G protein-coupled receptor

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLQ6_LEIBR

TriTrypDb:

LbrM.33.2220 , LBRM2903_330029100

Length:

626

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

A4HLQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLQ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.613
CLV_C14_Caspase3-7	413	417	PF00656	0.282
CLV_C14_Caspase3-7	60	64	PF00656	0.730
CLV_NRD_NRD_1	585	587	PF00675	0.707
CLV_NRD_NRD_1	8	10	PF00675	0.547
CLV_PCSK_FUR_1	334	338	PF00082	0.499
CLV_PCSK_KEX2_1	190	192	PF00082	0.400
CLV_PCSK_KEX2_1	336	338	PF00082	0.548
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.297
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.600
CLV_PCSK_SKI1_1	128	132	PF00082	0.389
CLV_PCSK_SKI1_1	337	341	PF00082	0.590
DEG_COP1_1	300	310	PF00400	0.457
DEG_MDM2_SWIB_1	271	279	PF02201	0.282
DEG_MDM2_SWIB_1	403	410	PF02201	0.327
DOC_ANK_TNKS_1	612	619	PF00023	0.380
DOC_CDC14_PxL_1	506	514	PF14671	0.186
DOC_MAPK_FxFP_2	359	362	PF00069	0.282
DOC_MAPK_gen_1	331	340	PF00069	0.343
DOC_MAPK_gen_1	382	391	PF00069	0.444
DOC_MAPK_HePTP_8	494	506	PF00069	0.210
DOC_MAPK_MEF2A_6	221	230	PF00069	0.564
DOC_MAPK_MEF2A_6	382	390	PF00069	0.444
DOC_MAPK_MEF2A_6	497	506	PF00069	0.354
DOC_MAPK_RevD_3	321	337	PF00069	0.448
DOC_PP1_RVXF_1	28	34	PF00149	0.576
DOC_PP1_RVXF_1	501	507	PF00149	0.300
DOC_PP1_RVXF_1	532	539	PF00149	0.623
DOC_PP1_RVXF_1	577	583	PF00149	0.377
DOC_PP2B_LxvP_1	305	308	PF13499	0.615
DOC_PP4_FxxP_1	15	18	PF00568	0.656
DOC_PP4_FxxP_1	174	177	PF00568	0.585
DOC_PP4_FxxP_1	359	362	PF00568	0.345
DOC_PP4_FxxP_1	591	594	PF00568	0.342
DOC_SPAK_OSR1_1	590	594	PF12202	0.339
DOC_USP7_MATH_1	102	106	PF00917	0.537
DOC_USP7_MATH_1	211	215	PF00917	0.522
DOC_USP7_MATH_1	605	609	PF00917	0.457
DOC_USP7_MATH_2	431	437	PF00917	0.251
DOC_WW_Pin1_4	160	165	PF00397	0.524
DOC_WW_Pin1_4	306	311	PF00397	0.513
DOC_WW_Pin1_4	574	579	PF00397	0.291
DOC_WW_Pin1_4	601	606	PF00397	0.379
LIG_14-3-3_CanoR_1	180	188	PF00244	0.606
LIG_14-3-3_CanoR_1	349	357	PF00244	0.341
LIG_14-3-3_CanoR_1	434	442	PF00244	0.291
LIG_14-3-3_CanoR_1	467	473	PF00244	0.504
LIG_14-3-3_CanoR_1	503	513	PF00244	0.391
LIG_14-3-3_CanoR_1	539	543	PF00244	0.451
LIG_14-3-3_CanoR_1	9	17	PF00244	0.793
LIG_Actin_WH2_2	174	192	PF00022	0.588
LIG_Actin_WH2_2	481	499	PF00022	0.210
LIG_APCC_ABBA_1	518	523	PF00400	0.222
LIG_BRCT_BRCA1_1	261	265	PF00533	0.338
LIG_BRCT_BRCA1_1	350	354	PF00533	0.221
