Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HLR4_LEIBR

TriTrypDb:

LbrM.33.2300 , LBRM2903_330030100

Length:

849

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HLR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.656
CLV_NRD_NRD_1	328	330	PF00675	0.459
CLV_NRD_NRD_1	380	382	PF00675	0.612
CLV_NRD_NRD_1	384	386	PF00675	0.588
CLV_NRD_NRD_1	568	570	PF00675	0.865
CLV_NRD_NRD_1	625	627	PF00675	0.528
CLV_PCSK_FUR_1	326	330	PF00082	0.459
CLV_PCSK_FUR_1	685	689	PF00082	0.401
CLV_PCSK_KEX2_1	328	330	PF00082	0.456
CLV_PCSK_KEX2_1	342	344	PF00082	0.480
CLV_PCSK_KEX2_1	380	382	PF00082	0.612
CLV_PCSK_KEX2_1	384	386	PF00082	0.588
CLV_PCSK_KEX2_1	568	570	PF00082	0.849
CLV_PCSK_KEX2_1	625	627	PF00082	0.507
CLV_PCSK_KEX2_1	687	689	PF00082	0.400
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.454
CLV_PCSK_PC1ET2_1	687	689	PF00082	0.400
CLV_PCSK_PC7_1	380	386	PF00082	0.532
CLV_PCSK_SKI1_1	14	18	PF00082	0.372
CLV_PCSK_SKI1_1	267	271	PF00082	0.464
CLV_PCSK_SKI1_1	427	431	PF00082	0.492
CLV_PCSK_SKI1_1	442	446	PF00082	0.461
CLV_PCSK_SKI1_1	493	497	PF00082	0.463
CLV_PCSK_SKI1_1	54	58	PF00082	0.669
CLV_PCSK_SKI1_1	705	709	PF00082	0.476
DEG_APCC_DBOX_1	624	632	PF00400	0.721
DEG_APCC_DBOX_1	704	712	PF00400	0.466
DEG_SCF_FBW7_1	444	449	PF00400	0.713
DOC_CKS1_1	551	556	PF01111	0.523
DOC_CYCLIN_RxL_1	36	45	PF00134	0.459
DOC_CYCLIN_RxL_1	8	20	PF00134	0.447
DOC_CYCLIN_yCln2_LP_2	215	218	PF00134	0.674
DOC_CYCLIN_yCln2_LP_2	774	780	PF00134	0.452
DOC_CYCLIN_yCln2_LP_2	822	825	PF00134	0.565
DOC_MAPK_FxFP_2	762	765	PF00069	0.429
DOC_MAPK_gen_1	702	711	PF00069	0.590
DOC_MAPK_MEF2A_6	267	274	PF00069	0.665
DOC_MAPK_MEF2A_6	702	710	PF00069	0.569
DOC_MAPK_NFAT4_5	267	275	PF00069	0.665
DOC_PP1_RVXF_1	340	347	PF00149	0.653
DOC_PP2B_LxvP_1	147	150	PF13499	0.686
DOC_PP2B_LxvP_1	192	195	PF13499	0.757
DOC_PP2B_LxvP_1	215	218	PF13499	0.674
DOC_PP2B_LxvP_1	395	398	PF13499	0.668
DOC_PP2B_LxvP_1	444	447	PF13499	0.804
DOC_PP2B_LxvP_1	774	777	PF13499	0.445
DOC_PP2B_LxvP_1	815	818	PF13499	0.562
DOC_PP2B_LxvP_1	822	825	PF13499	0.565
DOC_PP2B_LxvP_1	840	843	PF13499	0.433
DOC_PP4_FxxP_1	762	765	PF00568	0.429
DOC_SPAK_OSR1_1	438	442	PF12202	0.659
DOC_USP7_MATH_1	117	121	PF00917	0.732
DOC_USP7_MATH_1	142	146	PF00917	0.651
DOC_USP7_MATH_1	182	186	PF00917	0.729
DOC_USP7_MATH_1	447	451	PF00917	0.726
