.622
MOD_CK1_1 319 325 PF00069 0.635
MOD_CK1_1 383 389 PF00069 0.344
MOD_CK1_1 465 471 PF00069 0.371
MOD_CK1_1 540 546 PF00069 0.489
MOD_CK1_1 573 579 PF00069 0.705
MOD_CK1_1 580 586 PF00069 0.534
MOD_CK1_1 588 594 PF00069 0.420
MOD_CK1_1 629 635 PF00069 0.525
MOD_CK1_1 687 693 PF00069 0.509
MOD_CK2_1 116 122 PF00069 0.398
MOD_CK2_1 200 206 PF00069 0.433
MOD_CK2_1 239 245 PF00069 0.430
MOD_CK2_1 442 448 PF00069 0.488
MOD_CK2_1 523 529 PF00069 0.575
MOD_CK2_1 580 586 PF00069 0.517
MOD_CK2_1 63 69 PF00069 0.516
MOD_CK2_1 635 641 PF00069 0.479
MOD_CK2_1 768 774 PF00069 0.420
MOD_GlcNHglycan 112 115 PF01048 0.356
MOD_GlcNHglycan 167 170 PF01048 0.647
MOD_GlcNHglycan 177 180 PF01048 0.619
MOD_GlcNHglycan 241 244 PF01048 0.694
MOD_GlcNHglycan 267 270 PF01048 0.529
MOD_GlcNHglycan 289 292 PF01048 0.526
MOD_GlcNHglycan 325 328 PF01048 0.735
MOD_GlcNHglycan 517 520 PF01048 0.427
MOD_GlcNHglycan 553 556 PF01048 0.436
MOD_GlcNHglycan 572 575 PF01048 0.464
MOD_GlcNHglycan 577 580 PF01048 0.442
MOD_GlcNHglycan 689 692 PF01048 0.607
MOD_GlcNHglycan 735 738 PF01048 0.371
MOD_GlcNHglycan 97 100 PF01048 0.517
MOD_GSK3_1 106 113 PF00069 0.351
MOD_GSK3_1 287 294 PF00069 0.327
MOD_GSK3_1 316 323 PF00069 0.622
MOD_GSK3_1 380 387 PF00069 0.469
MOD_GSK3_1 481 488 PF00069 0.496
MOD_GSK3_1 504 511 PF00069 0.529
MOD_GSK3_1 515 522 PF00069 0.456
MOD_GSK3_1 536 543 PF00069 0.439
MOD_GSK3_1 569 576 PF00069 0.663
MOD_GSK3_1 601 608 PF00069 0.557
MOD_GSK3_1 668 675 PF00069 0.479
MOD_GSK3_1 678 685 PF00069 0.416
MOD_GSK3_1 768 775 PF00069 0.461
MOD_GSK3_1 95 102 PF00069 0.524
MOD_N-GLC_1 154 159 PF02516 0.379
MOD_N-GLC_1 200 205 PF02516 0.533
MOD_N-GLC_1 442 447 PF02516 0.535
MOD_N-GLC_1 629 634 PF02516 0.559
MOD_N-GLC_1 768 773 PF02516 0.401
MOD_NEK2_1 125 130 PF00069 0.581
MOD_NEK2_1 236 241 PF00069 0.431
MOD_NEK2_1 320 325 PF00069 0.700
MOD_NEK2_1 384 389 PF00069 0.385
MOD_NEK2_1 58 63 PF00069 0.393
MOD_NEK2_1 649 654 PF00069 0.280
MOD_NEK2_1 747 752 PF00069 0.506
MOD_NEK2_1 83 88 PF00069 0.440
MOD_NEK2_2 160 165 PF00069 0.511
MOD_PIKK_1 123 129 PF00454 0.587
MOD_PIKK_1 154 160 PF00454 0.367
MOD_PIKK_1 274 280 PF00454 0.456
MOD_PIKK_1 475 481 PF00454 0.540
MOD_PIKK_1 635 641 PF00454 0.508
MOD_PIKK_1 649 655 PF00454 0.391
