Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLR1_LEIBR

TriTrypDb:

LbrM.33.2270 , LBRM2903_330029800

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.562
CLV_C14_Caspase3-7	227	231	PF00656	0.530
CLV_C14_Caspase3-7	457	461	PF00656	0.547
CLV_NRD_NRD_1	261	263	PF00675	0.708
CLV_NRD_NRD_1	264	266	PF00675	0.685
CLV_NRD_NRD_1	42	44	PF00675	0.570
CLV_PCSK_FUR_1	262	266	PF00082	0.560
CLV_PCSK_KEX2_1	261	263	PF00082	0.708
CLV_PCSK_KEX2_1	264	266	PF00082	0.691
CLV_PCSK_KEX2_1	42	44	PF00082	0.435
CLV_PCSK_KEX2_1	490	492	PF00082	0.675
CLV_PCSK_KEX2_1	560	562	PF00082	0.606
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.675
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.631
CLV_PCSK_SKI1_1	299	303	PF00082	0.567
CLV_PCSK_SKI1_1	44	48	PF00082	0.434
CLV_PCSK_SKI1_1	491	495	PF00082	0.533
CLV_PCSK_SKI1_1	552	556	PF00082	0.597
CLV_PCSK_SKI1_1	557	561	PF00082	0.571
CLV_Separin_Metazoa	296	300	PF03568	0.532
DEG_APCC_DBOX_1	61	69	PF00400	0.537
DEG_Nend_UBRbox_4	1	3	PF02207	0.585
DEG_SPOP_SBC_1	470	474	PF00917	0.569
DOC_CYCLIN_RxL_1	370	380	PF00134	0.528
DOC_MAPK_gen_1	456	465	PF00069	0.544
DOC_MAPK_gen_1	507	516	PF00069	0.559
DOC_MAPK_gen_1	557	567	PF00069	0.626
DOC_USP7_MATH_1	176	180	PF00917	0.645
DOC_USP7_MATH_1	22	26	PF00917	0.620
DOC_USP7_MATH_1	220	224	PF00917	0.664
DOC_USP7_MATH_1	243	247	PF00917	0.634
DOC_USP7_MATH_1	339	343	PF00917	0.673
DOC_USP7_MATH_1	350	354	PF00917	0.583
DOC_USP7_MATH_1	454	458	PF00917	0.636
DOC_USP7_MATH_1	464	468	PF00917	0.555
DOC_USP7_MATH_1	519	523	PF00917	0.543
DOC_USP7_MATH_1	528	532	PF00917	0.535
DOC_USP7_MATH_1	55	59	PF00917	0.560
DOC_USP7_MATH_1	77	81	PF00917	0.604
DOC_USP7_UBL2_3	501	505	PF12436	0.692
DOC_WW_Pin1_4	162	167	PF00397	0.706
DOC_WW_Pin1_4	169	174	PF00397	0.641
DOC_WW_Pin1_4	190	195	PF00397	0.583
DOC_WW_Pin1_4	211	216	PF00397	0.730
DOC_WW_Pin1_4	299	304	PF00397	0.714
DOC_WW_Pin1_4	53	58	PF00397	0.498
DOC_WW_Pin1_4	565	570	PF00397	0.650
DOC_WW_Pin1_4	60	65	PF00397	0.517
LIG_14-3-3_CanoR_1	144	149	PF00244	0.539
LIG_14-3-3_CanoR_1	43	52	PF00244	0.440
LIG_14-3-3_CanoR_1	510	515	PF00244	0.568
LIG_14-3-3_CanoR_1	529	535	PF00244	0.647
LIG_BRCT_BRCA1_1	228	232	PF00533	0.529
LIG_Clathr_ClatBox_1	285	289	PF01394	0.604
LIG_eIF4E_1	397	403	PF01652	0.524
LIG_FHA_1	185	191	PF00498	0.629
LIG_FHA_1	236	242	PF00498	0.603
LIG_FHA_1	249	255	PF00498	0.534