DOC_USP7_MATH_1	472	476	PF00917	0.662
DOC_USP7_MATH_1	535	539	PF00917	0.712
DOC_USP7_MATH_1	831	835	PF00917	0.515
DOC_USP7_MATH_2	516	522	PF00917	0.684
DOC_WW_Pin1_4	158	163	PF00397	0.772
DOC_WW_Pin1_4	177	182	PF00397	0.647
DOC_WW_Pin1_4	206	211	PF00397	0.698
DOC_WW_Pin1_4	224	229	PF00397	0.782
DOC_WW_Pin1_4	272	277	PF00397	0.802
DOC_WW_Pin1_4	402	407	PF00397	0.675
DOC_WW_Pin1_4	428	433	PF00397	0.658
DOC_WW_Pin1_4	442	447	PF00397	0.852
DOC_WW_Pin1_4	470	475	PF00397	0.734
DOC_WW_Pin1_4	550	555	PF00397	0.396
DOC_WW_Pin1_4	558	563	PF00397	0.580
DOC_WW_Pin1_4	695	700	PF00397	0.582
DOC_WW_Pin1_4	779	784	PF00397	0.550
LIG_14-3-3_CanoR_1	200	204	PF00244	0.661
LIG_14-3-3_CanoR_1	345	350	PF00244	0.683
LIG_14-3-3_CanoR_1	380	387	PF00244	0.668
LIG_14-3-3_CanoR_1	436	442	PF00244	0.685
LIG_14-3-3_CanoR_1	537	543	PF00244	0.511
LIG_14-3-3_CanoR_1	568	575	PF00244	0.575
LIG_14-3-3_CanoR_1	688	693	PF00244	0.664
LIG_14-3-3_CanoR_1	779	783	PF00244	0.574
LIG_14-3-3_CanoR_1	807	813	PF00244	0.612
LIG_Actin_WH2_2	185	202	PF00022	0.659
LIG_Actin_WH2_2	29	46	PF00022	0.517
LIG_APCC_Cbox_2	499	505	PF00515	0.635
LIG_BRCT_BRCA1_1	74	78	PF00533	0.270
LIG_BRCT_BRCA1_1	758	762	PF00533	0.415
LIG_BRCT_BRCA1_1	781	785	PF00533	0.568
LIG_CtBP_PxDLS_1	271	275	PF00389	0.660
LIG_CtBP_PxDLS_1	844	848	PF00389	0.459
LIG_eIF4E_1	703	709	PF01652	0.530
LIG_EVH1_1	216	220	PF00568	0.681
LIG_FHA_1	135	141	PF00498	0.672
LIG_FHA_1	317	323	PF00498	0.728
LIG_FHA_1	357	363	PF00498	0.676
LIG_FHA_1	369	375	PF00498	0.642
LIG_FHA_1	428	434	PF00498	0.654
LIG_FHA_1	443	449	PF00498	0.810
LIG_FHA_1	486	492	PF00498	0.777
LIG_FHA_1	594	600	PF00498	0.427
LIG_FHA_1	630	636	PF00498	0.587
LIG_FHA_1	665	671	PF00498	0.618
LIG_FHA_1	729	735	PF00498	0.625
LIG_FHA_2	139	145	PF00498	0.712
LIG_FHA_2	368	374	PF00498	0.679
LIG_FHA_2	663	669	PF00498	0.620
LIG_FHA_2	786	792	PF00498	0.512
LIG_Integrin_RGD_1	125	127	PF01839	0.454
LIG_IRF3_LxIS_1	13	19	PF10401	0.447
LIG_LIR_Apic_2	546	552	PF02991	0.349
LIG_LIR_Apic_2	759	765	PF02991	0.422
LIG_LIR_Gen_1	28	37	PF02991	0.266
LIG_LIR_Gen_1	499	505	PF02991	0.635
LIG_LIR_Gen_1	538	547	PF02991	0.266
LIG_LIR_Gen_1	594	605	PF02991	0.271
LIG_LIR_Gen_1	681	689	PF02991	0.701
LIG_LIR_Gen_1	700	711	PF02991	0.454
LIG_LIR_Gen_1	736	746	PF02991	0.533
LIG_LIR_LC3C_4	30	34	PF02991	0.266
