Nucleolar GTP-binding protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleolar GTP-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HLP8_LEIBR

TriTrypDb:

LbrM.33.2140 , LBRM2903_330027900

Length:

652

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HLP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLP8

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0022613	ribonucleoprotein complex biogenesis	4	12
GO:0042254	ribosome biogenesis	5	11
GO:0044085	cellular component biogenesis	3	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0042273	ribosomal large subunit biogenesis	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0003924	GTPase activity	7	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	435	439	PF00656	0.232
CLV_C14_Caspase3-7	536	540	PF00656	0.686
CLV_NRD_NRD_1	28	30	PF00675	0.232
CLV_NRD_NRD_1	396	398	PF00675	0.271
CLV_NRD_NRD_1	417	419	PF00675	0.269
CLV_NRD_NRD_1	473	475	PF00675	0.548
CLV_NRD_NRD_1	49	51	PF00675	0.232
CLV_NRD_NRD_1	511	513	PF00675	0.470
CLV_NRD_NRD_1	546	548	PF00675	0.648
CLV_NRD_NRD_1	621	623	PF00675	0.588
CLV_PCSK_FUR_1	394	398	PF00082	0.488
CLV_PCSK_KEX2_1	131	133	PF00082	0.232
CLV_PCSK_KEX2_1	394	396	PF00082	0.511
CLV_PCSK_KEX2_1	511	513	PF00082	0.470
CLV_PCSK_KEX2_1	525	527	PF00082	0.472
CLV_PCSK_KEX2_1	548	550	PF00082	0.558
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.232
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.566
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.558
CLV_PCSK_SKI1_1	116	120	PF00082	0.232
CLV_PCSK_SKI1_1	128	132	PF00082	0.103
CLV_PCSK_SKI1_1	137	141	PF00082	0.232
CLV_PCSK_SKI1_1	170	174	PF00082	0.296
CLV_PCSK_SKI1_1	204	208	PF00082	0.301
CLV_PCSK_SKI1_1	318	322	PF00082	0.317
CLV_PCSK_SKI1_1	490	494	PF00082	0.415
CLV_PCSK_SKI1_1	497	501	PF00082	0.394
CLV_PCSK_SKI1_1	50	54	PF00082	0.232
CLV_PCSK_SKI1_1	503	507	PF00082	0.421
CLV_PCSK_SKI1_1	605	609	PF00082	0.410
CLV_PCSK_SKI1_1	94	98	PF00082	0.232
CLV_Separin_Metazoa	391	395	PF03568	0.617
DEG_APCC_DBOX_1	131	139	PF00400	0.232
DOC_CKS1_1	221	226	PF01111	0.275
DOC_CYCLIN_RxL_1	201	211	PF00134	0.297
DOC_CYCLIN_RxL_1	450	461	PF00134	0.456
DOC_CYCLIN_yCln2_LP_2	423	429	PF00134	0.150
DOC_MAPK_gen_1	188	196	PF00069	0.324
DOC_MAPK_gen_1	490	498	PF00069	0.417
DOC_MAPK_MEF2A_6	17	24	PF00069	0.232
DOC_PIKK_1	460	468	PF02985	0.535
DOC_PP1_RVXF_1	48	55	PF00149	0.247
DOC_PP1_RVXF_1	60	66	PF00149	0.247
DOC_USP7_MATH_1	343	347	PF00917	0.394
DOC_USP7_MATH_1	538	542	PF00917	0.658
DOC_USP7_MATH_1	568	572	PF00917	0.665
DOC_USP7_MATH_1	581	585	PF00917	0.639
DOC_USP7_UBL2_3	26	30	PF12436	0.247
DOC_USP7_UBL2_3	493	497	PF12436	0.439
DOC_USP7_UBL2_3	53	57	PF12436	0.232
DOC_WW_Pin1_4	220	225	PF00397	0.270
DOC_WW_Pin1_4	28	33	PF00397	0.232
DOC_WW_Pin1_4	363	368	PF00397	0.528
DOC_WW_Pin1_4	579	584	PF00397	0.491
LIG_14-3-3_CanoR_1	137	145	PF00244	0.232
LIG_14-3-3_CanoR_1	395	405	PF00244	0.249
LIG_14-3-3_CanoR_1	418	422	PF00244	0.268
LIG_14-3-3_CanoR_1	511	520	PF00244	0.546
LIG_14-3-3_CanoR_1	549	554	PF00244	0.543
LIG_14-3-3_CanoR_1	576	583	PF00244	0.591
LIG_14-3-3_CanoR_1	587	592	PF00244	0.506
LIG_Actin_WH2_2	103	121	PF00022	0.232
