COesterase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLP1_LEIBR

TriTrypDb:

LbrM.33.2070 , LBRM2903_330027100

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLP1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.379
CLV_NRD_NRD_1	115	117	PF00675	0.379
CLV_NRD_NRD_1	119	121	PF00675	0.390
CLV_NRD_NRD_1	355	357	PF00675	0.391
CLV_PCSK_KEX2_1	115	117	PF00082	0.396
CLV_PCSK_SKI1_1	116	120	PF00082	0.373
CLV_PCSK_SKI1_1	3	7	PF00082	0.433
DEG_APCC_KENBOX_2	208	212	PF00400	0.497
DOC_CKS1_1	240	245	PF01111	0.334
DOC_CYCLIN_yClb5_NLxxxL_5	163	172	PF00134	0.403
DOC_MAPK_FxFP_2	122	125	PF00069	0.463
DOC_MAPK_gen_1	356	362	PF00069	0.412
DOC_PP4_FxxP_1	122	125	PF00568	0.513
DOC_USP7_MATH_1	233	237	PF00917	0.416
DOC_USP7_MATH_1	78	82	PF00917	0.538
DOC_WW_Pin1_4	239	244	PF00397	0.420
LIG_14-3-3_CanoR_1	120	125	PF00244	0.445
LIG_14-3-3_CanoR_1	234	243	PF00244	0.439
LIG_APCC_ABBA_1	14	19	PF00400	0.347
LIG_BIR_II_1	1	5	PF00653	0.435
LIG_BRCT_BRCA1_1	189	193	PF00533	0.237
LIG_BRCT_BRCA1_1	216	220	PF00533	0.480
LIG_BRCT_BRCA1_1	237	241	PF00533	0.470
LIG_BRCT_BRCA1_1	321	325	PF00533	0.298
LIG_deltaCOP1_diTrp_1	186	193	PF00928	0.325
LIG_FHA_2	160	166	PF00498	0.363
LIG_FHA_2	32	38	PF00498	0.422
LIG_FHA_2	82	88	PF00498	0.389
LIG_HP1_1	233	237	PF01393	0.385
LIG_KLC1_Yacidic_2	83	87	PF13176	0.258
LIG_LIR_Apic_2	119	125	PF02991	0.517
LIG_LIR_Apic_2	210	215	PF02991	0.486
LIG_LIR_Apic_2	238	243	PF02991	0.323
LIG_LIR_Apic_2	355	361	PF02991	0.459
LIG_LIR_Apic_2	73	78	PF02991	0.504
LIG_LIR_Apic_2	87	93	PF02991	0.276
LIG_LIR_Gen_1	147	157	PF02991	0.272
LIG_LIR_Gen_1	269	279	PF02991	0.334
LIG_LIR_Nem_3	105	111	PF02991	0.439
LIG_LIR_Nem_3	130	135	PF02991	0.465
LIG_LIR_Nem_3	146	152	PF02991	0.320
LIG_LIR_Nem_3	171	177	PF02991	0.404
LIG_LIR_Nem_3	186	191	PF02991	0.478
LIG_LIR_Nem_3	225	231	PF02991	0.331
LIG_LIR_Nem_3	269	274	PF02991	0.334
LIG_LIR_Nem_3	317	323	PF02991	0.430
LIG_LIR_Nem_3	47	51	PF02991	0.456
LIG_LIR_Nem_3	55	61	PF02991	0.398
LIG_LIR_Nem_3	81	85	PF02991	0.350
LIG_MLH1_MIPbox_1	237	241	PF16413	0.470
LIG_MLH1_MIPbox_1	321	325	PF16413	0.298
LIG_Pex14_1	58	62	PF04695	0.479
LIG_Pex14_2	170	174	PF04695	0.292
LIG_Pex14_2	241	245	PF04695	0.425
LIG_PTB_Apo_2	368	375	PF02174	0.289
LIG_REV1ctd_RIR_1	218	226	PF16727	0.425
LIG_SH2_CRK	132	136	PF00017	0.491
LIG_SH2_CRK	150	154	PF00017	0.214
LIG_SH2_CRK	358	362	PF00017	0.390
LIG_SH2_CRK	75	79	PF00017	0.377
LIG_SH2_CRK	90	94	PF00017	0.277
LIG_SH2_GRB2like	149	152	PF00017	0.258
LIG_SH2_NCK_1	150	154	PF00017	0.355
LIG_SH2_PTP2	212	215	PF00017	0.435
