PPR_long domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLQ7_LEIBR

TriTrypDb:

LbrM.33.2230 , LBRM2903_330029200

Length:

705

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:0005739	mitochondrion	5	1

Expansion

Sequence features

A4HLQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLQ7

Function

Biological processes
Term	Name	Level	Count
GO:0000966	RNA 5'-end processing	7	1
GO:0001682	tRNA 5'-leader removal	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006396	RNA processing	6	9
GO:0006399	tRNA metabolic process	7	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008033	tRNA processing	8	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0034470	ncRNA processing	7	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0034660	ncRNA metabolic process	6	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:0099116	tRNA 5'-end processing	8	1
GO:1901360	organic cyclic compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004518	nuclease activity	4	8
GO:0004519	endonuclease activity	5	7
GO:0004521	RNA endonuclease activity	5	7
GO:0004526	ribonuclease P activity	6	7
GO:0004540	RNA nuclease activity	4	7
GO:0004549	tRNA-specific ribonuclease activity	5	7
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	7
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	7
GO:0140098	catalytic activity, acting on RNA	3	7
GO:0140101	catalytic activity, acting on a tRNA	4	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	271	275	PF00656	0.484
CLV_C14_Caspase3-7	30	34	PF00656	0.679
CLV_C14_Caspase3-7	410	414	PF00656	0.452
CLV_NRD_NRD_1	153	155	PF00675	0.300
CLV_NRD_NRD_1	2	4	PF00675	0.366
CLV_NRD_NRD_1	326	328	PF00675	0.445
CLV_NRD_NRD_1	87	89	PF00675	0.301
CLV_PCSK_FUR_1	151	155	PF00082	0.288
CLV_PCSK_FUR_1	324	328	PF00082	0.503
CLV_PCSK_KEX2_1	10	12	PF00082	0.408
CLV_PCSK_KEX2_1	153	155	PF00082	0.290
CLV_PCSK_KEX2_1	2	4	PF00082	0.372
CLV_PCSK_KEX2_1	21	23	PF00082	0.478
CLV_PCSK_KEX2_1	326	328	PF00082	0.476
CLV_PCSK_KEX2_1	336	338	PF00082	0.236
CLV_PCSK_KEX2_1	571	573	PF00082	0.535
CLV_PCSK_KEX2_1	87	89	PF00082	0.316
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.395
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.373
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.483
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.535
CLV_PCSK_SKI1_1	154	158	PF00082	0.294
CLV_PCSK_SKI1_1	190	194	PF00082	0.412
CLV_PCSK_SKI1_1	21	25	PF00082	0.488
CLV_PCSK_SKI1_1	212	216	PF00082	0.403
CLV_PCSK_SKI1_1	312	316	PF00082	0.410
CLV_PCSK_SKI1_1	327	331	PF00082	0.418
CLV_PCSK_SKI1_1	440	444	PF00082	0.412
CLV_PCSK_SKI1_1	519	523	PF00082	0.474
CLV_PCSK_SKI1_1	529	533	PF00082	0.352
CLV_PCSK_SKI1_1	55	59	PF00082	0.462
DEG_Nend_UBRbox_1	1	4	PF02207	0.408
DEG_SCF_FBW7_2	636	643	PF00400	0.515
DEG_SPOP_SBC_1	50	54	PF00917	0.401
DOC_CYCLIN_RxL_1	186	198	PF00134	0.179
DOC_MAPK_gen_1	324	332	PF00069	0.479
DOC_MAPK_gen_1	523	532	PF00069	0.343
DOC_MAPK_MEF2A_6	212	221	PF00069	0.445
DOC_MAPK_MEF2A_6	401	409	PF00069	0.368
DOC_PP1_RVXF_1	151	158	PF00149	0.395