LIG_LIR_Nem_3	28	32	PF02991	0.306
LIG_LIR_Nem_3	499	504	PF02991	0.633
LIG_LIR_Nem_3	538	542	PF02991	0.266
LIG_LIR_Nem_3	58	64	PF02991	0.254
LIG_LIR_Nem_3	594	600	PF02991	0.521
LIG_LIR_Nem_3	681	686	PF02991	0.701
LIG_LIR_Nem_3	700	706	PF02991	0.588
LIG_LIR_Nem_3	736	742	PF02991	0.528
LIG_LIR_Nem_3	75	80	PF02991	0.209
LIG_LIR_Nem_3	759	764	PF02991	0.425
LIG_LIR_Nem_3	811	815	PF02991	0.564
LIG_LYPXL_yS_3	84	87	PF13949	0.685
LIG_MLH1_MIPbox_1	74	78	PF16413	0.266
LIG_MLH1_MIPbox_1	758	762	PF16413	0.415
LIG_MYND_1	210	214	PF01753	0.656
LIG_PCNA_yPIPBox_3	125	135	PF02747	0.669
LIG_Pex14_2	25	29	PF04695	0.266
LIG_Pex14_2	526	530	PF04695	0.674
LIG_Pex14_2	539	543	PF04695	0.223
LIG_SH2_CRK	703	707	PF00017	0.447
LIG_SH2_CRK	739	743	PF00017	0.541
LIG_SH2_GRB2like	664	667	PF00017	0.620
LIG_SH2_NCK_1	703	707	PF00017	0.530
LIG_SH2_PTP2	10	13	PF00017	0.573
LIG_SH2_PTP2	501	504	PF00017	0.649
LIG_SH2_STAP1	246	250	PF00017	0.664
LIG_SH2_STAP1	593	597	PF00017	0.376
LIG_SH2_STAP1	703	707	PF00017	0.530
LIG_SH2_STAT5	10	13	PF00017	0.645
LIG_SH2_STAT5	42	45	PF00017	0.491
LIG_SH2_STAT5	501	504	PF00017	0.696
LIG_SH2_STAT5	590	593	PF00017	0.490
LIG_SH2_STAT5	605	608	PF00017	0.355
LIG_SH2_STAT5	616	619	PF00017	0.383
LIG_SH2_STAT5	664	667	PF00017	0.620
LIG_SH2_STAT5	703	706	PF00017	0.566
LIG_SH3_3	208	214	PF00018	0.701
LIG_SH3_3	284	290	PF00018	0.662
LIG_SH3_3	291	297	PF00018	0.641
LIG_SH3_3	319	325	PF00018	0.675
LIG_SH3_3	344	350	PF00018	0.776
LIG_SH3_3	360	366	PF00018	0.725
LIG_SH3_3	477	483	PF00018	0.793
LIG_SH3_3	507	513	PF00018	0.812
LIG_SH3_3	556	562	PF00018	0.482
LIG_SH3_3	578	584	PF00018	0.568
LIG_SH3_3	780	786	PF00018	0.533
LIG_SH3_3	79	85	PF00018	0.399
LIG_SH3_3	792	798	PF00018	0.508
LIG_SH3_3	838	844	PF00018	0.561
LIG_SUMO_SIM_anti_2	632	638	PF11976	0.584
LIG_SUMO_SIM_par_1	270	275	PF11976	0.698
LIG_SUMO_SIM_par_1	709	714	PF11976	0.424
LIG_TRAF2_1	229	232	PF00917	0.685
LIG_TRAF2_1	506	509	PF00917	0.806
LIG_TRAF2_1	516	519	PF00917	0.698
LIG_TRAF2_1	93	96	PF00917	0.621
LIG_TYR_ITIM	701	706	PF00017	0.582
LIG_TYR_ITIM	737	742	PF00017	0.530
LIG_TYR_ITIM	82	87	PF00017	0.592
LIG_UBA3_1	586	592	PF00899	0.543
LIG_WRC_WIRS_1	809	814	PF05994	0.564
MOD_CDK_SPxxK_3	158	165	PF00069	0.731
MOD_CDK_SPxxK_3	470	477	PF00069	0.724
MOD_CDK_SPxxK_3	695	702	PF00069	0.582
MOD_CK1_1	138	144	PF00069	0.687
