Ig-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLQ0_LEIBR

TriTrypDb:

LbrM.33.2160 , LBRM2903_330028400

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HLQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLQ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	244	248	PF00656	0.314
CLV_C14_Caspase3-7	3	7	PF00656	0.306
CLV_C14_Caspase3-7	300	304	PF00656	0.442
CLV_C14_Caspase3-7	574	578	PF00656	0.418
CLV_NRD_NRD_1	143	145	PF00675	0.692
CLV_NRD_NRD_1	231	233	PF00675	0.652
CLV_NRD_NRD_1	382	384	PF00675	0.611
CLV_NRD_NRD_1	497	499	PF00675	0.703
CLV_PCSK_KEX2_1	143	145	PF00082	0.692
CLV_PCSK_KEX2_1	231	233	PF00082	0.706
CLV_PCSK_KEX2_1	267	269	PF00082	0.667
CLV_PCSK_KEX2_1	382	384	PF00082	0.611
CLV_PCSK_KEX2_1	497	499	PF00082	0.703
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.551
CLV_PCSK_PC1ET2_1	497	499	PF00082	0.703
CLV_PCSK_PC7_1	493	499	PF00082	0.765
CLV_PCSK_SKI1_1	239	243	PF00082	0.542
CLV_PCSK_SKI1_1	271	275	PF00082	0.581
CLV_PCSK_SKI1_1	549	553	PF00082	0.608
CLV_PCSK_SKI1_1	8	12	PF00082	0.498
DEG_APCC_DBOX_1	548	556	PF00400	0.341
DEG_COP1_1	150	158	PF00400	0.412
DEG_SPOP_SBC_1	32	36	PF00917	0.438
DEG_SPOP_SBC_1	410	414	PF00917	0.547
DEG_SPOP_SBC_1	522	526	PF00917	0.503
DOC_CKS1_1	325	330	PF01111	0.457
DOC_MAPK_gen_1	497	507	PF00069	0.442
DOC_MAPK_MEF2A_6	447	454	PF00069	0.520
DOC_MAPK_MEF2A_6	549	556	PF00069	0.336
DOC_MAPK_NFAT4_5	549	557	PF00069	0.343
DOC_PP1_RVXF_1	179	185	PF00149	0.317
DOC_PP2B_LxvP_1	163	166	PF13499	0.450
DOC_PP4_FxxP_1	436	439	PF00568	0.381
DOC_USP7_MATH_1	154	158	PF00917	0.521
DOC_USP7_MATH_1	166	170	PF00917	0.329
DOC_USP7_MATH_1	243	247	PF00917	0.357
DOC_USP7_MATH_1	314	318	PF00917	0.522
DOC_USP7_MATH_1	361	365	PF00917	0.413
DOC_USP7_MATH_1	416	420	PF00917	0.564
DOC_USP7_MATH_1	508	512	PF00917	0.499
DOC_USP7_MATH_1	523	527	PF00917	0.603
DOC_USP7_MATH_1	72	76	PF00917	0.358
DOC_USP7_MATH_1	82	86	PF00917	0.356
DOC_USP7_MATH_1	87	91	PF00917	0.419
DOC_USP7_UBL2_3	177	181	PF12436	0.440
DOC_USP7_UBL2_3	443	447	PF12436	0.420
DOC_USP7_UBL2_3	497	501	PF12436	0.503
DOC_WW_Pin1_4	158	163	PF00397	0.517
DOC_WW_Pin1_4	190	195	PF00397	0.440
DOC_WW_Pin1_4	28	33	PF00397	0.432
DOC_WW_Pin1_4	324	329	PF00397	0.516
DOC_WW_Pin1_4	516	521	PF00397	0.572
LIG_14-3-3_CanoR_1	106	111	PF00244	0.354
LIG_14-3-3_CanoR_1	340	349	PF00244	0.452
LIG_14-3-3_CanoR_1	383	393	PF00244	0.370
LIG_14-3-3_CanoR_1	480	484	PF00244	0.575
LIG_Actin_WH2_2	168	185	PF00022	0.421
LIG_APCC_ABBA_1	10	15	PF00400	0.302