DOC_PP1_RVXF_1	188	195	PF00149	0.179
DOC_PP1_RVXF_1	527	533	PF00149	0.358
DOC_PP2B_LxvP_1	317	320	PF13499	0.413
DOC_PP2B_LxvP_1	547	550	PF13499	0.462
DOC_PP2B_LxvP_1	618	621	PF13499	0.482
DOC_USP7_MATH_1	204	208	PF00917	0.403
DOC_USP7_MATH_1	272	276	PF00917	0.640
DOC_USP7_MATH_1	305	309	PF00917	0.492
DOC_USP7_MATH_1	37	41	PF00917	0.687
DOC_USP7_MATH_1	45	49	PF00917	0.734
DOC_USP7_MATH_1	493	497	PF00917	0.625
DOC_USP7_MATH_1	580	584	PF00917	0.596
DOC_USP7_MATH_1	590	594	PF00917	0.772
DOC_USP7_MATH_1	597	601	PF00917	0.537
DOC_USP7_MATH_1	604	608	PF00917	0.461
DOC_USP7_MATH_1	612	616	PF00917	0.605
DOC_WW_Pin1_4	254	259	PF00397	0.687
DOC_WW_Pin1_4	459	464	PF00397	0.383
DOC_WW_Pin1_4	483	488	PF00397	0.517
DOC_WW_Pin1_4	514	519	PF00397	0.398
DOC_WW_Pin1_4	571	576	PF00397	0.750
DOC_WW_Pin1_4	586	591	PF00397	0.626
DOC_WW_Pin1_4	636	641	PF00397	0.516
LIG_14-3-3_CanoR_1	135	143	PF00244	0.262
LIG_14-3-3_CanoR_1	233	241	PF00244	0.474
LIG_14-3-3_CanoR_1	55	63	PF00244	0.411
LIG_14-3-3_CanoR_1	87	94	PF00244	0.409
LIG_Actin_WH2_2	121	139	PF00022	0.274
LIG_APCC_ABBA_1	349	354	PF00400	0.422
LIG_APCC_ABBA_1	697	702	PF00400	0.408
LIG_APCC_ABBAyCdc20_2	540	546	PF00400	0.452
LIG_eIF4E_1	175	181	PF01652	0.179
LIG_FHA_1	120	126	PF00498	0.450
LIG_FHA_1	225	231	PF00498	0.531
LIG_FHA_1	313	319	PF00498	0.332
LIG_FHA_1	415	421	PF00498	0.432
LIG_FHA_1	445	451	PF00498	0.451
LIG_FHA_1	637	643	PF00498	0.519
LIG_FHA_1	94	100	PF00498	0.316
LIG_FHA_2	169	175	PF00498	0.395
LIG_FHA_2	384	390	PF00498	0.522
LIG_FHA_2	675	681	PF00498	0.646
LIG_FHA_2	696	702	PF00498	0.425
LIG_HP1_1	428	432	PF01393	0.386
LIG_LIR_Apic_2	542	548	PF02991	0.498
LIG_LIR_Apic_2	559	564	PF02991	0.659
LIG_LIR_Apic_2	599	604	PF02991	0.430
LIG_LIR_Gen_1	172	183	PF02991	0.297
LIG_LIR_Gen_1	216	226	PF02991	0.460
LIG_LIR_Gen_1	27	35	PF02991	0.432
LIG_LIR_Nem_3	140	145	PF02991	0.278
LIG_LIR_Nem_3	172	178	PF02991	0.325
LIG_LIR_Nem_3	191	196	PF02991	0.380
LIG_LIR_Nem_3	27	31	PF02991	0.493
LIG_LIR_Nem_3	333	338	PF02991	0.382
LIG_LIR_Nem_3	364	369	PF02991	0.434
LIG_LIR_Nem_3	510	516	PF02991	0.427
LIG_Pex14_1	601	605	PF04695	0.524
LIG_SH2_CRK	460	464	PF00017	0.333
LIG_SH2_CRK	474	478	PF00017	0.358
LIG_SH2_CRK	561	565	PF00017	0.493
LIG_SH2_NCK_1	561	565	PF00017	0.493
LIG_SH2_PTP2	175	178	PF00017	0.191
LIG_SH2_STAP1	160	164	PF00017	0.274
LIG_SH2_STAP1	551	555	PF00017	0.389
LIG_SH2_STAT3	127	130	PF00017	0.395
LIG_SH2_STAT5	127	130	PF00017	0.403
LIG_SH2_STAT5	145	148	PF00017	0.375
LIG_SH2_STAT5	175	178	PF00017	0.274
LIG_SH2_STAT5	460	463	PF00017	0.338
LIG_SH2_STAT5	561	564	PF00017	0.487
LIG_SH3_3	182	188	PF00018	0.353
LIG_SH3_3	211	217	PF00018	0.293
LIG_SH3_3	252	258	PF00018	0.591
LIG_SUMO_SIM_anti_2	78	85	PF11976	0.403
LIG_SUMO_SIM_par_1	416	422	PF11976	0.364
LIG_SUMO_SIM_par_1	428	434	PF11976	0.303
LIG_SUMO_SIM_par_1	667	673	PF11976	0.478
LIG_TRAF2_1	678	681	PF00917	0.746
LIG_TYR_ITIM	358	363	PF00017	0.356
MOD_CDK_SPK_2	514	519	PF00069	0.398
MOD_CK1_1	254	260	PF00069	0.695
MOD_CK1_1	27	33	PF00069	0.532
MOD_CK1_1	383	389	PF00069	0.584
MOD_CK1_1	40	46	PF00069	0.689
