Dual-specificity kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dual-specificity protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HLP3_LEIBR

TriTrypDb:

LbrM.33.2090 , LBRM2903_330027300

Length:

951

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005856	cytoskeleton	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLP3

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018107	peptidyl-threonine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0018210	peptidyl-threonine modification	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0004712	protein serine/threonine/tyrosine kinase activity	4	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	480	484	PF00656	0.554
CLV_NRD_NRD_1	117	119	PF00675	0.385
CLV_NRD_NRD_1	313	315	PF00675	0.371
CLV_NRD_NRD_1	32	34	PF00675	0.455
CLV_NRD_NRD_1	533	535	PF00675	0.601
CLV_NRD_NRD_1	729	731	PF00675	0.634
CLV_NRD_NRD_1	753	755	PF00675	0.683
CLV_NRD_NRD_1	899	901	PF00675	0.530
CLV_PCSK_FUR_1	313	317	PF00082	0.385
CLV_PCSK_FUR_1	531	535	PF00082	0.699
CLV_PCSK_FUR_1	751	755	PF00082	0.542
CLV_PCSK_KEX2_1	313	315	PF00082	0.385
CLV_PCSK_KEX2_1	533	535	PF00082	0.601
CLV_PCSK_KEX2_1	729	731	PF00082	0.634
CLV_PCSK_KEX2_1	753	755	PF00082	0.683
CLV_PCSK_KEX2_1	899	901	PF00082	0.593
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.243
CLV_PCSK_PC7_1	529	535	PF00082	0.707
CLV_PCSK_SKI1_1	118	122	PF00082	0.385
CLV_PCSK_SKI1_1	176	180	PF00082	0.243
CLV_PCSK_SKI1_1	316	320	PF00082	0.385
CLV_PCSK_SKI1_1	360	364	PF00082	0.385
CLV_PCSK_SKI1_1	385	389	PF00082	0.450
CLV_PCSK_SKI1_1	495	499	PF00082	0.560
CLV_PCSK_SKI1_1	913	917	PF00082	0.649
CLV_PCSK_SKI1_1	933	937	PF00082	0.579
DEG_APCC_DBOX_1	753	761	PF00400	0.550
DOC_CKS1_1	941	946	PF01111	0.552
DOC_CYCLIN_yClb5_NLxxxL_5	164	173	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	557	563	PF00134	0.692
DOC_CYCLIN_yCln2_LP_2	854	860	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	909	912	PF00134	0.656
DOC_MAPK_FxFP_2	386	389	PF00069	0.593
DOC_MAPK_gen_1	153	160	PF00069	0.243
DOC_MAPK_gen_1	174	183	PF00069	0.343
DOC_MAPK_gen_1	751	760	PF00069	0.683
DOC_MAPK_HePTP_8	173	185	PF00069	0.243
DOC_MAPK_HePTP_8	244	256	PF00069	0.527
DOC_MAPK_MEF2A_6	176	185	PF00069	0.378
DOC_MAPK_MEF2A_6	192	199	PF00069	0.414
DOC_MAPK_MEF2A_6	247	256	PF00069	0.527
DOC_MAPK_MEF2A_6	836	843	PF00069	0.547
DOC_PP2B_LxvP_1	299	302	PF13499	0.385
