Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLQ8_LEIBR

TriTrypDb:

LbrM.33.2240 , LBRM2903_330029400

Length:

429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLQ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.657
CLV_C14_Caspase3-7	25	29	PF00656	0.534
CLV_C14_Caspase3-7	309	313	PF00656	0.632
CLV_NRD_NRD_1	233	235	PF00675	0.601
CLV_NRD_NRD_1	268	270	PF00675	0.567
CLV_PCSK_SKI1_1	14	18	PF00082	0.671
DEG_SCF_FBW7_1	239	245	PF00400	0.743
DEG_SCF_FBW7_1	98	105	PF00400	0.567
DEG_SCF_SKP2-CKS1_1	97	104	PF00560	0.606
DEG_SIAH_1	220	228	PF03145	0.576
DOC_CKS1_1	227	232	PF01111	0.823
DOC_CKS1_1	236	241	PF01111	0.671
DOC_MAPK_DCC_7	249	258	PF00069	0.591
DOC_MAPK_FxFP_2	15	18	PF00069	0.806
DOC_MAPK_MEF2A_6	249	258	PF00069	0.732
DOC_MAPK_RevD_3	254	270	PF00069	0.516
DOC_PP2B_LxvP_1	240	243	PF13499	0.576
DOC_PP4_FxxP_1	15	18	PF00568	0.806
DOC_USP7_MATH_1	102	106	PF00917	0.713
DOC_USP7_MATH_1	111	115	PF00917	0.797
DOC_USP7_MATH_1	128	132	PF00917	0.798
DOC_USP7_MATH_1	168	172	PF00917	0.779
DOC_USP7_MATH_1	211	215	PF00917	0.664
DOC_USP7_MATH_1	228	232	PF00917	0.571
DOC_USP7_MATH_1	27	31	PF00917	0.760
DOC_USP7_MATH_1	342	346	PF00917	0.553
DOC_USP7_MATH_1	356	360	PF00917	0.598
DOC_USP7_MATH_2	107	113	PF00917	0.835
DOC_WW_Pin1_4	226	231	PF00397	0.784
DOC_WW_Pin1_4	235	240	PF00397	0.672
DOC_WW_Pin1_4	365	370	PF00397	0.638
DOC_WW_Pin1_4	408	413	PF00397	0.545
DOC_WW_Pin1_4	98	103	PF00397	0.607
LIG_14-3-3_CanoR_1	335	341	PF00244	0.686
LIG_14-3-3_CanoR_1	413	421	PF00244	0.720
LIG_14-3-3_CanoR_1	80	86	PF00244	0.561
LIG_BIR_II_1	1	5	PF00653	0.559
LIG_eIF4E_1	172	178	PF01652	0.548
LIG_eIF4E_1	365	371	PF01652	0.703
LIG_FHA_1	227	233	PF00498	0.579
LIG_FHA_1	278	284	PF00498	0.523
LIG_FHA_1	342	348	PF00498	0.438
LIG_FHA_1	366	372	PF00498	0.594
LIG_FHA_1	73	79	PF00498	0.563
LIG_FHA_1	82	88	PF00498	0.532
LIG_FHA_2	155	161	PF00498	0.576
LIG_HCF-1_HBM_1	169	172	PF13415	0.567
LIG_LIR_Apic_2	12	18	PF02991	0.555
LIG_LIR_Apic_2	169	175	PF02991	0.554
LIG_LIR_Apic_2	47	53	PF02991	0.691
LIG_LIR_Gen_1	28	36	PF02991	0.602
LIG_LIR_Nem_3	28	34	PF02991	0.537
LIG_NRBOX	380	386	PF00104	0.699
LIG_SH2_CRK	50	54	PF00017	0.837
LIG_SH2_NCK_1	50	54	PF00017	0.837
LIG_SH3_1	50	56	PF00018	0.568
LIG_SH3_2	230	235	PF14604	0.624
LIG_SH3_2	244	249	PF14604	0.548
LIG_SH3_2	53	58	PF14604	0.567
LIG_SH3_3	224	230	PF00018	0.822
LIG_SH3_3	233	239	PF00018	0.670
LIG_SH3_3	241	247	PF00018	0.535
LIG_SH3_3	29	35	PF00018	0.534
LIG_SH3_3	368	374	PF00018	0.578