LIG_BRCT_BRCA1_1	91	95	PF00533	0.612
LIG_Clathr_ClatBox_1	21	25	PF01394	0.635
LIG_CtBP_PxDLS_1	18	22	PF00389	0.651
LIG_deltaCOP1_diTrp_1	378	385	PF00928	0.513
LIG_EH1_1	124	132	PF00400	0.514
LIG_EH1_1	443	451	PF00400	0.186
LIG_eIF4E_1	263	269	PF01652	0.282
LIG_eIF4E_1	444	450	PF01652	0.186
LIG_eIF4E_1	552	558	PF01652	0.445
LIG_FHA_1	240	246	PF00498	0.411
LIG_FHA_1	265	271	PF00498	0.330
LIG_FHA_1	457	463	PF00498	0.410
LIG_FHA_1	499	505	PF00498	0.316
LIG_FHA_1	569	575	PF00498	0.477
LIG_FHA_2	133	139	PF00498	0.519
LIG_FHA_2	148	154	PF00498	0.546
LIG_FHA_2	286	292	PF00498	0.455
LIG_FHA_2	60	66	PF00498	0.712
LIG_GBD_Chelix_1	438	446	PF00786	0.282
LIG_GBD_Chelix_1	488	496	PF00786	0.271
LIG_LIR_Apic_2	12	18	PF02991	0.808
LIG_LIR_Apic_2	171	177	PF02991	0.549
LIG_LIR_Apic_2	588	594	PF02991	0.334
LIG_LIR_Gen_1	192	201	PF02991	0.495
LIG_LIR_Gen_1	301	312	PF02991	0.636
LIG_LIR_Gen_1	322	332	PF02991	0.386
LIG_LIR_Gen_1	352	362	PF02991	0.386
LIG_LIR_Gen_1	483	494	PF02991	0.307
LIG_LIR_Gen_1	505	514	PF02991	0.448
LIG_LIR_LC3C_4	20	23	PF02991	0.646
LIG_LIR_Nem_3	192	197	PF02991	0.528
LIG_LIR_Nem_3	262	268	PF02991	0.268
LIG_LIR_Nem_3	301	307	PF02991	0.644
LIG_LIR_Nem_3	309	314	PF02991	0.622
LIG_LIR_Nem_3	322	327	PF02991	0.177
LIG_LIR_Nem_3	351	357	PF02991	0.290
LIG_LIR_Nem_3	483	489	PF02991	0.308
LIG_LIR_Nem_3	505	509	PF02991	0.362
LIG_LIR_Nem_3	541	547	PF02991	0.461
LIG_LIR_Nem_3	548	552	PF02991	0.268
LIG_LIR_Nem_3	92	98	PF02991	0.567
LIG_NRBOX	553	559	PF00104	0.445
LIG_PCNA_PIPBox_1	148	157	PF02747	0.523
LIG_PCNA_yPIPBox_3	145	155	PF02747	0.564
LIG_Pex14_1	549	553	PF04695	0.426
LIG_Pex14_2	174	178	PF04695	0.549
LIG_Pex14_2	271	275	PF04695	0.282
LIG_Pex14_2	403	407	PF04695	0.387
LIG_Pex14_2	538	542	PF04695	0.626
LIG_PTB_Apo_2	224	231	PF02174	0.444
LIG_PTB_Apo_2	532	539	PF02174	0.560
LIG_Rb_pABgroove_1	195	203	PF01858	0.476
LIG_Rb_pABgroove_1	315	323	PF01858	0.186
LIG_REV1ctd_RIR_1	171	176	PF16727	0.470
LIG_SH2_CRK	186	190	PF00017	0.620
LIG_SH2_CRK	266	270	PF00017	0.330
LIG_SH2_CRK	355	359	PF00017	0.397
LIG_SH2_GRB2like	369	372	PF00017	0.570
LIG_SH2_NCK_1	355	359	PF00017	0.470
LIG_SH2_PTP2	196	199	PF00017	0.597
LIG_SH2_PTP2	311	314	PF00017	0.564
LIG_SH2_PTP2	387	390	PF00017	0.462
LIG_SH2_PTP2	486	489	PF00017	0.474
LIG_SH2_PTP2	491	494	PF00017	0.249
LIG_SH2_SRC	355	358	PF00017	0.421
LIG_SH2_STAP1	266	270	PF00017	0.308
LIG_SH2_STAP1	355	359	PF00017	0.186
LIG_SH2_STAP1	405	409	PF00017	0.391
LIG_SH2_STAT3	201	204	PF00017	0.499