DOC_PP2B_LxvP_1	466	469	PF13499	0.542
DOC_PP2B_LxvP_1	557	560	PF13499	0.663
DOC_PP2B_LxvP_1	673	676	PF13499	0.549
DOC_PP2B_LxvP_1	841	844	PF13499	0.544
DOC_PP2B_LxvP_1	854	857	PF13499	0.477
DOC_PP2B_LxvP_1	909	912	PF13499	0.656
DOC_PP4_FxxP_1	386	389	PF00568	0.593
DOC_PP4_FxxP_1	514	517	PF00568	0.567
DOC_USP7_MATH_1	389	393	PF00917	0.632
DOC_USP7_MATH_1	408	412	PF00917	0.504
DOC_USP7_MATH_1	428	432	PF00917	0.521
DOC_USP7_MATH_1	446	450	PF00917	0.529
DOC_USP7_MATH_1	459	463	PF00917	0.580
DOC_USP7_MATH_1	506	510	PF00917	0.629
DOC_USP7_MATH_1	551	555	PF00917	0.707
DOC_USP7_MATH_1	563	567	PF00917	0.605
DOC_USP7_MATH_1	635	639	PF00917	0.657
DOC_USP7_MATH_1	642	646	PF00917	0.692
DOC_USP7_MATH_1	724	728	PF00917	0.673
DOC_USP7_MATH_1	798	802	PF00917	0.622
DOC_USP7_MATH_1	844	848	PF00917	0.626
DOC_USP7_MATH_1	850	854	PF00917	0.558
DOC_USP7_UBL2_3	933	937	PF12436	0.581
DOC_WW_Pin1_4	369	374	PF00397	0.243
DOC_WW_Pin1_4	52	57	PF00397	0.510
DOC_WW_Pin1_4	581	586	PF00397	0.683
DOC_WW_Pin1_4	607	612	PF00397	0.605
DOC_WW_Pin1_4	640	645	PF00397	0.652
DOC_WW_Pin1_4	734	739	PF00397	0.703
DOC_WW_Pin1_4	763	768	PF00397	0.540
DOC_WW_Pin1_4	806	811	PF00397	0.594
DOC_WW_Pin1_4	835	840	PF00397	0.686
DOC_WW_Pin1_4	852	857	PF00397	0.502
DOC_WW_Pin1_4	940	945	PF00397	0.680
LIG_14-3-3_CanoR_1	192	198	PF00244	0.298
LIG_14-3-3_CanoR_1	487	492	PF00244	0.567
LIG_14-3-3_CanoR_1	531	541	PF00244	0.695
LIG_14-3-3_CanoR_1	660	669	PF00244	0.579
LIG_14-3-3_CanoR_1	706	716	PF00244	0.699
LIG_14-3-3_CanoR_1	886	896	PF00244	0.594
LIG_14-3-3_CanoR_1	918	922	PF00244	0.665
LIG_Actin_WH2_2	588	605	PF00022	0.558
LIG_APCC_ABBA_1	791	796	PF00400	0.693
LIG_BRCT_BRCA1_1	474	478	PF00533	0.546
LIG_BRCT_BRCA1_1	90	94	PF00533	0.385
LIG_CtBP_PxDLS_1	762	766	PF00389	0.542
LIG_deltaCOP1_diTrp_1	265	269	PF00928	0.385
LIG_EH1_1	142	150	PF00400	0.243
LIG_EVH1_2	302	306	PF00568	0.385
LIG_EVH1_2	856	860	PF00568	0.510
LIG_FHA_1	235	241	PF00498	0.243
LIG_FHA_1	621	627	PF00498	0.605
LIG_FHA_1	668	674	PF00498	0.668
LIG_FHA_1	684	690	PF00498	0.546
LIG_FHA_1	711	717	PF00498	0.569
LIG_FHA_1	941	947	PF00498	0.669
LIG_FHA_2	27	33	PF00498	0.448
LIG_FHA_2	327	333	PF00498	0.243
LIG_FHA_2	388	394	PF00498	0.564
LIG_FHA_2	439	445	PF00498	0.530
LIG_FHA_2	478	484	PF00498	0.567
LIG_FHA_2	627	633	PF00498	0.555
LIG_Integrin_isoDGR_2	524	526	PF01839	0.589
LIG_LIR_Apic_2	246	252	PF02991	0.385
LIG_LIR_Apic_2	297	301	PF02991	0.385
