RNA editing complex protein MP46

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA editing complex protein MP46

Species:

Leishmania braziliensis

UniProt:

A4HLQ9_LEIBR

TriTrypDb:

LbrM.33.2250 , LBRM2903_330029500

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLQ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.540
CLV_NRD_NRD_1	116	118	PF00675	0.492
CLV_NRD_NRD_1	145	147	PF00675	0.444
CLV_NRD_NRD_1	338	340	PF00675	0.569
CLV_NRD_NRD_1	73	75	PF00675	0.430
CLV_NRD_NRD_1	79	81	PF00675	0.357
CLV_PCSK_KEX2_1	115	117	PF00082	0.507
CLV_PCSK_KEX2_1	145	147	PF00082	0.444
CLV_PCSK_KEX2_1	337	339	PF00082	0.601
CLV_PCSK_KEX2_1	78	80	PF00082	0.377
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.601
CLV_PCSK_PC7_1	74	80	PF00082	0.487
CLV_PCSK_SKI1_1	132	136	PF00082	0.337
CLV_PCSK_SKI1_1	146	150	PF00082	0.469
CLV_PCSK_SKI1_1	454	458	PF00082	0.606
CLV_PCSK_SKI1_1	93	97	PF00082	0.430
DEG_SCF_FBW7_1	17	24	PF00400	0.549
DEG_SPOP_SBC_1	422	426	PF00917	0.633
DOC_ANK_TNKS_1	114	121	PF00023	0.459
DOC_CKS1_1	437	442	PF01111	0.505
DOC_CYCLIN_yClb1_LxF_4	467	472	PF00134	0.607
DOC_CYCLIN_yClb5_NLxxxL_5	306	313	PF00134	0.463
DOC_MAPK_gen_1	112	121	PF00069	0.466
DOC_MAPK_gen_1	463	472	PF00069	0.462
DOC_MAPK_RevD_3	61	75	PF00069	0.505
DOC_PP4_FxxP_1	44	47	PF00568	0.439
DOC_SPAK_OSR1_1	42	46	PF12202	0.469
DOC_USP7_MATH_1	21	25	PF00917	0.490
DOC_USP7_MATH_1	240	244	PF00917	0.780
DOC_USP7_MATH_1	249	253	PF00917	0.704
DOC_USP7_MATH_1	376	380	PF00917	0.742
DOC_USP7_MATH_1	384	388	PF00917	0.680
DOC_USP7_MATH_1	390	394	PF00917	0.452
DOC_USP7_MATH_1	427	431	PF00917	0.742
DOC_USP7_MATH_1	47	51	PF00917	0.561
DOC_USP7_UBL2_3	480	484	PF12436	0.503
DOC_WW_Pin1_4	104	109	PF00397	0.645
DOC_WW_Pin1_4	17	22	PF00397	0.541
DOC_WW_Pin1_4	234	239	PF00397	0.827
DOC_WW_Pin1_4	247	252	PF00397	0.492
DOC_WW_Pin1_4	379	384	PF00397	0.626
DOC_WW_Pin1_4	423	428	PF00397	0.770
DOC_WW_Pin1_4	436	441	PF00397	0.619
DOC_WW_Pin1_4	473	478	PF00397	0.725
LIG_14-3-3_CanoR_1	132	139	PF00244	0.318
LIG_14-3-3_CanoR_1	209	213	PF00244	0.499
LIG_14-3-3_CanoR_1	241	247	PF00244	0.565
LIG_14-3-3_CanoR_1	256	266	PF00244	0.442
LIG_14-3-3_CanoR_1	283	288	PF00244	0.498
LIG_14-3-3_CanoR_1	338	347	PF00244	0.591
LIG_14-3-3_CanoR_1	364	372	PF00244	0.693
LIG_14-3-3_CanoR_1	398	404	PF00244	0.419
LIG_Actin_WH2_2	50	68	PF00022	0.521
LIG_Actin_WH2_2	81	99	PF00022	0.398
LIG_BIR_III_2	235	239	PF00653	0.534
LIG_deltaCOP1_diTrp_1	466	472	PF00928	0.618
LIG_FHA_1	133	139	PF00498	0.398
LIG_FHA_1	172	178	PF00498	0.441
LIG_FHA_1	372	378	PF00498	0.762
LIG_FHA_1	455	461	PF00498	0.575
LIG_FHA_2	230	236	PF00498	0.538
LIG_FHA_2	436	442	PF00498	0.642
LIG_LIR_Gen_1	204	214	PF02991	0.495
LIG_LIR_Gen_1	466	474	PF02991	0.621
LIG_LIR_Nem_3	204	210	PF02991	0.495
LIG_LIR_Nem_3	401	406	PF02991	0.576
LIG_LIR_Nem_3	466	470	PF02991	0.613
LIG_NRBOX	185	191	PF00104	0.435
LIG_NRP_CendR_1	483	486	PF00754	0.654
LIG_SH2_CRK	98	102	PF00017	0.290
LIG_SH2_NCK_1	98	102	PF00017	0.301
LIG_SH2_STAT5	170	173	PF00017	0.433
LIG_SH2_STAT5	22	25	PF00017	0.475
LIG_SH2_STAT5	266	269	PF00017	0.399
LIG_SH2_STAT5	403	406	PF00017	0.558
LIG_SH3_1	98	104	PF00018	0.314