MOD_PKA_2 422 428 PF00069 0.371
MOD_PKA_2 551 557 PF00069 0.493
MOD_PKA_2 747 753 PF00069 0.495
MOD_Plk_1 154 160 PF00069 0.378
MOD_Plk_1 200 206 PF00069 0.433
MOD_Plk_1 254 260 PF00069 0.502
MOD_Plk_1 465 471 PF00069 0.371
MOD_Plk_1 536 542 PF00069 0.403
MOD_Plk_1 58 64 PF00069 0.421
MOD_Plk_1 588 594 PF00069 0.466
MOD_Plk_1 629 635 PF00069 0.449
MOD_Plk_1 706 712 PF00069 0.501
MOD_Plk_4 200 206 PF00069 0.433
MOD_Plk_4 316 322 PF00069 0.616
MOD_Plk_4 422 428 PF00069 0.369
MOD_Plk_4 508 514 PF00069 0.418
MOD_Plk_4 519 525 PF00069 0.369
MOD_Plk_4 537 543 PF00069 0.304
MOD_Plk_4 588 594 PF00069 0.480
MOD_Plk_4 672 678 PF00069 0.329
MOD_Plk_4 684 690 PF00069 0.403
MOD_Plk_4 83 89 PF00069 0.442
MOD_ProDKin_1 178 184 PF00069 0.605
MOD_ProDKin_1 369 375 PF00069 0.538
MOD_ProDKin_1 573 579 PF00069 0.673
MOD_ProDKin_1 698 704 PF00069 0.635
MOD_SUMO_rev_2 342 350 PF00179 0.328
TRG_DiLeu_BaEn_1 351 356 PF01217 0.381
TRG_DiLeu_BaEn_1 472 477 PF01217 0.379
TRG_DiLeu_BaEn_4 75 81 PF01217 0.466
TRG_DiLeu_LyEn_5 351 356 PF01217 0.381
TRG_ENDOCYTIC_2 258 261 PF00928 0.395
TRG_ENDOCYTIC_2 35 38 PF00928 0.459
TRG_ENDOCYTIC_2 391 394 PF00928 0.459
TRG_ENDOCYTIC_2 427 430 PF00928 0.344
TRG_ENDOCYTIC_2 509 512 PF00928 0.445
TRG_ENDOCYTIC_2 715 718 PF00928 0.487
TRG_ENDOCYTIC_2 741 744 PF00928 0.504
TRG_ER_diArg_1 28 30 PF00400 0.546
TRG_ER_diArg_1 415 418 PF00400 0.425
TRG_ER_diArg_1 420 423 PF00400 0.366
TRG_ER_diArg_1 48 50 PF00400 0.190
TRG_ER_diArg_1 513 515 PF00400 0.267
TRG_ER_diArg_1 544 546 PF00400 0.410
TRG_ER_diArg_1 764 767 PF00400 0.585
TRG_NES_CRM1_1 405 419 PF08389 0.389
TRG_Pf-PMV_PEXEL_1 305 309 PF00026 0.392
TRG_Pf-PMV_PEXEL_1 545 549 PF00026 0.454
TRG_Pf-PMV_PEXEL_1 631 636 PF00026 0.457
TRG_Pf-PMV_PEXEL_1 678 682 PF00026 0.355

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IAQ9 Leptomonas seymouri 75% 88%
A0A0S4J8I7 Bodo saltans 31% 100%
A0A1X0P3M8 Trypanosomatidae 44% 100%
A0A3Q8IMG5 Leishmania donovani 89% 100%
A0A422N462 Trypanosoma rangeli 44% 99%
A4I942 Leishmania infantum 89% 100%
D0A6A9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 99%
E9B442 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q3Y3 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS