CAF1C_H4-bd domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosome assembly protein RRB1, putative

Species:

Leishmania braziliensis

UniProt:

A4HLQ3_LEIBR

TriTrypDb:

LbrM.33.2190 , LBRM2903_330028700

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HLQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLQ3

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0022613	ribonucleoprotein complex biogenesis	4	1
GO:0042254	ribosome biogenesis	5	1
GO:0044085	cellular component biogenesis	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.521
CLV_C14_Caspase3-7	246	250	PF00656	0.590
CLV_C14_Caspase3-7	8	12	PF00656	0.629
CLV_NRD_NRD_1	467	469	PF00675	0.375
CLV_PCSK_KEX2_1	2	4	PF00082	0.580
CLV_PCSK_KEX2_1	44	46	PF00082	0.510
CLV_PCSK_KEX2_1	467	469	PF00082	0.495
CLV_PCSK_KEX2_1	6	8	PF00082	0.571
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.579
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.547
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.579
CLV_PCSK_SKI1_1	23	27	PF00082	0.476
CLV_PCSK_SKI1_1	257	261	PF00082	0.442
CLV_PCSK_SKI1_1	3	7	PF00082	0.598
CLV_PCSK_SKI1_1	302	306	PF00082	0.417
CLV_PCSK_SKI1_1	468	472	PF00082	0.488
CLV_PCSK_SKI1_1	477	481	PF00082	0.397
CLV_PCSK_SKI1_1	483	487	PF00082	0.315
CLV_PCSK_SKI1_1	98	102	PF00082	0.433
DEG_APCC_DBOX_1	199	207	PF00400	0.509
DEG_APCC_KENBOX_2	176	180	PF00400	0.355
DEG_Nend_UBRbox_1	1	4	PF02207	0.590
DOC_CKS1_1	335	340	PF01111	0.380
DOC_CKS1_1	469	474	PF01111	0.424
DOC_CYCLIN_yClb1_LxF_4	145	150	PF00134	0.586
DOC_MAPK_gen_1	328	335	PF00069	0.416
DOC_MAPK_gen_1	421	430	PF00069	0.485
DOC_MAPK_gen_1	444	453	PF00069	0.344
DOC_MAPK_gen_1	482	490	PF00069	0.403
DOC_MAPK_MEF2A_6	162	170	PF00069	0.410
DOC_MAPK_MEF2A_6	200	208	PF00069	0.501
DOC_PP1_RVXF_1	145	151	PF00149	0.366
DOC_PP1_RVXF_1	425	431	PF00149	0.353
DOC_PP1_RVXF_1	573	580	PF00149	0.219
DOC_PP1_RVXF_1	99	106	PF00149	0.477
DOC_PP4_FxxP_1	335	338	PF00568	0.362
DOC_USP7_MATH_1	123	127	PF00917	0.593
DOC_USP7_MATH_1	277	281	PF00917	0.519
DOC_USP7_MATH_1	338	342	PF00917	0.390
DOC_USP7_MATH_1	432	436	PF00917	0.382
DOC_USP7_MATH_1	484	488	PF00917	0.437
DOC_USP7_UBL2_3	2	6	PF12436	0.617
DOC_USP7_UBL2_3	26	30	PF12436	0.390
DOC_WW_Pin1_4	334	339	PF00397	0.375
DOC_WW_Pin1_4	396	401	PF00397	0.322
DOC_WW_Pin1_4	468	473	PF00397	0.480
LIG_14-3-3_CanoR_1	302	310	PF00244	0.476
LIG_14-3-3_CanoR_1	378	383	PF00244	0.364
LIG_14-3-3_CanoR_1	446	453	PF00244	0.361
LIG_APCC_ABBA_1	490	495	PF00400	0.330
LIG_BIR_III_4	14	18	PF00653	0.484
LIG_BRCT_BRCA1_1	101	105	PF00533	0.621
LIG_BRCT_BRCA1_1	486	490	PF00533	0.292
LIG_CaM_NSCaTE_8	128	135	PF13499	0.551
LIG_eIF4E_1	568	574	PF01652	0.293
LIG_FHA_1	185	191	PF00498	0.514