LIG_SH3_2	251	256	PF14604	0.462
LIG_SH3_3	207	213	PF00018	0.651
LIG_SH3_3	248	254	PF00018	0.615
LIG_SH3_3	378	384	PF00018	0.703
LIG_SH3_3	468	474	PF00018	0.737
LIG_SH3_3	98	104	PF00018	0.487
LIG_SUMO_SIM_anti_2	182	188	PF11976	0.434
LIG_UBA3_1	155	160	PF00899	0.301
MOD_CDC14_SPxK_1	253	256	PF00782	0.529
MOD_CDK_SPxK_1	250	256	PF00069	0.553
MOD_CDK_SPxK_1	423	429	PF00069	0.587
MOD_CDK_SPxxK_3	234	241	PF00069	0.535
MOD_CDK_SPxxK_3	473	480	PF00069	0.644
MOD_CK1_1	106	112	PF00069	0.576
MOD_CK1_1	202	208	PF00069	0.539
MOD_CK1_1	227	233	PF00069	0.698
MOD_CK1_1	286	292	PF00069	0.485
MOD_CK1_1	379	385	PF00069	0.675
MOD_CK1_1	428	434	PF00069	0.752
MOD_CK1_1	99	105	PF00069	0.461
MOD_CK2_1	182	188	PF00069	0.452
MOD_CK2_1	472	478	PF00069	0.683
MOD_Cter_Amidation	113	116	PF01082	0.481
MOD_GlcNHglycan	201	204	PF01048	0.550
MOD_GlcNHglycan	219	222	PF01048	0.718
MOD_GlcNHglycan	227	230	PF01048	0.608
MOD_GlcNHglycan	3	6	PF01048	0.624
MOD_GlcNHglycan	355	359	PF01048	0.658
MOD_GlcNHglycan	384	387	PF01048	0.566
MOD_GlcNHglycan	392	395	PF01048	0.569
MOD_GlcNHglycan	448	451	PF01048	0.685
MOD_GSK3_1	17	24	PF00069	0.532
MOD_GSK3_1	225	232	PF00069	0.702
MOD_GSK3_1	354	361	PF00069	0.607
MOD_GSK3_1	421	428	PF00069	0.701
MOD_GSK3_1	432	439	PF00069	0.764
MOD_GSK3_1	99	106	PF00069	0.508
MOD_N-GLC_1	257	262	PF02516	0.433
MOD_N-GLC_1	345	350	PF02516	0.548
MOD_NEK2_1	171	176	PF00069	0.399
MOD_NEK2_1	399	404	PF00069	0.594
MOD_NEK2_1	446	451	PF00069	0.600
MOD_NEK2_1	96	101	PF00069	0.412
MOD_PK_1	283	289	PF00069	0.493
MOD_PK_1	49	55	PF00069	0.516
MOD_PKA_2	208	214	PF00069	0.497
MOD_PKA_2	240	246	PF00069	0.536
MOD_PKA_2	363	369	PF00069	0.630
MOD_PKA_2	96	102	PF00069	0.377
MOD_Plk_1	182	188	PF00069	0.452
MOD_Plk_1	354	360	PF00069	0.593
MOD_Plk_1	432	438	PF00069	0.517
MOD_Plk_2-3	182	188	PF00069	0.452
MOD_Plk_4	163	169	PF00069	0.348
MOD_Plk_4	182	188	PF00069	0.505
MOD_Plk_4	202	208	PF00069	0.441
MOD_Plk_4	323	329	PF00069	0.529
MOD_Plk_4	399	405	PF00069	0.550
MOD_Plk_4	49	55	PF00069	0.529
MOD_ProDKin_1	104	110	PF00069	0.650
MOD_ProDKin_1	17	23	PF00069	0.549
MOD_ProDKin_1	234	240	PF00069	0.826
MOD_ProDKin_1	247	253	PF00069	0.488
MOD_ProDKin_1	379	385	PF00069	0.662
MOD_ProDKin_1	423	429	PF00069	0.771
MOD_ProDKin_1	436	442	PF00069	0.620
MOD_ProDKin_1	473	479	PF00069	0.727
MOD_SUMO_rev_2	260	265	PF00179	0.470
MOD_SUMO_rev_2	475	481	PF00179	0.677
MOD_SUMO_rev_2	58	68	PF00179	0.516
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.511
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.461
TRG_ENDOCYTIC_2	403	406	PF00928	0.640
TRG_ER_diArg_1	115	117	PF00400	0.486
TRG_ER_diArg_1	144	146	PF00400	0.427
TRG_ER_diArg_1	460	463	PF00400	0.729
TRG_ER_diArg_1	78	80	PF00400	0.377
TRG_ER_diLys_1	483	486	PF00400	0.555
TRG_Pf-PMV_PEXEL_1	339	344	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7J1	Leptomonas seymouri	41%	77%
A0A3S7X6X4	Leishmania donovani	74%	98%
A4I959	Leishmania infantum	74%	98%
D0A6B3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B435	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	98%
Q4Q3Z0	Leishmania major	73%	100%
V5BYM8	Trypanosoma cruzi	38%	100%