LIG_SH2_SRC	212	215	PF00017	0.435
LIG_SH2_SRC	85	88	PF00017	0.407
LIG_SH2_STAP1	321	325	PF00017	0.219
LIG_SH2_STAP1	82	86	PF00017	0.369
LIG_SH2_STAT5	212	215	PF00017	0.375
LIG_SH2_STAT5	228	231	PF00017	0.263
LIG_SH2_STAT5	240	243	PF00017	0.558
LIG_SH2_STAT5	281	284	PF00017	0.393
LIG_SH2_STAT5	358	361	PF00017	0.314
LIG_SH2_STAT5	373	376	PF00017	0.288
LIG_SH2_STAT5	85	88	PF00017	0.389
LIG_SH2_STAT5	90	93	PF00017	0.438
LIG_SH3_3	197	203	PF00018	0.419
LIG_SH3_3	66	72	PF00018	0.607
LIG_SUMO_SIM_par_1	336	342	PF11976	0.339
LIG_TRAF2_1	244	247	PF00917	0.329
LIG_WRC_WIRS_1	174	179	PF05994	0.323
MOD_CK1_1	179	185	PF00069	0.462
MOD_CK1_1	236	242	PF00069	0.459
MOD_CK1_1	333	339	PF00069	0.443
MOD_CK1_1	81	87	PF00069	0.385
MOD_CK2_1	159	165	PF00069	0.344
MOD_CK2_1	241	247	PF00069	0.529
MOD_CK2_1	97	103	PF00069	0.399
MOD_GlcNHglycan	180	184	PF01048	0.235
MOD_GlcNHglycan	200	203	PF01048	0.388
MOD_GlcNHglycan	216	219	PF01048	0.220
MOD_GlcNHglycan	264	267	PF01048	0.470
MOD_GlcNHglycan	75	78	PF01048	0.493
MOD_GSK3_1	116	123	PF00069	0.418
MOD_GSK3_1	235	242	PF00069	0.464
MOD_GSK3_1	262	269	PF00069	0.441
MOD_GSK3_1	81	88	PF00069	0.337
MOD_N-GLC_1	20	25	PF02516	0.358
MOD_NEK2_1	159	164	PF00069	0.335
MOD_NEK2_1	168	173	PF00069	0.325
MOD_NEK2_1	216	221	PF00069	0.447
MOD_NEK2_1	282	287	PF00069	0.401
MOD_NEK2_2	85	90	PF00069	0.426
MOD_PIKK_1	311	317	PF00454	0.547
MOD_PKA_1	120	126	PF00069	0.474
MOD_PKA_2	233	239	PF00069	0.404
MOD_PKA_2	7	13	PF00069	0.483
MOD_Plk_1	179	185	PF00069	0.359
MOD_Plk_1	20	26	PF00069	0.361
MOD_Plk_1	333	339	PF00069	0.358
MOD_Plk_4	20	26	PF00069	0.406
MOD_Plk_4	216	222	PF00069	0.411
MOD_Plk_4	236	242	PF00069	0.230
MOD_Plk_4	319	325	PF00069	0.359
MOD_Plk_4	333	339	PF00069	0.341
MOD_Plk_4	345	351	PF00069	0.349
MOD_Plk_4	81	87	PF00069	0.251
MOD_ProDKin_1	239	245	PF00069	0.414
TRG_DiLeu_BaEn_3	186	192	PF01217	0.262
TRG_ENDOCYTIC_2	132	135	PF00928	0.497
TRG_ENDOCYTIC_2	149	152	PF00928	0.260
TRG_ENDOCYTIC_2	320	323	PF00928	0.340
TRG_ENDOCYTIC_2	48	51	PF00928	0.433
TRG_ER_diArg_1	114	116	PF00400	0.468
TRG_ER_FFAT_2	236	246	PF00635	0.311
TRG_Pf-PMV_PEXEL_1	3	7	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM57	Leptomonas seymouri	69%	95%
A0A0S4JGX9	Bodo saltans	38%	100%
A0A1X0P3L5	Trypanosomatidae	48%	100%
A0A3Q8IME8	Leishmania donovani	85%	100%
A0A422N3E6	Trypanosoma rangeli	48%	97%
A4I976	Leishmania infantum	86%	100%
D0A6D2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B417	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q407	Leishmania major	85%	100%
V5BTX0	Trypanosoma cruzi	48%	100%