Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLP9_LEIBR

TriTrypDb:

LbrM.33.2150 , LBRM2903_330028300

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLP9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.511
CLV_NRD_NRD_1	208	210	PF00675	0.444
CLV_NRD_NRD_1	278	280	PF00675	0.524
CLV_NRD_NRD_1	77	79	PF00675	0.525
CLV_PCSK_KEX2_1	208	210	PF00082	0.444
CLV_PCSK_KEX2_1	278	280	PF00082	0.524
CLV_PCSK_KEX2_1	77	79	PF00082	0.672
CLV_PCSK_SKI1_1	191	195	PF00082	0.543
CLV_PCSK_SKI1_1	226	230	PF00082	0.469
CLV_PCSK_SKI1_1	246	250	PF00082	0.573
CLV_PCSK_SKI1_1	251	255	PF00082	0.669
CLV_PCSK_SKI1_1	281	285	PF00082	0.583
CLV_PCSK_SKI1_1	77	81	PF00082	0.653
CLV_Separin_Metazoa	132	136	PF03568	0.366
DEG_APCC_DBOX_1	280	288	PF00400	0.507
DOC_MAPK_FxFP_2	289	292	PF00069	0.479
DOC_PP1_RVXF_1	135	141	PF00149	0.511
DOC_PP4_FxxP_1	289	292	PF00568	0.479
DOC_USP7_MATH_1	142	146	PF00917	0.516
DOC_USP7_MATH_1	164	168	PF00917	0.626
LIG_14-3-3_CanoR_1	112	116	PF00244	0.373
LIG_14-3-3_CanoR_1	135	141	PF00244	0.511
LIG_14-3-3_CanoR_1	226	236	PF00244	0.600
LIG_14-3-3_CanoR_1	246	254	PF00244	0.466
LIG_14-3-3_CanoR_1	260	268	PF00244	0.611
LIG_14-3-3_CanoR_1	269	274	PF00244	0.639
LIG_14-3-3_CanoR_1	5	14	PF00244	0.484
LIG_14-3-3_CanoR_1	56	66	PF00244	0.414
LIG_APCC_ABBA_1	127	132	PF00400	0.381
LIG_BRCT_BRCA1_1	287	291	PF00533	0.490
LIG_CaM_IQ_9	258	273	PF13499	0.614
LIG_deltaCOP1_diTrp_1	12	20	PF00928	0.473
LIG_FHA_1	1	7	PF00498	0.467
LIG_FHA_1	122	128	PF00498	0.512
LIG_FHA_1	58	64	PF00498	0.387
LIG_FHA_1	88	94	PF00498	0.443
LIG_FHA_2	43	49	PF00498	0.501
LIG_LIR_Apic_2	288	294	PF02991	0.473
LIG_LIR_Gen_1	122	130	PF02991	0.522
LIG_LIR_Gen_1	139	148	PF02991	0.341
LIG_LIR_Gen_1	45	54	PF02991	0.532
LIG_LIR_Gen_1	94	105	PF02991	0.377
LIG_LIR_Nem_3	12	17	PF02991	0.529
LIG_LIR_Nem_3	122	126	PF02991	0.495
LIG_LIR_Nem_3	139	143	PF02991	0.334
LIG_LIR_Nem_3	263	268	PF02991	0.617
LIG_LIR_Nem_3	45	50	PF02991	0.645
LIG_LIR_Nem_3	94	100	PF02991	0.517
LIG_PCNA_PIPBox_1	13	22	PF02747	0.389
LIG_PDZ_Class_2	292	297	PF00595	0.464
LIG_SH2_STAP1	119	123	PF00017	0.474
LIG_SH2_STAP1	130	134	PF00017	0.406
LIG_SH2_STAT5	43	46	PF00017	0.610
LIG_TRAF2_1	129	132	PF00917	0.379
LIG_UBA3_1	216	224	PF00899	0.561
LIG_UBA3_1	239	243	PF00899	0.505
MOD_CK1_1	175	181	PF00069	0.468
MOD_CK1_1	182	188	PF00069	0.408
MOD_CK1_1	227	233	PF00069	0.615
MOD_CK1_1	272	278	PF00069	0.514
MOD_CK2_1	119	125	PF00069	0.521
MOD_CK2_1	42	48	PF00069	0.504
MOD_Cter_Amidation	75	78	PF01082	0.377
MOD_GlcNHglycan	179	182	PF01048	0.583
MOD_GlcNHglycan	22	25	PF01048	0.524
MOD_GlcNHglycan	233	236	PF01048	0.605
MOD_GlcNHglycan	255	259	PF01048	0.702
MOD_GlcNHglycan	262	265	PF01048	0.547
MOD_GSK3_1	111	118	PF00069	0.467
MOD_GSK3_1	172	179	PF00069	0.599
MOD_GSK3_1	224	231	PF00069	0.476
MOD_GSK3_1	256	263	PF00069	0.525
MOD_NEK2_1	111	116	PF00069	0.425
MOD_NEK2_1	163	168	PF00069	0.644
MOD_NEK2_1	172	177	PF00069	0.540
MOD_NEK2_1	20	25	PF00069	0.553
MOD_NEK2_1	228	233	PF00069	0.538
MOD_NEK2_1	254	259	PF00069	0.590
MOD_NEK2_1	58	63	PF00069	0.431
MOD_NEK2_1	92	97	PF00069	0.449
MOD_PK_1	269	275	PF00069	0.509
MOD_PKA_2	111	117	PF00069	0.373
MOD_PKA_2	136	142	PF00069	0.510
MOD_PKA_2	164	170	PF00069	0.659
MOD_Plk_1	173	179	PF00069	0.538
MOD_Plk_1	93	99	PF00069	0.472
MOD_Plk_2-3	192	198	PF00069	0.418
MOD_Plk_2-3	42	48	PF00069	0.504
MOD_Plk_4	111	117	PF00069	0.424
TRG_DiLeu_BaEn_1	65	70	PF01217	0.505
TRG_DiLeu_BaEn_2	74	80	PF01217	0.513
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.559
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.413
TRG_ENDOCYTIC_2	130	133	PF00928	0.630
TRG_ENDOCYTIC_2	17	20	PF00928	0.527
TRG_ENDOCYTIC_2	47	50	PF00928	0.654
TRG_ER_diArg_1	134	137	PF00400	0.501
TRG_ER_diArg_1	268	271	PF00400	0.638
TRG_ER_diArg_1	277	279	PF00400	0.541
TRG_ER_diArg_1	77	79	PF00400	0.525
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	5	9	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6V8	Leishmania donovani	71%	100%
E9AHN7	Leishmania infantum	71%	100%
E9B424	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4Q400	Leishmania major	71%	100%