MOD_CK1_1	183	189	PF00069	0.780
MOD_CK1_1	206	212	PF00069	0.711
MOD_CK1_1	254	260	PF00069	0.710
MOD_CK1_1	277	283	PF00069	0.663
MOD_CK1_1	312	318	PF00069	0.651
MOD_CK1_1	356	362	PF00069	0.779
MOD_CK1_1	431	437	PF00069	0.655
MOD_CK1_1	475	481	PF00069	0.770
MOD_CK1_1	538	544	PF00069	0.490
MOD_CK1_1	561	567	PF00069	0.582
MOD_CK1_1	573	579	PF00069	0.577
MOD_CK1_1	676	682	PF00069	0.667
MOD_CK1_1	787	793	PF00069	0.534
MOD_CK2_1	117	123	PF00069	0.687
MOD_CK2_1	254	260	PF00069	0.808
MOD_CK2_1	312	318	PF00069	0.651
MOD_CK2_1	367	373	PF00069	0.677
MOD_CK2_1	503	509	PF00069	0.732
MOD_CK2_1	662	668	PF00069	0.628
MOD_CK2_1	678	684	PF00069	0.560
MOD_CK2_1	740	746	PF00069	0.540
MOD_CK2_1	760	766	PF00069	0.379
MOD_CK2_1	785	791	PF00069	0.455
MOD_Cter_Amidation	340	343	PF01082	0.454
MOD_DYRK1A_RPxSP_1	442	446	PF00069	0.661
MOD_DYRK1A_RPxSP_1	779	783	PF00069	0.590
MOD_GlcNHglycan	101	104	PF01048	0.534
MOD_GlcNHglycan	137	140	PF01048	0.489
MOD_GlcNHglycan	224	227	PF01048	0.517
MOD_GlcNHglycan	246	249	PF01048	0.505
MOD_GlcNHglycan	310	314	PF01048	0.495
MOD_GlcNHglycan	414	417	PF01048	0.503
MOD_GlcNHglycan	44	47	PF01048	0.626
MOD_GlcNHglycan	470	473	PF01048	0.569
MOD_GlcNHglycan	477	480	PF01048	0.601
MOD_GlcNHglycan	530	533	PF01048	0.642
MOD_GlcNHglycan	65	68	PF01048	0.379
MOD_GlcNHglycan	766	769	PF01048	0.633
MOD_GlcNHglycan	818	821	PF01048	0.758
MOD_GlcNHglycan	835	838	PF01048	0.778
MOD_GSK3_1	117	124	PF00069	0.743
MOD_GSK3_1	134	141	PF00069	0.693
MOD_GSK3_1	167	174	PF00069	0.839
MOD_GSK3_1	17	24	PF00069	0.373
MOD_GSK3_1	199	206	PF00069	0.690
MOD_GSK3_1	240	247	PF00069	0.783
MOD_GSK3_1	251	258	PF00069	0.755
MOD_GSK3_1	270	277	PF00069	0.752
MOD_GSK3_1	312	319	PF00069	0.703
MOD_GSK3_1	427	434	PF00069	0.790
MOD_GSK3_1	442	449	PF00069	0.702
MOD_GSK3_1	453	460	PF00069	0.717
MOD_GSK3_1	468	475	PF00069	0.775
MOD_GSK3_1	481	488	PF00069	0.662
MOD_GSK3_1	514	521	PF00069	0.768
MOD_GSK3_1	570	577	PF00069	0.512
MOD_GSK3_1	658	665	PF00069	0.707
MOD_GSK3_1	671	678	PF00069	0.672
MOD_GSK3_1	688	695	PF00069	0.693
MOD_GSK3_1	756	763	PF00069	0.448
MOD_N-GLC_1	421	426	PF02516	0.605
MOD_NEK2_1	134	139	PF00069	0.695
MOD_NEK2_1	16	21	PF00069	0.339
MOD_NEK2_1	199	204	PF00069	0.775
MOD_NEK2_1	25	30	PF00069	0.369
MOD_NEK2_1	265	270	PF00069	0.694
MOD_NEK2_1	421	426	PF00069	0.722
MOD_NEK2_1	543	548	PF00069	0.349