LIG_FHA_1	95	101	PF00498	0.546
LIG_FHA_2	134	140	PF00498	0.426
LIG_FHA_2	191	197	PF00498	0.514
LIG_FHA_2	212	218	PF00498	0.406
LIG_FHA_2	399	405	PF00498	0.361
LIG_FHA_2	452	458	PF00498	0.297
LIG_FHA_2	484	490	PF00498	0.291
LIG_FHA_2	506	512	PF00498	0.305
LIG_FHA_2	564	570	PF00498	0.437
LIG_FHA_2	6	12	PF00498	0.633
LIG_Integrin_RGD_1	129	131	PF01839	0.607
LIG_LIR_Gen_1	169	175	PF02991	0.413
LIG_LIR_Gen_1	350	359	PF02991	0.259
LIG_LIR_Gen_1	82	91	PF02991	0.539
LIG_LIR_Nem_3	156	161	PF02991	0.410
LIG_LIR_Nem_3	163	168	PF02991	0.410
LIG_LIR_Nem_3	169	173	PF02991	0.410
LIG_LIR_Nem_3	350	354	PF02991	0.327
LIG_LIR_Nem_3	376	382	PF02991	0.317
LIG_LIR_Nem_3	565	571	PF02991	0.292
LIG_LIR_Nem_3	82	88	PF02991	0.523
LIG_LYPXL_yS_3	165	168	PF13949	0.410
LIG_PCNA_PIPBox_1	522	531	PF02747	0.541
LIG_PCNA_yPIPBox_3	516	529	PF02747	0.527
LIG_PTB_Apo_2	149	156	PF02174	0.410
LIG_PTB_Phospho_1	149	155	PF10480	0.410
LIG_REV1ctd_RIR_1	156	165	PF16727	0.410
LIG_SH2_NCK_1	216	220	PF00017	0.614
LIG_SH2_STAP1	155	159	PF00017	0.424
LIG_SH2_STAT3	536	539	PF00017	0.492
LIG_SH2_STAT5	207	210	PF00017	0.431
LIG_SH2_STAT5	228	231	PF00017	0.572
LIG_SH3_3	367	373	PF00018	0.302
LIG_SUMO_SIM_anti_2	202	207	PF11976	0.483
LIG_SUMO_SIM_anti_2	495	504	PF11976	0.385
LIG_SUMO_SIM_par_1	280	288	PF11976	0.329
LIG_SUMO_SIM_par_1	495	504	PF11976	0.306
LIG_TRAF2_1	392	395	PF00917	0.309
LIG_UBA3_1	573	580	PF00899	0.442
MOD_CK1_1	308	314	PF00069	0.519
MOD_CK1_1	341	347	PF00069	0.372
MOD_CK1_1	353	359	PF00069	0.355
MOD_CK1_1	381	387	PF00069	0.394
MOD_CK1_1	496	502	PF00069	0.324
MOD_CK2_1	101	107	PF00069	0.652
MOD_CK2_1	133	139	PF00069	0.433
MOD_CK2_1	389	395	PF00069	0.336
MOD_CK2_1	451	457	PF00069	0.440
MOD_CK2_1	483	489	PF00069	0.301
MOD_CK2_1	563	569	PF00069	0.436
MOD_Cter_Amidation	326	329	PF01082	0.401
MOD_GlcNHglycan	277	280	PF01048	0.497
MOD_GlcNHglycan	360	363	PF01048	0.269
MOD_GlcNHglycan	457	460	PF01048	0.306
MOD_GlcNHglycan	529	532	PF01048	0.544
MOD_GlcNHglycan	91	95	PF01048	0.620
MOD_GSK3_1	217	224	PF00069	0.491
MOD_GSK3_1	334	341	PF00069	0.378
MOD_GSK3_1	349	356	PF00069	0.323
MOD_GSK3_1	378	385	PF00069	0.350
MOD_GSK3_1	451	458	PF00069	0.299
MOD_GSK3_1	90	97	PF00069	0.588
MOD_LATS_1	481	487	PF00433	0.411
MOD_N-GLC_1	178	183	PF02516	0.221
MOD_N-GLC_1	221	226	PF02516	0.659
MOD_N-GLC_1	308	313	PF02516	0.466
MOD_N-GLC_1	493	498	PF02516	0.323
MOD_N-GLC_2	210	212	PF02516	0.210
MOD_NEK2_1	148	153	PF00069	0.410
MOD_NEK2_1	206	211	PF00069	0.421
MOD_NEK2_1	349	354	PF00069	0.253
MOD_NEK2_1	406	411	PF00069	0.226
MOD_NEK2_1	451	456	PF00069	0.291
MOD_NEK2_2	364	369	PF00069	0.365
MOD_PIKK_1	190	196	PF00454	0.410
MOD_PIKK_1	277	283	PF00454	0.501