LIG_Actin_WH2_2	321	336	PF00022	0.450
LIG_Clathr_ClatBox_1	253	257	PF01394	0.232
LIG_Clathr_ClatBox_1	454	458	PF01394	0.372
LIG_DLG_GKlike_1	549	557	PF00625	0.555
LIG_FHA_1	169	175	PF00498	0.280
LIG_FHA_1	201	207	PF00498	0.309
LIG_FHA_1	215	221	PF00498	0.316
LIG_FHA_1	29	35	PF00498	0.232
LIG_FHA_1	320	326	PF00498	0.302
LIG_FHA_1	418	424	PF00498	0.232
LIG_FHA_1	573	579	PF00498	0.548
LIG_FHA_1	612	618	PF00498	0.579
LIG_FHA_1	62	68	PF00498	0.247
LIG_FHA_1	638	644	PF00498	0.463
LIG_FHA_1	7	13	PF00498	0.212
LIG_FHA_2	188	194	PF00498	0.321
LIG_FHA_2	294	300	PF00498	0.311
LIG_FHA_2	322	328	PF00498	0.330
LIG_FHA_2	397	403	PF00498	0.232
LIG_FHA_2	56	62	PF00498	0.232
LIG_Integrin_RGD_1	593	595	PF01839	0.611
LIG_LIR_Gen_1	113	120	PF02991	0.232
LIG_LIR_Gen_1	18	24	PF02991	0.233
LIG_LIR_Gen_1	216	226	PF02991	0.332
LIG_LIR_Gen_1	271	280	PF02991	0.205
LIG_LIR_Gen_1	352	363	PF02991	0.410
LIG_LIR_Nem_3	113	117	PF02991	0.232
LIG_LIR_Nem_3	175	180	PF02991	0.278
LIG_LIR_Nem_3	18	22	PF02991	0.234
LIG_LIR_Nem_3	216	221	PF02991	0.332
LIG_LIR_Nem_3	271	276	PF02991	0.232
LIG_LIR_Nem_3	352	358	PF02991	0.409
LIG_LIR_Nem_3	595	600	PF02991	0.452
LIG_MYND_1	631	635	PF01753	0.437
LIG_NRP_CendR_1	649	652	PF00754	0.471
LIG_PTB_Apo_2	357	364	PF02174	0.377
LIG_PTB_Phospho_1	357	363	PF10480	0.377
LIG_Rb_pABgroove_1	82	90	PF01858	0.232
LIG_SH2_CRK	355	359	PF00017	0.448
LIG_SH2_GRB2like	443	446	PF00017	0.247
LIG_SH2_NCK_1	443	447	PF00017	0.232
LIG_SH2_PTP2	114	117	PF00017	0.232
LIG_SH2_SRC	443	446	PF00017	0.244
LIG_SH2_STAT5	114	117	PF00017	0.255
LIG_SH2_STAT5	151	154	PF00017	0.232
LIG_SH2_STAT5	215	218	PF00017	0.419
LIG_SH2_STAT5	363	366	PF00017	0.376
LIG_SH2_STAT5	479	482	PF00017	0.512
LIG_SH3_3	370	376	PF00018	0.439
LIG_SUMO_SIM_anti_2	9	14	PF11976	0.253
LIG_SUMO_SIM_par_1	170	175	PF11976	0.276
LIG_SUMO_SIM_par_1	453	458	PF11976	0.391
LIG_TRAF2_1	230	233	PF00917	0.393
LIG_TRAF2_1	303	306	PF00917	0.361
LIG_TRAF2_1	311	314	PF00917	0.360
LIG_TRAF2_1	459	462	PF00917	0.469
LIG_TRAF2_1	555	558	PF00917	0.514
LIG_WW_3	391	395	PF00397	0.617
MOD_CDC14_SPxK_1	582	585	PF00782	0.454
MOD_CDK_SPxK_1	579	585	PF00069	0.461
MOD_CDK_SPxxK_3	363	370	PF00069	0.532
MOD_CK1_1	323	329	PF00069	0.321
MOD_CK1_1	571	577	PF00069	0.609
MOD_CK1_1	579	585	PF00069	0.551
MOD_CK2_1	227	233	PF00069	0.373
MOD_CK2_1	298	304	PF00069	0.342
MOD_CK2_1	55	61	PF00069	0.247
MOD_GlcNHglycan	146	149	PF01048	0.259
MOD_GlcNHglycan	257	261	PF01048	0.325
MOD_GlcNHglycan	350	354	PF01048	0.402
MOD_GlcNHglycan	539	543	PF01048	0.603
MOD_GlcNHglycan	553	556	PF01048	0.519
MOD_GlcNHglycan	563	567	PF01048	0.579
MOD_GlcNHglycan	578	581	PF01048	0.558
MOD_GSK3_1	157	164	PF00069	0.232
MOD_GSK3_1	168	175	PF00069	0.287
MOD_GSK3_1	24	31	PF00069	0.244
MOD_GSK3_1	268	275	PF00069	0.232
MOD_GSK3_1	319	326	PF00069	0.316
MOD_GSK3_1	564	571	PF00069	0.551
MOD_GSK3_1	572	579	PF00069	0.569
MOD_GSK3_1	581	588	PF00069	0.527
MOD_GSK3_1	607	614	PF00069	0.486
MOD_N-GLC_2	290	292	PF02516	0.329
MOD_NEK2_1	172	177	PF00069	0.269
MOD_NEK2_1	24	29	PF00069	0.238
MOD_NEK2_1	256	261	PF00069	0.236
MOD_NEK2_1	272	277	PF00069	0.232
MOD_NEK2_1	470	475	PF00069	0.467