LIG_FHA_1	364	370	PF00498	0.434
LIG_FHA_1	385	391	PF00498	0.553
LIG_FHA_1	415	421	PF00498	0.470
LIG_FHA_1	471	477	PF00498	0.631
LIG_FHA_2	134	140	PF00498	0.622
LIG_FHA_2	145	151	PF00498	0.519
LIG_FHA_2	198	204	PF00498	0.582
LIG_FHA_2	404	410	PF00498	0.545
LIG_FHA_2	515	521	PF00498	0.549
LIG_FHA_2	534	540	PF00498	0.487
LIG_FHA_2	54	60	PF00498	0.509
LIG_Integrin_RGD_1	82	84	PF01839	0.690
LIG_LIR_Apic_2	438	442	PF02991	0.640
LIG_LIR_Apic_2	95	99	PF02991	0.665
LIG_LIR_Gen_1	275	283	PF02991	0.629
LIG_LIR_Nem_3	270	276	PF02991	0.661
LIG_LIR_Nem_3	31	35	PF02991	0.577
LIG_PCNA_yPIPBox_3	370	379	PF02747	0.525
LIG_SH2_NCK_1	244	248	PF00017	0.596
LIG_SH2_NCK_1	90	94	PF00017	0.515
LIG_SH2_STAP1	124	128	PF00017	0.653
LIG_SH2_STAP1	244	248	PF00017	0.596
LIG_SH2_STAT3	113	116	PF00017	0.668
LIG_SH2_STAT5	266	269	PF00017	0.682
LIG_SH2_STAT5	32	35	PF00017	0.575
LIG_SH2_STAT5	397	400	PF00017	0.571
LIG_SH2_STAT5	7	10	PF00017	0.715
LIG_SH3_3	178	184	PF00018	0.615
LIG_SH3_3	188	194	PF00018	0.636
LIG_SH3_3	460	466	PF00018	0.594
LIG_SUMO_SIM_par_1	362	368	PF11976	0.663
LIG_SUMO_SIM_par_1	374	380	PF11976	0.414
LIG_SUMO_SIM_par_1	543	548	PF11976	0.608
LIG_TRAF2_1	149	152	PF00917	0.534
LIG_TRAF2_1	406	409	PF00917	0.554
LIG_UBA3_1	555	560	PF00899	0.612
LIG_WRC_WIRS_1	140	145	PF05994	0.644
LIG_WRC_WIRS_1	411	416	PF05994	0.699
MOD_CK1_1	17	23	PF00069	0.649
MOD_CK1_1	172	178	PF00069	0.542
MOD_CK1_1	223	229	PF00069	0.616
MOD_CK1_1	231	237	PF00069	0.519
MOD_CK1_1	329	335	PF00069	0.588
MOD_CK1_1	353	359	PF00069	0.652
MOD_CK1_1	413	419	PF00069	0.680
MOD_CK1_1	471	477	PF00069	0.589
MOD_CK1_1	58	64	PF00069	0.528
MOD_CK2_1	133	139	PF00069	0.623
MOD_CK2_1	144	150	PF00069	0.515
MOD_CK2_1	386	392	PF00069	0.570
MOD_CK2_1	403	409	PF00069	0.375
MOD_CK2_1	435	441	PF00069	0.652
MOD_CK2_1	476	482	PF00069	0.544
MOD_CK2_1	514	520	PF00069	0.557
MOD_CK2_1	53	59	PF00069	0.504
MOD_GlcNHglycan	174	177	PF01048	0.703
MOD_GlcNHglycan	178	181	PF01048	0.736
MOD_GlcNHglycan	206	209	PF01048	0.663
MOD_GlcNHglycan	24	27	PF01048	0.461
MOD_GlcNHglycan	245	248	PF01048	0.564
MOD_GlcNHglycan	251	254	PF01048	0.743
MOD_GlcNHglycan	455	459	PF01048	0.651
MOD_GlcNHglycan	473	476	PF01048	0.566
MOD_GlcNHglycan	9	12	PF01048	0.611
MOD_GSK3_1	172	179	PF00069	0.654
MOD_GSK3_1	220	227	PF00069	0.639
MOD_GSK3_1	228	235	PF00069	0.546
MOD_GSK3_1	299	306	PF00069	0.726
