Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HLP6_LEIBR

TriTrypDb:

LbrM.33.2120 , LBRM2903_330027700

Length:

253

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLP6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.699
CLV_NRD_NRD_1	220	222	PF00675	0.372
CLV_NRD_NRD_1	24	26	PF00675	0.555
CLV_NRD_NRD_1	32	34	PF00675	0.500
CLV_PCSK_KEX2_1	220	222	PF00082	0.372
CLV_PCSK_KEX2_1	32	34	PF00082	0.497
CLV_PCSK_SKI1_1	32	36	PF00082	0.506
CLV_PCSK_SKI1_1	9	13	PF00082	0.536
DOC_CYCLIN_RxL_1	30	40	PF00134	0.394
DOC_CYCLIN_yCln2_LP_2	133	139	PF00134	0.512
DOC_MAPK_gen_1	192	199	PF00069	0.625
DOC_MAPK_MEF2A_6	228	236	PF00069	0.448
DOC_PP2B_LxvP_1	133	136	PF13499	0.502
DOC_PP4_FxxP_1	140	143	PF00568	0.515
DOC_USP7_MATH_1	67	71	PF00917	0.632
DOC_USP7_MATH_1	75	79	PF00917	0.608
DOC_WW_Pin1_4	139	144	PF00397	0.503
DOC_WW_Pin1_4	73	78	PF00397	0.784
LIG_APCC_ABBA_1	197	202	PF00400	0.527
LIG_BIR_II_1	1	5	PF00653	0.555
LIG_eIF4E_1	207	213	PF01652	0.534
LIG_FHA_1	101	107	PF00498	0.612
LIG_FHA_1	179	185	PF00498	0.469
LIG_FHA_1	239	245	PF00498	0.380
LIG_FHA_2	11	17	PF00498	0.414
LIG_LIR_Apic_2	138	143	PF02991	0.513
LIG_LIR_Gen_1	150	160	PF02991	0.565
LIG_LIR_Gen_1	179	188	PF02991	0.374
LIG_LIR_Nem_3	150	156	PF02991	0.529
LIG_LIR_Nem_3	179	185	PF02991	0.378
LIG_PTB_Apo_2	35	42	PF02174	0.485
LIG_PTB_Phospho_1	35	41	PF10480	0.480
LIG_SH2_CRK	52	56	PF00017	0.480
LIG_SH3_3	102	108	PF00018	0.811
LIG_SUMO_SIM_anti_2	183	190	PF11976	0.600
LIG_SUMO_SIM_anti_2	230	236	PF11976	0.338
LIG_SUMO_SIM_par_1	183	190	PF11976	0.562
LIG_UBA3_1	125	134	PF00899	0.487
LIG_WRC_WIRS_1	245	250	PF05994	0.616
MOD_CDC14_SPxK_1	142	145	PF00782	0.504
MOD_CDK_SPxK_1	139	145	PF00069	0.499
MOD_CK1_1	100	106	PF00069	0.672
MOD_CK1_1	176	182	PF00069	0.570
MOD_CK1_1	198	204	PF00069	0.648
MOD_CK1_1	214	220	PF00069	0.632
MOD_CK1_1	230	236	PF00069	0.326
MOD_CK1_1	70	76	PF00069	0.548
MOD_CK1_1	89	95	PF00069	0.690
MOD_CK2_1	10	16	PF00069	0.411
MOD_CK2_1	79	85	PF00069	0.537
MOD_GlcNHglycan	159	163	PF01048	0.634
MOD_GlcNHglycan	165	168	PF01048	0.632
MOD_GlcNHglycan	175	178	PF01048	0.519
MOD_GlcNHglycan	215	219	PF01048	0.380
MOD_GlcNHglycan	229	232	PF01048	0.446
MOD_GlcNHglycan	67	70	PF01048	0.671
MOD_GlcNHglycan	73	76	PF01048	0.696
MOD_GlcNHglycan	82	85	PF01048	0.691
MOD_GlcNHglycan	88	91	PF01048	0.697
MOD_GlcNHglycan	92	95	PF01048	0.723
MOD_GSK3_1	135	142	PF00069	0.474
MOD_GSK3_1	147	154	PF00069	0.422
MOD_GSK3_1	172	179	PF00069	0.676
MOD_GSK3_1	67	74	PF00069	0.676
MOD_GSK3_1	75	82	PF00069	0.683
MOD_GSK3_1	86	93	PF00069	0.697
MOD_N-GLC_1	171	176	PF02516	0.727
MOD_N-GLC_1	238	243	PF02516	0.592
MOD_NEK2_1	151	156	PF00069	0.542
MOD_NEK2_2	195	200	PF00069	0.505
MOD_PKA_2	100	106	PF00069	0.656
MOD_PKA_2	41	47	PF00069	0.522
MOD_Plk_1	214	220	PF00069	0.632
MOD_Plk_4	147	153	PF00069	0.463
MOD_Plk_4	195	201	PF00069	0.510
MOD_Plk_4	76	82	PF00069	0.529
MOD_ProDKin_1	139	145	PF00069	0.499
MOD_ProDKin_1	73	79	PF00069	0.784
TRG_ENDOCYTIC_2	152	155	PF00928	0.527
TRG_ENDOCYTIC_2	52	55	PF00928	0.475
TRG_ER_diArg_1	219	221	PF00400	0.376
TRG_ER_diArg_1	31	33	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P841	Leptomonas seymouri	58%	100%
A0A3S7X6W7	Leishmania donovani	74%	99%
A4I947	Leishmania infantum	74%	99%
E9B421	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
Q4Q403	Leishmania major	75%	98%