LIG_SH3_3	406	412	PF00018	0.566
LIG_SH3_3	50	56	PF00018	0.750
LIG_SUMO_SIM_anti_2	84	90	PF11976	0.560
LIG_SUMO_SIM_par_1	190	196	PF11976	0.604
LIG_SUMO_SIM_par_1	376	382	PF11976	0.683
LIG_TRAF2_1	137	140	PF00917	0.701
LIG_TRAF2_1	271	274	PF00917	0.459
MOD_CDK_SPK_2	408	413	PF00069	0.545
MOD_CDK_SPxK_1	98	104	PF00069	0.609
MOD_CK1_1	141	147	PF00069	0.834
MOD_CK1_1	149	155	PF00069	0.732
MOD_CK1_1	261	267	PF00069	0.522
MOD_CK1_1	295	301	PF00069	0.727
MOD_CK1_1	30	36	PF00069	0.532
MOD_CK1_1	302	308	PF00069	0.757
MOD_CK1_1	333	339	PF00069	0.687
MOD_CK1_1	39	45	PF00069	0.505
MOD_CK1_1	81	87	PF00069	0.633
MOD_CK1_1	90	96	PF00069	0.668
MOD_CK2_1	111	117	PF00069	0.591
MOD_CK2_1	118	124	PF00069	0.528
MOD_CK2_1	134	140	PF00069	0.705
MOD_CK2_1	149	155	PF00069	0.811
MOD_CK2_1	286	292	PF00069	0.777
MOD_GlcNHglycan	113	116	PF01048	0.774
MOD_GlcNHglycan	294	297	PF01048	0.684
MOD_GlcNHglycan	331	335	PF01048	0.690
MOD_GlcNHglycan	344	347	PF01048	0.456
MOD_GlcNHglycan	41	44	PF01048	0.800
MOD_GlcNHglycan	423	426	PF01048	0.781
MOD_GlcNHglycan	80	83	PF01048	0.597
MOD_GlcNHglycan	89	92	PF01048	0.539
MOD_GSK3_1	134	141	PF00069	0.801
MOD_GSK3_1	191	198	PF00069	0.637
MOD_GSK3_1	206	213	PF00069	0.802
MOD_GSK3_1	238	245	PF00069	0.846
MOD_GSK3_1	258	265	PF00069	0.455
MOD_GSK3_1	282	289	PF00069	0.541
MOD_GSK3_1	295	302	PF00069	0.719
MOD_GSK3_1	30	37	PF00069	0.742
MOD_GSK3_1	303	310	PF00069	0.767
MOD_GSK3_1	39	46	PF00069	0.505
MOD_GSK3_1	74	81	PF00069	0.651
MOD_GSK3_1	83	90	PF00069	0.667
MOD_GSK3_1	98	105	PF00069	0.538
MOD_LATS_1	197	203	PF00433	0.576
MOD_N-GLC_1	109	114	PF02516	0.566
MOD_NEK2_1	178	183	PF00069	0.550
MOD_NEK2_1	195	200	PF00069	0.522
MOD_PIKK_1	138	144	PF00454	0.827
MOD_PIKK_1	199	205	PF00454	0.580
MOD_PIKK_1	317	323	PF00454	0.401
MOD_PKA_2	149	155	PF00069	0.784
MOD_PKA_2	327	333	PF00069	0.695
MOD_Plk_1	118	124	PF00069	0.796
MOD_Plk_1	168	174	PF00069	0.659
MOD_Plk_1	261	267	PF00069	0.763
MOD_Plk_1	317	323	PF00069	0.612
MOD_Plk_4	27	33	PF00069	0.651
MOD_Plk_4	356	362	PF00069	0.455
MOD_Plk_4	83	89	PF00069	0.828
MOD_ProDKin_1	226	232	PF00069	0.785
MOD_ProDKin_1	235	241	PF00069	0.672
MOD_ProDKin_1	365	371	PF00069	0.639
MOD_ProDKin_1	408	414	PF00069	0.547
MOD_ProDKin_1	98	104	PF00069	0.609
MOD_SUMO_rev_2	152	159	PF00179	0.728

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6Z0	Leishmania donovani	63%	79%
A4I958	Leishmania infantum	63%	79%
E9B434	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	79%
Q4Q3Z1	Leishmania major	64%	100%