MOD_GSK3_1	309	316	PF00069	0.767
MOD_GSK3_1	325	332	PF00069	0.661
MOD_GSK3_1	339	346	PF00069	0.630
MOD_GSK3_1	349	356	PF00069	0.595
MOD_GSK3_1	393	400	PF00069	0.392
MOD_GSK3_1	410	417	PF00069	0.587
MOD_GSK3_1	427	434	PF00069	0.626
MOD_GSK3_1	44	51	PF00069	0.502
MOD_GSK3_1	464	471	PF00069	0.592
MOD_GSK3_1	476	483	PF00069	0.554
MOD_GSK3_1	510	517	PF00069	0.682
MOD_GSK3_1	529	536	PF00069	0.529
MOD_GSK3_1	53	60	PF00069	0.522
MOD_GSK3_1	561	568	PF00069	0.636
MOD_NEK2_1	232	237	PF00069	0.670
MOD_NEK2_1	384	389	PF00069	0.568
MOD_NEK2_1	393	398	PF00069	0.382
MOD_NEK2_1	414	419	PF00069	0.598
MOD_NEK2_1	514	519	PF00069	0.559
MOD_NEK2_2	2	7	PF00069	0.596
MOD_NEK2_2	77	82	PF00069	0.559
MOD_PIKK_1	326	332	PF00454	0.692
MOD_PIKK_1	339	345	PF00454	0.554
MOD_PIKK_1	384	390	PF00454	0.565
MOD_PK_1	561	567	PF00069	0.634
MOD_PKA_2	248	254	PF00069	0.675
MOD_PKA_2	309	315	PF00069	0.642
MOD_PKA_2	431	437	PF00069	0.520
MOD_PKA_2	528	534	PF00069	0.625
MOD_PKB_1	144	152	PF00069	0.555
MOD_Plk_1	138	144	PF00069	0.496
MOD_Plk_1	221	227	PF00069	0.540
MOD_Plk_1	353	359	PF00069	0.536
MOD_Plk_1	427	433	PF00069	0.518
MOD_Plk_1	561	567	PF00069	0.634
MOD_Plk_1	77	83	PF00069	0.559
MOD_Plk_2-3	317	323	PF00069	0.606
MOD_Plk_2-3	377	383	PF00069	0.529
MOD_Plk_4	2	8	PF00069	0.598
MOD_Plk_4	386	392	PF00069	0.551
MOD_Plk_4	393	399	PF00069	0.469
MOD_Plk_4	410	416	PF00069	0.691
MOD_Plk_4	530	536	PF00069	0.540
MOD_Plk_4	561	567	PF00069	0.634
MOD_Plk_4	92	98	PF00069	0.666
MOD_ProDKin_1	162	168	PF00069	0.706
MOD_ProDKin_1	169	175	PF00069	0.639
MOD_ProDKin_1	190	196	PF00069	0.581
MOD_ProDKin_1	211	217	PF00069	0.731
MOD_ProDKin_1	299	305	PF00069	0.715
MOD_ProDKin_1	53	59	PF00069	0.504
MOD_ProDKin_1	60	66	PF00069	0.517
TRG_DiLeu_BaEn_2	282	288	PF01217	0.599
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.518
TRG_DiLeu_BaLyEn_6	541	546	PF01217	0.630
TRG_ENDOCYTIC_2	273	276	PF00928	0.661
TRG_ENDOCYTIC_2	38	41	PF00928	0.573
TRG_ER_diArg_1	143	146	PF00400	0.558
TRG_ER_diArg_1	261	264	PF00400	0.706
TRG_ER_diArg_1	41	43	PF00400	0.458
TRG_NES_CRM1_1	283	296	PF08389	0.615
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.656
TRG_Pf-PMV_PEXEL_1	43	48	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEY7	Leishmania donovani	68%	99%
A4I961	Leishmania infantum	68%	88%
E9B437	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	99%
Q4Q3Y8	Leishmania major	69%	98%