MOD_PIKK_1	398	404	PF00454	0.372
MOD_PK_1	378	384	PF00069	0.278
MOD_PKA_1	6	12	PF00069	0.670
MOD_PKA_2	6	12	PF00069	0.672
MOD_PKB_1	444	452	PF00069	0.394
MOD_Plk_1	349	355	PF00069	0.259
MOD_Plk_1	493	499	PF00069	0.336
MOD_Plk_1	510	516	PF00069	0.261
MOD_Plk_2-3	133	139	PF00069	0.457
MOD_Plk_2-3	217	223	PF00069	0.488
MOD_Plk_2-3	232	238	PF00069	0.561
MOD_Plk_2-3	52	58	PF00069	0.580
MOD_Plk_4	123	129	PF00069	0.524
MOD_Plk_4	184	190	PF00069	0.413
MOD_Plk_4	364	370	PF00069	0.292
MOD_Plk_4	459	465	PF00069	0.209
MOD_Plk_4	493	499	PF00069	0.306
MOD_Plk_4	505	511	PF00069	0.275
MOD_Plk_4	578	584	PF00069	0.472
MOD_ProDKin_1	334	340	PF00069	0.379
MOD_ProDKin_1	396	402	PF00069	0.330
MOD_ProDKin_1	468	474	PF00069	0.474
MOD_SUMO_for_1	146	149	PF00179	0.554
MOD_SUMO_for_1	29	32	PF00179	0.501
TRG_ENDOCYTIC_2	155	158	PF00928	0.410
TRG_ENDOCYTIC_2	165	168	PF00928	0.410
TRG_ENDOCYTIC_2	568	571	PF00928	0.330
TRG_ENDOCYTIC_2	85	88	PF00928	0.519
TRG_ER_diArg_1	35	38	PF00400	0.562
TRG_ER_diArg_1	466	468	PF00400	0.504
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P833	Leptomonas seymouri	81%	100%
A0A0S4IIU6	Bodo saltans	63%	97%
A0A1X0P3N3	Trypanosomatidae	63%	100%
A0A3S7X390	Leishmania donovani	23%	90%
A0A3S7X6T4	Leishmania donovani	88%	100%
A0A422N600	Trypanosoma rangeli	60%	100%
A4I5C6	Leishmania infantum	23%	90%
A4I953	Leishmania infantum	88%	100%
D0A6C1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9B0M4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	90%
E9B428	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O22466	Solanum lycopersicum	24%	100%
O22467	Arabidopsis thaliana	24%	100%
O22468	Arabidopsis thaliana	23%	100%
O22469	Arabidopsis thaliana	23%	100%
P90916	Caenorhabditis elegans	24%	100%
Q04225	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q10G81	Oryza sativa subsp. japonica	23%	100%
Q1JQD2	Bos taurus	31%	100%
Q24572	Drosophila melanogaster	24%	100%
Q2UA71	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	22%	100%
Q4I7L0	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	21%	100%
Q4P553	Ustilago maydis (strain 521 / FGSC 9021)	25%	100%
Q4Q3Z6	Leishmania major	89%	100%
Q4WEI5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	23%	100%
Q54ED4	Dictyostelium discoideum	33%	100%
Q54SD4	Dictyostelium discoideum	25%	100%
Q5XI13	Rattus norvegicus	31%	100%
Q61Y48	Caenorhabditis briggsae	23%	100%
Q7S7N3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	21%	100%
Q810D6	Mus musculus	31%	100%
Q9BQ67	Homo sapiens	33%	100%
Q9I8G9	Gallus gallus	23%	100%
Q9P783	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q9SU78	Arabidopsis thaliana	23%	100%
Q9ZUN8	Arabidopsis thaliana	33%	100%
V5BPB2	Trypanosoma cruzi	57%	94%