Presenilin enhancer protein 2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Presenilin enhancer-2 subunit of gamma secretase, putative

Species:

Leishmania braziliensis

UniProt:

A4HLR2_LEIBR

TriTrypDb:

LbrM.33.2280 , LBRM2903_330029900

Length:

122

Annotations

LeishMANIAdb annotations

Homologous to animal gamma-secretase subunits.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0032991	protein-containing complex	1	1
GO:0070765	gamma-secretase complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0098797	plasma membrane protein complex	3	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HLR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLR2

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	12
GO:0007166	cell surface receptor signaling pathway	3	12
GO:0007219	Notch signaling pathway	4	12
GO:0009987	cellular process	1	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0065007	biological regulation	1	12
GO:0006508	proteolysis	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0019538	protein metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008233	peptidase activity	3	2
GO:0016787	hydrolase activity	2	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.302
CLV_NRD_NRD_1	56	58	PF00675	0.323
CLV_PCSK_FUR_1	54	58	PF00082	0.291
CLV_PCSK_KEX2_1	53	55	PF00082	0.339
CLV_PCSK_KEX2_1	56	58	PF00082	0.365
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.260
DEG_Nend_Nbox_1	1	3	PF02207	0.395
DEG_SPOP_SBC_1	109	113	PF00917	0.306
DOC_CDC14_PxL_1	24	32	PF14671	0.274
DOC_PP1_RVXF_1	19	25	PF00149	0.376
DOC_PP4_FxxP_1	25	28	PF00568	0.417
DOC_PP4_FxxP_1	75	78	PF00568	0.523
DOC_USP7_MATH_1	109	113	PF00917	0.482
LIG_14-3-3_CanoR_1	4	10	PF00244	0.420
LIG_AP2alpha_1	89	93	PF02296	0.423
LIG_APCC_ABBA_1	86	91	PF00400	0.467
LIG_BRCT_BRCA1_1	117	121	PF00533	0.307
LIG_EH1_1	65	73	PF00400	0.323
LIG_FHA_1	78	84	PF00498	0.376
LIG_LIR_Nem_3	92	98	PF02991	0.434
LIG_NRBOX	29	35	PF00104	0.303
LIG_PDZ_Class_1	117	122	PF00595	0.312
LIG_Pex14_2	25	29	PF04695	0.308
LIG_Pex14_2	89	93	PF04695	0.428
LIG_REV1ctd_RIR_1	35	43	PF16727	0.417
LIG_SH2_NCK_1	116	120	PF00017	0.306
LIG_SH2_NCK_1	58	62	PF00017	0.341
LIG_SH2_STAT5	51	54	PF00017	0.465
LIG_SH2_STAT5	97	100	PF00017	0.419
LIG_SH3_3	82	88	PF00018	0.354
LIG_SUMO_SIM_anti_2	70	75	PF11976	0.193
MOD_CK1_1	112	118	PF00069	0.386
MOD_GlcNHglycan	117	120	PF01048	0.583
MOD_GlcNHglycan	13	16	PF01048	0.556
MOD_GlcNHglycan	80	83	PF01048	0.566
MOD_GSK3_1	108	115	PF00069	0.444
MOD_LATS_1	40	46	PF00433	0.379
MOD_N-GLC_1	100	105	PF02516	0.662
MOD_N-GLC_1	109	114	PF02516	0.669
MOD_NEK2_1	89	94	PF00069	0.468
MOD_PK_1	56	62	PF00069	0.491
MOD_PKA_1	56	62	PF00069	0.491
MOD_PKA_2	56	62	PF00069	0.527
MOD_PKB_1	54	62	PF00069	0.553
MOD_Plk_4	67	73	PF00069	0.390
TRG_ENDOCYTIC_2	19	22	PF00928	0.315
TRG_ENDOCYTIC_2	97	100	PF00928	0.467
TRG_ER_diArg_1	54	57	PF00400	0.513
TRG_NLS_MonoExtC_3	52	57	PF00514	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P831	Leptomonas seymouri	59%	98%
A0A0S4J486	Bodo saltans	39%	100%
A0A0S4J7I6	Bodo saltans	38%	100%
A0A1X0P406	Trypanosomatidae	41%	100%
A0A3R7NE49	Trypanosoma rangeli	45%	100%
A0A3S7X6Y2	Leishmania donovani	76%	100%
A4I962	Leishmania infantum	76%	100%
D0A696	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B438	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q3Y7	Leishmania major	79%	100%