LIG_SH2_STAT3	537	540	PF00017	0.446
LIG_SH2_STAT5	125	128	PF00017	0.510
LIG_SH2_STAT5	169	172	PF00017	0.504
LIG_SH2_STAT5	186	189	PF00017	0.517
LIG_SH2_STAT5	196	199	PF00017	0.596
LIG_SH2_STAT5	266	269	PF00017	0.320
LIG_SH2_STAT5	304	307	PF00017	0.508
LIG_SH2_STAT5	311	314	PF00017	0.512
LIG_SH2_STAT5	329	332	PF00017	0.290
LIG_SH2_STAT5	369	372	PF00017	0.510
LIG_SH2_STAT5	387	390	PF00017	0.405
LIG_SH2_STAT5	444	447	PF00017	0.361
LIG_SH2_STAT5	486	489	PF00017	0.421
LIG_SH2_STAT5	491	494	PF00017	0.400
LIG_SH2_STAT5	537	540	PF00017	0.560
LIG_SH2_STAT5	546	549	PF00017	0.264
LIG_SH2_STAT5	552	555	PF00017	0.224
LIG_SH2_STAT5	76	79	PF00017	0.653
LIG_SH3_3	20	26	PF00018	0.770
LIG_SH3_3	205	211	PF00018	0.576
LIG_SH3_3	304	310	PF00018	0.578
LIG_SH3_3	313	319	PF00018	0.293
LIG_SUMO_SIM_anti_2	20	25	PF11976	0.639
LIG_SUMO_SIM_anti_2	480	486	PF11976	0.396
LIG_SUMO_SIM_par_1	20	25	PF11976	0.639
LIG_SUMO_SIM_par_1	475	481	PF11976	0.404
LIG_SUMO_SIM_par_1	516	523	PF11976	0.406
LIG_SUMO_SIM_par_1	76	82	PF11976	0.646
LIG_TRFH_1	304	308	PF08558	0.433
LIG_TYR_ITIM	353	358	PF00017	0.186
LIG_TYR_ITIM	484	489	PF00017	0.258
LIG_UBA3_1	492	497	PF00899	0.210
LIG_UBA3_1	580	587	PF00899	0.392
LIG_WRC_WIRS_1	170	175	PF05994	0.469
MOD_CDK_SPK_2	574	579	PF00069	0.291
MOD_CK1_1	259	265	PF00069	0.320
MOD_CK1_1	348	354	PF00069	0.429
MOD_CK1_1	480	486	PF00069	0.276
MOD_CK1_1	609	615	PF00069	0.385
MOD_CK1_1	8	14	PF00069	0.784
MOD_CK1_1	89	95	PF00069	0.651
MOD_CK2_1	132	138	PF00069	0.513
MOD_CK2_1	147	153	PF00069	0.623
MOD_CK2_1	189	195	PF00069	0.484
MOD_CK2_1	290	296	PF00069	0.600
MOD_CK2_1	445	451	PF00069	0.466
MOD_GlcNHglycan	132	135	PF01048	0.344
MOD_GlcNHglycan	191	194	PF01048	0.331
MOD_GlcNHglycan	435	438	PF01048	0.507
MOD_GlcNHglycan	81	84	PF01048	0.401
MOD_GSK3_1	132	139	PF00069	0.627
MOD_GSK3_1	345	352	PF00069	0.295
MOD_GSK3_1	445	452	PF00069	0.449
MOD_GSK3_1	498	505	PF00069	0.336
MOD_GSK3_1	596	603	PF00069	0.416
MOD_GSK3_1	605	612	PF00069	0.389
MOD_N-GLC_1	217	222	PF02516	0.409
MOD_N-GLC_1	256	261	PF02516	0.612
MOD_N-GLC_1	51	56	PF02516	0.472
MOD_N-GLC_1	574	579	PF02516	0.491
MOD_N-GLC_1	606	611	PF02516	0.592
MOD_N-GLC_1	89	94	PF02516	0.270
MOD_NEK2_1	189	194	PF00069	0.554
MOD_NEK2_1	449	454	PF00069	0.301
MOD_NEK2_1	456	461	PF00069	0.334
MOD_NEK2_1	51	56	PF00069	0.791
MOD_NEK2_1	538	543	PF00069	0.605
MOD_NEK2_2	169	174	PF00069	0.503
MOD_PIKK_1	24	30	PF00454	0.562
MOD_PIKK_1	290	296	PF00454	0.479