MOD_NEK2_2	120	125	PF00069	0.232
MOD_PIKK_1	24	30	PF00454	0.232
MOD_PIKK_1	512	518	PF00454	0.534
MOD_PIKK_1	52	58	PF00454	0.232
MOD_PIKK_1	526	532	PF00454	0.426
MOD_PK_1	161	167	PF00069	0.232
MOD_PK_1	533	539	PF00069	0.678
MOD_PK_1	587	593	PF00069	0.538
MOD_PKA_1	396	402	PF00069	0.271
MOD_PKA_2	374	380	PF00069	0.459
MOD_PKA_2	386	392	PF00069	0.550
MOD_PKA_2	396	402	PF00069	0.245
MOD_PKA_2	417	423	PF00069	0.271
MOD_PKA_2	510	516	PF00069	0.494
MOD_PKB_1	394	402	PF00069	0.266
MOD_PKB_1	547	555	PF00069	0.549
MOD_PKB_1	562	570	PF00069	0.518
MOD_PKB_1	585	593	PF00069	0.522
MOD_Plk_1	227	233	PF00069	0.373
MOD_Plk_1	585	591	PF00069	0.541
MOD_Plk_2-3	293	299	PF00069	0.315
MOD_Plk_2-3	417	423	PF00069	0.232
MOD_Plk_2-3	477	483	PF00069	0.509
MOD_Plk_4	120	126	PF00069	0.232
MOD_Plk_4	181	187	PF00069	0.295
MOD_Plk_4	202	208	PF00069	0.301
MOD_Plk_4	268	274	PF00069	0.273
MOD_Plk_4	30	36	PF00069	0.232
MOD_Plk_4	374	380	PF00069	0.450
MOD_Plk_4	61	67	PF00069	0.375
MOD_ProDKin_1	220	226	PF00069	0.272
MOD_ProDKin_1	28	34	PF00069	0.232
MOD_ProDKin_1	363	369	PF00069	0.530
MOD_ProDKin_1	579	585	PF00069	0.491
MOD_SUMO_for_1	499	502	PF00179	0.445
MOD_SUMO_rev_2	327	336	PF00179	0.252
TRG_DiLeu_BaEn_2	373	379	PF01217	0.489
TRG_DiLeu_BaEn_2	486	492	PF01217	0.400
TRG_DiLeu_BaEn_2	60	66	PF01217	0.150
TRG_DiLeu_BaEn_4	460	466	PF01217	0.385
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.232
TRG_DiLeu_BaLyEn_6	450	455	PF01217	0.379
TRG_ENDOCYTIC_2	114	117	PF00928	0.232
TRG_ENDOCYTIC_2	16	19	PF00928	0.247
TRG_ENDOCYTIC_2	355	358	PF00928	0.449
TRG_ENDOCYTIC_2	443	446	PF00928	0.232
TRG_ENDOCYTIC_2	597	600	PF00928	0.480
TRG_ENDOCYTIC_2	80	83	PF00928	0.245
TRG_ER_diArg_1	393	396	PF00400	0.509
TRG_ER_diArg_1	510	512	PF00400	0.492
TRG_NLS_MonoExtC_3	546	551	PF00514	0.587
TRG_NLS_MonoExtN_4	545	552	PF00514	0.622
TRG_Pf-PMV_PEXEL_1	453	458	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	615	620	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE10	Leptomonas seymouri	93%	100%
A0A0S4IM98	Bodo saltans	79%	100%
A0A1X0P3L0	Trypanosomatidae	83%	100%
A0A3S5IQL0	Trypanosoma rangeli	81%	100%
A0A3S7X6S7	Leishmania donovani	96%	100%
A4I949	Leishmania infantum	95%	100%
D0A6C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	81%	100%
E9B423	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
G0S8F1	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	44%	99%
O44411	Caenorhabditis elegans	44%	96%
O94659	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	100%
Q02892	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	100%
Q4Q401	Leishmania major	96%	100%
Q54N72	Dictyostelium discoideum	47%	97%
Q6CM00	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	42%	100%
Q6FRV0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	43%	100%
Q74ZK6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	44%	100%
Q8SVJ8	Encephalitozoon cuniculi (strain GB-M1)	50%	100%
Q99ME9	Mus musculus	50%	100%
Q99P77	Rattus norvegicus	48%	100%
Q9BZE4	Homo sapiens	51%	100%
Q9C6I8	Arabidopsis thaliana	49%	97%
Q9U6A9	Trypanosoma brucei brucei	81%	100%
Q9V411	Drosophila melanogaster	48%	100%
V5BYN7	Trypanosoma cruzi	82%	100%