Charged multivesicular body protein 1a

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vesicular protein trafficking mediator, putative

Species:

Leishmania braziliensis

UniProt:

A4HLQ2_LEIBR

TriTrypDb:

LbrM.33.2180 , LBRM2903_330028600

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000815	ESCRT III complex	3	8
GO:0016363	nuclear matrix	2	8
GO:0032991	protein-containing complex	1	8
GO:0036452	ESCRT complex	2	8
GO:0098796	membrane protein complex	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005768	endosome	7	1
GO:0005770	late endosome	8	1
GO:0005771	multivesicular body	9	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A4HLQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLQ2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006996	organelle organization	4	8
GO:0007034	vacuolar transport	4	12
GO:0007076	mitotic chromosome condensation	4	8
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	8
GO:0016192	vesicle-mediated transport	4	8
GO:0022402	cell cycle process	2	8
GO:0030261	chromosome condensation	6	8
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051276	chromosome organization	5	8
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0071840	cellular component organization or biogenesis	2	8
GO:1903047	mitotic cell cycle process	3	8
GO:0008104	protein localization	4	1
GO:0015031	protein transport	4	1
GO:0016197	endosomal transport	4	1
GO:0032509	endosome transport via multivesicular body sorting pathway	5	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0045324	late endosome to vacuole transport	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071985	multivesicular body sorting pathway	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.256
CLV_C14_Caspase3-7	150	154	PF00656	0.174
CLV_C14_Caspase3-7	73	77	PF00656	0.256
CLV_NRD_NRD_1	184	186	PF00675	0.616
CLV_NRD_NRD_1	59	61	PF00675	0.315
CLV_PCSK_KEX2_1	61	63	PF00082	0.310
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.310
CLV_PCSK_SKI1_1	113	117	PF00082	0.449
CLV_PCSK_SKI1_1	19	23	PF00082	0.332
CLV_PCSK_SKI1_1	40	44	PF00082	0.302
CLV_PCSK_SKI1_1	89	93	PF00082	0.375
DEG_SPOP_SBC_1	94	98	PF00917	0.174
DOC_USP7_MATH_1	25	29	PF00917	0.345
DOC_USP7_MATH_1	77	81	PF00917	0.310
DOC_USP7_UBL2_3	100	104	PF12436	0.269
DOC_USP7_UBL2_3	15	19	PF12436	0.334
DOC_USP7_UBL2_3	170	174	PF12436	0.174
DOC_USP7_UBL2_3	30	34	PF12436	0.288
DOC_USP7_UBL2_3	41	45	PF12436	0.323
DOC_USP7_UBL2_3	89	93	PF12436	0.388
LIG_14-3-3_CanoR_1	113	118	PF00244	0.174
LIG_14-3-3_CanoR_1	81	90	PF00244	0.368
LIG_DLG_GKlike_1	62	69	PF00625	0.225
LIG_FHA_1	125	131	PF00498	0.315
LIG_FHA_1	144	150	PF00498	0.323
LIG_FHA_2	114	120	PF00498	0.293
LIG_FHA_2	148	154	PF00498	0.407
LIG_LIR_Gen_1	65	75	PF02991	0.200
LIG_LIR_Nem_3	65	71	PF02991	0.200
LIG_Pex14_2	12	16	PF04695	0.338
LIG_PTB_Apo_2	10	17	PF02174	0.449
LIG_SH2_STAP1	54	58	PF00017	0.310
LIG_SH2_STAT5	68	71	PF00017	0.310
LIG_TYR_ITIM	66	71	PF00017	0.345
LIG_UBA3_1	10	19	PF00899	0.314
MOD_CK1_1	142	148	PF00069	0.308
MOD_CK1_1	28	34	PF00069	0.294
MOD_CK2_1	151	157	PF00069	0.339
MOD_GlcNHglycan	142	145	PF01048	0.304
MOD_GlcNHglycan	166	170	PF01048	0.355
MOD_GlcNHglycan	23	26	PF01048	0.310
MOD_GlcNHglycan	29	33	PF01048	0.310
MOD_GSK3_1	139	146	PF00069	0.318
MOD_GSK3_1	147	154	PF00069	0.336
MOD_GSK3_1	15	22	PF00069	0.314
MOD_GSK3_1	165	172	PF00069	0.139
MOD_GSK3_1	77	84	PF00069	0.365
MOD_GSK3_1	89	96	PF00069	0.189
MOD_N-GLC_1	140	145	PF02516	0.174
MOD_N-GLC_1	62	67	PF02516	0.225
MOD_NEK2_1	139	144	PF00069	0.323
MOD_NEK2_1	176	181	PF00069	0.710
MOD_NEK2_1	21	26	PF00069	0.344
MOD_NEK2_1	95	100	PF00069	0.297
MOD_PKB_1	60	68	PF00069	0.225
MOD_Plk_1	62	68	PF00069	0.216
MOD_Plk_2-3	151	157	PF00069	0.200
MOD_Plk_4	113	119	PF00069	0.174
MOD_Plk_4	151	157	PF00069	0.310
TRG_DiLeu_BaEn_1	151	156	PF01217	0.345
TRG_ENDOCYTIC_2	68	71	PF00928	0.302
TRG_ER_diArg_1	59	62	PF00400	0.310