LIG_LIR_Apic_2	384	389	PF02991	0.585
LIG_LIR_Apic_2	784	788	PF02991	0.702
LIG_LIR_Gen_1	161	170	PF02991	0.428
LIG_LIR_Gen_1	239	249	PF02991	0.336
LIG_LIR_Gen_1	344	353	PF02991	0.328
LIG_LIR_Gen_1	354	363	PF02991	0.349
LIG_LIR_Gen_1	700	708	PF02991	0.562
LIG_LIR_Nem_3	161	165	PF02991	0.428
LIG_LIR_Nem_3	239	244	PF02991	0.259
LIG_LIR_Nem_3	265	269	PF02991	0.387
LIG_LIR_Nem_3	344	349	PF02991	0.328
LIG_LIR_Nem_3	352	358	PF02991	0.368
LIG_LIR_Nem_3	700	704	PF02991	0.584
LIG_LIR_Nem_3	855	861	PF02991	0.514
LIG_LIR_Nem_3	91	97	PF02991	0.385
LIG_MYND_1	464	468	PF01753	0.555
LIG_MYND_1	852	856	PF01753	0.662
LIG_NRP_CendR_1	950	951	PF00754	0.546
LIG_Pex14_2	358	362	PF04695	0.385
LIG_Pex14_2	94	98	PF04695	0.385
LIG_PTB_Apo_2	148	155	PF02174	0.385
LIG_SH2_CRK	143	147	PF00017	0.385
LIG_SH2_CRK	785	789	PF00017	0.701
LIG_SH2_CRK	858	862	PF00017	0.528
LIG_SH2_NCK_1	39	43	PF00017	0.310
LIG_SH2_PTP2	241	244	PF00017	0.243
LIG_SH2_SRC	241	244	PF00017	0.243
LIG_SH2_STAP1	39	43	PF00017	0.310
LIG_SH2_STAT3	44	47	PF00017	0.423
LIG_SH2_STAT5	172	175	PF00017	0.437
LIG_SH2_STAT5	241	244	PF00017	0.461
LIG_SH2_STAT5	298	301	PF00017	0.527
LIG_SH2_STAT5	71	74	PF00017	0.444
LIG_SH3_1	836	842	PF00018	0.547
LIG_SH3_2	422	427	PF14604	0.661
LIG_SH3_2	517	522	PF14604	0.562
LIG_SH3_3	278	284	PF00018	0.385
LIG_SH3_3	419	425	PF00018	0.653
LIG_SH3_3	50	56	PF00018	0.368
LIG_SH3_3	514	520	PF00018	0.685
LIG_SH3_3	538	544	PF00018	0.696
LIG_SH3_3	592	598	PF00018	0.561
LIG_SH3_3	605	611	PF00018	0.576
LIG_SH3_3	836	842	PF00018	0.580
LIG_SH3_3	846	852	PF00018	0.641
LIG_SH3_3	932	938	PF00018	0.690
LIG_SH3_3	941	947	PF00018	0.632
LIG_SUMO_SIM_anti_2	688	693	PF11976	0.619
LIG_SUMO_SIM_par_1	193	198	PF11976	0.385
LIG_SUMO_SIM_par_1	615	623	PF11976	0.600
LIG_SUMO_SIM_par_1	624	630	PF11976	0.598
LIG_SUMO_SIM_par_1	761	766	PF11976	0.545
LIG_TRAF2_1	124	127	PF00917	0.385
LIG_TYR_ITIM	160	165	PF00017	0.385
LIG_TYR_ITIM	37	42	PF00017	0.467
LIG_WRC_WIRS_1	355	360	PF05994	0.385
LIG_WW_2	839	842	PF00397	0.529
LIG_WW_3	910	914	PF00397	0.664
MOD_CDC14_SPxK_1	766	769	PF00782	0.536
MOD_CDK_SPK_2	369	374	PF00069	0.243
MOD_CDK_SPxK_1	763	769	PF00069	0.543
MOD_CDK_SPxxK_3	806	813	PF00069	0.511
MOD_CDK_SPxxK_3	852	859	PF00069	0.630
MOD_CK1_1	10	16	PF00069	0.430
MOD_CK1_1	234	240	PF00069	0.250
MOD_CK1_1	400	406	PF00069	0.679
MOD_CK1_1	431	437	PF00069	0.623
MOD_CK1_1	438	444	PF00069	0.568