MOD_NEK2_1	575	580	PF00069	0.529
MOD_NEK2_1	62	67	PF00069	0.404
MOD_NEK2_1	650	655	PF00069	0.602
MOD_NEK2_1	658	663	PF00069	0.613
MOD_NEK2_1	711	716	PF00069	0.466
MOD_NEK2_1	756	761	PF00069	0.532
MOD_NEK2_1	833	838	PF00069	0.594
MOD_NEK2_2	437	442	PF00069	0.664
MOD_NEK2_2	593	598	PF00069	0.377
MOD_PIKK_1	277	283	PF00454	0.663
MOD_PIKK_1	518	524	PF00454	0.817
MOD_PIKK_1	678	684	PF00454	0.741
MOD_PIKK_1	740	746	PF00454	0.410
MOD_PKA_1	380	386	PF00069	0.723
MOD_PKA_2	135	141	PF00069	0.687
MOD_PKA_2	199	205	PF00069	0.660
MOD_PKA_2	379	385	PF00069	0.722
MOD_PKA_2	437	443	PF00069	0.660
MOD_PKA_2	567	573	PF00069	0.576
MOD_PKA_2	701	707	PF00069	0.590
MOD_PKA_2	778	784	PF00069	0.632
MOD_PKB_1	343	351	PF00069	0.651
MOD_Plk_1	183	189	PF00069	0.666
MOD_Plk_1	421	427	PF00069	0.664
MOD_Plk_1	593	599	PF00069	0.389
MOD_Plk_1	756	762	PF00069	0.412
MOD_Plk_4	538	544	PF00069	0.266
MOD_Plk_4	630	636	PF00069	0.772
MOD_Plk_4	692	698	PF00069	0.591
MOD_Plk_4	711	717	PF00069	0.506
MOD_Plk_4	72	78	PF00069	0.294
MOD_Plk_4	756	762	PF00069	0.412
MOD_ProDKin_1	158	164	PF00069	0.772
MOD_ProDKin_1	177	183	PF00069	0.645
MOD_ProDKin_1	206	212	PF00069	0.701
MOD_ProDKin_1	224	230	PF00069	0.782
MOD_ProDKin_1	272	278	PF00069	0.802
MOD_ProDKin_1	402	408	PF00069	0.675
MOD_ProDKin_1	428	434	PF00069	0.657
MOD_ProDKin_1	442	448	PF00069	0.855
MOD_ProDKin_1	470	476	PF00069	0.736
MOD_ProDKin_1	550	556	PF00069	0.396
MOD_ProDKin_1	558	564	PF00069	0.581
MOD_ProDKin_1	695	701	PF00069	0.582
MOD_ProDKin_1	779	785	PF00069	0.551
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.669
TRG_ENDOCYTIC_2	10	13	PF00928	0.669
TRG_ENDOCYTIC_2	501	504	PF00928	0.649
TRG_ENDOCYTIC_2	604	607	PF00928	0.480
TRG_ENDOCYTIC_2	683	686	PF00928	0.627
TRG_ENDOCYTIC_2	703	706	PF00928	0.447
TRG_ENDOCYTIC_2	739	742	PF00928	0.541
TRG_ENDOCYTIC_2	84	87	PF00928	0.685
TRG_ER_diArg_1	343	346	PF00400	0.686
TRG_ER_diArg_1	379	381	PF00400	0.810
TRG_ER_diArg_1	384	386	PF00400	0.788
TRG_ER_diArg_1	436	439	PF00400	0.660
TRG_ER_diArg_1	624	626	PF00400	0.704
TRG_ER_diArg_1	87	90	PF00400	0.701
TRG_NLS_Bipartite_1	328	346	PF00514	0.658
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7U8	Leishmania donovani	50%	100%
A4I964	Leishmania infantum	51%	100%
E9B440	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	98%
Q4Q3Y5	Leishmania major	51%	100%