RSN1_TM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphate transport (Pho88), putative

Species:

Leishmania braziliensis

UniProt:

A4HLQ4_LEIBR

TriTrypDb:

LbrM.33.2200 , LBRM2903_330028800

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	11
GO:0016020	membrane	2	10
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HLQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLQ4

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	11
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0033365	protein localization to organelle	5	11
GO:0045047	protein targeting to ER	6	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0070972	protein localization to endoplasmic reticulum	6	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0072594	establishment of protein localization to organelle	4	11
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	187	189	PF00082	0.722
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.722
CLV_PCSK_SKI1_1	166	170	PF00082	0.669
CLV_PCSK_SKI1_1	82	86	PF00082	0.207
DEG_Nend_UBRbox_3	1	3	PF02207	0.260
DOC_PP1_RVXF_1	24	30	PF00149	0.294
DOC_USP7_UBL2_3	162	166	PF12436	0.462
DOC_USP7_UBL2_3	183	187	PF12436	0.614
DOC_WW_Pin1_4	174	179	PF00397	0.531
LIG_14-3-3_CanoR_1	26	32	PF00244	0.330
LIG_BRCT_BRCA1_1	122	126	PF00533	0.332
LIG_deltaCOP1_diTrp_1	151	157	PF00928	0.249
LIG_FHA_1	100	106	PF00498	0.372
LIG_FHA_1	28	34	PF00498	0.463
LIG_FHA_1	6	12	PF00498	0.331
LIG_FHA_2	17	23	PF00498	0.260
LIG_FHA_2	63	69	PF00498	0.460
LIG_LIR_Gen_1	30	39	PF02991	0.313
LIG_LIR_Gen_1	41	49	PF02991	0.326
LIG_LIR_Nem_3	101	106	PF02991	0.307
LIG_LIR_Nem_3	30	34	PF02991	0.264
LIG_LIR_Nem_3	41	47	PF02991	0.288
LIG_NRP_CendR_1	187	189	PF00754	0.700
LIG_Pex14_2	46	50	PF04695	0.283
LIG_SH2_STAT5	28	31	PF00017	0.273
LIG_SH2_STAT5	44	47	PF00017	0.344
LIG_SH2_STAT5	64	67	PF00017	0.439
LIG_SH3_3	172	178	PF00018	0.405
LIG_SH3_3	57	63	PF00018	0.541
LIG_SUMO_SIM_anti_2	8	13	PF11976	0.319
LIG_SUMO_SIM_par_1	107	113	PF11976	0.332
LIG_SUMO_SIM_par_1	7	13	PF11976	0.289
LIG_UBA3_1	110	118	PF00899	0.320
LIG_UBA3_1	125	131	PF00899	0.237
LIG_WRC_WIRS_1	28	33	PF05994	0.200
MOD_CK1_1	160	166	PF00069	0.393
MOD_CK1_1	182	188	PF00069	0.527
MOD_CK2_1	62	68	PF00069	0.533
MOD_GlcNHglycan	170	173	PF01048	0.645
MOD_GlcNHglycan	95	98	PF01048	0.436
MOD_GSK3_1	12	19	PF00069	0.285
MOD_GSK3_1	157	164	PF00069	0.409
MOD_GSK3_1	62	69	PF00069	0.538
MOD_N-GLC_1	157	162	PF02516	0.682
MOD_NEK2_1	110	115	PF00069	0.312
MOD_NEK2_1	168	173	PF00069	0.489
MOD_NEK2_1	5	10	PF00069	0.335
MOD_NEK2_1	84	89	PF00069	0.482
MOD_NEK2_1	98	103	PF00069	0.377
MOD_Plk_1	53	59	PF00069	0.493
MOD_Plk_1	82	88	PF00069	0.554
MOD_Plk_2-3	62	68	PF00069	0.522
MOD_Plk_4	53	59	PF00069	0.541
MOD_ProDKin_1	174	180	PF00069	0.534
MOD_SUMO_for_1	130	133	PF00179	0.305
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.266
TRG_ENDOCYTIC_2	103	106	PF00928	0.335
TRG_ENDOCYTIC_2	28	31	PF00928	0.323
TRG_ENDOCYTIC_2	44	47	PF00928	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP6	Leptomonas seymouri	60%	100%
A0A0S4IMC9	Bodo saltans	33%	94%
A0A3S7X6X6	Leishmania donovani	69%	100%
A0A422N623	Trypanosoma rangeli	39%	100%
A4HJX0	Leishmania braziliensis	98%	99%
A4I954	Leishmania infantum	69%	100%
D0A6C0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B429	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4Q3Z5	Leishmania major	70%	100%