MOD_CK1_1	584	590	PF00069	0.672
MOD_CK1_1	615	621	PF00069	0.550
MOD_CK1_1	702	708	PF00069	0.565
MOD_CK1_1	741	747	PF00069	0.691
MOD_CK1_1	832	838	PF00069	0.668
MOD_CK1_1	890	896	PF00069	0.580
MOD_CK1_1	939	945	PF00069	0.553
MOD_CK2_1	13	19	PF00069	0.501
MOD_CK2_1	26	32	PF00069	0.337
MOD_CK2_1	326	332	PF00069	0.246
MOD_CK2_1	369	375	PF00069	0.251
MOD_CK2_1	387	393	PF00069	0.520
MOD_CK2_1	438	444	PF00069	0.533
MOD_CK2_1	563	569	PF00069	0.711
MOD_CK2_1	635	641	PF00069	0.590
MOD_CK2_1	668	674	PF00069	0.548
MOD_GlcNHglycan	15	18	PF01048	0.414
MOD_GlcNHglycan	231	234	PF01048	0.385
MOD_GlcNHglycan	310	313	PF01048	0.385
MOD_GlcNHglycan	408	411	PF01048	0.680
MOD_GlcNHglycan	452	455	PF01048	0.640
MOD_GlcNHglycan	461	464	PF01048	0.627
MOD_GlcNHglycan	474	477	PF01048	0.615
MOD_GlcNHglycan	479	483	PF01048	0.623
MOD_GlcNHglycan	498	501	PF01048	0.539
MOD_GlcNHglycan	564	569	PF01048	0.678
MOD_GlcNHglycan	644	647	PF01048	0.610
MOD_GlcNHglycan	652	655	PF01048	0.603
MOD_GlcNHglycan	663	666	PF01048	0.650
MOD_GlcNHglycan	722	725	PF01048	0.702
MOD_GlcNHglycan	726	729	PF01048	0.665
MOD_GlcNHglycan	743	746	PF01048	0.525
MOD_GlcNHglycan	846	849	PF01048	0.678
MOD_GlcNHglycan	863	866	PF01048	0.489
MOD_GlcNHglycan	9	12	PF01048	0.601
MOD_GlcNHglycan	90	93	PF01048	0.385
MOD_GlcNHglycan	904	907	PF01048	0.537
MOD_GlcNHglycan	927	930	PF01048	0.567
MOD_GSK3_1	337	344	PF00069	0.243
MOD_GSK3_1	365	372	PF00069	0.243
MOD_GSK3_1	406	413	PF00069	0.640
MOD_GSK3_1	431	438	PF00069	0.631
MOD_GSK3_1	446	453	PF00069	0.515
MOD_GSK3_1	468	475	PF00069	0.601
MOD_GSK3_1	483	490	PF00069	0.567
MOD_GSK3_1	496	503	PF00069	0.580
MOD_GSK3_1	580	587	PF00069	0.666
MOD_GSK3_1	6	13	PF00069	0.471
MOD_GSK3_1	615	622	PF00069	0.642
MOD_GSK3_1	640	647	PF00069	0.730
MOD_GSK3_1	679	686	PF00069	0.678
MOD_GSK3_1	702	709	PF00069	0.617
MOD_GSK3_1	720	727	PF00069	0.622
MOD_GSK3_1	729	736	PF00069	0.660
MOD_GSK3_1	887	894	PF00069	0.538
MOD_GSK3_1	925	932	PF00069	0.630
MOD_GSK3_1	933	940	PF00069	0.670
MOD_N-GLC_1	406	411	PF02516	0.624
MOD_N-GLC_1	483	488	PF02516	0.564
MOD_N-GLC_1	551	556	PF02516	0.706
MOD_N-GLC_1	661	666	PF02516	0.571
MOD_N-GLC_1	925	930	PF02516	0.563
MOD_NEK2_1	104	109	PF00069	0.385
MOD_NEK2_1	185	190	PF00069	0.369
MOD_NEK2_1	193	198	PF00069	0.274
MOD_NEK2_1	498	503	PF00069	0.589
MOD_NEK2_1	575	580	PF00069	0.566
MOD_NEK2_1	619	624	PF00069	0.693
MOD_NEK2_1	7	12	PF00069	0.539
