Macrophage migration inhibitory factor-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

macrophage migration inhibitory factor-like protein

Species:

Leishmania braziliensis

UniProt:

A4HLN6_LEIBR

TriTrypDb:

LbrM.33.2020 , LBRM2903_330026600

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLN6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	37	43	PF00089	0.672
CLV_NRD_NRD_1	119	121	PF00675	0.488
CLV_NRD_NRD_1	255	257	PF00675	0.733
CLV_PCSK_KEX2_1	119	121	PF00082	0.488
CLV_PCSK_KEX2_1	255	257	PF00082	0.733
CLV_PCSK_SKI1_1	101	105	PF00082	0.415
CLV_PCSK_SKI1_1	255	259	PF00082	0.686
DOC_MAPK_RevD_3	145	160	PF00069	0.358
DOC_PP2B_LxvP_1	249	252	PF13499	0.718
DOC_USP7_MATH_1	112	116	PF00917	0.612
DOC_USP7_MATH_1	184	188	PF00917	0.468
DOC_WW_Pin1_4	101	106	PF00397	0.423
DOC_WW_Pin1_4	238	243	PF00397	0.641
DOC_WW_Pin1_4	47	52	PF00397	0.715
LIG_14-3-3_CanoR_1	107	112	PF00244	0.511
LIG_BRCT_BRCA1_1	48	52	PF00533	0.752
LIG_deltaCOP1_diTrp_1	141	148	PF00928	0.653
LIG_FHA_1	172	178	PF00498	0.497
LIG_FHA_1	24	30	PF00498	0.671
LIG_FHA_1	9	15	PF00498	0.646
LIG_FHA_2	123	129	PF00498	0.507
LIG_FHA_2	239	245	PF00498	0.487
LIG_LIR_Nem_3	152	156	PF02991	0.442
LIG_NRP_CendR_1	256	259	PF00754	0.654
LIG_Pex14_2	207	211	PF04695	0.592
LIG_SH2_CRK	38	42	PF00017	0.783
LIG_SH2_NCK_1	6	10	PF00017	0.741
LIG_SH2_STAT5	122	125	PF00017	0.471
LIG_SH2_STAT5	57	60	PF00017	0.552
LIG_SH2_STAT5	72	75	PF00017	0.605
LIG_SH3_3	213	219	PF00018	0.480
LIG_SUMO_SIM_anti_2	212	218	PF11976	0.490
LIG_SUMO_SIM_par_1	93	100	PF11976	0.616
LIG_TYR_ITIM	36	41	PF00017	0.532
LIG_WW_3	104	108	PF00397	0.468
MOD_CDK_SPxK_1	101	107	PF00069	0.497
MOD_CK2_1	122	128	PF00069	0.485
MOD_CK2_1	238	244	PF00069	0.548
MOD_Cter_Amidation	157	160	PF01082	0.383
MOD_GlcNHglycan	115	118	PF01048	0.575
MOD_GlcNHglycan	182	185	PF01048	0.441
MOD_GlcNHglycan	186	189	PF01048	0.394
MOD_GlcNHglycan	226	229	PF01048	0.573
MOD_GSK3_1	122	129	PF00069	0.583
MOD_GSK3_1	171	178	PF00069	0.481
MOD_GSK3_1	180	187	PF00069	0.498
MOD_GSK3_1	20	27	PF00069	0.683
MOD_N-GLC_1	126	131	PF02516	0.525
MOD_NEK2_1	177	182	PF00069	0.420
MOD_NEK2_1	29	34	PF00069	0.682
MOD_NEK2_1	8	13	PF00069	0.737
MOD_NEK2_2	75	80	PF00069	0.580
MOD_PIKK_1	128	134	PF00454	0.577
MOD_PIKK_1	171	177	PF00454	0.556
MOD_PKA_2	106	112	PF00069	0.606
MOD_Plk_1	126	132	PF00069	0.500
MOD_ProDKin_1	101	107	PF00069	0.432
MOD_ProDKin_1	238	244	PF00069	0.637
MOD_ProDKin_1	47	53	PF00069	0.714
MOD_SUMO_rev_2	183	193	PF00179	0.433
MOD_SUMO_rev_2	27	32	PF00179	0.673
TRG_DiLeu_BaEn_1	244	249	PF01217	0.661
TRG_ENDOCYTIC_2	38	41	PF00928	0.783
TRG_ER_diArg_1	118	120	PF00400	0.515
TRG_ER_diArg_1	255	257	PF00400	0.683

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P844	Leptomonas seymouri	56%	68%
A0A3Q8IHJ6	Leishmania donovani	79%	96%
A4I972	Leishmania infantum	79%	96%
E9B413	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	96%
Q4Q411	Leishmania major	81%	100%