LIG_BRCT_BRCA1_1	210	214	PF00533	0.389
LIG_BRCT_BRCA1_1	248	252	PF00533	0.279
LIG_BRCT_BRCA1_1	53	57	PF00533	0.357
LIG_deltaCOP1_diTrp_1	256	263	PF00928	0.336
LIG_deltaCOP1_diTrp_1	595	602	PF00928	0.406
LIG_FHA_1	158	164	PF00498	0.483
LIG_FHA_1	168	174	PF00498	0.321
LIG_FHA_1	343	349	PF00498	0.435
LIG_FHA_1	385	391	PF00498	0.350
LIG_FHA_1	54	60	PF00498	0.311
LIG_FHA_1	574	580	PF00498	0.421
LIG_FHA_2	1	7	PF00498	0.309
LIG_FHA_2	242	248	PF00498	0.317
LIG_FHA_2	267	273	PF00498	0.338
LIG_FHA_2	471	477	PF00498	0.470
LIG_FHA_2	516	522	PF00498	0.502
LIG_FHA_2	572	578	PF00498	0.414
LIG_Integrin_RGD_1	97	99	PF01839	0.688
LIG_LIR_Gen_1	247	254	PF02991	0.400
LIG_LIR_Gen_1	369	380	PF02991	0.431
LIG_LIR_Gen_1	54	65	PF02991	0.311
LIG_LIR_Gen_1	6	14	PF02991	0.302
LIG_LIR_Nem_3	211	217	PF02991	0.388
LIG_LIR_Nem_3	247	253	PF02991	0.402
LIG_LIR_Nem_3	369	375	PF02991	0.435
LIG_LIR_Nem_3	432	438	PF02991	0.382
LIG_LIR_Nem_3	54	60	PF02991	0.347
LIG_LIR_Nem_3	6	12	PF02991	0.298
LIG_PCNA_yPIPBox_3	545	555	PF02747	0.349
LIG_Pex14_2	566	570	PF04695	0.434
LIG_SH2_CRK	61	65	PF00017	0.303
LIG_SH2_STAT5	435	438	PF00017	0.373
LIG_SH3_2	319	324	PF14604	0.458
LIG_SH3_3	150	156	PF00018	0.411
LIG_SH3_3	192	198	PF00018	0.321
LIG_SH3_3	316	322	PF00018	0.508
LIG_SH3_3	482	488	PF00018	0.453
LIG_SH3_3	517	523	PF00018	0.455
LIG_SUMO_SIM_anti_2	75	81	PF11976	0.251
LIG_SUMO_SIM_par_1	169	176	PF11976	0.395
LIG_TYR_ITIM	433	438	PF00017	0.539
LIG_TYR_ITIM	59	64	PF00017	0.340
LIG_UBA3_1	171	177	PF00899	0.327
LIG_WRC_WIRS_1	107	112	PF05994	0.384
MOD_CDK_SPxxK_3	324	331	PF00069	0.571
MOD_CK1_1	157	163	PF00069	0.598
MOD_CK1_1	193	199	PF00069	0.537
MOD_CK1_1	246	252	PF00069	0.334
MOD_CK1_1	31	37	PF00069	0.546
MOD_CK1_1	323	329	PF00069	0.608
MOD_CK1_1	364	370	PF00069	0.406
MOD_CK1_1	409	415	PF00069	0.692
MOD_CK1_1	478	484	PF00069	0.631
MOD_CK1_1	486	492	PF00069	0.612
MOD_CK1_1	51	57	PF00069	0.434
MOD_CK1_1	516	522	PF00069	0.728
MOD_CK1_1	525	531	PF00069	0.640
MOD_CK1_1	535	541	PF00069	0.574
MOD_CK1_1	598	604	PF00069	0.233
MOD_CK2_1	108	114	PF00069	0.390
MOD_CK2_1	266	272	PF00069	0.520
MOD_CK2_1	275	281	PF00069	0.412
MOD_CK2_1	470	476	PF00069	0.615
MOD_CK2_1	489	495	PF00069	0.746
MOD_CK2_1	515	521	PF00069	0.660
MOD_Cter_Amidation	265	268	PF01082	0.390
MOD_Cter_Amidation	495	498	PF01082	0.635
MOD_GlcNHglycan	163	166	PF01048	0.632
MOD_GlcNHglycan	195	198	PF01048	0.367
MOD_GlcNHglycan	293	296	PF01048	0.535
MOD_GlcNHglycan	418	421	PF01048	0.693
MOD_GlcNHglycan	463	467	PF01048	0.745
MOD_GlcNHglycan	515	518	PF01048	0.602