MOD_NEK2_1	861	866	PF00069	0.519
MOD_NEK2_2	410	415	PF00069	0.679
MOD_PIKK_1	365	371	PF00454	0.243
MOD_PIKK_1	387	393	PF00454	0.559
MOD_PIKK_1	416	422	PF00454	0.626
MOD_PIKK_1	711	717	PF00454	0.657
MOD_PIKK_1	768	774	PF00454	0.561
MOD_PKA_1	533	539	PF00069	0.601
MOD_PKA_1	729	735	PF00069	0.569
MOD_PKA_2	532	538	PF00069	0.611
MOD_PKA_2	711	717	PF00069	0.584
MOD_PKA_2	729	735	PF00069	0.530
MOD_PKA_2	917	923	PF00069	0.631
MOD_PKB_1	531	539	PF00069	0.693
MOD_PKB_1	720	728	PF00069	0.574
MOD_Plk_1	104	110	PF00069	0.385
MOD_Plk_1	483	489	PF00069	0.566
MOD_Plk_1	552	558	PF00069	0.621
MOD_Plk_1	699	705	PF00069	0.547
MOD_Plk_1	829	835	PF00069	0.674
MOD_Plk_1	890	896	PF00069	0.534
MOD_Plk_4	10	16	PF00069	0.412
MOD_Plk_4	104	110	PF00069	0.385
MOD_Plk_4	195	201	PF00069	0.350
MOD_Plk_4	236	242	PF00069	0.378
MOD_Plk_4	354	360	PF00069	0.385
MOD_Plk_4	431	437	PF00069	0.542
MOD_Plk_4	446	452	PF00069	0.512
MOD_Plk_4	668	674	PF00069	0.548
MOD_Plk_4	891	897	PF00069	0.533
MOD_Plk_4	917	923	PF00069	0.552
MOD_ProDKin_1	369	375	PF00069	0.243
MOD_ProDKin_1	52	58	PF00069	0.523
MOD_ProDKin_1	581	587	PF00069	0.679
MOD_ProDKin_1	607	613	PF00069	0.605
MOD_ProDKin_1	640	646	PF00069	0.651
MOD_ProDKin_1	734	740	PF00069	0.706
MOD_ProDKin_1	763	769	PF00069	0.543
MOD_ProDKin_1	806	812	PF00069	0.587
MOD_ProDKin_1	835	841	PF00069	0.686
MOD_ProDKin_1	852	858	PF00069	0.506
MOD_ProDKin_1	940	946	PF00069	0.680
MOD_SUMO_for_1	210	213	PF00179	0.385
MOD_SUMO_rev_2	136	142	PF00179	0.385
MOD_SUMO_rev_2	203	212	PF00179	0.385
MOD_SUMO_rev_2	232	240	PF00179	0.385
MOD_SUMO_rev_2	26	36	PF00179	0.311
MOD_SUMO_rev_2	392	397	PF00179	0.664
TRG_DiLeu_BaEn_2	350	356	PF01217	0.385
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.243
TRG_DiLeu_BaLyEn_6	461	466	PF01217	0.571
TRG_DiLeu_BaLyEn_6	944	949	PF01217	0.548
TRG_ENDOCYTIC_2	143	146	PF00928	0.414
TRG_ENDOCYTIC_2	162	165	PF00928	0.385
TRG_ENDOCYTIC_2	170	173	PF00928	0.311
TRG_ENDOCYTIC_2	241	244	PF00928	0.363
TRG_ENDOCYTIC_2	39	42	PF00928	0.455
TRG_ENDOCYTIC_2	83	86	PF00928	0.385
TRG_ENDOCYTIC_2	858	861	PF00928	0.531
TRG_ER_diArg_1	313	316	PF00400	0.385
TRG_ER_diArg_1	531	534	PF00400	0.703
TRG_Pf-PMV_PEXEL_1	380	384	PF00026	0.243

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6S4	Leishmania donovani	70%	99%
A4I978	Leishmania infantum	70%	99%
E9B419	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	99%
Q4Q405	Leishmania major	68%	100%