MOD_CK1_1	444	450	PF00069	0.565
MOD_CK1_1	494	500	PF00069	0.465
MOD_CK1_1	78	84	PF00069	0.451
MOD_CK2_1	562	568	PF00069	0.577
MOD_CK2_1	674	680	PF00069	0.571
MOD_CK2_1	695	701	PF00069	0.409
MOD_Cter_Amidation	8	11	PF01082	0.307
MOD_GlcNHglycan	137	140	PF01048	0.366
MOD_GlcNHglycan	264	267	PF01048	0.769
MOD_GlcNHglycan	270	273	PF01048	0.528
MOD_GlcNHglycan	274	277	PF01048	0.726
MOD_GlcNHglycan	297	300	PF01048	0.466
MOD_GlcNHglycan	39	42	PF01048	0.701
MOD_GlcNHglycan	47	50	PF01048	0.701
MOD_GlcNHglycan	582	585	PF01048	0.569
MOD_GlcNHglycan	592	595	PF01048	0.563
MOD_GlcNHglycan	606	609	PF01048	0.560
MOD_GlcNHglycan	610	613	PF01048	0.620
MOD_GlcNHglycan	614	617	PF01048	0.704
MOD_GlcNHglycan	618	621	PF01048	0.711
MOD_GlcNHglycan	643	648	PF01048	0.555
MOD_GlcNHglycan	77	80	PF01048	0.379
MOD_GSK3_1	254	261	PF00069	0.716
MOD_GSK3_1	262	269	PF00069	0.687
MOD_GSK3_1	40	47	PF00069	0.634
MOD_GSK3_1	440	447	PF00069	0.422
MOD_GSK3_1	493	500	PF00069	0.620
MOD_GSK3_1	580	587	PF00069	0.755
MOD_GSK3_1	604	611	PF00069	0.514
MOD_GSK3_1	612	619	PF00069	0.653
MOD_GSK3_1	88	95	PF00069	0.347
MOD_NEK2_1	251	256	PF00069	0.438
MOD_NEK2_1	441	446	PF00069	0.512
MOD_NEK2_1	51	56	PF00069	0.528
MOD_NEK2_2	16	21	PF00069	0.240
MOD_NEK2_2	188	193	PF00069	0.274
MOD_PIKK_1	281	287	PF00454	0.460
MOD_PIKK_1	441	447	PF00454	0.350
MOD_PKA_1	87	93	PF00069	0.331
MOD_PKA_2	266	272	PF00069	0.490
MOD_PKA_2	383	389	PF00069	0.513
MOD_PKA_2	649	655	PF00069	0.501
MOD_PKA_2	87	93	PF00069	0.331
MOD_PKB_1	135	143	PF00069	0.274
MOD_Plk_1	224	230	PF00069	0.473
MOD_Plk_4	103	109	PF00069	0.317
MOD_Plk_4	649	655	PF00069	0.501
MOD_Plk_4	78	84	PF00069	0.403
MOD_ProDKin_1	254	260	PF00069	0.688
MOD_ProDKin_1	459	465	PF00069	0.386
MOD_ProDKin_1	483	489	PF00069	0.528
MOD_ProDKin_1	514	520	PF00069	0.393
MOD_ProDKin_1	571	577	PF00069	0.749
MOD_ProDKin_1	586	592	PF00069	0.624
MOD_ProDKin_1	636	642	PF00069	0.515
MOD_SUMO_rev_2	434	442	PF00179	0.415
MOD_SUMO_rev_2	619	627	PF00179	0.715
TRG_DiLeu_BaEn_1	129	134	PF01217	0.403
TRG_DiLeu_BaEn_1	313	318	PF01217	0.399
TRG_DiLeu_BaLyEn_6	511	516	PF01217	0.470
TRG_ENDOCYTIC_2	175	178	PF00928	0.317
TRG_ENDOCYTIC_2	360	363	PF00928	0.359
TRG_ENDOCYTIC_2	474	477	PF00928	0.321
TRG_ER_diArg_1	1	3	PF00400	0.409
TRG_ER_diArg_1	134	137	PF00400	0.313
TRG_ER_diArg_1	153	155	PF00400	0.296
TRG_ER_diArg_1	230	233	PF00400	0.415
TRG_ER_diArg_1	324	327	PF00400	0.417
TRG_ER_diArg_1	527	530	PF00400	0.370
TRG_ER_diArg_1	86	88	PF00400	0.323
TRG_NES_CRM1_1	468	481	PF08389	0.438
TRG_Pf-PMV_PEXEL_1	312	316	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM55	Leptomonas seymouri	53%	94%
A0A1X0P3X4	Trypanosomatidae	43%	100%
A0A3Q8IHV9	Leishmania donovani	81%	100%
A0A422MWI6	Trypanosoma rangeli	45%	100%
A4HNH1	Leishmania braziliensis	30%	100%
A4I957	Leishmania infantum	81%	100%
D0A6B5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B432	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
F4JKB6	Arabidopsis thaliana	22%	100%
Q4Q3Z2	Leishmania major	80%	98%
Q680B9	Arabidopsis thaliana	23%	100%
V5BPA7	Trypanosoma cruzi	45%	100%