MOD_GlcNHglycan	525	528	PF01048	0.674
MOD_GlcNHglycan	534	537	PF01048	0.566
MOD_GlcNHglycan	560	563	PF01048	0.461
MOD_GlcNHglycan	84	87	PF01048	0.472
MOD_GlcNHglycan	89	92	PF01048	0.552
MOD_GSK3_1	154	161	PF00069	0.618
MOD_GSK3_1	193	200	PF00069	0.535
MOD_GSK3_1	235	242	PF00069	0.615
MOD_GSK3_1	275	282	PF00069	0.464
MOD_GSK3_1	28	35	PF00069	0.541
MOD_GSK3_1	291	298	PF00069	0.620
MOD_GSK3_1	320	327	PF00069	0.613
MOD_GSK3_1	366	373	PF00069	0.530
MOD_GSK3_1	406	413	PF00069	0.725
MOD_GSK3_1	416	423	PF00069	0.720
MOD_GSK3_1	442	449	PF00069	0.611
MOD_GSK3_1	458	465	PF00069	0.811
MOD_GSK3_1	475	482	PF00069	0.611
MOD_GSK3_1	48	55	PF00069	0.430
MOD_GSK3_1	521	528	PF00069	0.619
MOD_GSK3_1	82	89	PF00069	0.407
MOD_NEK2_1	108	113	PF00069	0.481
MOD_NEK2_1	21	26	PF00069	0.396
MOD_NEK2_1	351	356	PF00069	0.408
MOD_NEK2_1	442	447	PF00069	0.580
MOD_NEK2_1	52	57	PF00069	0.394
MOD_NEK2_2	208	213	PF00069	0.341
MOD_NEK2_2	266	271	PF00069	0.382
MOD_PIKK_1	275	281	PF00454	0.462
MOD_PIKK_1	342	348	PF00454	0.480
MOD_PK_1	501	507	PF00069	0.543
MOD_PKA_1	143	149	PF00069	0.651
MOD_PKA_1	501	507	PF00069	0.618
MOD_PKA_2	143	149	PF00069	0.649
MOD_PKA_2	479	485	PF00069	0.589
MOD_Plk_1	21	27	PF00069	0.406
MOD_Plk_1	256	262	PF00069	0.399
MOD_Plk_1	314	320	PF00069	0.565
MOD_Plk_1	370	376	PF00069	0.510
MOD_Plk_1	478	484	PF00069	0.561
MOD_Plk_4	100	106	PF00069	0.489
MOD_Plk_4	167	173	PF00069	0.422
MOD_Plk_4	197	203	PF00069	0.422
MOD_Plk_4	246	252	PF00069	0.334
MOD_Plk_4	353	359	PF00069	0.393
MOD_Plk_4	598	604	PF00069	0.233
MOD_ProDKin_1	158	164	PF00069	0.647
MOD_ProDKin_1	190	196	PF00069	0.539
MOD_ProDKin_1	28	34	PF00069	0.533
MOD_ProDKin_1	324	330	PF00069	0.646
MOD_ProDKin_1	516	522	PF00069	0.728
TRG_DiLeu_BaEn_1	114	119	PF01217	0.405
TRG_DiLeu_BaLyEn_6	550	555	PF01217	0.478
TRG_ENDOCYTIC_2	435	438	PF00928	0.449
TRG_ENDOCYTIC_2	61	64	PF00928	0.361
TRG_ER_diArg_1	142	144	PF00400	0.560
TRG_ER_diArg_1	231	234	PF00400	0.635
TRG_ER_diArg_1	334	337	PF00400	0.557
TRG_ER_diArg_1	381	383	PF00400	0.541
TRG_NLS_MonoCore_2	496	501	PF00514	0.624
TRG_NLS_MonoExtC_3	496	501	PF00514	0.634
TRG_NLS_MonoExtN_4	497	504	PF00514	0.629
TRG_Pf-PMV_PEXEL_1	136	141	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	340	344	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I907	Leptomonas seymouri	47%	100%
A0A3S7X6X8	Leishmania donovani	69%	100%
A4I950	Leishmania infantum	69%	100%
E9B425	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4Q3Z9	Leishmania major	69%	100%