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2G2	Leptomonas seymouri	49%	100%
A0A0N1IMC7	Leptomonas seymouri	75%	100%
A0A0S4IQI9	Bodo saltans	65%	96%
A0A0S4JPB9	Bodo saltans	45%	100%
A0A1X0P5A2	Trypanosomatidae	45%	99%
A0A3Q8IGX6	Leishmania donovani	86%	100%
A0A3R7NNK8	Trypanosoma rangeli	43%	99%
A0A3S7X9V9	Leishmania donovani	46%	99%
A0A422N603	Trypanosoma rangeli	64%	97%
A4HNA9	Leishmania braziliensis	47%	100%
A4I952	Leishmania infantum	86%	100%
A4IBY0	Leishmania infantum	46%	99%
C9ZYM6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	99%
D0A6C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	82%
E9AFR7	Leishmania major	46%	100%
E9B427	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9B6X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	99%
O60074	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	100%
O96552	Dictyostelium discoideum	41%	100%
P69771	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
Q3SX42	Bos taurus	30%	96%
Q4Q3Z7	Leishmania major	84%	100%
Q54DB1	Dictyostelium discoideum	25%	100%
Q5E994	Bos taurus	40%	100%
Q5F3A2	Gallus gallus	28%	95%
Q5R605	Pongo abelii	47%	100%
Q5RAV2	Pongo abelii	29%	96%
Q5ZKX1	Gallus gallus	40%	100%
Q66IV6	Xenopus laevis	27%	95%
Q6DF27	Xenopus tropicalis	41%	100%
Q6NUD8	Xenopus laevis	46%	100%
Q6NVL7	Xenopus tropicalis	26%	95%
Q6NXD2	Danio rerio	26%	95%
Q6PHF0	Danio rerio	45%	100%
Q7LBR1	Homo sapiens	40%	100%
Q7SYR0	Xenopus laevis	24%	95%
Q7SZB5	Xenopus laevis	41%	100%
Q7ZVB1	Danio rerio	41%	100%
Q84VG1	Oryza sativa subsp. japonica	42%	100%
Q8BJF9	Mus musculus	30%	96%
Q8LE58	Arabidopsis thaliana	43%	100%
Q921W0	Mus musculus	47%	100%
Q941D5	Arabidopsis thaliana	28%	97%
Q99LU0	Mus musculus	40%	100%
Q9CQD4	Mus musculus	40%	100%
Q9HD42	Homo sapiens	47%	100%
Q9SKI2	Arabidopsis thaliana	28%	91%
Q9SSM4	Arabidopsis thaliana	43%	100%
Q9UQN3	Homo sapiens	29%	96%