MOD_PIKK_1	363	369	PF00454	0.320
MOD_PK_1	349	355	PF00069	0.186
MOD_PKA_1	586	592	PF00069	0.400
MOD_PKA_1	596	602	PF00069	0.394
MOD_PKA_2	179	185	PF00069	0.598
MOD_PKA_2	348	354	PF00069	0.435
MOD_PKA_2	433	439	PF00069	0.367
MOD_PKA_2	502	508	PF00069	0.400
MOD_PKA_2	538	544	PF00069	0.509
MOD_PKA_2	8	14	PF00069	0.769
MOD_Plk_1	290	296	PF00069	0.666
MOD_Plk_1	373	379	PF00069	0.649
MOD_Plk_1	497	503	PF00069	0.425
MOD_Plk_1	51	57	PF00069	0.750
MOD_Plk_2-3	132	138	PF00069	0.650
MOD_Plk_2-3	61	67	PF00069	0.736
MOD_Plk_4	169	175	PF00069	0.486
MOD_Plk_4	184	190	PF00069	0.441
MOD_Plk_4	211	217	PF00069	0.570
MOD_Plk_4	264	270	PF00069	0.390
MOD_Plk_4	349	355	PF00069	0.335
MOD_Plk_4	445	451	PF00069	0.352
MOD_Plk_4	51	57	PF00069	0.748
MOD_Plk_4	538	544	PF00069	0.563
MOD_ProDKin_1	160	166	PF00069	0.517
MOD_ProDKin_1	306	312	PF00069	0.513
MOD_ProDKin_1	574	580	PF00069	0.295
MOD_ProDKin_1	601	607	PF00069	0.382
TRG_DiLeu_BaEn_1	195	200	PF01217	0.477
TRG_DiLeu_BaEn_2	450	456	PF01217	0.426
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.711
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.327
TRG_DiLeu_BaLyEn_6	576	581	PF01217	0.371
TRG_ENDOCYTIC_2	167	170	PF00928	0.495
TRG_ENDOCYTIC_2	186	189	PF00928	0.539
TRG_ENDOCYTIC_2	196	199	PF00928	0.533
TRG_ENDOCYTIC_2	266	269	PF00928	0.335
TRG_ENDOCYTIC_2	304	307	PF00928	0.572
TRG_ENDOCYTIC_2	311	314	PF00928	0.489
TRG_ENDOCYTIC_2	355	358	PF00928	0.255
TRG_ENDOCYTIC_2	387	390	PF00928	0.372
TRG_ENDOCYTIC_2	405	408	PF00928	0.326
TRG_ENDOCYTIC_2	486	489	PF00928	0.447
TRG_ENDOCYTIC_2	491	494	PF00928	0.438
TRG_ENDOCYTIC_2	552	555	PF00928	0.303
TRG_ER_diArg_1	286	289	PF00400	0.608
TRG_ER_diArg_1	381	384	PF00400	0.544
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.318
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A4	Leptomonas seymouri	23%	89%
A0A0S4IIV3	Bodo saltans	26%	82%
A0A1X0NUP0	Trypanosomatidae	21%	99%
A0A1X0P3P0	Trypanosomatidae	36%	91%
A0A3Q8IDV0	Leishmania donovani	77%	96%
A0A3R7R847	Trypanosoma rangeli	34%	94%
A0A3S7X5M8	Leishmania donovani	23%	100%
A0A422MY34	Trypanosoma rangeli	23%	99%
A4HKK2	Leishmania braziliensis	22%	100%
A4I834	Leishmania infantum	23%	100%
A4I956	Leishmania infantum	77%	96%
D0A6B6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	94%
E9B2Z2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q3Z3	Leishmania major	76%	100%
Q4Q564	Leishmania major	23%	100%
V5B8R5	Trypanosoma cruzi	33%	95%
V5BBK9	Trypanosoma cruzi	24%	100%